-
1
-
-
33845607123
-
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
-
Daniels M., et al. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 2006, 444:724-729.
-
(2006)
Nature
, vol.444
, pp. 724-729
-
-
Daniels, M.1
-
2
-
-
77953506249
-
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection
-
Juang J., et al. Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J. Exp. Med. 2010, 207:1223-1234.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1223-1234
-
-
Juang, J.1
-
3
-
-
27844541328
-
Modeling T cell antigen discrimination based on feedback control of digital ERK responses
-
Altan-Bonnet G., Germain R.N. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol. 2005, 3:e356.
-
(2005)
PLoS Biol.
, vol.3
-
-
Altan-Bonnet, G.1
Germain, R.N.2
-
4
-
-
79958213129
-
Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
-
Dushek O., et al. Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation. Sci. Signal. 2011, 4:ra39.
-
(2011)
Sci. Signal.
, vol.4
-
-
Dushek, O.1
-
5
-
-
0035286588
-
Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex
-
Kalergis A.M., et al. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat. Immunol. 2001, 2:229-234.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 229-234
-
-
Kalergis, A.M.1
-
6
-
-
77952712883
-
Fast on-rates allow short dwell time ligands to activate T cells
-
Govern C.C., et al. Fast on-rates allow short dwell time ligands to activate T cells. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:8724-8729.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 8724-8729
-
-
Govern, C.C.1
-
7
-
-
76949085272
-
Dependence of T cell antigen recognition on T cell receptor--peptide MHC confinement time
-
Aleksic M., et al. Dependence of T cell antigen recognition on T cell receptor--peptide MHC confinement time. Immunity 2010, 32:163-174.
-
(2010)
Immunity
, vol.32
, pp. 163-174
-
-
Aleksic, M.1
-
8
-
-
0029063148
-
Kinetic proofreading in T-cell receptor signal transduction
-
McKeithan T.W. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:5042-5046.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 5042-5046
-
-
McKeithan, T.W.1
-
9
-
-
0032968708
-
The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation
-
Germain R., Stefanová I. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu. Rev. Immunol. 1999, 17:467-522.
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 467-522
-
-
Germain, R.1
Stefanová, I.2
-
10
-
-
0035826696
-
Cooperative enhancement of specificity in a lattice of T cell receptors
-
Chan C., et al. Cooperative enhancement of specificity in a lattice of T cell receptors. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:5758-5763.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 5758-5763
-
-
Chan, C.1
-
11
-
-
0037338890
-
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
-
Stefanová I., et al. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat. Immunol. 2003, 4:248-254.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 248-254
-
-
Stefanová, I.1
-
12
-
-
73449105773
-
A role for rebinding in rapid and reliable T cell responses to antigen
-
Dushek O., et al. A role for rebinding in rapid and reliable T cell responses to antigen. PLoS Comput. Biol. 2009, 5:e1000578.
-
(2009)
PLoS Comput. Biol.
, vol.5
-
-
Dushek, O.1
-
13
-
-
84874632154
-
Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism
-
Francois P., et al. Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:E888-E897.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
-
-
Francois, P.1
-
14
-
-
0035108309
-
Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen
-
Fahmy T.M., et al. Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen. Immunity 2001, 14:135-143.
-
(2001)
Immunity
, vol.14
, pp. 135-143
-
-
Fahmy, T.M.1
-
15
-
-
36749092326
-
Memory in receptor-ligand-mediated cell adhesion
-
Zarnitsyna V.I., et al. Memory in receptor-ligand-mediated cell adhesion. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:18037-18042.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 18037-18042
-
-
Zarnitsyna, V.I.1
-
16
-
-
23944469458
-
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response
-
Schamel W.W., et al. Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. J. Exp. Med. 2005, 202:493-503.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 493-503
-
-
Schamel, W.W.1
-
17
-
-
33746011209
-
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
-
Varma R., et al. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 2006, 25:117-127.
-
(2006)
Immunity
, vol.25
, pp. 117-127
-
-
Varma, R.1
-
18
-
-
74049157769
-
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
-
Lillemeier B.F., et al. TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nat. Immunol. 2010, 11:90-96.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 90-96
-
-
Lillemeier, B.F.1
-
19
-
-
81955164142
-
Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor
-
Sherman E., et al. Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor. Immunity 2011, 35:705-720.
-
(2011)
Immunity
, vol.35
, pp. 705-720
-
-
Sherman, E.1
-
20
-
-
82955169510
-
Quantum dot fluorescence characterizes the nanoscale organization of T cell receptors for antigen
-
Boyle S., et al. Quantum dot fluorescence characterizes the nanoscale organization of T cell receptors for antigen. Biophys. J. 2011, 101:L57-L59.
-
(2011)
Biophys. J.
, vol.101
-
-
Boyle, S.1
-
21
-
-
80053132781
-
Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes
-
Kumar R., et al. Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes. Immunity 2011, 35:375-387.
-
(2011)
Immunity
, vol.35
, pp. 375-387
-
-
Kumar, R.1
-
22
-
-
36749064485
-
Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells
-
James J.R., et al. Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:17662-17667.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 17662-17667
-
-
James, J.R.1
-
23
-
-
69349092619
-
DySCo: quantitating associations of membrane proteins using two-color single-molecule tracking
-
Dunne P.D., et al. DySCo: quantitating associations of membrane proteins using two-color single-molecule tracking. Biophys. J. 2009, 97:L5-L7.
-
(2009)
Biophys. J.
, vol.97
-
-
Dunne, P.D.1
-
24
-
-
74049144148
-
Taking T cells beyond the diffraction limit
-
van der Merwe P.A., et al. Taking T cells beyond the diffraction limit. Nat. Immunol. 2010, 11:51-52.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 51-52
-
-
van der Merwe, P.A.1
-
25
-
-
0037331525
-
Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
-
Holler P.D., Kranz D.M. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity 2003, 18:255-264.
-
(2003)
Immunity
, vol.18
, pp. 255-264
-
-
Holler, P.D.1
Kranz, D.M.2
-
26
-
-
70249091519
-
The impact of TCR-binding properties and antigen presentation format on T cell responsiveness
-
Chervin A.S., et al. The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. J. Immunol. 2009, 183:1166-1178.
-
(2009)
J. Immunol.
, vol.183
, pp. 1166-1178
-
-
Chervin, A.S.1
-
27
-
-
77950809538
-
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
-
Huang J., et al. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. Nature 2010, 464:932-936.
-
(2010)
Nature
, vol.464
, pp. 932-936
-
-
Huang, J.1
-
28
-
-
77249114784
-
TCR peptide MHC interactions in situ show accelerated kinetics and increased affinity
-
Huppa J.B., et al. TCR peptide MHC interactions in situ show accelerated kinetics and increased affinity. Nature 2010, 463:963-967.
-
(2010)
Nature
, vol.463
, pp. 963-967
-
-
Huppa, J.B.1
-
29
-
-
84856020544
-
Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands
-
Robert P., et al. Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands. Biophys. J. 2012, 102:248-257.
-
(2012)
Biophys. J.
, vol.102
, pp. 248-257
-
-
Robert, P.1
-
30
-
-
78751683710
-
Late arrival: recruiting coreceptors to the T cell receptor complex
-
van der Merwe P.A., Cordoba S.P. Late arrival: recruiting coreceptors to the T cell receptor complex. Immunity 2011, 34:1-3.
-
(2011)
Immunity
, vol.34
, pp. 1-3
-
-
van der Merwe, P.A.1
Cordoba, S.P.2
-
31
-
-
55449138409
-
Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif
-
Xu C., et al. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell 2008, 135:702-713.
-
(2008)
Cell
, vol.135
, pp. 702-713
-
-
Xu, C.1
-
32
-
-
82755165363
-
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
-
Zhang H., et al. Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:19323-19328.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 19323-19328
-
-
Zhang, H.1
-
33
-
-
84874066474
-
Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?
-
van der Merwe P.A., et al. Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?. Front. Immunol. 2012, 3:29.
-
(2012)
Front. Immunol.
, vol.3
, pp. 29
-
-
van der Merwe, P.A.1
-
34
-
-
78751696945
-
Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination
-
Jiang N., et al. Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination. Immunity 2011, 34:13-23.
-
(2011)
Immunity
, vol.34
, pp. 13-23
-
-
Jiang, N.1
-
35
-
-
84860333171
-
Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells
-
Sage P.T., et al. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J. Immunol. 2012, 188:3686-3699.
-
(2012)
J. Immunol.
, vol.188
, pp. 3686-3699
-
-
Sage, P.T.1
-
36
-
-
84892165063
-
T cell antigen receptor activation and actin cytoskeleton remodeling
-
Kumari S., et al. T cell antigen receptor activation and actin cytoskeleton remodeling. Biochim. Biophys. Acta 2013, 1838:546-556.
-
(2013)
Biochim. Biophys. Acta
, vol.1838
, pp. 546-556
-
-
Kumari, S.1
-
37
-
-
28444449872
-
Effects of receptor clustering on ligand dissociation kinetics: theory and simulations
-
Gopalakrishnan M., et al. Effects of receptor clustering on ligand dissociation kinetics: theory and simulations. Biophys. J. 2005, 89:3686-3700.
-
(2005)
Biophys. J.
, vol.89
, pp. 3686-3700
-
-
Gopalakrishnan, M.1
-
38
-
-
22244467106
-
Serial rebinding of ligands to clustered receptors as exemplified by bacterial chemotaxis
-
Andrews S.S. Serial rebinding of ligands to clustered receptors as exemplified by bacterial chemotaxis. Phys. Biol. 2005, 2:111-122.
-
(2005)
Phys. Biol.
, vol.2
, pp. 111-122
-
-
Andrews, S.S.1
-
39
-
-
79960897879
-
Transforming binding affinities from three dimensions to two with application to cadherin clustering
-
Wu Y., et al. Transforming binding affinities from three dimensions to two with application to cadherin clustering. Nature 2011, 475:510-513.
-
(2011)
Nature
, vol.475
, pp. 510-513
-
-
Wu, Y.1
-
40
-
-
84863243912
-
Membrane clustering and the role of rebinding in biochemical signaling
-
Mugler A., et al. Membrane clustering and the role of rebinding in biochemical signaling. Biophys. J. 2012, 102:1069-1078.
-
(2012)
Biophys. J.
, vol.102
, pp. 1069-1078
-
-
Mugler, A.1
-
41
-
-
34447647655
-
Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist
-
Huse M., et al. Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity 2007, 27:76-88.
-
(2007)
Immunity
, vol.27
, pp. 76-88
-
-
Huse, M.1
-
42
-
-
84858759719
-
Mechanical modulation of receptor-ligand interactions at cell-cell interfaces
-
Allard J.F., et al. Mechanical modulation of receptor-ligand interactions at cell-cell interfaces. Biophys. J. 2012, 102:1265-1273.
-
(2012)
Biophys. J.
, vol.102
, pp. 1265-1273
-
-
Allard, J.F.1
|