High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women

Multiple Sclerosis Journal

Volumn 18, Issue 9, 2012, Pages 1334-1336

  Hedström, Anna K ^a   Olsson, Tomas ^b   Alfredsson, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; OBESITY; RISK FACTOR;

EID: 84866034486     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458512436596     Document Type: Article

References (12)

1. Munger KL, Chitnis T, Ascherio A. Body size and risk of MS in two cohorts of US women. Neurology. 2009 ; 73: 1543-1550
2. Hedström AK, Sundqvist E, Baarnhielm M, et al. Smoking and two HLA genes interact to increase the risk for multiple sclerosis. Brain. 2011 ; 134: 653-664
3. Troy LM, Hunter DJ, Manson JE, et al. The validity of recalled weight among younger women. Int J Obes Relat Metab Disord. 1995 ; 19: 570-572
4. Internet-based information, http://www.scb.se (accessed 25 July 2011).
5. Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000 ; 72: 690-693
6. Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006 ; 296: 2832-2838
7. Subramanian V, Ferrante AW. Obesity, inflammation, and macrophages. Nestle Nutr Workshop Ser Pediatr Program ; 2009 ; 2009. 151.
8. Lumeng CN, Bodzin JL, Deyoung SM, et al. Increased inflammatory properties of adipose tissue macrophages recruited during diet induced obesity. Diabetes. 2007 ; 56: 16-23
9. Matarese G, Procaccini C, De Rosa V. The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis?. J Leukocyte Biol. 2008 ; 84: 893-899
10. Tremblay MS, Katzmarzyk PT, Willms JD. Temporal trends in overweight and obesity in Canada, 1981-1996. Int J Obesity. 2002 ; 26 (4). 538-543
11. Tjepkema M. Measured Obesity Adult obesity in Canada: Measured height and weight Nutrition: Findings from the Canadian Community Health Survey (1) Statistics Canada Catalogue no. 82-620-MWE2005001..:
12. Warren SA, Svenson LW, Warren KG. Contribution of incidence to increasing prevalence of multiple sclerosis in Alberta, Canada. Mult Scler. 2008 ; 14: 872-879