Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

Science

Volumn 344, Issue 6185, 2014, Pages

  Brooks, Andrew J ^a   Dai, Wei ^b   O'Mara, Megan L ^a   Abankwa, Daniel ^a   Chhabra, Yash ^a   Pelekanos, Rebecca A ^a   Gardon, Olivier ^a   Tunny, Kathryn A ^a   Blucher, Kristopher M ^a   Morton, Craig J ^c   Parker, Michael W ^c,d   Sierecki, Emma ^a   Gambin, Yann ^a   Gomez, Guillermo A ^a   Alexandrov, Kirill ^a   Wilson, Ian A ^e   Doxastakis, Manolis ^b   Mark, Alan E ^a   Waters, Michael J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF HOUSTON   (United States)

^c ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GROWTH HORMONE RECEPTOR; JANUS KINASE 2; LEUCINE ZIPPER PROTEIN; PROTEIN KINASE; PSEUDOKINASE; UNCLASSIFIED DRUG; JAK2 PROTEIN, HUMAN;

CRYSTAL STRUCTURE; ENZYME ACTIVITY; HORMONE; MEMBRANE; NUMERICAL MODEL; PROTEIN; SIGNALING;

ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; DIMERIZATION; DISULFIDE BOND; ENZYME ACTIVATION; ENZYME STRUCTURE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN MOTIF; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CYSTEINE; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; JANUS KINASE 2; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, SOMATOTROPIN;

EID: 84900432315     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1249783     Document Type: Article

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