Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex

Acta Neuropathologica

Volumn 125, Issue 2, 2013, Pages 231-243

  Witte, Maarten E ^a   Nijland, Philip G ^a   Drexhage, Joost A R ^a   Gerritsen, Wouter ^a   Geerts, Dirk ^b   Van Het Hof, Bert ^a   Reijerkerk, Arie ^a   De Vries, Helga E ^a   Van Der Valk, Paul ^a   Van Horssen, Jack ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Mitochondria; Multiple sclerosis; Neurodegeneration; PGC 1 ; ROS

Indexed keywords

ANTIOXIDANT; MANGANESE SUPEROXIDE DISMUTASE; PEROXIREDOXIN 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 4; UNCOUPLING PROTEIN 5;

ADULT; AGED; ARTICLE; CELL LOSS; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; FRONTAL CORTEX; GENE EXPRESSION; GENE SILENCING; GRAY MATTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR PATHOLOGY; MULTIPLE SCLEROSIS; NERVE CELL NECROSIS; NERVE DEGENERATION; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CELL COUNT; CEREBRAL CORTEX; DOWN-REGULATION; FEMALE; GENETIC VECTORS; GYRUS CINGULI; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LENTIVIRUS; MALE; MIDDLE AGED; MITOCHONDRIA; MULTIPLE SCLEROSIS; NEURONS; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; PYRAMIDAL CELLS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TISSUE BANKS; TRANSCRIPTION FACTORS;

EID: 84878532264     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-1052-y     Document Type: Article

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