메뉴 건너뛰기




Volumn 53, Issue 5, 2016, Pages 2815-2825

SIRT1 and Neural Cell Fate Determination

Author keywords

Deacetylation; Differentiation; Neural stem cells; Neuron; SIRT1

Indexed keywords

MICRORNA; NOTCH RECEPTOR; PROTEIN P53; SIRTUIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1;

EID: 84927537778     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9158-6     Document Type: Review
Times cited : (35)

References (124)
  • 1
    • 84865274411 scopus 로고    scopus 로고
    • The neurobiology of sirtuins and their role in neurodegeneration
    • COI: 1:CAS:528:DC%2BC38XpsVOktrk%3D, PID: 22749331
    • Donmez G (2012) The neurobiology of sirtuins and their role in neurodegeneration. Trends Pharmacol Sci 33(9):494–501
    • (2012) Trends Pharmacol Sci , vol.33 , Issue.9 , pp. 494-501
    • Donmez, G.1
  • 2
    • 34547914840 scopus 로고    scopus 로고
    • Sirtuins: the ‘magnificent seven’, function, metabolism and longevity
    • COI: 1:CAS:528:DC%2BD2sXovFymurY%3D, PID: 17701476
    • Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, Auwerx J (2007) Sirtuins: the ‘magnificent seven’, function, metabolism and longevity. Ann Med 39(5):335–345
    • (2007) Ann Med , vol.39 , Issue.5 , pp. 335-345
    • Dali-Youcef, N.1    Lagouge, M.2    Froelich, S.3    Koehl, C.4    Schoonjans, K.5    Auwerx, J.6
  • 3
    • 79953043473 scopus 로고    scopus 로고
    • Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
    • COI: 1:CAS:528:DC%2BC3cXisVGktrs%3D, PID: 21364612
    • Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L et al (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1:e10
    • (2010) Cell Death Dis , vol.1 , pp. e10
    • Morselli, E.1    Maiuri, M.C.2    Markaki, M.3    Megalou, E.4    Pasparaki, A.5    Palikaras, K.6    Criollo, A.7    Galluzzi, L.8
  • 4
    • 0033887456 scopus 로고    scopus 로고
    • Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    • COI: 1:CAS:528:DC%2BD3cXkt1Kmurg%3D, PID: 10873683
    • Frye RA (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273(2):793–798
    • (2000) Biochem Biophys Res Commun , vol.273 , Issue.2 , pp. 793-798
    • Frye, R.A.1
  • 5
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • COI: 1:CAS:528:DC%2BD2cXmslags7c%3D, PID: 15189148
    • Blander G, Guarente L (2004) The Sir2 family of protein deacetylases. Annu Rev Biochem 73:417–435
    • (2004) Annu Rev Biochem , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 6
    • 84887999390 scopus 로고    scopus 로고
    • Brain activation of SIRT1: role in neuropathology
    • PID: 23615921, COI: 1:CAS:528:DC%2BC3sXhslelur%2FI
    • Paraíso AF, Mendes KL, Santos SH (2013) Brain activation of SIRT1: role in neuropathology. Mol Neurobiol 48(3):681–689
    • (2013) Mol Neurobiol , vol.48 , Issue.3 , pp. 681-689
    • Paraíso, A.F.1    Mendes, K.L.2    Santos, S.H.3
  • 7
    • 84863453769 scopus 로고    scopus 로고
    • SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
    • COI: 1:CAS:528:DC%2BC38XpvVWjur8%3D, PID: 22722849
    • Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S et al (2012) SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 487(7405):114–118
    • (2012) Nature , vol.487 , Issue.7405 , pp. 114-118
    • Barber, M.F.1    Michishita-Kioi, E.2    Xi, Y.3    Tasselli, L.4    Kioi, M.5    Moqtaderi, Z.6    Tennen, R.I.7    Paredes, S.8
  • 8
    • 4944245398 scopus 로고    scopus 로고
    • Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin
    • COI: 1:CAS:528:DC%2BD2cXptVKqtrw%3D, PID: 15469825
    • Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D (2004) Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin. Mol Cell 16(1):93–105
    • (2004) Mol Cell , vol.16 , Issue.1 , pp. 93-105
    • Vaquero, A.1    Scher, M.2    Lee, D.3    Erdjument-Bromage, H.4    Tempst, P.5    Reinberg, D.6
  • 9
    • 54249107873 scopus 로고    scopus 로고
    • The ups and downs of SIRT1
    • COI: 1:CAS:528:DC%2BD1cXhtlSgs7vJ, PID: 18805010
    • Kwon HS, Ott M (2008) The ups and downs of SIRT1. Trends Biochem Sci 33(11):517–525
    • (2008) Trends Biochem Sci , vol.33 , Issue.11 , pp. 517-525
    • Kwon, H.S.1    Ott, M.2
  • 10
    • 77149172855 scopus 로고    scopus 로고
    • SIRT2-mediated protein deacetylation: an emerging key regulator in brain physiology and pathology
    • COI: 1:CAS:528:DC%2BC3cXltFSksbc%3D, PID: 20004495
    • Harting K, Knöll B (2010) SIRT2-mediated protein deacetylation: an emerging key regulator in brain physiology and pathology. Eur J Cell Biol 89(2–3):262–269
    • (2010) Eur J Cell Biol , vol.89 , Issue.2-3 , pp. 262-269
    • Harting, K.1    Knöll, B.2
  • 11
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: insights into their biological function
    • COI: 1:CAS:528:DC%2BD2sXks1ansr4%3D, PID: 17447894
    • Michan S, Sinclair D (2007) Sirtuins in mammals: insights into their biological function. Biochem J 404(1):1–13
    • (2007) Biochem J , vol.404 , Issue.1 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 12
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: biological insights and disease relevance
    • COI: 1:CAS:528:DC%2BC3cXivFekt7c%3D, PID: 20078221
    • Haigis MC, Sinclair DA (2010) Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5:253–295
    • (2010) Annu Rev Pathol , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 13
    • 80052645243 scopus 로고    scopus 로고
    • Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
    • COI: 1:CAS:528:DC%2BC3MXhtFClsbvO, PID: 21826702
    • Guo W, Qian L, Zhang J, Zhang W, Morrison A, Hayes P, Wilson S, Chen T et al (2011) Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. J Neurosci Res 89(11):1723–1736
    • (2011) J Neurosci Res , vol.89 , Issue.11 , pp. 1723-1736
    • Guo, W.1    Qian, L.2    Zhang, J.3    Zhang, W.4    Morrison, A.5    Hayes, P.6    Wilson, S.7    Chen, T.8
  • 14
    • 84874815449 scopus 로고    scopus 로고
    • SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
    • COI: 1:CAS:528:DC%2BC3sXisVSlur0%3D, PID: 23404532
    • Saharan S, Jhaveri DJ, Bartlett PF (2013) SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. J Neurosci Res 91(5):642–659
    • (2013) J Neurosci Res , vol.91 , Issue.5 , pp. 642-659
    • Saharan, S.1    Jhaveri, D.J.2    Bartlett, P.F.3
  • 15
    • 84882665923 scopus 로고    scopus 로고
    • Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia
    • COI: 1:CAS:528:DC%2BC3sXht1Kgt7zK, PID: 23899523
    • Lee OH, Kim J, Kim JM, Lee H, Kim EH, Bae SK, Choi Y, Nam HS et al (2013) Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia. Biochem Biophys Res Commun 438(2):388–394
    • (2013) Biochem Biophys Res Commun , vol.438 , Issue.2 , pp. 388-394
    • Lee, O.H.1    Kim, J.2    Kim, J.M.3    Lee, H.4    Kim, E.H.5    Bae, S.K.6    Choi, Y.7    Nam, H.S.8
  • 16
    • 34250221512 scopus 로고    scopus 로고
    • Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase
    • COI: 1:CAS:528:DC%2BD2sXmsFykt7k%3D, PID: 17560549
    • Suzuki K, Koike T (2007) Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase. Biochem Biophys Res Commun 359(3):665–671
    • (2007) Biochem Biophys Res Commun , vol.359 , Issue.3 , pp. 665-671
    • Suzuki, K.1    Koike, T.2
  • 17
    • 84874709843 scopus 로고    scopus 로고
    • SIRT1 and SIRT2: emerging targets in neurodegeneration
    • COI: 1:CAS:528:DC%2BC3sXjsFKht7s%3D, PID: 23417962
    • Donmez G, Outeiro TF (2013) SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med 5(3):344–352
    • (2013) EMBO Mol Med , vol.5 , Issue.3 , pp. 344-352
    • Donmez, G.1    Outeiro, T.F.2
  • 18
    • 79952353862 scopus 로고    scopus 로고
    • Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture
    • COI: 1:CAS:528:DC%2BC3MXjtFejtbo%3D, PID: 21390294
    • Kim SH, Lu HF, Alano CC (2011) Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture. PLoS One 6(3):e14731
    • (2011) PLoS One , vol.6 , Issue.3 , pp. e14731
    • Kim, S.H.1    Lu, H.F.2    Alano, C.C.3
  • 19
    • 0346094379 scopus 로고    scopus 로고
    • Predominant expression of Sir2α, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain
    • COI: 1:CAS:528:DC%2BD2cXovVWg, PID: 14706864
    • Sakamoto J, Miura T, Shimamoto K, Horio Y (2004) Predominant expression of Sir2α, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain. FEBS Lett 556(1–3):281–286
    • (2004) FEBS Lett , vol.556 , Issue.1-3 , pp. 281-286
    • Sakamoto, J.1    Miura, T.2    Shimamoto, K.3    Horio, Y.4
  • 21
    • 77955344258 scopus 로고    scopus 로고
    • SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateralnuclei of the hypothalamus
    • COI: 1:CAS:528:DC%2BC3cXhtVahsrzI, PID: 20668205
    • Satoh A, Brace CS, Ben-Josef G, West T, Wozniak DF, Holtzman DM, Herzog ED, Imai S (2010) SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateralnuclei of the hypothalamus. J Neurosci 30(30):10220–10232
    • (2010) J Neurosci , vol.30 , Issue.30 , pp. 10220-10232
    • Satoh, A.1    Brace, C.S.2    Ben-Josef, G.3    West, T.4    Wozniak, D.F.5    Holtzman, D.M.6    Herzog, E.D.7    Imai, S.8
  • 23
    • 84874228973 scopus 로고    scopus 로고
    • The ways and means that fine tune Sirt1 activity
    • COI: 1:CAS:528:DC%2BC3sXit1yksbg%3D, PID: 23394938
    • Revollo JR, Li X (2013) The ways and means that fine tune Sirt1 activity. Trends Biochem Sci 38(3):160–167
    • (2013) Trends Biochem Sci , vol.38 , Issue.3 , pp. 160-167
    • Revollo, J.R.1    Li, X.2
  • 25
    • 84867880208 scopus 로고    scopus 로고
    • SIRT1 in metabolic syndrome: where to target matters
    • COI: 1:CAS:528:DC%2BC38Xht12lsbvM, PID: 22939883
    • Wang Y, Xu C, Liang Y, Vanhoutte PM (2012) SIRT1 in metabolic syndrome: where to target matters. Pharmacol Ther 136(3):305–318
    • (2012) Pharmacol Ther , vol.136 , Issue.3 , pp. 305-318
    • Wang, Y.1    Xu, C.2    Liang, Y.3    Vanhoutte, P.M.4
  • 26
    • 84858339102 scopus 로고    scopus 로고
    • Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment
    • COI: 1:CAS:528:DC%2BC38XjvFKrtLc%3D, PID: 22198152
    • Peled T, Shoham H, Aschengrau D, Yackoubov D, Frei G, Rosenheimer GN, Lerrer B, Cohen HY et al (2012) Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment. Exp Hematol 40(4):342–355
    • (2012) Exp Hematol , vol.40 , Issue.4 , pp. 342-355
    • Peled, T.1    Shoham, H.2    Aschengrau, D.3    Yackoubov, D.4    Frei, G.5    Rosenheimer, G.N.6    Lerrer, B.7    Cohen, H.Y.8
  • 27
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • COI: 1:CAS:528:DC%2BD2cXisVGlt70%3D, PID: 14976264
    • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE et al (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303(5666):2011–2015
    • (2004) Science , vol.303 , Issue.5666 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3    Chua, K.F.4    Greer, P.L.5    Lin, Y.6    Tran, H.7    Ross, S.E.8
  • 28
    • 35349011726 scopus 로고    scopus 로고
    • Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
    • COI: 1:CAS:528:DC%2BD2sXhtlShtr7N, PID: 17964266
    • Kim EJ, Kho JH, Kang MR, Um SJ (2007) Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol Cell 28(2):277–290
    • (2007) Mol Cell , vol.28 , Issue.2 , pp. 277-290
    • Kim, E.J.1    Kho, J.H.2    Kang, M.R.3    Um, S.J.4
  • 29
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • COI: 1:CAS:528:DC%2BD2cXkvVeku7Y%3D, PID: 15152190
    • Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23(12):2369–2380
    • (2004) EMBO J , vol.23 , Issue.12 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7
  • 30
    • 84859480382 scopus 로고    scopus 로고
    • SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
    • COI: 1:CAS:528:DC%2BC38XlslShtrg%3D, PID: 21074897
    • Seo JS, Moon MH, Jeong JK, Seol JW, Lee YJ, Park BH, Park SY (2012) SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death. Neurobiol Aging 33(6):1110–1120
    • (2012) Neurobiol Aging , vol.33 , Issue.6 , pp. 1110-1120
    • Seo, J.S.1    Moon, M.H.2    Jeong, J.K.3    Seol, J.W.4    Lee, Y.J.5    Park, B.H.6    Park, S.Y.7
  • 31
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • COI: 1:CAS:528:DC%2BD2cXhvVKru7s%3D, PID: 14980222
    • Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M et al (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116(4):551–563
    • (2004) Cell , vol.116 , Issue.4 , pp. 551-563
    • Motta, M.C.1    Divecha, N.2    Lemieux, M.3    Kamel, C.4    Chen, D.5    Gu, W.6    Bultsma, Y.7    McBurney, M.8
  • 32
    • 84869412264 scopus 로고    scopus 로고
    • Sirt1: def-eating senescence?
    • COI: 1:CAS:528:DC%2BC3sXhsFSgurY%3D, PID: 22983125
    • Fusco S, Maulucci G, Pani G (2012) Sirt1: def-eating senescence? Cell Cycle 11(22):4135–4146
    • (2012) Cell Cycle , vol.11 , Issue.22 , pp. 4135-4146
    • Fusco, S.1    Maulucci, G.2    Pani, G.3
  • 33
    • 84866314843 scopus 로고    scopus 로고
    • MicroRNA Regulation of SIRT1
    • COI: 1:CAS:528:DC%2BC38XmsFGqtro%3D, PID: 22479251
    • Yamakuchi M (2012) MicroRNA Regulation of SIRT1. Front Physiol 3:68
    • (2012) Front Physiol , vol.3 , pp. 68
    • Yamakuchi, M.1
  • 34
    • 78650843340 scopus 로고    scopus 로고
    • Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. 2(7):415–431, (Albany NY)
    • Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E (2010) miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) 2(7):415–431
    • (2010) Aging
  • 35
    • 77951225449 scopus 로고    scopus 로고
    • DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
    • COI: 1:CAS:528:DC%2BC3cXkvVGisbw%3D, PID: 20167603
    • Guo X, Williams JG, Schug TT, Li X (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem 285(17):13223–13232
    • (2010) J Biol Chem , vol.285 , Issue.17 , pp. 13223-13232
    • Guo, X.1    Williams, J.G.2    Schug, T.T.3    Li, X.4
  • 36
    • 79952124926 scopus 로고    scopus 로고
    • Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin1 (SIRT1)
    • COI: 1:CAS:528:DC%2BC3MXhslyjsb8%3D, PID: 21245319
    • Liu X, Wang D, Zhao Y, Tu B, Zheng Z, Wang L, Wang H, Gu W et al (2011) Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin1 (SIRT1). Proc Natl Acad Sci U S A 108(5):1925–1930
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.5 , pp. 1925-1930
    • Liu, X.1    Wang, D.2    Zhao, Y.3    Tu, B.4    Zheng, Z.5    Wang, L.6    Wang, H.7    Gu, W.8
  • 37
    • 35748962613 scopus 로고    scopus 로고
    • SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
    • COI: 1:CAS:528:DC%2BD2sXht1Cgu7fO, PID: 17934453
    • Yang Y, Fu W, Chen J, Olashaw N, Zhang X, Nicosia SV, Bhalla K, Bai W (2007) SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol 9(11):1253–1262
    • (2007) Nat Cell Biol , vol.9 , Issue.11 , pp. 1253-1262
    • Yang, Y.1    Fu, W.2    Chen, J.3    Olashaw, N.4    Zhang, X.5    Nicosia, S.V.6    Bhalla, K.7    Bai, W.8
  • 39
    • 84861461517 scopus 로고    scopus 로고
    • USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development
    • COI: 1:CAS:528:DC%2BC38Xmt1GrtLc%3D, PID: 22542455
    • Lin Z, Yang H, Kong Q, Li J, Lee SM, Gao B, Dong H, Wei J et al (2012) USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell 46(4):484–494
    • (2012) Mol Cell , vol.46 , Issue.4 , pp. 484-494
    • Lin, Z.1    Yang, H.2    Kong, Q.3    Li, J.4    Lee, S.M.5    Gao, B.6    Dong, H.7    Wei, J.8
  • 40
    • 84896739647 scopus 로고    scopus 로고
    • Small molecule SIRT1 activators for the treatment of aging and age-related diseases
    • COI: 1:CAS:528:DC%2BC2cXjsVWgurg%3D, PID: 24439680
    • Hubbard BP, Sinclair DA (2014) Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci 35(3):146–154
    • (2014) Trends Pharmacol Sci , vol.35 , Issue.3 , pp. 146-154
    • Hubbard, B.P.1    Sinclair, D.A.2
  • 41
    • 84855544817 scopus 로고    scopus 로고
    • Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets
    • PID: 22179319, COI: 1:CAS:528:DC%2BC3MXhs1eitr%2FL
    • Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q et al (2011) Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets. Nat Med 18(1):153–158
    • (2011) Nat Med , vol.18 , Issue.1 , pp. 153-158
    • Jiang, M.1    Wang, J.2    Fu, J.3    Du, L.4    Jeong, H.5    West, T.6    Xiang, L.7    Peng, Q.8
  • 42
    • 40849135481 scopus 로고    scopus 로고
    • The Sirtuin family: therapeutic targets to treat diseases of aging
    • COI: 1:CAS:528:DC%2BD1cXktFelsb4%3D, PID: 18282481
    • Milne JC, Denu JM (2008) The Sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 12(1):11–17
    • (2008) Curr Opin Chem Biol , vol.12 , Issue.1 , pp. 11-17
    • Milne, J.C.1    Denu, J.M.2
  • 43
    • 20444444649 scopus 로고    scopus 로고
    • Mechanism of human SIRT1 activation by resveratrol
    • COI: 1:CAS:528:DC%2BD2MXjsFOgtb8%3D, PID: 15749705
    • Borra MT, Smith BC, Denu JM (2005) Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 280(17):17187–17195
    • (2005) J Biol Chem , vol.280 , Issue.17 , pp. 17187-17195
    • Borra, M.T.1    Smith, B.C.2    Denu, J.M.3
  • 44
    • 36749087548 scopus 로고    scopus 로고
    • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXhtlKmtbrM, PID: 18046409
    • Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O et al (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450(7170):712–716
    • (2007) Nature , vol.450 , Issue.7170 , pp. 712-716
    • Milne, J.C.1    Lambert, P.D.2    Schenk, S.3    Carney, D.P.4    Smith, J.J.5    Gagne, D.J.6    Jin, L.7    Boss, O.8
  • 45
    • 15244355745 scopus 로고    scopus 로고
    • +Cosubstrate Specificity of a Sir2 Enzyme
    • COI: 1:CAS:528:DC%2BD2MXjt1Ghurg%3D, PID: 15780941
    • +Cosubstrate Specificity of a Sir2 Enzyme. Mol Cell 17(6):855–868
    • (2005) Mol Cell , vol.17 , Issue.6 , pp. 855-868
    • Avalos, J.L.1    Bever, K.M.2    Wolberger, C.3
  • 46
    • 34447317859 scopus 로고    scopus 로고
    • Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2
    • COI: 1:CAS:528:DC%2BD2sXnslSjtLY%3D, PID: 17516596
    • Gey C, Kyrylenko S, Hennig L, Nguyen LH, Buttner A, Pham HD, Giannis A (2007) Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew Chem Int Ed Engl 46(27):5219–5222
    • (2007) Angew Chem Int Ed Engl , vol.46 , Issue.27 , pp. 5219-5222
    • Gey, C.1    Kyrylenko, S.2    Hennig, L.3    Nguyen, L.H.4    Buttner, A.5    Pham, H.D.6    Giannis, A.7
  • 47
    • 77958126835 scopus 로고    scopus 로고
    • Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1
    • COI: 1:CAS:528:DC%2BC3cXhsVajs7%2FJ, PID: 20713551
    • Oh WK, Cho KB, Hien TT, Kim TH, Kim HS, Dao TT, Han HK, Kwon SM et al (2010) Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1. Mol Pharmacol 78(5):855–864
    • (2010) Mol Pharmacol , vol.78 , Issue.5 , pp. 855-864
    • Oh, W.K.1    Cho, K.B.2    Hien, T.T.3    Kim, T.H.4    Kim, H.S.5    Dao, T.T.6    Han, H.K.7    Kwon, S.M.8
  • 48
    • 65649111534 scopus 로고    scopus 로고
    • Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity
    • COI: 1:CAS:528:DC%2BD1MXjvFKltbo%3D, PID: 19419202
    • Medda F, Russell RJ, Higgins M, McCarthy AR, Campbell J, Slawin AM, Lane DP, Lain S et al (2009) Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity. J Med Chem 52(9):2673–2682
    • (2009) J Med Chem , vol.52 , Issue.9 , pp. 2673-2682
    • Medda, F.1    Russell, R.J.2    Higgins, M.3    McCarthy, A.R.4    Campbell, J.5    Slawin, A.M.6    Lane, D.P.7    Lain, S.8
  • 49
    • 77951697156 scopus 로고    scopus 로고
    • Identification of Tri- and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors
    • COI: 1:CAS:528:DC%2BC3cXlsVOltLY%3D, PID: 20391556
    • Rotili D, Tarantino D, Carafa V, Lara E, Meade S, Botta G, Nebbioso A, Schemies J et al (2010) Identification of Tri- and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors. ChemMedChem 5(5):674–677
    • (2010) ChemMedChem , vol.5 , Issue.5 , pp. 674-677
    • Rotili, D.1    Tarantino, D.2    Carafa, V.3    Lara, E.4    Meade, S.5    Botta, G.6    Nebbioso, A.7    Schemies, J.8
  • 50
    • 33645221885 scopus 로고    scopus 로고
    • Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage
    • COI: 1:CAS:528:DC%2BD28XjslaqsLs%3D, PID: 16354677
    • Solomon JM, Pasupuleti R, Xu L, McDonagh T, Curtis R, DiStefano PS, Huber LJ (2006) Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage. Mol Cell Biol 26(1):28–38
    • (2006) Mol Cell Biol , vol.26 , Issue.1 , pp. 28-38
    • Solomon, J.M.1    Pasupuleti, R.2    Xu, L.3    McDonagh, T.4    Curtis, R.5    DiStefano, P.S.6    Huber, L.J.7
  • 51
    • 84860371953 scopus 로고    scopus 로고
    • Epigenetic protein families: a new frontier for drug discovery
    • COI: 1:CAS:528:DC%2BC38XlsFWjsbs%3D, PID: 22498752
    • Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M (2012) Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov 11(5):384–400
    • (2012) Nat Rev Drug Discov , vol.11 , Issue.5 , pp. 384-400
    • Arrowsmith, C.H.1    Bountra, C.2    Fish, P.V.3    Lee, K.4    Schapira, M.5
  • 52
  • 53
    • 39749087530 scopus 로고    scopus 로고
    • SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
    • COI: 1:CAS:528:DC%2BD1cXjslegtr0%3D, PID: 18371449
    • Han MK, Song EK, Guo Y, Ou X, Mantel C, Broxmeyer HE (2008) SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2(3):241–251
    • (2008) Cell Stem Cell , vol.2 , Issue.3 , pp. 241-251
    • Han, M.K.1    Song, E.K.2    Guo, Y.3    Ou, X.4    Mantel, C.5    Broxmeyer, H.E.6
  • 54
    • 84891823754 scopus 로고    scopus 로고
    • Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation
    • PID: 24038750, COI: 1:CAS:528:DC%2BC2cXksFSjtL4%3D
    • Zhang ZN, Chung SK, Xu Z, Xu Y (2014) Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation. Stem Cells 32(1):157–165
    • (2014) Stem Cells , vol.32 , Issue.1 , pp. 157-165
    • Zhang, Z.N.1    Chung, S.K.2    Xu, Z.3    Xu, Y.4
  • 55
    • 84912060361 scopus 로고    scopus 로고
    • SIRT1 Directly Regulates SOX2 to Maintain Self-Renewal and Multipotency in Bone Marrow-Derived Mesenchymal Stem Cells
    • COI: 1:CAS:528:DC%2BC2MXosV2lsg%3D%3D, PID: 25132403
    • Yoon DS, Choi Y, Jang Y, Lee M, Choi WJ, Kim SH, Lee JW (2014) SIRT1 Directly Regulates SOX2 to Maintain Self-Renewal and Multipotency in Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells 32(12):3219–3231
    • (2014) Stem Cells , vol.32 , Issue.12 , pp. 3219-3231
    • Yoon, D.S.1    Choi, Y.2    Jang, Y.3    Lee, M.4    Choi, W.J.5    Kim, S.H.6    Lee, J.W.7
  • 56
    • 84875266606 scopus 로고    scopus 로고
    • SIRT1 Inhibits p53 but not NF-κB Transcriptional Activity during Differentiation of Mouse Embryonic Stem Cells into Embryoid Bodies
    • Lhee SJ, Song EK, Kim YR, Han MK (2012) SIRT1 Inhibits p53 but not NF-κB Transcriptional Activity during Differentiation of Mouse Embryonic Stem Cells into Embryoid Bodies. Int J Stem Cells 5(2):125–129
    • (2012) Int J Stem Cells , vol.5 , Issue.2 , pp. 125-129
    • Lhee, S.J.1    Song, E.K.2    Kim, Y.R.3    Han, M.K.4
  • 57
    • 84882395972 scopus 로고    scopus 로고
    • The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2)
    • COI: 1:CAS:528:DC%2BC3sXht1yiu73E, PID: 23760504
    • Sussman RT, Stanek TJ, Esteso P, Gearhart JD, Knudsen KE, McMahon SB (2013) The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2). J Biol Chem 288(33):24234–24246
    • (2013) J Biol Chem , vol.288 , Issue.33 , pp. 24234-24246
    • Sussman, R.T.1    Stanek, T.J.2    Esteso, P.3    Gearhart, J.D.4    Knudsen, K.E.5    McMahon, S.B.6
  • 58
    • 10944226097 scopus 로고    scopus 로고
    • Human embryonic stem cells as a model for early human development
    • PID: 15582547
    • Dvash T, Benvenisty N (2004) Human embryonic stem cells as a model for early human development. Best Pract Res Clin Obstet Gynaecol 18(6):929–940
    • (2004) Best Pract Res Clin Obstet Gynaecol , vol.18 , Issue.6 , pp. 929-940
    • Dvash, T.1    Benvenisty, N.2
  • 60
    • 0028907753 scopus 로고
    • Embryonic stem cells express neuronal properties in vitro
    • COI: 1:CAS:528:DyaK2MXltVSltbg%3D, PID: 7729574
    • Bain G, Kitchens D, Yao M, Huettner JE, Gottlieb DI (1995) Embryonic stem cells express neuronal properties in vitro. Dev Biol 168(2):342–357
    • (1995) Dev Biol , vol.168 , Issue.2 , pp. 342-357
    • Bain, G.1    Kitchens, D.2    Yao, M.3    Huettner, J.E.4    Gottlieb, D.I.5
  • 61
    • 0030601129 scopus 로고    scopus 로고
    • Retinoic Acid Promotes Neural and Represses Mesodermal Gene Expression in Mouse Embryonic Stem Cells in Culture
    • COI: 1:CAS:528:DyaK28XjvFCru74%3D, PID: 8687458
    • Bain G, Ray WJ, Yao M, Gottlieb DI (1996) Retinoic Acid Promotes Neural and Represses Mesodermal Gene Expression in Mouse Embryonic Stem Cells in Culture. Biochem Biophys Res Commun 223(3):691–694
    • (1996) Biochem Biophys Res Commun , vol.223 , Issue.3 , pp. 691-694
    • Bain, G.1    Ray, W.J.2    Yao, M.3    Gottlieb, D.I.4
  • 62
    • 84907983116 scopus 로고    scopus 로고
    • SIRT1-Mediated Deacetylation of CRABPII Regulates Cellular Retinoic Acid Signaling and Modulates Embryonic Stem Cell Differentiation
    • COI: 1:CAS:528:DC%2BC2cXhsVKntrjE, PID: 25155613
    • Tang S, Huang G, Fan W, Chen Y, Ward JM, Xu X, Xu Q, Kang A et al (2014) SIRT1-Mediated Deacetylation of CRABPII Regulates Cellular Retinoic Acid Signaling and Modulates Embryonic Stem Cell Differentiation. Mol Cell 55(6):843–855
    • (2014) Mol Cell , vol.55 , Issue.6 , pp. 843-855
    • Tang, S.1    Huang, G.2    Fan, W.3    Chen, Y.4    Ward, J.M.5    Xu, X.6    Xu, Q.7    Kang, A.8
  • 63
    • 84892586984 scopus 로고    scopus 로고
    • MicroRNA Profiling Reveals Distinct Mechanisms Governing Cardiac and Neural Lineage-Specification of Pluripotent Human Embryonic Stem Cells
    • PID: 23355957, COI: 1:CAS:528:DC%2BC2cXmvVCkur0%3D
    • Parsons XH (2012) MicroRNA Profiling Reveals Distinct Mechanisms Governing Cardiac and Neural Lineage-Specification of Pluripotent Human Embryonic Stem Cells. J Stem Cell Res Ther 2(3):124
    • (2012) J Stem Cell Res Ther , vol.2 , Issue.3 , pp. 124
    • Parsons, X.H.1
  • 64
    • 84866691285 scopus 로고    scopus 로고
    • Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways
    • COI: 1:CAS:528:DC%2BC38XhsVelsb%2FM, PID: 23029150
    • Lee YL, Peng Q, Fong SW, Chen AC, Lee KF, Ng EH, Nagy A, Yeung WS (2012) Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways. PLoS One 7(9):e45633
    • (2012) PLoS One , vol.7 , Issue.9 , pp. e45633
    • Lee, Y.L.1    Peng, Q.2    Fong, S.W.3    Chen, A.C.4    Lee, K.F.5    Ng, E.H.6    Nagy, A.7    Yeung, W.S.8
  • 65
    • 84904358531 scopus 로고    scopus 로고
    • Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells
    • COI: 1:CAS:528:DC%2BC2cXotFGntrY%3D, PID: 24832395
    • Hu B, Guo Y, Chen C, Li Q, Niu X, Guo S, Zhang A, Wang Y et al (2014) Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells. Cell Mol Neurobiol 34(6):905–912
    • (2014) Cell Mol Neurobiol , vol.34 , Issue.6 , pp. 905-912
    • Hu, B.1    Guo, Y.2    Chen, C.3    Li, Q.4    Niu, X.5    Guo, S.6    Zhang, A.7    Wang, Y.8
  • 66
    • 0036069639 scopus 로고    scopus 로고
    • Neural stem cells
    • PID: 12115869
    • Kennea NL, Mehmet H (2002) Neural stem cells. J Pathol 197(4):536–550
    • (2002) J Pathol , vol.197 , Issue.4 , pp. 536-550
    • Kennea, N.L.1    Mehmet, H.2
  • 67
    • 0032080116 scopus 로고    scopus 로고
    • Experience-induced neurogenesis in the senescent dentate gyrus
    • Kempermann G, Kuhn HG, Gage FH (1998) Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci 18(9):3206–3212
    • (1998) J Neurosci , vol.18 , Issue.9 , pp. 3206-3212
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 68
    • 0036266738 scopus 로고    scopus 로고
    • Regulation of adult hippocampal neurogenesis – implications for novel theories of major depression
    • PID: 12047492
    • Kempermann G (2002) Regulation of adult hippocampal neurogenesis – implications for novel theories of major depression. Bipolar Disord 4(1):17–33
    • (2002) Bipolar Disord , vol.4 , Issue.1 , pp. 17-33
    • Kempermann, G.1
  • 70
    • 84901236321 scopus 로고    scopus 로고
    • SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response
    • COI: 1:CAS:528:DC%2BC2cXosFahu78%3D, PID: 24435709
    • Liu DJ, Hammer D, Komlos D, Chen KY, Firestein BL, Liu AY (2014) SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response. J Cell Physiol 229(9):1224–1235
    • (2014) J Cell Physiol , vol.229 , Issue.9 , pp. 1224-1235
    • Liu, D.J.1    Hammer, D.2    Komlos, D.3    Chen, K.Y.4    Firestein, B.L.5    Liu, A.Y.6
  • 71
    • 84908638621 scopus 로고    scopus 로고
    • Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BC2cXhvVSnu7%2FJ, PID: 25459285
    • Joe IS, Jeong SG, Cho GW (2015) Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells. Neurosci Lett 584:97–102
    • (2015) Neurosci Lett , vol.584 , pp. 97-102
    • Joe, I.S.1    Jeong, S.G.2    Cho, G.W.3
  • 72
    • 84926609109 scopus 로고    scopus 로고
    • Dynamic expression and roles of Hes factors in neural development
    • COI: 1:CAS:528:DC%2BC2cXosFClt7k%3D, PID: 24850276
    • Kageyama R, Shimojo H, Imayoshi I (2015) Dynamic expression and roles of Hes factors in neural development. Cell Tissue Res 359(1):125–133
    • (2015) Cell Tissue Res , vol.359 , Issue.1 , pp. 125-133
    • Kageyama, R.1    Shimojo, H.2    Imayoshi, I.3
  • 73
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway: unfolding the activation mechanism
    • Kopan R, Ilagan MX (2009) The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137(2):216–233
    • (2009) Cell , vol.137 , Issue.2 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 74
    • 31444447881 scopus 로고    scopus 로고
    • Notch signalling in vertebrate neural development
    • COI: 1:CAS:528:DC%2BD28XlvV2quw%3D%3D, PID: 16429119
    • Louvi A, Artavanis-Tsakonas S (2006) Notch signalling in vertebrate neural development. Nat Rev Neurosci 7(2):93–102
    • (2006) Nat Rev Neurosci , vol.7 , Issue.2 , pp. 93-102
    • Louvi, A.1    Artavanis-Tsakonas, S.2
  • 75
    • 34248139757 scopus 로고    scopus 로고
    • The Hes gene family: repressors and oscillators that orchestrate embryogenesis
    • COI: 1:CAS:528:DC%2BD2sXlt1Oksr8%3D, PID: 17329370
    • Kageyama R, Ohtsuka T, Kobayashi T (2007) The Hes gene family: repressors and oscillators that orchestrate embryogenesis. Development 134(7):1243–1251
    • (2007) Development , vol.134 , Issue.7 , pp. 1243-1251
    • Kageyama, R.1    Ohtsuka, T.2    Kobayashi, T.3
  • 76
    • 0029595271 scopus 로고
    • Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
    • COI: 1:CAS:528:DyaK28XhvVynsg%3D%3D, PID: 8543157
    • Ishibashi M, Ang SL, Shiota K, Nakanishi S, Kageyama R, Guillemot F (1995) Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev 9(24):3136–3148
    • (1995) Genes Dev , vol.9 , Issue.24 , pp. 3136-3148
    • Ishibashi, M.1    Ang, S.L.2    Shiota, K.3    Nakanishi, S.4    Kageyama, R.5    Guillemot, F.6
  • 77
    • 0029977614 scopus 로고    scopus 로고
    • Mammalian hairy and Enhancer of Split Homolog 1 Regulates Differentiation of Retinal Neurons and Is Essential for Eye Morphogenesis
    • COI: 1:CAS:528:DyaK28XislCms7w%3D, PID: 8607991
    • Tomita K, Ishibashi M, Nakahara K, Ang SL, Nakanishi S, Guillemot F, Kageyama R (1996) Mammalian hairy and Enhancer of Split Homolog 1 Regulates Differentiation of Retinal Neurons and Is Essential for Eye Morphogenesis. Neuron 16(4):723–734
    • (1996) Neuron , vol.16 , Issue.4 , pp. 723-734
    • Tomita, K.1    Ishibashi, M.2    Nakahara, K.3    Ang, S.L.4    Nakanishi, S.5    Guillemot, F.6    Kageyama, R.7
  • 78
  • 80
    • 84870565938 scopus 로고    scopus 로고
    • BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
    • COI: 1:CAS:528:DC%2BC38Xhs1ymtrvJ, PID: 23160044
    • Tiberi L, van den Ameele J, Dimidschstein J, Piccirilli J, Gall D, Herpoel A, Bilheu A, Bonnefont J et al (2012) BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat Neurosci 15(12):1627–1635
    • (2012) Nat Neurosci , vol.15 , Issue.12 , pp. 1627-1635
    • Tiberi, L.1    van den Ameele, J.2    Dimidschstein, J.3    Piccirilli, J.4    Gall, D.5    Herpoel, A.6    Bilheu, A.7    Bonnefont, J.8
  • 81
    • 84919479487 scopus 로고    scopus 로고
    • A BCL6/BCOR/SIRT1 Complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signaling
    • COI: 1:CAS:528:DC%2BC2cXitFygsr7E, PID: 25490446
    • Tiberi L, Bonnefont J, van den Ameele J, Le Bon SD, Herpoel A, Bilheu A, Baron BW, Vanderhaeghen P (2014) A BCL6/BCOR/SIRT1 Complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signaling. Cancer Cell 26(6):797–812
    • (2014) Cancer Cell , vol.26 , Issue.6 , pp. 797-812
    • Tiberi, L.1    Bonnefont, J.2    van den Ameele, J.3    Le Bon, S.D.4    Herpoel, A.5    Bilheu, A.6    Baron, B.W.7    Vanderhaeghen, P.8
  • 82
    • 78651082584 scopus 로고    scopus 로고
    • Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells
    • PID: 20954243
    • Wang W, Osenbroch P, Skinnes R, Esbensen Y, Bjørås M, Eide L (2010) Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells. Stem Cells 28(12):2195–2204
    • (2010) Stem Cells , vol.28 , Issue.12 , pp. 2195-2204
    • Wang, W.1    Osenbroch, P.2    Skinnes, R.3    Esbensen, Y.4    Bjørås, M.5    Eide, L.6
  • 83
    • 79960022038 scopus 로고    scopus 로고
    • Mitochondrial DNA damage level determines neural stem cell differentiation fate
    • COI: 1:CAS:528:DC%2BC3MXoslCjsL8%3D, PID: 21715639
    • Wang W, Esbensen Y, Kunke D, Suganthan R, Rachek L, Bjørås M, Eide L (2011) Mitochondrial DNA damage level determines neural stem cell differentiation fate. J Neurosci 31(26):9746–9751
    • (2011) J Neurosci , vol.31 , Issue.26 , pp. 9746-9751
    • Wang, W.1    Esbensen, Y.2    Kunke, D.3    Suganthan, R.4    Rachek, L.5    Bjørås, M.6    Eide, L.7
  • 84
    • 84872501397 scopus 로고    scopus 로고
    • Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state
    • COI: 1:CAS:528:DC%2BC3sXjvVGjtA%3D%3D, PID: 23054678
    • Santos DM, Santos MM, Moreira R, Solá S, Rodrigues CM (2013) Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state. Mol Neurobiol 47(1):313–324
    • (2013) Mol Neurobiol , vol.47 , Issue.1 , pp. 313-324
    • Santos, D.M.1    Santos, M.M.2    Moreira, R.3    Solá, S.4    Rodrigues, C.M.5
  • 85
    • 34848818037 scopus 로고    scopus 로고
    • Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation
    • COI: 1:CAS:528:DC%2BD2sXhtFWkurnK, PID: 17873065
    • Sun G, Yu RT, Evans RM, Shi Y (2007) Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A 104(39):15282–15287
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.39 , pp. 15282-15287
    • Sun, G.1    Yu, R.T.2    Evans, R.M.3    Shi, Y.4
  • 86
    • 67650469708 scopus 로고    scopus 로고
    • Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
    • COI: 1:CAS:528:DC%2BD1MXos12lsb0%3D, PID: 19555662
    • Iwahara N, Hisahara S, Hayashi T, Horio Y (2009) Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX. Biochem Biophys Res Commun 386(4):671–675
    • (2009) Biochem Biophys Res Commun , vol.386 , Issue.4 , pp. 671-675
    • Iwahara, N.1    Hisahara, S.2    Hayashi, T.3    Horio, Y.4
  • 88
    • 0029793892 scopus 로고    scopus 로고
    • RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells
    • COI: 1:CAS:528:DyaK28Xks1Wntrc%3D, PID: 8801169
    • Horn V, Minucci S, Ogryzko VV, Adamson ED, Howard BH, Levin AA, Ozato K (1996) RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells. FASEB J 10(9):1071–1077
    • (1996) FASEB J , vol.10 , Issue.9 , pp. 1071-1077
    • Horn, V.1    Minucci, S.2    Ogryzko, V.V.3    Adamson, E.D.4    Howard, B.H.5    Levin, A.A.6    Ozato, K.7
  • 89
    • 0042818072 scopus 로고    scopus 로고
    • Nuclear Coactivator-62 kDa/Ski-interacting Protein Is a Nuclear Matrix-associated Coactivator That May Couple Vitamin D Receptor-mediated Transcription and RNA Splicing
    • COI: 1:CAS:528:DC%2BD3sXntVWqurY%3D, PID: 12840015
    • Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, MacDonald PN (2003) Nuclear Coactivator-62 kDa/Ski-interacting Protein Is a Nuclear Matrix-associated Coactivator That May Couple Vitamin D Receptor-mediated Transcription and RNA Splicing. J Biol Chem 278(37):35325–35336
    • (2003) J Biol Chem , vol.278 , Issue.37 , pp. 35325-35336
    • Zhang, C.1    Dowd, D.R.2    Staal, A.3    Gu, C.4    Lian, J.B.5    van Wijnen, A.J.6    Stein, G.S.7    MacDonald, P.N.8
  • 90
    • 77950364510 scopus 로고    scopus 로고
    • Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells
    • COI: 1:CAS:528:DC%2BC3cXitVSksro%3D, PID: 19934264
    • Kang MR, Lee SW, Um E, Kang HT, Hwang ES, Kim EJ, Um SJ (2010) Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells. Nucleic Acids Res 38(3):822–831
    • (2010) Nucleic Acids Res , vol.38 , Issue.3 , pp. 822-831
    • Kang, M.R.1    Lee, S.W.2    Um, E.3    Kang, H.T.4    Hwang, E.S.5    Kim, E.J.6    Um, S.J.7
  • 91
    • 84871259864 scopus 로고    scopus 로고
    • Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta)
    • COI: 1:CAS:528:DC%2BC38Xhslyks7zE, PID: 23105114
    • Yu S, Levi L, Siegel R, Noy N (2012) Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). J Biol Chem 287(50):42195–42205
    • (2012) J Biol Chem , vol.287 , Issue.50 , pp. 42195-42205
    • Yu, S.1    Levi, L.2    Siegel, R.3    Noy, N.4
  • 92
    • 0038076109 scopus 로고    scopus 로고
    • Negative Feedback Regulation of Dicer-Like1in Arabidopsis by microRNA-Guided mRNA Degradation
    • COI: 1:CAS:528:DC%2BD3sXjsVGlur8%3D, PID: 12725739
    • Xie Z, Kasschau KD, Carrington JC (2003) Negative Feedback Regulation of Dicer-Like1in Arabidopsis by microRNA-Guided mRNA Degradation. Curr Biol 13(9):784–789
    • (2003) Curr Biol , vol.13 , Issue.9 , pp. 784-789
    • Xie, Z.1    Kasschau, K.D.2    Carrington, J.C.3
  • 93
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • COI: 1:CAS:528:DC%2BD2MXhtleqsLs%3D, PID: 15685193
    • Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS et al (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433(7027):769–773
    • (2005) Nature , vol.433 , Issue.7027 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3    Grimson, A.4    Schelter, J.M.5    Castle, J.6    Bartel, D.P.7    Linsley, P.S.8
  • 94
    • 79961058496 scopus 로고    scopus 로고
    • miR-34a regulates mouse neural stem cell differentiation
    • COI: 1:CAS:528:DC%2BC3MXhtFWitLfM, PID: 21857907
    • Aranha MM, Santos DM, Sola S, Steer CJ, Rodrigues CM (2011) miR-34a regulates mouse neural stem cell differentiation. PLoS One 6(8):e21396
    • (2011) PLoS One , vol.6 , Issue.8 , pp. e21396
    • Aranha, M.M.1    Santos, D.M.2    Sola, S.3    Steer, C.J.4    Rodrigues, C.M.5
  • 95
    • 77949903674 scopus 로고    scopus 로고
    • MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors
    • COI: 1:CAS:528:DC%2BC3cXlt1Khtrw%3D, PID: 20362537
    • Delaloy C, Liu L, Lee JA, Su H, Shen F, Yang GY, Young WL, Ivey KN et al (2010) MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell 6(4):323–335
    • (2010) Cell Stem Cell , vol.6 , Issue.4 , pp. 323-335
    • Delaloy, C.1    Liu, L.2    Lee, J.A.3    Su, H.4    Shen, F.5    Yang, G.Y.6    Young, W.L.7    Ivey, K.N.8
  • 96
    • 67650084412 scopus 로고    scopus 로고
    • Caspases and p53 Modulate FOXO3A/Id1 Signaling During Mouse Neural Stem Cell Differentiation
    • COI: 1:CAS:528:DC%2BD1MXosFGgtL8%3D, PID: 19415678
    • Aranha MM, Solá S, Low WC, Steer CJ, Rodrigues CM (2009) Caspases and p53 Modulate FOXO3A/Id1 Signaling During Mouse Neural Stem Cell Differentiation. J Cell Biochem 107(4):748–758
    • (2009) J Cell Biochem , vol.107 , Issue.4 , pp. 748-758
    • Aranha, M.M.1    Solá, S.2    Low, W.C.3    Steer, C.J.4    Rodrigues, C.M.5
  • 97
    • 32244436592 scopus 로고    scopus 로고
    • p53 suppresses the self-renewal of adult neural stem cells
    • COI: 1:CAS:528:DC%2BD28XhsFamsrk%3D, PID: 16368933
    • Meletis K, Wirta V, Hede SM, Nistér M, Lundeberg J, Frisen J (2006) p53 suppresses the self-renewal of adult neural stem cells. Development 133(2):363–369
    • (2006) Development , vol.133 , Issue.2 , pp. 363-369
    • Meletis, K.1    Wirta, V.2    Hede, S.M.3    Nistér, M.4    Lundeberg, J.5    Frisen, J.6
  • 99
    • 84922529967 scopus 로고    scopus 로고
    • SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner
    • PID: 25096191
    • Lee JS, Park JR, Kwon OS, Lee TH, Nakano I, Miyoshi H, Chun KH, Park MJ et al (2015) SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner. Neuro Oncol 17(1):95–106
    • (2015) Neuro Oncol , vol.17 , Issue.1 , pp. 95-106
    • Lee, J.S.1    Park, J.R.2    Kwon, O.S.3    Lee, T.H.4    Nakano, I.5    Miyoshi, H.6    Chun, K.H.7    Park, M.J.8
  • 100
    • 84862105779 scopus 로고    scopus 로고
    • Divergent modulation of neuronal differentiation by caspase-2 and -9
    • COI: 1:CAS:528:DC%2BC38XnvFais7g%3D, PID: 22629307
    • Pistritto G, Papaleo V, Sanchez P, Ceci C, Barbaccia ML (2012) Divergent modulation of neuronal differentiation by caspase-2 and -9. PLoS One 7(5):e36002
    • (2012) PLoS One , vol.7 , Issue.5 , pp. e36002
    • Pistritto, G.1    Papaleo, V.2    Sanchez, P.3    Ceci, C.4    Barbaccia, M.L.5
  • 101
    • 21244485072 scopus 로고    scopus 로고
    • Human Motor Neuron Differentiation from Human Embryonic Stem Cells
    • COI: 1:CAS:528:DC%2BD2MXltlynsbg%3D, PID: 15969621
    • Shin SDS, Stice SL (2005) Human Motor Neuron Differentiation from Human Embryonic Stem Cells. Stem Cells Dev 14(3):266–269
    • (2005) Stem Cells Dev , vol.14 , Issue.3 , pp. 266-269
    • Shin, S.D.S.1    Stice, S.L.2
  • 102
    • 45849146018 scopus 로고    scopus 로고
    • Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules
    • COI: 1:CAS:528:DC%2BD1cXmtFKltLc%3D, PID: 18238853
    • Li XJ, Hu BY, Jones SA, Zhang YS, Lavaute T, Du ZW, Zhang SC (2008) Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells 26(4):886–893
    • (2008) Stem Cells , vol.26 , Issue.4 , pp. 886-893
    • Li, X.J.1    Hu, B.Y.2    Jones, S.A.3    Zhang, Y.S.4    Lavaute, T.5    Du, Z.W.6    Zhang, S.C.7
  • 103
    • 78651358721 scopus 로고    scopus 로고
    • Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
    • COI: 1:CAS:528:DC%2BC3MXntVWmsQ%3D%3D, PID: 21144831
    • Zhang Y, Wang J, Chen G, Fan D, Deng M (2011) Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells. Biochem Biophys Res Commun 404(2):610–614
    • (2011) Biochem Biophys Res Commun , vol.404 , Issue.2 , pp. 610-614
    • Zhang, Y.1    Wang, J.2    Chen, G.3    Fan, D.4    Deng, M.5
  • 104
    • 64549121554 scopus 로고    scopus 로고
    • Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
    • COI: 1:CAS:528:DC%2BD1MXjsFKgtL4%3D, PID: 19144721
    • Jacobs FM, van Erp S, van der Linden AJ, von Oerthel L, Burbach JP, Smidt MP (2009) Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development 136(4):531–540
    • (2009) Development , vol.136 , Issue.4 , pp. 531-540
    • Jacobs, F.M.1    van Erp, S.2    van der Linden, A.J.3    von Oerthel, L.4    Burbach, J.P.5    Smidt, M.P.6
  • 105
    • 84881523773 scopus 로고    scopus 로고
    • Nurr1 Represses Tyrosine Hydroxylase Expression via SIRT1 in Human Neural Stem Cells
    • COI: 1:CAS:528:DC%2BC3sXhtleru7rK, PID: 23977047
    • Kim TE, Seo JS, Yang JW, Kim MW, Kausar R, Joe E, Kim BY, Lee MA (2013) Nurr1 Represses Tyrosine Hydroxylase Expression via SIRT1 in Human Neural Stem Cells. PLoS One 8(8):e71469
    • (2013) PLoS One , vol.8 , Issue.8 , pp. e71469
    • Kim, T.E.1    Seo, J.S.2    Yang, J.W.3    Kim, M.W.4    Kausar, R.5    Joe, E.6    Kim, B.Y.7    Lee, M.A.8
  • 106
    • 62849090437 scopus 로고    scopus 로고
    • SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
    • COI: 1:CAS:528:DC%2BD1MXjslOqtLs%3D, PID: 19285077
    • Kim MJ, Ahn K, Park SH, Kang HJ, Jang BG, Oh SJ, Oh SM, Jeong YJ et al (2009) SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a. FEBS Lett 583(7):1183–1188
    • (2009) FEBS Lett , vol.583 , Issue.7 , pp. 1183-1188
    • Kim, M.J.1    Ahn, K.2    Park, S.H.3    Kang, H.J.4    Jang, B.G.5    Oh, S.J.6    Oh, S.M.7    Jeong, Y.J.8
  • 107
    • 0035997205 scopus 로고    scopus 로고
    • Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation
    • COI: 1:CAS:528:DC%2BD38XlvV2msLw%3D
    • Beuckmann CT, Yanagisawa M (2002) Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. J Mol Med (Berl) 80(6):329–342
    • (2002) J Mol Med (Berl) , vol.80 , Issue.6 , pp. 329-342
    • Beuckmann, C.T.1    Yanagisawa, M.2
  • 108
    • 84879063538 scopus 로고    scopus 로고
    • Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells
    • COI: 1:CAS:528:DC%2BC3sXpsFagsrY%3D, PID: 23625921
    • Hayakawa K, Hirosawa M, Tabei Y, Arai D, Tanaka S, Murakami N, Yagi S, Shiota K (2013) Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem 288(24):17099–17110
    • (2013) J Biol Chem , vol.288 , Issue.24 , pp. 17099-17110
    • Hayakawa, K.1    Hirosawa, M.2    Tabei, Y.3    Arai, D.4    Tanaka, S.5    Murakami, N.6    Yagi, S.7    Shiota, K.8
  • 109
    • 0036337504 scopus 로고    scopus 로고
    • Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma
    • COI: 1:CAS:528:DC%2BD38XitF2nsr8%3D, PID: 11830579
    • Barbieri AM, Broccoli V, Bovolenta P, Alfano G, Marchitiello A, Mocchetti C, Crippa L, Bulfone A et al (2002) Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma. Development 129(3):805–813
    • (2002) Development , vol.129 , Issue.3 , pp. 805-813
    • Barbieri, A.M.1    Broccoli, V.2    Bovolenta, P.3    Alfano, G.4    Marchitiello, A.5    Mocchetti, C.6    Crippa, L.7    Bulfone, A.8
  • 110
    • 52049096152 scopus 로고    scopus 로고
    • Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons
    • COI: 1:CAS:528:DC%2BD1cXhtVyksL3F, PID: 18753379
    • Hasegawa K, Yoshikawa K (2008) Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. J Neurosci 28(35):8772–8784
    • (2008) J Neurosci , vol.28 , Issue.35 , pp. 8772-8784
    • Hasegawa, K.1    Yoshikawa, K.2
  • 111
    • 84870319123 scopus 로고    scopus 로고
    • Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic functions
    • COI: 1:CAS:528:DC%2BC38Xhs1Kjs73F, PID: 23141968
    • Hayakawa N, Shiozaki M, Shibata M, Koike M, Uchiyama Y, Matsuura N, Gotow T (2013) Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic functions. Eur J Cell Biol 92(1):30–43
    • (2013) Eur J Cell Biol , vol.92 , Issue.1 , pp. 30-43
    • Hayakawa, N.1    Shiozaki, M.2    Shibata, M.3    Koike, M.4    Uchiyama, Y.5    Matsuura, N.6    Gotow, T.7
  • 112
    • 84888024761 scopus 로고    scopus 로고
    • Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells
    • COI: 1:CAS:528:DC%2BC3sXhvFOgs7bK, PID: 24183892
    • Fujino K, Ogura Y, Sato K, Nedachi T (2013) Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells. Neurosci Lett 557:148–153
    • (2013) Neurosci Lett , vol.557 , pp. 148-153
    • Fujino, K.1    Ogura, Y.2    Sato, K.3    Nedachi, T.4
  • 113
    • 84870052893 scopus 로고    scopus 로고
    • The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response and sustaining the mitochondrial biomass
    • PID: 20517466, COI: 1:CAS:528:DC%2BC3cXntVWntLs%3D
    • Uittenbogaard M, Baxter KK, Chiaramello A (2010) The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response and sustaining the mitochondrial biomass. ASN Neuro 2(2):e00034
    • (2010) ASN Neuro , vol.2 , Issue.2 , pp. e00034
    • Uittenbogaard, M.1    Baxter, K.K.2    Chiaramello, A.3
  • 115
    • 0037106145 scopus 로고    scopus 로고
    • Adult neurogenesis and neural stem cells of the central nervous system in mammals
    • COI: 1:CAS:528:DC%2BD38XntFGntLs%3D, PID: 12205667
    • Taupin P, Gage FH (2002) Adult neurogenesis and neural stem cells of the central nervous system in mammals. J Neurosci Res 69(6):745–749
    • (2002) J Neurosci Res , vol.69 , Issue.6 , pp. 745-749
    • Taupin, P.1    Gage, F.H.2
  • 117
    • 84919387678 scopus 로고    scopus 로고
    • SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
    • COI: 1:CAS:528:DC%2BC2MXitFOjurg%3D, PID: 25468938
    • Ma CY, Yao MJ, Zhai QW, Jiao JW, Yuan XB, Poo MM (2014) SIRT1 suppresses self-renewal of adult hippocampal neural stem cells. Development 141(24):4697–4709
    • (2014) Development , vol.141 , Issue.24 , pp. 4697-4709
    • Ma, C.Y.1    Yao, M.J.2    Zhai, Q.W.3    Jiao, J.W.4    Yuan, X.B.5    Poo, M.M.6
  • 119
    • 84878584955 scopus 로고    scopus 로고
    • Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
    • COI: 1:CAS:528:DC%2BC3sXntVeju7g%3D, PID: 23644469
    • Rafalski VA, Ho PP, Brett JO, Ucar D, Dugas JC, Pollina EA, Chow LM, Ibrahim A et al (2013) Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain. Nat Cell Biol 15(6):614–624
    • (2013) Nat Cell Biol , vol.15 , Issue.6 , pp. 614-624
    • Rafalski, V.A.1    Ho, P.P.2    Brett, J.O.3    Ucar, D.4    Dugas, J.C.5    Pollina, E.A.6    Chow, L.M.7    Ibrahim, A.8
  • 120
    • 84906922582 scopus 로고    scopus 로고
    • Pharmacological upregulation of PGC1alpha in oligodendrocytes: implications for Huntington’s Disease
    • COI: 1:CAS:528:DC%2BC3sXhslaqu7vK, PID: 25063433
    • Xiang Z, Krainc D (2013) Pharmacological upregulation of PGC1alpha in oligodendrocytes: implications for Huntington’s Disease. J Huntingtons Dis 2(1):101–105
    • (2013) J Huntingtons Dis , vol.2 , Issue.1 , pp. 101-105
    • Xiang, Z.1    Krainc, D.2
  • 121
    • 84878805127 scopus 로고    scopus 로고
    • Promoting myelination in an in vitro mouse model of the peripheral nervous system: the effect of wine ingredients
    • COI: 1:CAS:528:DC%2BC3sXhtVSkurfJ, PID: 23762469
    • Stettner M, Wolffram K, Mausberg AK, Albrecht P, Derksen A, Methner A, Dehmel T, Hartung HP et al (2013) Promoting myelination in an in vitro mouse model of the peripheral nervous system: the effect of wine ingredients. PLoS One 8(6):e66079
    • (2013) PLoS One , vol.8 , Issue.6 , pp. e66079
    • Stettner, M.1    Wolffram, K.2    Mausberg, A.K.3    Albrecht, P.4    Derksen, A.5    Methner, A.6    Dehmel, T.7    Hartung, H.P.8
  • 122
    • 84903276373 scopus 로고    scopus 로고
    • Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging
    • Stein LR, Imai S (2014) Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging. EMBO J 33(12):1321–1340
    • (2014) EMBO J , vol.33 , Issue.12 , pp. 1321-1340
    • Stein, L.R.1    Imai, S.2
  • 123
    • 84881286310 scopus 로고    scopus 로고
    • An Engraftable Human Embryonic Stem Cell Neuronal Lineage-Specific Derivative Retains Embryonic Chromatin Plasticity for Scale-Up CNS Regeneration
    • PID: 23542901, COI: 1:CAS:528:DC%2BC2cXmvFyru74%3D
    • Parsons XH (2012) An Engraftable Human Embryonic Stem Cell Neuronal Lineage-Specific Derivative Retains Embryonic Chromatin Plasticity for Scale-Up CNS Regeneration. J Regen Med Tissue Eng 1(1):3
    • (2012) J Regen Med Tissue Eng , vol.1 , Issue.1 , pp. 3
    • Parsons, X.H.1
  • 124
    • 84938898538 scopus 로고    scopus 로고
    • Embedding the Future of Regenerative Medicine into the Open Epigenomic Landscape of Pluripotent Human Embryonic Stem Cells
    • COI: 1:CAS:528:DC%2BC2MXlsVCnsLk%3D, PID: 25309947
    • Parsons XH (2013) Embedding the Future of Regenerative Medicine into the Open Epigenomic Landscape of Pluripotent Human Embryonic Stem Cells. Annu Res Rev Biol 3(4):323–349
    • (2013) Annu Res Rev Biol , vol.3 , Issue.4 , pp. 323-349
    • Parsons, X.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.