Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination

Acta Neuropathologica

Volumn 120, Issue 2, 2010, Pages 223-236

  Sharma, Rakhi ^a   Fischer, Marie Therese ^a   Bauer, Jan ^a   Felts, Paul A ^b,c   Smith, Kenneth J ^b   Misu, Tatsuro ^d   Fujihara, Kazuo ^d   Bradl, Monika ^a   Lassmann, Hans ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Astrocytes; Brain inflammation; Demyelination neuromyelitis optica; Multiple sclerosis

Indexed keywords

AQUAPORIN 4; AUTOANTIBODY; GAP JUNCTION PROTEIN; LIPOPOLYSACCHARIDE; AQP4 PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN; POLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DEMYELINATING DISEASE; ENCEPHALITIS; HUMAN; HUMAN TISSUE; INNATE IMMUNITY; MICROGLIA; MOLECULAR MECHANICS; MULTIPLE SCLEROSIS; MYELOOPTIC NEUROPATHY; NEUROPATHOLOGY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN TARGETING; RAT; WHITE MATTER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL; CELL CULTURE; CENTRAL NERVOUS SYSTEM; COCULTURE; CONFOCAL MICROSCOPY; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GLIA; IMMUNOLOGY; METABOLISM; METHODOLOGY; PATHOLOGY; TIME;

ANIMALS; AQUAPORIN 4; ASTROCYTES; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MULTIPLE SCLEROSIS; NERVE TISSUE PROTEINS; NEUROGLIA; POLYSACCHARIDES; RATS; TIME FACTORS;

EID: 77957275551     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0704-z     Document Type: Article

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