CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

Journal of Experimental Medicine

Volumn 188, Issue 12, 1998, Pages 2301-2311

  Azzam, Hala S ^a   Grinberg, Alex ^a   Lui, Kin ^a   Shen, Howard ^a   Shores, Elizabeth W ^b   Love, Paul E ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

CD5; Development; Signal transduction; Thymocyte

Indexed keywords

CD4 ANTIGEN; CD5 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL SPECIFICITY; IMMUNOREGULATION; LIGAND BINDING; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ANIMALS; ANTIBODIES; ANTIGENS, CD; ANTIGENS, CD5; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; FEMALE; FLOW CYTOMETRY; GENE REARRANGEMENT, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); LYMPHOCYTE SUBSETS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; UP-REGULATION;

EID: 0032445491     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.12.2301     Document Type: Article

References (11)

1. Ledbetter, J.A., R.V. Rouse, H.S. Micklem, and L.A. Herzenberg. 1980. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens: two parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J. Exp. Med. 152:280-294.
2. Hayakawa, K., R.R. Hardy, D.R. Parks, and L.A. Herzenberg. 1983. The "Ly-1 B" cell subpopulation in normal, immunodefective, and autoimmune mice. J. Exp. Med. 157:202-218.
3. Fowlkes, B.J., L. Edison, B.J. Mathieson, and T.M. Chused. 1985. Early T lymphocytes: differentiation in vivo of adult intrathymic precursor cells. J. Exp. Med. 162:802-822.
4. Huang, H.J., N.H. Jones, J.L. Strominger, and L.A. Hertzenberg. 1987. Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5). Proc. Natl. Acad. Sci. USA. 84:204-208.
5. Van De Helde, H., I. Von Hoegen, W. Luo, J.R. Parnes, and K. Thielemans. 1991. The B-cell surface protein CD72/Lyb2 is the ligand for CD5. Nature. 351:662-665.
6. Biancone, L., M.A. Bowen, A. Lim, A. Aruffo, G. Andes, and I. Stamenkovic. 1996. Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes. J. Exp. Med. 184:811-819.
7. Thomas, M.L. 1995. Of ITAMs and ITIMs: turning on and off the B cell antigen receptor. J. Exp. Med. 181:1953-1956.
8. Davies, A.A., S.C. Ley, and M.J. Crumpton. 1992. CD5 is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex. Proc. Natl. Acad. Sci. USA. 89:6368-6372.
9. Beyers, A.D., L.L. Spruyt, and A.F. Williams. 1992. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. USA. 89:2945-2949.
10. fyn. Proc. Natl. Acad. Sci. USA. 89:9311-9315.
11. Pani, G., K.-D. Fischer, I. Mlinaric-Rascan, and K.A. Siminovitch. 1996. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J. Exp. Med. 184:839-852.