Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma

Development

Volumn 129, Issue 3, 2002, Pages 805-813

  Barbieri, Anna Marie ^a   Broccoli, Vania ^a   Bovolenta, Paola ^a   Alfano, Giovanna ^a   Marchitiello, Anna ^a   Mocchetti, Cristina ^a   Crippa, Luca ^a   Bulfone, Alessandro ^a   Marigo, Valeria ^a   Ballabio, Andrea ^a   Banfi, Sandro ^a  

^a TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

Author keywords

Coloboma; Eye development; Homeobox; Mouse; Optic fibres

Indexed keywords

HOMEODOMAIN PROTEIN; T BOX TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VAX2 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; COLOBOMA; CONTROLLED STUDY; EMBRYO; EYE DEVELOPMENT; GENE INACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; HOMEOBOX; HOMOZYGOSITY; MOLECULAR BIOLOGY; MOUSE; NERVE PROJECTION; NONHUMAN; OPTIC CHIASM; OPTIC NERVE FIBER; PHENOTYPE; PRIORITY JOURNAL; RETINA DEVELOPMENT; RETINA GANGLION CELL; XENOPUS;

ANIMALS; ANTIGENS, DIFFERENTIATION; AXONS; BODY PATTERNING; COLOBOMA; DNA-BINDING PROTEINS; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; HOMOZYGOTE; MICE; MICE, KNOCKOUT; OPTIC CHIASM; PAX2 TRANSCRIPTION FACTOR; PENETRANCE; PHENOTYPE; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPHB2; RETINA; RETINAL GANGLION CELLS; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTORS; VISUAL PATHWAYS; XENOPUS PROTEINS;

ANIMALIA; GALLUS GALLUS; MAMMALIA;

EID: 0036337504     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Drosophila-related expressed sequences
2. Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching
3. A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis
4. Congenital eye malformations: Clinical-epidemiological analysis of 1,124,654 consecutive births in Spain
5. The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain
6. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina
7. Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development
8. Expression and embryonic function of empty spiracles: A Drosophila homeo box gene with two patterning functions on the anterior-posterior axis of the embryo
9. The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney
10. The ephrins and Eph receptors in neural development
11. Dosage requirement of Pitx2 for development of multiple organs
12. Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development
13. Expression of T-box genes Tbx2-Tbx5 during chick organogenesis
14. Prenatal and postnatal development of retinogeniculate and retinocollicular projections in the mouse
15. Developmental determinants at the mammalian optic chiasm
16. Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system
17. Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain
18. Expression of winged helix genes, BF-1 and BF-2, define adjacent domains within the developing forebrain and retina
19. Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system
20. Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons
21. Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression
22. Tbx5 and the retinotectum projection
23. Ephrin-B regulates the Ipsilateral routing of retinal axons at the optic chiasm
24. Expression of the Vax family homeobox genes suggests multiple roles in eye development
25. Ocular colobomata
26. Expression pattern of the Kallmann syndrome gene in the olfactory system suggests a role in neuronal targeting
27. Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux
28. Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map
29. Nested expression fomains of four homeobox genes in developing rostral brain
30. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
31. Chemoaffinity in the orderly growth of nerve fiber patterns and connections
32. Distribution of cone photoreceptors in the mammalian retina
33. Pax2 contributes to inner ear patterning and optic nerve trajectory
34. Colobomatous microphthalmia, anophthalmia, and associated malformation syndromes
35. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
36. Multiple roles of EPH receptors and ephrins in neural development
37. Non-injection methods for the production of embryonic stem cell-embryo chimaeras
38. Visual projection map specified by topographic expression of transcription factors in the retina