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Volumn 14, Issue 4, 2015, Pages 406-419

Role of the innate and adaptive immune responses in the course of multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; ANTIGEN RECOGNITION; ASTROCYTE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COMMUNITY; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE COURSE; DISEASE PREDISPOSITION; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; HUMAN; INNATE IMMUNITY; MACROPHAGE; MULTIPLE SCLEROSIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REVIEW; ANIMAL; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL (TOPIC); DISABLED PERSON; DISEASE MODEL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; IMMUNOLOGY; INCIDENCE; PATHOLOGY; PERIPHERAL NERVOUS SYSTEM; STATISTICS AND NUMERICAL DATA; T LYMPHOCYTE;

EID: 84926336855     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(14)70305-9     Document Type: Review
Times cited : (424)

References (148)
  • 1
    • 77950610036 scopus 로고    scopus 로고
    • The changing demographic pattern of multiple sclerosis epidemiology
    • Koch-Henriksen N, Sørensen PS The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol 2010, 9:520-532.
    • (2010) Lancet Neurol , vol.9 , pp. 520-532
    • Koch-Henriksen, N.1    Sørensen, P.S.2
  • 2
    • 80054757199 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis: current concepts and future perspectives
    • Buck D, Hemmer B Treatment of multiple sclerosis: current concepts and future perspectives. J Neurol 2011, 258:1747-1762.
    • (2011) J Neurol , vol.258 , pp. 1747-1762
    • Buck, D.1    Hemmer, B.2
  • 3
    • 67649404131 scopus 로고    scopus 로고
    • Blood monocytes: development, heterogeneity, and relationship with dendritic cells
    • Auffray C, Sieweke MH, Geissmann F Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 2009, 27:669-692.
    • (2009) Annu Rev Immunol , vol.27 , pp. 669-692
    • Auffray, C.1    Sieweke, M.H.2    Geissmann, F.3
  • 4
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray PJ, Wynn TA Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011, 11:723-737.
    • (2011) Nat Rev Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 6
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • Sica A, Mantovani A Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012, 122:787-795.
    • (2012) J Clin Invest , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 7
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F, Greter M, Leboeuf M, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010, 330:841-845.
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3
  • 8
    • 80053233055 scopus 로고    scopus 로고
    • Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    • Prinz M, Priller J, Sisodia SS, Ransohoff RM Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci 2011, 14:1227-1235.
    • (2011) Nat Neurosci , vol.14 , pp. 1227-1235
    • Prinz, M.1    Priller, J.2    Sisodia, S.S.3    Ransohoff, R.M.4
  • 9
    • 84893745524 scopus 로고    scopus 로고
    • Identification of a unique TGF-β-dependent molecular and functional signature in microglia
    • Butovsky O, Jedrychowski MP, Moore CS, et al. Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci 2014, 17:131-143.
    • (2014) Nat Neurosci , vol.17 , pp. 131-143
    • Butovsky, O.1    Jedrychowski, M.P.2    Moore, C.S.3
  • 10
    • 78149435065 scopus 로고    scopus 로고
    • The myeloid cells of the central nervous system parenchyma
    • Ransohoff RM, Cardona AE The myeloid cells of the central nervous system parenchyma. Nature 2010, 468:253-262.
    • (2010) Nature , vol.468 , pp. 253-262
    • Ransohoff, R.M.1    Cardona, A.E.2
  • 11
    • 84872176512 scopus 로고    scopus 로고
    • Microglia: new roles for the synaptic stripper
    • Kettenmann H, Kirchhoff F, Verkhratsky A Microglia: new roles for the synaptic stripper. Neuron 2013, 77:10-18.
    • (2013) Neuron , vol.77 , pp. 10-18
    • Kettenmann, H.1    Kirchhoff, F.2    Verkhratsky, A.3
  • 13
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 14
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos D, Grutzendler J, Yang G, et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005, 8:752-758.
    • (2005) Nat Neurosci , vol.8 , pp. 752-758
    • Davalos, D.1    Grutzendler, J.2    Yang, G.3
  • 15
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • Tremblay ME, Lowery RL, Majewska AK Microglial interactions with synapses are modulated by visual experience. PLoS Biol 2010, 8:e1000527.
    • (2010) PLoS Biol , vol.8 , pp. e1000527
    • Tremblay, M.E.1    Lowery, R.L.2    Majewska, A.K.3
  • 16
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli RC, Bolasco G, Pagani F, et al. Synaptic pruning by microglia is necessary for normal brain development. Science 2011, 333:1456-1458.
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1    Bolasco, G.2    Pagani, F.3
  • 17
    • 84894574217 scopus 로고    scopus 로고
    • Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
    • Parkhurst CN, Yang G, Ninan I, et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 2013, 155:1596-1609.
    • (2013) Cell , vol.155 , pp. 1596-1609
    • Parkhurst, C.N.1    Yang, G.2    Ninan, I.3
  • 18
    • 61949241207 scopus 로고    scopus 로고
    • T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides
    • Harkiolaki M, Holmes SL, Svendsen P, et al. T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides. Immunity 2009, 30:348-357.
    • (2009) Immunity , vol.30 , pp. 348-357
    • Harkiolaki, M.1    Holmes, S.L.2    Svendsen, P.3
  • 19
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 2001, 27:18-20.
    • (2001) Nat Genet , vol.27 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3
  • 20
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001, 27:20-21.
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 21
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012, 30:531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 22
    • 2142821465 scopus 로고    scopus 로고
    • Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease
    • Waldner H, Collins M, Kuchroo VK Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J Clin Invest 2004, 113:990-997.
    • (2004) J Clin Invest , vol.113 , pp. 990-997
    • Waldner, H.1    Collins, M.2    Kuchroo, V.K.3
  • 24
    • 0035348175 scopus 로고    scopus 로고
    • Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells
    • Kaech SM, Ahmed R Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol 2001, 2:415-422.
    • (2001) Nat Immunol , vol.2 , pp. 415-422
    • Kaech, S.M.1    Ahmed, R.2
  • 25
    • 0035348246 scopus 로고    scopus 로고
    • Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
    • van Stipdonk MJ, Lemmens EE, Schoenberger SP Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat Immunol 2001, 2:423-429.
    • (2001) Nat Immunol , vol.2 , pp. 423-429
    • van Stipdonk, M.J.1    Lemmens, E.E.2    Schoenberger, S.P.3
  • 27
    • 0021956416 scopus 로고
    • Antigen-specific interaction between T and B cells
    • Lanzavecchia A Antigen-specific interaction between T and B cells. Nature 1985, 314:537-539.
    • (1985) Nature , vol.314 , pp. 537-539
    • Lanzavecchia, A.1
  • 28
    • 42649124913 scopus 로고    scopus 로고
    • Not always the bad guys: B cells as regulators of autoimmune pathology
    • Fillatreau S, Gray D, Anderton SM Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol 2008, 8:391-397.
    • (2008) Nat Rev Immunol , vol.8 , pp. 391-397
    • Fillatreau, S.1    Gray, D.2    Anderton, S.M.3
  • 29
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • the International Multiple Sclerosis Genetics Consortium, the Wellcome Trust Case Control Consortium 2the Wellcome Trust Case Control Consortium 2
    • Sawcer S, Hellenthal G, Pirinen M, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011, 476:214-219. the International Multiple Sclerosis Genetics Consortium, the Wellcome Trust Case Control Consortium 2the Wellcome Trust Case Control Consortium 2.
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3
  • 30
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
    • the International Multiple Sclerosis Genetics Consortium (IMSGC), the Wellcome Trust Case Control Consortium 2 (WTCCC2)the Wellcome Trust Case Control Consortium 2 (WTCCC2), the International IBD Genetics Consortium (IIBDGC)the International IBD Genetics Consortium (IIBDGC)
    • Beecham AH, Patsopoulos NA, Xifara DK, et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 2013, 45:1353-1360. the International Multiple Sclerosis Genetics Consortium (IMSGC), the Wellcome Trust Case Control Consortium 2 (WTCCC2)the Wellcome Trust Case Control Consortium 2 (WTCCC2), the International IBD Genetics Consortium (IIBDGC)the International IBD Genetics Consortium (IIBDGC).
    • (2013) Nat Genet , vol.45 , pp. 1353-1360
    • Beecham, A.H.1    Patsopoulos, N.A.2    Xifara, D.K.3
  • 31
    • 84923326765 scopus 로고    scopus 로고
    • Genetic and epigenetic fine mapping of causal autoimmune disease variants
    • Farh KK-H, Marson A, Zhu J, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 2014, 518:337-343.
    • (2014) Nature , vol.518 , pp. 337-343
    • Farh, K.K.-H.1    Marson, A.2    Zhu, J.3
  • 32
    • 84900338300 scopus 로고    scopus 로고
    • Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
    • Raj T, Rothamel K, Mostafavi S, et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 2014, 344:519-523.
    • (2014) Science , vol.344 , pp. 519-523
    • Raj, T.1    Rothamel, K.2    Mostafavi, S.3
  • 33
    • 84865261493 scopus 로고    scopus 로고
    • TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    • Gregory AP, Dendrou CA, Attfield KE, et al. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature 2012, 488:508-511.
    • (2012) Nature , vol.488 , pp. 508-511
    • Gregory, A.P.1    Dendrou, C.A.2    Attfield, K.E.3
  • 34
    • 56349105544 scopus 로고    scopus 로고
    • Genetic epidemiology: the use of old and new tools for multiple sclerosis
    • Ramagopalan SV, Dyment DA, Ebers GC Genetic epidemiology: the use of old and new tools for multiple sclerosis. Trends Neurosci 2008, 31:645-652.
    • (2008) Trends Neurosci , vol.31 , pp. 645-652
    • Ramagopalan, S.V.1    Dyment, D.A.2    Ebers, G.C.3
  • 35
    • 21944448962 scopus 로고    scopus 로고
    • Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis
    • Cepok S, Rosche B, Grummel V, et al. Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis. Brain 2005, 128:1667-1676.
    • (2005) Brain , vol.128 , pp. 1667-1676
    • Cepok, S.1    Rosche, B.2    Grummel, V.3
  • 36
    • 77952921203 scopus 로고    scopus 로고
    • Primary infection with the Epstein-Barr virus and risk of multiple sclerosis
    • Levin LI, Munger KL, O'Reilly EJ, Falk KI, Ascherio A Primary infection with the Epstein-Barr virus and risk of multiple sclerosis. Ann Neurol 2010, 67:824-830.
    • (2010) Ann Neurol , vol.67 , pp. 824-830
    • Levin, L.I.1    Munger, K.L.2    O'Reilly, E.J.3    Falk, K.I.4    Ascherio, A.5
  • 37
    • 76449119260 scopus 로고    scopus 로고
    • Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis
    • Simon KC, Munger KL, Xing Yang, Ascherio A Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis. Mult Scler 2010, 16:133-138.
    • (2010) Mult Scler , vol.16 , pp. 133-138
    • Simon, K.C.1    Munger, K.L.2    Xing, Y.3    Ascherio, A.4
  • 39
    • 84865184750 scopus 로고    scopus 로고
    • A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers
    • Allen AC, Kelly S, Basdeo SA, et al. A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers. Mult Scler 2012, 18:1797-1800.
    • (2012) Mult Scler , vol.18 , pp. 1797-1800
    • Allen, A.C.1    Kelly, S.2    Basdeo, S.A.3
  • 40
    • 73549089256 scopus 로고    scopus 로고
    • Multiple sclerosis: distribution of inflammatory cells in newly forming lesions
    • Henderson AP, Barnett MH, Parratt JD, Prineas JW Multiple sclerosis: distribution of inflammatory cells in newly forming lesions. Ann Neurol 2009, 66:739-753.
    • (2009) Ann Neurol , vol.66 , pp. 739-753
    • Henderson, A.P.1    Barnett, M.H.2    Parratt, J.D.3    Prineas, J.W.4
  • 41
    • 77957275551 scopus 로고    scopus 로고
    • Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination
    • Sharma R, Fischer M-T, Bauer J, et al. Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination. Acta Neuropathol 2010, 120:223-236.
    • (2010) Acta Neuropathol , vol.120 , pp. 223-236
    • Sharma, R.1    Fischer, M.-T.2    Bauer, J.3
  • 42
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion
    • Barnett MH, Prineas JW Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol 2004, 55:458-468.
    • (2004) Ann Neurol , vol.55 , pp. 458-468
    • Barnett, M.H.1    Prineas, J.W.2
  • 43
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
    • Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000, 47:707-717.
    • (2000) Ann Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 44
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • Chang A, Tourtellotte WW, Rudick R, Trapp BD Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 2002, 346:165-173.
    • (2002) N Engl J Med , vol.346 , pp. 165-173
    • Chang, A.1    Tourtellotte, W.W.2    Rudick, R.3    Trapp, B.D.4
  • 45
    • 33845294412 scopus 로고    scopus 로고
    • Remyelination is extensive in a subset of multiple sclerosis patients
    • Patrikios P, Stadelmann C, Kutzelnigg A, et al. Remyelination is extensive in a subset of multiple sclerosis patients. Brain 2006, 129:3165-3172.
    • (2006) Brain , vol.129 , pp. 3165-3172
    • Patrikios, P.1    Stadelmann, C.2    Kutzelnigg, A.3
  • 47
    • 84869098364 scopus 로고    scopus 로고
    • Measurement and clinical effect of grey matter pathology in multiple sclerosis
    • Geurts JJ, Calabrese M, Fisher E, Rudick RA Measurement and clinical effect of grey matter pathology in multiple sclerosis. Lancet Neurol 2012, 11:1082-1092.
    • (2012) Lancet Neurol , vol.11 , pp. 1082-1092
    • Geurts, J.J.1    Calabrese, M.2    Fisher, E.3    Rudick, R.A.4
  • 48
    • 80052927697 scopus 로고    scopus 로고
    • Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis
    • Howell OW, Reeves CA, Nicholas R, et al. Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain 2011, 134:2755-2771.
    • (2011) Brain , vol.134 , pp. 2755-2771
    • Howell, O.W.1    Reeves, C.A.2    Nicholas, R.3
  • 49
    • 77956898047 scopus 로고    scopus 로고
    • Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis
    • Korn T, Mitsdoerffer M, Kuchroo VK Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis. Results Probl Cell Differ 2010, 51:43-74.
    • (2010) Results Probl Cell Differ , vol.51 , pp. 43-74
    • Korn, T.1    Mitsdoerffer, M.2    Kuchroo, V.K.3
  • 51
    • 0024213789 scopus 로고
    • Susceptibility to PLP-induced EAE is regulated by non-H-2 genes
    • Tuohy VK, Sobel RA, Lees MB Susceptibility to PLP-induced EAE is regulated by non-H-2 genes. Ann N Y Acad Sci 1988, 540:709-711.
    • (1988) Ann N Y Acad Sci , vol.540 , pp. 709-711
    • Tuohy, V.K.1    Sobel, R.A.2    Lees, M.B.3
  • 52
    • 0029038922 scopus 로고
    • A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells
    • Mendel I, Kerlero de Rosbo N, Ben-Nun A A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. Eur J Immunol 1995, 25:1951-1959.
    • (1995) Eur J Immunol , vol.25 , pp. 1951-1959
    • Mendel, I.1    Kerlero de Rosbo, N.2    Ben-Nun, A.3
  • 53
    • 0027990803 scopus 로고
    • Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia
    • Kojima K, Berger T, Lassmann H, et al. Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia. J Exp Med 1994, 180:817-829.
    • (1994) J Exp Med , vol.180 , pp. 817-829
    • Kojima, K.1    Berger, T.2    Lassmann, H.3
  • 54
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
    • Ben-Nun A, Wekerle H, Cohen IR The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 1981, 11:195-199.
    • (1981) Eur J Immunol , vol.11 , pp. 195-199
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 55
    • 65249175159 scopus 로고    scopus 로고
    • C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    • Reboldi A, Coisne C, Baumjohann D, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 2009, 10:514-523.
    • (2009) Nat Immunol , vol.10 , pp. 514-523
    • Reboldi, A.1    Coisne, C.2    Baumjohann, D.3
  • 56
    • 84855475637 scopus 로고    scopus 로고
    • Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE
    • Rothhammer V, Heink S, Petermann F, et al. Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE. J Exp Med 2011, 208:2465-2476.
    • (2011) J Exp Med , vol.208 , pp. 2465-2476
    • Rothhammer, V.1    Heink, S.2    Petermann, F.3
  • 57
    • 58149159798 scopus 로고    scopus 로고
    • Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis
    • Lees JR, Golumbek PT, Sim J, Dorsey D, Russell JH Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis. J Exp Med 2008, 205:2633-2642.
    • (2008) J Exp Med , vol.205 , pp. 2633-2642
    • Lees, J.R.1    Golumbek, P.T.2    Sim, J.3    Dorsey, D.4    Russell, J.H.5
  • 58
    • 46949104323 scopus 로고    scopus 로고
    • IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med 2008, 205:1535-1541.
    • (2008) J Exp Med , vol.205 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 59
    • 81855167104 scopus 로고    scopus 로고
    • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
    • Berer K, Mues M, Koutrolos M, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 2011, 479:538-541.
    • (2011) Nature , vol.479 , pp. 538-541
    • Berer, K.1    Mues, M.2    Koutrolos, M.3
  • 60
    • 0035877190 scopus 로고    scopus 로고
    • Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice
    • Sun D, Whitaker JN, Huang Z, et al. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol 2001, 166:7579-7587.
    • (2001) J Immunol , vol.166 , pp. 7579-7587
    • Sun, D.1    Whitaker, J.N.2    Huang, Z.3
  • 61
    • 0035801332 scopus 로고    scopus 로고
    • A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
    • Huseby ES, Liggitt D, Brabb T, Schnabel B, Ohlén C, Goverman J A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med 2001, 194:669-676.
    • (2001) J Exp Med , vol.194 , pp. 669-676
    • Huseby, E.S.1    Liggitt, D.2    Brabb, T.3    Schnabel, B.4    Ohlén, C.5    Goverman, J.6
  • 62
    • 0032209673 scopus 로고    scopus 로고
    • B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
    • Hjelmström P, Juedes AE, Fjell J, Ruddle NH B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J Immunol 1998, 161:4480-4483.
    • (1998) J Immunol , vol.161 , pp. 4480-4483
    • Hjelmström, P.1    Juedes, A.E.2    Fjell, J.3    Ruddle, N.H.4
  • 63
    • 0038643518 scopus 로고    scopus 로고
    • Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice
    • Oliver AR, Lyon GM, Ruddle NH Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. J Immunol 2003, 171:462-468.
    • (2003) J Immunol , vol.171 , pp. 462-468
    • Oliver, A.R.1    Lyon, G.M.2    Ruddle, N.H.3
  • 64
    • 84890819172 scopus 로고    scopus 로고
    • MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
    • Molnarfi N, Schulze-Topphoff U, Weber MS, et al. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med 2013, 210:2921-2937.
    • (2013) J Exp Med , vol.210 , pp. 2921-2937
    • Molnarfi, N.1    Schulze-Topphoff, U.2    Weber, M.S.3
  • 65
    • 0023931606 scopus 로고
    • Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein
    • Linington C, Bradl M, Lassmann H, Brunner C, Vass K Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol 1988, 130:443-454.
    • (1988) Am J Pathol , vol.130 , pp. 443-454
    • Linington, C.1    Bradl, M.2    Lassmann, H.3    Brunner, C.4    Vass, K.5
  • 66
    • 80052246111 scopus 로고    scopus 로고
    • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    • Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 2011, 14:1142-1149.
    • (2011) Nat Neurosci , vol.14 , pp. 1142-1149
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    McNagny, K.M.4    Rossi, F.M.5
  • 67
    • 20044376483 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis repressed by microglial paralysis
    • Heppner FL, Greter M, Marino D, et al. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med 2005, 11:146-152.
    • (2005) Nat Med , vol.11 , pp. 146-152
    • Heppner, F.L.1    Greter, M.2    Marino, D.3
  • 68
    • 84886953273 scopus 로고    scopus 로고
    • A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
    • Goldmann T, Wieghofer P, Müller PF, et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci 2013, 16:1618-1626.
    • (2013) Nat Neurosci , vol.16 , pp. 1618-1626
    • Goldmann, T.1    Wieghofer, P.2    Müller, P.F.3
  • 69
    • 84859218293 scopus 로고    scopus 로고
    • Primary oligodendrocyte death does not elicit anti-CNS immunity
    • Locatelli G, Wörtge S, Buch T, et al. Primary oligodendrocyte death does not elicit anti-CNS immunity. Nat Neurosci 2012, 15:543-550.
    • (2012) Nat Neurosci , vol.15 , pp. 543-550
    • Locatelli, G.1    Wörtge, S.2    Buch, T.3
  • 70
    • 0030796646 scopus 로고    scopus 로고
    • Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
    • Miller SD, Vanderlugt CL, Begolka WS, et al. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat Med 1997, 3:1133-1136.
    • (1997) Nat Med , vol.3 , pp. 1133-1136
    • Miller, S.D.1    Vanderlugt, C.L.2    Begolka, W.S.3
  • 71
    • 35348815545 scopus 로고    scopus 로고
    • Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM
    • Templeton SP, Perlman S Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM. Immunol Res 2007, 39:160-172.
    • (2007) Immunol Res , vol.39 , pp. 160-172
    • Templeton, S.P.1    Perlman, S.2
  • 72
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • the FREEDOMS Study Group
    • Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010, 362:387-401. the FREEDOMS Study Group.
    • (2010) N Engl J Med , vol.362 , pp. 387-401
    • Kappos, L.1    Radue, E.W.2    O'Connor, P.3
  • 73
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • the AFFIRM Investigators
    • Polman CH, O'Connor PW, Havrdova E, et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006, 354:899-910. the AFFIRM Investigators.
    • (2006) N Engl J Med , vol.354 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3
  • 74
    • 33646347610 scopus 로고    scopus 로고
    • Immune surveillance in multiple sclerosis patients treated with natalizumab
    • Stüve O, Marra CM, Jerome KR, et al. Immune surveillance in multiple sclerosis patients treated with natalizumab. Ann Neurol 2006, 59:743-747.
    • (2006) Ann Neurol , vol.59 , pp. 743-747
    • Stüve, O.1    Marra, C.M.2    Jerome, K.R.3
  • 75
    • 84869507357 scopus 로고    scopus 로고
    • Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial
    • the CARE-MS II investigators
    • Coles AJ, Twyman CL, Arnold DL, et al. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet 2012, 380:1829-1839. the CARE-MS II investigators.
    • (2012) Lancet , vol.380 , pp. 1829-1839
    • Coles, A.J.1    Twyman, C.L.2    Arnold, D.L.3
  • 76
    • 39049142995 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    • the HERMES Trial Group
    • Hauser SL, Waubant E, Arnold DL, et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med 2008, 358:676-688. the HERMES Trial Group.
    • (2008) N Engl J Med , vol.358 , pp. 676-688
    • Hauser, S.L.1    Waubant, E.2    Arnold, D.L.3
  • 77
    • 0023126661 scopus 로고
    • Exacerbations of multiple sclerosis in patients treated with gamma interferon
    • Panitch HS, Hirsch RL, Haley AS, Johnson KP Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1987, 1:893-895.
    • (1987) Lancet , vol.1 , pp. 893-895
    • Panitch, H.S.1    Hirsch, R.L.2    Haley, A.S.3    Johnson, K.P.4
  • 78
    • 0029899905 scopus 로고    scopus 로고
    • A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis
    • van Oosten BW, Rep MH, van Lier RA, et al. A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis. J Neuroimmunol 1996, 66:49-55.
    • (1996) J Neuroimmunol , vol.66 , pp. 49-55
    • van Oosten, B.W.1    Rep, M.H.2    van Lier, R.A.3
  • 79
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study
    • The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group
    • TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology 1999, 53:457-465. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group.
    • (1999) Neurology , vol.53 , pp. 457-465
  • 80
    • 84901703826 scopus 로고    scopus 로고
    • Sensitivity analysis of a phase IIa study of secukinumab in relapsing remitting multiple sclerosis
    • Havrdova E, Belova A, Goloborodko A, et al. Sensitivity analysis of a phase IIa study of secukinumab in relapsing remitting multiple sclerosis. Mult Scler 2013, 19:210-211.
    • (2013) Mult Scler , vol.19 , pp. 210-211
    • Havrdova, E.1    Belova, A.2    Goloborodko, A.3
  • 81
    • 0141816715 scopus 로고    scopus 로고
    • High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis
    • Nash RA, Bowen JD, McSweeney PA, et al. High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. Blood 2003, 102:2364-2372.
    • (2003) Blood , vol.102 , pp. 2364-2372
    • Nash, R.A.1    Bowen, J.D.2    McSweeney, P.A.3
  • 82
    • 0032526198 scopus 로고    scopus 로고
    • Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna
    • Lassmann H, Raine CS, Antel J, Prineas JW Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna. J Neuroimmunol 1998, 86:213-217.
    • (1998) J Neuroimmunol , vol.86 , pp. 213-217
    • Lassmann, H.1    Raine, C.S.2    Antel, J.3    Prineas, J.W.4
  • 84
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation
    • Bitsch A, Schuchardt J, Bunkowski S, Kuhlmann T, Brück W Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 2000, 123:1174-1183.
    • (2000) Brain , vol.123 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3    Kuhlmann, T.4    Brück, W.5
  • 85
    • 84857538385 scopus 로고    scopus 로고
    • NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury
    • Fischer MT, Sharma R, Lim JL, et al. NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain 2012, 135:886-899.
    • (2012) Brain , vol.135 , pp. 886-899
    • Fischer, M.T.1    Sharma, R.2    Lim, J.L.3
  • 86
    • 79959723400 scopus 로고    scopus 로고
    • Oxidative damage in multiple sclerosis lesions
    • Haider L, Fischer MT, Frischer JM, et al. Oxidative damage in multiple sclerosis lesions. Brain 2011, 134:1914-1924.
    • (2011) Brain , vol.134 , pp. 1914-1924
    • Haider, L.1    Fischer, M.T.2    Frischer, J.M.3
  • 87
    • 84878532264 scopus 로고    scopus 로고
    • Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
    • Witte ME, Nijland PG, Drexhage JA, et al. Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex. Acta Neuropathol 2013, 125:231-243.
    • (2013) Acta Neuropathol , vol.125 , pp. 231-243
    • Witte, M.E.1    Nijland, P.G.2    Drexhage, J.A.3
  • 88
    • 79953761792 scopus 로고    scopus 로고
    • A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Nikić I, Merkler D, Sorbara C, et al. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med 2011, 17:495-499.
    • (2011) Nat Med , vol.17 , pp. 495-499
    • Nikić, I.1    Merkler, D.2    Sorbara, C.3
  • 89
    • 84870815173 scopus 로고    scopus 로고
    • Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
    • Davalos D, Ryu JK, Merlini M, et al. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun 2012, 3:1227.
    • (2012) Nat Commun , vol.3 , pp. 1227
    • Davalos, D.1    Ryu, J.K.2    Merlini, M.3
  • 90
    • 68049143269 scopus 로고    scopus 로고
    • Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    • Shechter R, London A, Varol C, et al. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med 2009, 6:e1000113.
    • (2009) PLoS Med , vol.6 , pp. e1000113
    • Shechter, R.1    London, A.2    Varol, C.3
  • 91
    • 84875553508 scopus 로고    scopus 로고
    • Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus
    • Shechter R, Miller O, Yovel G, et al. Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 2013, 38:555-569.
    • (2013) Immunity , vol.38 , pp. 555-569
    • Shechter, R.1    Miller, O.2    Yovel, G.3
  • 92
    • 84883454794 scopus 로고    scopus 로고
    • M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
    • Miron VE, Boyd A, Zhao JW, et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci 2013, 16:1211-1218.
    • (2013) Nat Neurosci , vol.16 , pp. 1211-1218
    • Miron, V.E.1    Boyd, A.2    Zhao, J.W.3
  • 94
    • 0344443218 scopus 로고    scopus 로고
    • Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis
    • Bar-Or A, Nuttall RK, Duddy M, et al. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain 2003, 126:2738-2749.
    • (2003) Brain , vol.126 , pp. 2738-2749
    • Bar-Or, A.1    Nuttall, R.K.2    Duddy, M.3
  • 95
    • 84905116959 scopus 로고    scopus 로고
    • Differential roles of microglia and monocytes in the inflamed central nervous system
    • Yamasaki R, Lu H, Butovsky O, et al. Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med 2014, 211:1533-1549.
    • (2014) J Exp Med , vol.211 , pp. 1533-1549
    • Yamasaki, R.1    Lu, H.2    Butovsky, O.3
  • 96
    • 0034618094 scopus 로고    scopus 로고
    • Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    • Babbe H, Roers A, Waisman A, et al. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med 2000, 192:393-404.
    • (2000) J Exp Med , vol.192 , pp. 393-404
    • Babbe, H.1    Roers, A.2    Waisman, A.3
  • 97
    • 0036191549 scopus 로고    scopus 로고
    • Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients
    • Jacobsen M, Cepok S, Quak E, et al. Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients. Brain 2002, 125:538-550.
    • (2002) Brain , vol.125 , pp. 538-550
    • Jacobsen, M.1    Cepok, S.2    Quak, E.3
  • 98
    • 84862777442 scopus 로고    scopus 로고
    • Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    • Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature 2012, 483:227-231.
    • (2012) Nature , vol.483 , pp. 227-231
    • Jiang, X.1    Clark, R.A.2    Liu, L.3    Wagers, A.J.4    Fuhlbrigge, R.C.5    Kupper, T.S.6
  • 99
    • 78149278086 scopus 로고    scopus 로고
    • Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence
    • Wakim LM, Woodward-Davis A, Bevan MJ Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence. Proc Natl Acad Sci USA 2010, 107:17872-17879.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 17872-17879
    • Wakim, L.M.1    Woodward-Davis, A.2    Bevan, M.J.3
  • 100
    • 84860673664 scopus 로고    scopus 로고
    • Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides
    • Siewert K, Malotka J, Kawakami N, Wekerle H, Hohlfeld R, Dornmair K Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides. Nat Med 2012, 18:824-828.
    • (2012) Nat Med , vol.18 , pp. 824-828
    • Siewert, K.1    Malotka, J.2    Kawakami, N.3    Wekerle, H.4    Hohlfeld, R.5    Dornmair, K.6
  • 101
    • 0037816192 scopus 로고    scopus 로고
    • Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin
    • Kivisäkk P, Mahad DJ, Callahan MK, et al. Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci USA 2003, 100:8389-8394.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8389-8394
    • Kivisäkk, P.1    Mahad, D.J.2    Callahan, M.K.3
  • 102
    • 72649089874 scopus 로고    scopus 로고
    • Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
    • Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009, 132:3329-3341.
    • (2009) Brain , vol.132 , pp. 3329-3341
    • Brucklacher-Waldert, V.1    Stuerner, K.2    Kolster, M.3    Wolthausen, J.4    Tolosa, E.5
  • 103
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R Immunology of multiple sclerosis. Annu Rev Immunol 2005, 23:683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 104
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N, et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000, 6:1167-1175.
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3
  • 105
    • 0032719206 scopus 로고    scopus 로고
    • A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
    • Madsen LS, Andersson EC, Jansson L, et al. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet 1999, 23:343-347.
    • (1999) Nat Genet , vol.23 , pp. 343-347
    • Madsen, L.S.1    Andersson, E.C.2    Jansson, L.3
  • 106
    • 55549104692 scopus 로고    scopus 로고
    • Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis
    • Friese MA, Jakobsen KB, Friis L, et al. Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis. Nat Med 2008, 14:1227-1235.
    • (2008) Nat Med , vol.14 , pp. 1227-1235
    • Friese, M.A.1    Jakobsen, K.B.2    Friis, L.3
  • 107
    • 84865469861 scopus 로고    scopus 로고
    • T cells become licensed in the lung to enter the central nervous system
    • Odoardi F, Sie C, Streyl K, et al. T cells become licensed in the lung to enter the central nervous system. Nature 2012, 488:675-679.
    • (2012) Nature , vol.488 , pp. 675-679
    • Odoardi, F.1    Sie, C.2    Streyl, K.3
  • 108
    • 84876787121 scopus 로고    scopus 로고
    • Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
    • Kleinewietfeld M, Manzel A, Titze J, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013, 496:518-522.
    • (2013) Nature , vol.496 , pp. 518-522
    • Kleinewietfeld, M.1    Manzel, A.2    Titze, J.3
  • 109
    • 84868535570 scopus 로고    scopus 로고
    • The initiation and prevention of multiple sclerosis
    • Ascherio A, Munger KL, Lünemann JD The initiation and prevention of multiple sclerosis. Nat Rev Neurol 2012, 8:602-612.
    • (2012) Nat Rev Neurol , vol.8 , pp. 602-612
    • Ascherio, A.1    Munger, K.L.2    Lünemann, J.D.3
  • 110
    • 70349305736 scopus 로고    scopus 로고
    • Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis
    • Hedström AK, Bäärnhielm M, Olsson T, Alfredsson L Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis. Neurology 2009, 73:696-701.
    • (2009) Neurology , vol.73 , pp. 696-701
    • Hedström, A.K.1    Bäärnhielm, M.2    Olsson, T.3    Alfredsson, L.4
  • 111
    • 84866034486 scopus 로고    scopus 로고
    • High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women
    • Hedström AK, Olsson T, Alfredsson L High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult Scler 2012, 18:1334-1336.
    • (2012) Mult Scler , vol.18 , pp. 1334-1336
    • Hedström, A.K.1    Olsson, T.2    Alfredsson, L.3
  • 112
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi R, Howell O, Vora A, et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007, 130:1089-1104.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3
  • 113
    • 20244384231 scopus 로고    scopus 로고
    • BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
    • Krumbholz M, Theil D, Derfuss T, et al. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 2005, 201:195-200.
    • (2005) J Exp Med , vol.201 , pp. 195-200
    • Krumbholz, M.1    Theil, D.2    Derfuss, T.3
  • 114
    • 0042429215 scopus 로고    scopus 로고
    • Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid
    • Owens GP, Ritchie AM, Burgoon MP, Williamson RA, Corboy JR, Gilden DH Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid. J Immunol 2003, 171:2725-2733.
    • (2003) J Immunol , vol.171 , pp. 2725-2733
    • Owens, G.P.1    Ritchie, A.M.2    Burgoon, M.P.3    Williamson, R.A.4    Corboy, J.R.5    Gilden, D.H.6
  • 115
    • 84870498631 scopus 로고    scopus 로고
    • B cell exchange across the blood-brain barrier in multiple sclerosis
    • von Büdingen HC, Kuo TC, Sirota M, et al. B cell exchange across the blood-brain barrier in multiple sclerosis. J Clin Invest 2012, 122:4533-4543.
    • (2012) J Clin Invest , vol.122 , pp. 4533-4543
    • von Büdingen, H.C.1    Kuo, T.C.2    Sirota, M.3
  • 116
    • 84905988500 scopus 로고    scopus 로고
    • Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis
    • 248ra106
    • Palanichamy A, Apeltsin L, Kuo TC, et al. Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis. Sci Transl Med 2014, 6:248ra106.
    • (2014) Sci Transl Med , vol.6
    • Palanichamy, A.1    Apeltsin, L.2    Kuo, T.C.3
  • 117
    • 44949174084 scopus 로고    scopus 로고
    • Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis
    • Obermeier B, Mentele R, Malotka J, et al. Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nat Med 2008, 14:688-693.
    • (2008) Nat Med , vol.14 , pp. 688-693
    • Obermeier, B.1    Mentele, R.2    Malotka, J.3
  • 118
    • 84896548324 scopus 로고    scopus 로고
    • In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses
    • Bankoti J, Apeltsin L, Hauser SL, et al. In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses. Ann Neurol 2014, 75:266-276.
    • (2014) Ann Neurol , vol.75 , pp. 266-276
    • Bankoti, J.1    Apeltsin, L.2    Hauser, S.L.3
  • 119
    • 84879910017 scopus 로고    scopus 로고
    • Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude
    • Dobson R, Ramagopalan S, Davis A, Giovannoni G Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude. J Neurol Neurosurg Psychiatry 2013, 84:909-914.
    • (2013) J Neurol Neurosurg Psychiatry , vol.84 , pp. 909-914
    • Dobson, R.1    Ramagopalan, S.2    Davis, A.3    Giovannoni, G.4
  • 120
    • 84895731859 scopus 로고    scopus 로고
    • To look for a needle in a haystack: the search for autoantibodies in multiple sclerosis
    • Schirmer L, Srivastava R, Hemmer B To look for a needle in a haystack: the search for autoantibodies in multiple sclerosis. Mult Scler 2014, 20:271-279.
    • (2014) Mult Scler , vol.20 , pp. 271-279
    • Schirmer, L.1    Srivastava, R.2    Hemmer, B.3
  • 121
    • 34948864286 scopus 로고    scopus 로고
    • Neurofascin as a novel target for autoantibody-mediated axonal injury
    • Mathey EK, Derfuss T, Storch MK, et al. Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med 2007, 204:2363-2372.
    • (2007) J Exp Med , vol.204 , pp. 2363-2372
    • Mathey, E.K.1    Derfuss, T.2    Storch, M.K.3
  • 122
    • 84863649686 scopus 로고    scopus 로고
    • Potassium channel KIR4.1 as an immune target in multiple sclerosis
    • Srivastava R, Aslam M, Kalluri SR, et al. Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med 2012, 367:115-123.
    • (2012) N Engl J Med , vol.367 , pp. 115-123
    • Srivastava, R.1    Aslam, M.2    Kalluri, S.R.3
  • 123
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig KW, Strominger JL Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995, 80:695-705.
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 124
    • 30444445129 scopus 로고    scopus 로고
    • How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes
    • Hatterer E, Davoust N, Didier-Bazes M, et al. How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 2006, 107:806-812.
    • (2006) Blood , vol.107 , pp. 806-812
    • Hatterer, E.1    Davoust, N.2    Didier-Bazes, M.3
  • 126
    • 84866364390 scopus 로고    scopus 로고
    • The anatomical and cellular basis of immune surveillance in the central nervous system
    • Ransohoff RM, Engelhardt B The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol 2012, 12:623-635.
    • (2012) Nat Rev Immunol , vol.12 , pp. 623-635
    • Ransohoff, R.M.1    Engelhardt, B.2
  • 127
    • 79953675959 scopus 로고    scopus 로고
    • CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system
    • Prodinger C, Bunse J, Krüger M, et al. CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system. Acta Neuropathol 2011, 121:445-458.
    • (2011) Acta Neuropathol , vol.121 , pp. 445-458
    • Prodinger, C.1    Bunse, J.2    Krüger, M.3
  • 128
    • 84896752215 scopus 로고    scopus 로고
    • Immune cell trafficking from the brain maintains CNS immune tolerance
    • Mohammad MG, Tsai VW, Ruitenberg MJ, et al. Immune cell trafficking from the brain maintains CNS immune tolerance. J Clin Invest 2014, 124:1228-1241.
    • (2014) J Clin Invest , vol.124 , pp. 1228-1241
    • Mohammad, M.G.1    Tsai, V.W.2    Ruitenberg, M.J.3
  • 129
    • 84885775321 scopus 로고    scopus 로고
    • Sleep drives metabolite clearance from the adult brain
    • Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science 2013, 342:373-377.
    • (2013) Science , vol.342 , pp. 373-377
    • Xie, L.1    Kang, H.2    Xu, Q.3
  • 130
    • 34548861238 scopus 로고    scopus 로고
    • Immune response in leukodystrophies
    • Eichler F, Van Haren K Immune response in leukodystrophies. Pediatr Neurol 2007, 37:235-244.
    • (2007) Pediatr Neurol , vol.37 , pp. 235-244
    • Eichler, F.1    Van Haren, K.2
  • 131
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: an immune or neurodegenerative disorder?
    • Trapp BD, Nave KA Multiple sclerosis: an immune or neurodegenerative disorder?. Annu Rev Neurosci 2008, 31:247-269.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 133
    • 0034676548 scopus 로고    scopus 로고
    • Relapses and progression of disability in multiple sclerosis
    • Confavreux C, Vukusic S, Moreau T, Adeleine P Relapses and progression of disability in multiple sclerosis. N Engl J Med 2000, 343:1430-1438.
    • (2000) N Engl J Med , vol.343 , pp. 1430-1438
    • Confavreux, C.1    Vukusic, S.2    Moreau, T.3    Adeleine, P.4
  • 134
    • 77954382272 scopus 로고    scopus 로고
    • Evidence for a two-stage disability progression in multiple sclerosis
    • Leray E, Yaouanq J, Le Page E, et al. Evidence for a two-stage disability progression in multiple sclerosis. Brain 2010, 133:1900-1913.
    • (2010) Brain , vol.133 , pp. 1900-1913
    • Leray, E.1    Yaouanq, J.2    Le Page, E.3
  • 135
    • 0032486428 scopus 로고    scopus 로고
    • Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
    • Griffiths I, Klugmann M, Anderson T, et al. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 1998, 280:1610-1613.
    • (1998) Science , vol.280 , pp. 1610-1613
    • Griffiths, I.1    Klugmann, M.2    Anderson, T.3
  • 136
    • 0037370361 scopus 로고    scopus 로고
    • Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
    • Lappe-Siefke C, Goebbels S, Gravel M, et al. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet 2003, 33:366-374.
    • (2003) Nat Genet , vol.33 , pp. 366-374
    • Lappe-Siefke, C.1    Goebbels, S.2    Gravel, M.3
  • 137
    • 84857539822 scopus 로고    scopus 로고
    • Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis
    • Manrique-Hoyos N, Jürgens T, Grønborg M, et al. Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis. Ann Neurol 2012, 71:227-244.
    • (2012) Ann Neurol , vol.71 , pp. 227-244
    • Manrique-Hoyos, N.1    Jürgens, T.2    Grønborg, M.3
  • 138
    • 0037426402 scopus 로고    scopus 로고
    • Evidence of early cortical atrophy in MS: relevance to white matter changes and disability
    • De Stefano N, Matthews PM, Filippi M, et al. Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology 2003, 60:1157-1162.
    • (2003) Neurology , vol.60 , pp. 1157-1162
    • De Stefano, N.1    Matthews, P.M.2    Filippi, M.3
  • 139
    • 80051544967 scopus 로고    scopus 로고
    • The predictive value of gray matter atrophy in clinically isolated syndromes
    • Calabrese M, Rinaldi F, Mattisi I, et al. The predictive value of gray matter atrophy in clinically isolated syndromes. Neurology 2011, 77:257-263.
    • (2011) Neurology , vol.77 , pp. 257-263
    • Calabrese, M.1    Rinaldi, F.2    Mattisi, I.3
  • 140
    • 66549130329 scopus 로고    scopus 로고
    • The relation between inflammation and neurodegeneration in multiple sclerosis brains
    • Frischer JM, Bramow S, Dal-Bianco A, et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 2009, 132:1175-1189.
    • (2009) Brain , vol.132 , pp. 1175-1189
    • Frischer, J.M.1    Bramow, S.2    Dal-Bianco, A.3
  • 141
    • 84867707040 scopus 로고    scopus 로고
    • Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis
    • Choi SR, Howell OW, Carassiti D, et al. Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis. Brain 2012, 135:2925-2937.
    • (2012) Brain , vol.135 , pp. 2925-2937
    • Choi, S.R.1    Howell, O.W.2    Carassiti, D.3
  • 142
    • 33747886404 scopus 로고    scopus 로고
    • A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination
    • Merkler D, Ernsting T, Kerschensteiner M, Brück W, Stadelmann C A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination. Brain 2006, 129:1972-1983.
    • (2006) Brain , vol.129 , pp. 1972-1983
    • Merkler, D.1    Ernsting, T.2    Kerschensteiner, M.3    Brück, W.4    Stadelmann, C.5
  • 143
    • 84890599669 scopus 로고    scopus 로고
    • Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats
    • Gardner C, Magliozzi R, Durrenberger PF, Howell OW, Rundle J, Reynolds R Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats. Brain 2013, 136:3596-3608.
    • (2013) Brain , vol.136 , pp. 3596-3608
    • Gardner, C.1    Magliozzi, R.2    Durrenberger, P.F.3    Howell, O.W.4    Rundle, J.5    Reynolds, R.6
  • 145
    • 0034911054 scopus 로고    scopus 로고
    • Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage
    • Werner P, Pitt D, Raine CS Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage. Ann Neurol 2001, 50:169-180.
    • (2001) Ann Neurol , vol.50 , pp. 169-180
    • Werner, P.1    Pitt, D.2    Raine, C.S.3
  • 146
    • 0345327739 scopus 로고    scopus 로고
    • Glutamate uptake by oligodendrocytes: Implications for excitotoxicity in multiple sclerosis
    • Pitt D, Nagelmeier IE, Wilson HC, Raine CS Glutamate uptake by oligodendrocytes: Implications for excitotoxicity in multiple sclerosis. Neurology 2003, 61:1113-1120.
    • (2003) Neurology , vol.61 , pp. 1113-1120
    • Pitt, D.1    Nagelmeier, I.E.2    Wilson, H.C.3    Raine, C.S.4
  • 147
    • 79953291261 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
    • Campbell GR, Ziabreva I, Reeve AK, et al. Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol 2011, 69:481-492.
    • (2011) Ann Neurol , vol.69 , pp. 481-492
    • Campbell, G.R.1    Ziabreva, I.2    Reeve, A.K.3
  • 148
    • 84879647283 scopus 로고    scopus 로고
    • How B cells capture, process and present antigens: a crucial role for cell polarity
    • Yuseff MI, Pierobon P, Reversat A, Lennon-Duménil AM How B cells capture, process and present antigens: a crucial role for cell polarity. Nat Rev Immunol 2013, 13:475-486.
    • (2013) Nat Rev Immunol , vol.13 , pp. 475-486
    • Yuseff, M.I.1    Pierobon, P.2    Reversat, A.3    Lennon-Duménil, A.M.4


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