In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses

Annals of Neurology

Volumn 75, Issue 2, 2014, Pages 266-276

  Bankoti, Jaishree ^a   Apeltsin, Leonard ^a   Hauser, Stephen L ^a   Allen, Simon ^b   Albertolle, Matthew E ^b   Witkowska, H Ewa ^b   Von Büdingen, H Christian ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; OLIGOCLONAL BAND;

ADULT; AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE; BLOOD BRAIN BARRIER; CELL MIGRATION; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN HEAVY CHAIN GENE; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEOMICS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; YOUNG ADULT;

ADULT; B-LYMPHOCYTES; FEMALE; GENE EXPRESSION PROFILING; HUMANS; ISOELECTRIC FOCUSING; MALE; MASS SPECTROMETRY; MULTIPLE SCLEROSIS; OLIGOCLONAL BANDS; PROTEOME; YOUNG ADULT;

EID: 84896548324     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24088     Document Type: Article

References (40)

1. Walsh MJ, Tourtellotte WW, Roman J, Dreyer W,. Immunoglobulin G, A, and M-clonal restriction in multiple sclerosis cerebrospinal fluid and serum-analysis by two-dimensional electrophoresis. Clin Immunol Immunopathol 1985; 35: 313-327.
2. Obermeier B, Lovato L, Mentele R, et al. Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol 2011; 233: 245-248.
3. Obermeier B, Mentele R, Malotka J, et al. Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nat Med 2008; 14: 688-693.
4. Avasarala JR, Cross AH, Trotter JL,. Oligoclonal band number as a marker for prognosis in multiple sclerosis. Arch Neurol 2001; 58: 2044-2045.
5. Joseph FG, Hirst CL, Pickersgill TP, et al. CSF oligoclonal band status informs prognosis in multiple sclerosis: a case control study of 100 patients. J Neurol Neurosurg Psychiatry 2009; 80: 292-296.
6. Tintore M, Rovira A, Rio J, et al. Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis? Neurology 2008; 70: 1079-1083.
7. Villar LM, Garcia-Sanchez MI, Costa-Frossard L, et al. Immunological markers of optimal response to natalizumab in multiple sclerosis. Arch Neurol 2012; 69: 191-197.
8. Harrer A, Tumani H, Niendorf S, et al. Cerebrospinal fluid parameters of B cell-related activity in patients with active disease during natalizumab therapy. Mult Scler 2013; 19: 1209-1212.
9. Stuve O, Marra CM, Jerome KR, et al. Immune surveillance in multiple sclerosis patients treated with natalizumab. Ann Neurol 2006; 59: 743-747.
10. von Büdingen HC, Gulati M, Kuenzle S, et al. Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce "oligoclonal bands." J Neuroimmunol 2010; 218: 134-139.
11. Serafini B, Rosicarelli B, Magliozzi R, et al. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 2004; 14: 164-174.
12. Prineas JW,. Multiple sclerosis: presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord. Science 1979; 203: 1123-1125.
13. von Büdingen HC, Harrer MD, Kuenzle S, et al. Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodies. Eur J Immunol 2008; 38: 2014-2023.
14. Cruz M, Olsson T, Ernerudh J, et al. Immunoblot detection of oligoclonal anti-myelin basic protein IgG antibodies in cerebrospinal fluid in multiple sclerosis. Neurology 1987; 37: 1515-1519.
15. O'Connor KC, Appel H, Bregoli L, et al. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol 2005; 175: 1974-1982.
16. Cepok S, Zhou D, Srivastava R, et al. Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. J Clin Invest 2005; 115: 1352-1360.
17. Owens GP, Bennett JL, Lassmann H, et al. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann Neurol 2009; 65: 639-649.
18. von Büdingen HC, Kuo TC, Sirota M, et al. B cell exchange across the blood-brain barrier in multiple sclerosis. J Clin Invest 2012; 122: 4533-4543.
19. Bar-Or A, Fawaz L, Fan B, et al. Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS? Ann Neurol 2010; 67: 452-461.
20. Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69: 292-302.
21. Glanville J, Zhai W, Berka J, et al. Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire. Proc Natl Acad Sci U S A 2009; 106: 20216-20221.
22. Levenshtein VI,. Binary codes capable of correcting deletions, insertions, and reversals. Soviet Physics Dokl 1965; 10: 707-710.
23. Larkin MA, Blackshields G, Brown NP, et al. Clustal W and Clustal X version 2.0. Bioinformatics 2007; 23: 2947-2948.
24. Volpe JM, Cowell LG, Kepler TB,. SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations. Bioinformatics 2006; 22: 438-444.
25. Barak M, Zuckerman NS, Edelman H, et al. IgTree: creating immunoglobulin variable region gene lineage trees. J Immunol Methods 2008; 338: 67-74.
26. Smoot ME, Ono K, Ruscheinski J, et al. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 2011; 27: 431-432.
27. Katoh K, Toh H,. Recent developments in the MAFFT multiple sequence alignment program. Brief Bioinform 2008; 9: 286-298.
28. Waterhouse AM, Procter JB, Martin DM, et al. Jalview Version 2-a multiple sequence alignment editor and analysis workbench. Bioinformatics 2009; 25: 1189-1191.
29. Qin Y, Duquette P, Zhang Y, et al. Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis. J Clin Invest 1998; 102: 1045-1050.
30. Owens GP, Ritchie AM, Burgoon MP, et al. Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid. J Immunol 2003; 171: 2725-2733.
31. Baranzini SE, Jeong MC, Butunoi C, et al. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol 1999; 163: 5133-5144.
32. Walsh MJ, Tourtellotte WW,. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis. J Exp Med 1986; 163: 41-53.
33. Bar-Or A, Calabresi PA, Arnold D, et al. Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial. Ann Neurol 2008; 63: 395-400.
34. Hauser SL, Waubant E, Arnold DL, et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med 2008; 358: 676-688.
35. Kappos L, Li D, Calabresi PA, et al. Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial. Lancet 2011; 378: 1779-1787.
36. Cross AH, Stark JL, Lauber J, et al. Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 2006; 180: 63-70.
37. Srivastava R, Aslam M, Kalluri SR, et al. Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med 2012; 367: 115-123.
38. Stefferl A, Schubart A, Storch M, et al. Butyrophilin, a milk protein, modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis. J Immunol 2000; 165: 2859-2865.
39. Guggenmos J, Schubart AS, Ogg S, et al. Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk protein butyrophilin in multiple sclerosis. J Immunol 2004; 172: 661-668.
40. Wucherpfennig KW, Strominger JL,. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995; 80: 695-705.