Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions

Journal of Experimental Medicine

Volumn 192, Issue 4, 2000, Pages 495-505

  Grabovsky, Valentin ^a   Feigelson, Sara ^a   Chen, Chun ^a   Bleijs, Diederek A ^b   Peled, Amnon ^a   Cinamon, Guy ^a   Baleux, Francoise ^c   Arenzana Seisdenos, Fernando ^c   Lapidot, Tsvee ^a   Van Kooyk, Yvette ^b   Lobb, Roy R ^d   Alon, Ronen ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Unite d'Immunologie Virale   (France)

^d BIOGEN   (United States)

Author keywords

Adhesion; Chemokine; Endothelium; Integrin; Shear flow

Indexed keywords

BETA1 INTEGRIN; CHEMOKINE; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; LIGAND; VASCULAR CELL ADHESION MOLECULE 1; ALPHA CHEMOKINE; HOMING RECEPTOR; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA; VERY LATE ACTIVATION ANTIGEN 4;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; ENDOTHELIUM; FLOW; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; LEUKOCYTE MOTILITY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN AGGREGATION; SIGNAL TRANSDUCTION; CELL ADHESION; CELL CULTURE; CELL MOTION; CONFOCAL MICROSCOPY; CYTOLOGY; FLOW CYTOMETRY; GENETICS; LEUKOCYTE; METABOLISM; MICROSCOPY; PHYSIOLOGY; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

ANTIBODIES, MONOCLONAL; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINES, CXC; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRINS; LEUKOCYTES; MICROSCOPY, CONFOCAL; MICROSCOPY, VIDEO; RECEPTORS, LYMPHOCYTE HOMING; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0034698511     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.4.495     Document Type: Article

References (55)

1. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
2. Lymphocyte homing and homeostasis
3. Chemokines: Signal lamps for trafficking of T and B cells for development and effector function
4. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
5. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
6. + cells on vascular endothelium under shear flow
7. Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules
8. Biology of chemokine and classical chemoattractant receptors: Differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells
9. Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
10. Chemokines and the arrest of lymphocytes rolling under flow conditions
11. Molecular mechanisms of lymphocyte homing to peripheral lymph nodes
12. The pathophysiologic role of alpha 4 integrins in vivo
13. Adhesion and homing of blood-borne cells in bone marrow microvessels
14. Characterization of the cell surface heterodimer VLA-4 and related peptides
15. A direct binding assay for the vascular cell adhesion molecule-1 (VCAM1) interaction with alpha 4 integrins
16. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1
17. The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes
18. Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand
19. High affinity VLA-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow
20. Cytoplasmic tails of beta 1, beta 2, and beta 7 integrins differentially regulate LFA-1 function in K562 cells
21. Expression and functional characterization of a soluble form of vascular cell adhesion molecule 1
22. Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow
23. Regulation of the production of the RANTES chemokine by endothelial cells. Synergistic induction by IFN-gamma plus TNF-alpha and inhibition by IL-4 and IL-13
24. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
25. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
26. CCR5 is characteristic of Th1 lymphocytes
27. Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow
28. Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: Implications for transendothelial chemotaxis
29. Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: A juxtacrine system for adhesion and activation of neutrophils
30. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1 beta
31. Transcytosis and surface presentation of IL-8 by venular endothelial cells
32. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1
33. Measuring the lifetime of bonds made between surface-linked molecules
34. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
35. An automatic braking system that stabilizes leukocyte rolling by an increase in selectin bond number with shear
36. Isolation and characterization of cell lines with genetically distinct mutations downstream of protein kinase C that result in defective activation-dependent regulation of T cell integrin function
37. Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1
38. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins
39. Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis
40. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes
41. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways
42. Leukocyte polarization in cell migration and immune interactions
43. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
44. The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling
45. Phorbol ester modulation of integrin-mediated cell adhesion: A post receptor event
46. Affinity modulation of integrin alpha 5 beta 1: Regulation of the functional response by soluble fibronectin
47. Vascular cell adhesion molecule (VCAM)-1g fusion protein defines distinct affinity states of the very late antigen-4 (VLA-4) receptor
48. T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1
49. Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils
50. Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAd-CAM-1) under flow
51. α4 Integrins mediate lymphocyte attachment and rolling under physiologic flow
52. A central role for microvillous receptor presentation in leukocyte adhesion under flow
53. Presentation of integrins on leukocyte microvilli: A role for the extracellular domain in determining membrane localization
54. Integrin associated proteins
55. Role of primary and secondary capture for leukocyte accumulation in vivo