A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

Nature Neuroscience

Volumn 16, Issue 11, 2013, Pages 1618-1626

  Goldmann, Tobias ^a   Wieghofer, Peter ^a   Müller, Philippe F ^a   Wolf, Yochai ^b   Varol, Diana ^b   Yona, Simon ^b   Brendecke, Stefanie M ^a   Kierdorf, Katrin ^a   Staszewski, Ori ^a   Datta, Moumita ^a   Luedde, Tom ^c   Heikenwalder, Mathias ^d   Jung, Steffen ^b   Prinz, Marco ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR3; COMPLEMENTARY DNA; CRE RECOMBINASE; ENHANCED GREEN FLUORESCENT PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BRAIN; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE TARGETING; IMMUNE SYSTEM; INFLAMMATION; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD11C; ASTROCYTES; BRAIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ESTROGEN ANTAGONISTS; GENE EXPRESSION REGULATION; GENE TARGETING; LUMINESCENT PROTEINS; LYMPH NODES; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; NERVE TISSUE PROTEINS; RECEPTORS, CHEMOKINE; RNA, UNTRANSLATED; SIGNAL TRANSDUCTION; TAMOXIFEN;

EID: 84886953273     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3531     Document Type: Article

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