SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner

Neuro-Oncology

Volumn 17, Issue 1, 2015, Pages 95-106

  Lee, Ji Seon ^a   Park, Jeong Rak ^a   Kwon, Ok Seon ^a   Lee, Tae Hee ^b   Nakano, Ichiro ^c   Miyoshi, Hiroyuki ^d   Chun, Kwang Hoon ^e   Park, Myung Jin ^f   Lee, Hong Jun ^g,h   Kim, Seung U ^g,h   Cha, Hyuk Jin ^a  

^a Sogang University   (South Korea)

^b Sejong University   (South Korea)

^c OHIO STATE UNIVERSITY   (United States)

^d RIKEN BIORESOURCE CENTER   (Japan)

^e Gachon University College of Medicine   (South Korea)

^f Korea Institute of Radiation and Medical Science   (South Korea)

^g Chung Ang University   (South Korea)

^h UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Glioma stem cells; H Ras; Human neural stem cell; P53; SIRT1

Indexed keywords

CASPASE 3; CD133 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; K RAS PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NESTIN; PROTEIN KINASE B; PROTEIN P53; SIRTUIN 1; TRANSCRIPTION FACTOR SOX2; SIRT1 PROTEIN, HUMAN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER STEM CELL; CARCINOGENICITY; CELL AGING; CELL DEATH; CELL DIFFERENTIATION; CELL GROWTH; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; GLIOMA CELL LINE; HUMAN; HUMAN CELL; MALE; MOUSE; NEURAL STEM CELL; NONHUMAN; PROTEIN ACETYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SENESCENCE; ANIMAL; BRAIN TUMOR; GLIOBLASTOMA; METABOLISM; NUDE MOUSE; TUMOR CELL LINE;

ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MALE; MICE, NUDE; NEOPLASTIC STEM CELLS; NEURAL STEM CELLS; SIRTUIN 1; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84922529967     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nou145     Document Type: Article

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