메뉴 건너뛰기




Volumn 32, Issue 6, 2014, Pages 1111-1122

From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment

Author keywords

Apoptosis; Autophagy; Necrosis; Reactive oxygen species

Indexed keywords

CELL SIGNALING; DISEASES; PATIENT TREATMENT; PHYSIOLOGICAL MODELS; REACTIVE OXYGEN SPECIES; SCAFFOLDS (BIOLOGY); TISSUE HOMEOSTASIS; TUMORS;

EID: 84926257214     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2014.03.006     Document Type: Review
Times cited : (81)

References (176)
  • 1
    • 15044361086 scopus 로고    scopus 로고
    • Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning
    • Aggarwal B.B., Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci 2004, 1030:434-441.
    • (2004) Ann N Y Acad Sci , vol.1030 , pp. 434-441
    • Aggarwal, B.B.1    Shishodia, S.2
  • 2
    • 84866641762 scopus 로고    scopus 로고
    • NF-kappaB in cancer: a matter of life and death
    • Aggarwal B.B., Sung B. NF-kappaB in cancer: a matter of life and death. Cancer Discov 2011, 1:469-471.
    • (2011) Cancer Discov , vol.1 , pp. 469-471
    • Aggarwal, B.B.1    Sung, B.2
  • 3
    • 0032512698 scopus 로고    scopus 로고
    • Strand scission in DNA induced by curcumin in the presence of Cu(II)
    • Ahsan H., Hadi S.M. Strand scission in DNA induced by curcumin in the presence of Cu(II). Cancer Lett 1998, 124:23-30.
    • (1998) Cancer Lett , vol.124 , pp. 23-30
    • Ahsan, H.1    Hadi, S.M.2
  • 4
    • 34247232176 scopus 로고    scopus 로고
    • Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis
    • Allan L.A., Clarke P.R. Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis. Mol Cell 2007, 26:301-310.
    • (2007) Mol Cell , vol.26 , pp. 301-310
    • Allan, L.A.1    Clarke, P.R.2
  • 5
    • 34347238938 scopus 로고    scopus 로고
    • Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways
    • Aoki H., Takada Y., Kondo S., Sawaya R., Aggarwal B.B., Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 2007, 72:29-39.
    • (2007) Mol Pharmacol , vol.72 , pp. 29-39
    • Aoki, H.1    Takada, Y.2    Kondo, S.3    Sawaya, R.4    Aggarwal, B.B.5    Kondo, Y.6
  • 6
    • 84855480722 scopus 로고    scopus 로고
    • Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review
    • Bajwa N., Liao C., Nikolovska-Coleska Z. Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review. Expert Opin Ther Pat 2012, 22:37-55.
    • (2012) Expert Opin Ther Pat , vol.22 , pp. 37-55
    • Bajwa, N.1    Liao, C.2    Nikolovska-Coleska, Z.3
  • 7
    • 84926088320 scopus 로고    scopus 로고
    • A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death
    • Bana E., Sibille E., Valente S., Cerella C., Chaimbault P., Kirsch G., et al. A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death. Mol Carcinog 2013, 10.1002/mc.22094.
    • (2013) Mol Carcinog
    • Bana, E.1    Sibille, E.2    Valente, S.3    Cerella, C.4    Chaimbault, P.5    Kirsch, G.6
  • 8
    • 77955261430 scopus 로고    scopus 로고
    • Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells
    • Banerjee M., Singh P., Panda D. Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells. FEBS J 2010, 277:3437-3448.
    • (2010) FEBS J , vol.277 , pp. 3437-3448
    • Banerjee, M.1    Singh, P.2    Panda, D.3
  • 9
    • 77950224306 scopus 로고    scopus 로고
    • Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells
    • Banerjee S., Choi M., Aboukameel A., Wang Z., Mohammad M., Chen J., et al. Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells. Pancreas 2010, 39:323-331.
    • (2010) Pancreas , vol.39 , pp. 323-331
    • Banerjee, S.1    Choi, M.2    Aboukameel, A.3    Wang, Z.4    Mohammad, M.5    Chen, J.6
  • 10
    • 0031671581 scopus 로고    scopus 로고
    • Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein
    • Basu A., Haldar S. Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein. Int J Oncol 1998, 13:659-664.
    • (1998) Int J Oncol , vol.13 , pp. 659-664
    • Basu, A.1    Haldar, S.2
  • 11
    • 33745918631 scopus 로고    scopus 로고
    • Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells
    • Beevers C.S., Li F., Liu L., Huang S. Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. Int J Cancer 2006, 119:757-764.
    • (2006) Int J Cancer , vol.119 , pp. 757-764
    • Beevers, C.S.1    Li, F.2    Liu, L.3    Huang, S.4
  • 12
    • 59149091041 scopus 로고    scopus 로고
    • Curcumin disrupts the mammalian target of rapamycin-raptor complex
    • Beevers C.S., Chen L., Liu L., Luo Y., Webster N.J., Huang S. Curcumin disrupts the mammalian target of rapamycin-raptor complex. Cancer Res 2009, 69:1000-1008.
    • (2009) Cancer Res , vol.69 , pp. 1000-1008
    • Beevers, C.S.1    Chen, L.2    Liu, L.3    Luo, Y.4    Webster, N.J.5    Huang, S.6
  • 13
    • 79960895769 scopus 로고    scopus 로고
    • The ripoptosome: death decision in the cytosol
    • Bertrand M.J., Vandenabeele P. The ripoptosome: death decision in the cytosol. Mol Cell 2011, 43:323-325.
    • (2011) Mol Cell , vol.43 , pp. 323-325
    • Bertrand, M.J.1    Vandenabeele, P.2
  • 14
    • 33846565752 scopus 로고    scopus 로고
    • Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties
    • Bhat S.H., Azmi A.S., Hadi S.M. Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties. Toxicol Appl Pharmacol 2007, 218:249-255.
    • (2007) Toxicol Appl Pharmacol , vol.218 , pp. 249-255
    • Bhat, S.H.1    Azmi, A.S.2    Hadi, S.M.3
  • 15
    • 0034988898 scopus 로고    scopus 로고
    • Unwinding the loop of Bcl-2 phosphorylation
    • Blagosklonny M.V. Unwinding the loop of Bcl-2 phosphorylation. Leukemia 2001, 15:869-874.
    • (2001) Leukemia , vol.15 , pp. 869-874
    • Blagosklonny, M.V.1
  • 16
    • 84860508708 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: emerging drugs in cancer therapy
    • Bodur C., Basaga H. Bcl-2 inhibitors: emerging drugs in cancer therapy. Curr Med Chem 2012, 19:1804-1820.
    • (2012) Curr Med Chem , vol.19 , pp. 1804-1820
    • Bodur, C.1    Basaga, H.2
  • 17
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • Bollag D.M., McQueney P.A., Zhu J., Hensens O., Koupal L., Liesch J., et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 1995, 55:2325-2333.
    • (1995) Cancer Res , vol.55 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3    Hensens, O.4    Koupal, L.5    Liesch, J.6
  • 18
    • 0036998727 scopus 로고    scopus 로고
    • Epothilones: new tubulin polymerization agents in preclinical and clinical development
    • Borzilleri R., Vite G. Epothilones: new tubulin polymerization agents in preclinical and clinical development. Drugs Future 2002, 27:1149-1163.
    • (2002) Drugs Future , vol.27 , pp. 1149-1163
    • Borzilleri, R.1    Vite, G.2
  • 20
    • 0036217821 scopus 로고    scopus 로고
    • Natural products as targeted modulators of the nuclear factor-kappaB pathway
    • Bremner P., Heinrich M. Natural products as targeted modulators of the nuclear factor-kappaB pathway. J Pharm Pharmacol 2002, 54:453-472.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 453-472
    • Bremner, P.1    Heinrich, M.2
  • 21
    • 84886422014 scopus 로고    scopus 로고
    • Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress
    • Cao A., Li Q., Yin P., Dong Y., Shi H., Wang L., et al. Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. Apoptosis 2013, 18:1391-1402.
    • (2013) Apoptosis , vol.18 , pp. 1391-1402
    • Cao, A.1    Li, Q.2    Yin, P.3    Dong, Y.4    Shi, H.5    Wang, L.6
  • 22
  • 23
    • 80053450324 scopus 로고    scopus 로고
    • Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation
    • Castino R., Fiorentino I., Cagnin M., Giovia A., Isidoro C. Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Toxicol Sci 2011, 123:523-541.
    • (2011) Toxicol Sci , vol.123 , pp. 523-541
    • Castino, R.1    Fiorentino, I.2    Cagnin, M.3    Giovia, A.4    Isidoro, C.5
  • 24
    • 0032544449 scopus 로고    scopus 로고
    • Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
    • Cecconi F., Alvarez-Bolado G., Meyer B.I., Roth K.A., Gruss P. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 1998, 94:727-737.
    • (1998) Cell , vol.94 , pp. 727-737
    • Cecconi, F.1    Alvarez-Bolado, G.2    Meyer, B.I.3    Roth, K.A.4    Gruss, P.5
  • 25
    • 69149093517 scopus 로고    scopus 로고
    • Subapoptogenic oxidative stress strongly increases the activity of the glycolytic key enzyme glyceraldehyde 3-phosphate dehydrogenase
    • Cerella C., D'Alessio M., Cristofanon S., De Nicola M., Radogna F., Dicato M., et al. Subapoptogenic oxidative stress strongly increases the activity of the glycolytic key enzyme glyceraldehyde 3-phosphate dehydrogenase. Ann N Y Acad Sci 2009, 1171:583-590.
    • (2009) Ann N Y Acad Sci , vol.1171 , pp. 583-590
    • Cerella, C.1    D'Alessio, M.2    Cristofanon, S.3    De Nicola, M.4    Radogna, F.5    Dicato, M.6
  • 26
    • 77955973993 scopus 로고    scopus 로고
    • The dual role of calcium as messenger and stressor in cell damage, death, and survival
    • Cerella C., Diederich M., Ghibelli L. The dual role of calcium as messenger and stressor in cell damage, death, and survival. Int J Cell Biol 2010, 2010:546163.
    • (2010) Int J Cell Biol , vol.2010 , pp. 546163
    • Cerella, C.1    Diederich, M.2    Ghibelli, L.3
  • 27
    • 79954459360 scopus 로고    scopus 로고
    • Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds
    • Cerella C., Dicato M., Jacob C., Diederich M. Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds. Anticancer Agents Med Chem 2011, 11:267-271.
    • (2011) Anticancer Agents Med Chem , vol.11 , pp. 267-271
    • Cerella, C.1    Dicato, M.2    Jacob, C.3    Diederich, M.4
  • 29
    • 84883758835 scopus 로고    scopus 로고
    • Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides
    • Cerella C., Dicato M., Diederich M. Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides. Mitochondrion 2013, 13:225-234.
    • (2013) Mitochondrion , vol.13 , pp. 225-234
    • Cerella, C.1    Dicato, M.2    Diederich, M.3
  • 30
    • 33745033368 scopus 로고    scopus 로고
    • Cytotoxic effects and apoptotic signalling mechanisms of the sesquiterpenoid euplotin C, a secondary metabolite of the marine ciliate Euplotes crassus, in tumour cells
    • Cervia D., Martini D., Garcia-Gil M., Di Giuseppe G., Guella G., Dini F., et al. Cytotoxic effects and apoptotic signalling mechanisms of the sesquiterpenoid euplotin C, a secondary metabolite of the marine ciliate Euplotes crassus, in tumour cells. Apoptosis 2006, 11:829-843.
    • (2006) Apoptosis , vol.11 , pp. 829-843
    • Cervia, D.1    Martini, D.2    Garcia-Gil, M.3    Di Giuseppe, G.4    Guella, G.5    Dini, F.6
  • 31
    • 0038081194 scopus 로고    scopus 로고
    • Identification of chelerythrine as an inhibitor of BclXL function
    • Chan S.L., Lee M.C., Tan K.O., Yang L.K., Lee A.S., Flotow H., et al. Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem 2003, 278:20453-20456.
    • (2003) J Biol Chem , vol.278 , pp. 20453-20456
    • Chan, S.L.1    Lee, M.C.2    Tan, K.O.3    Yang, L.K.4    Lee, A.S.5    Flotow, H.6
  • 33
    • 0034786019 scopus 로고    scopus 로고
    • BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
    • Cheng E.H., Wei M.C., Weiler S., Flavell R.A., Mak T.W., Lindsten T., et al. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 2001, 8:705-711.
    • (2001) Mol Cell , vol.8 , pp. 705-711
    • Cheng, E.H.1    Wei, M.C.2    Weiler, S.3    Flavell, R.A.4    Mak, T.W.5    Lindsten, T.6
  • 34
    • 78650334862 scopus 로고    scopus 로고
    • Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax
    • Cheng S., Gao N., Zhang Z., Chen G., Budhraja A., Ke Z., et al. Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax. Clin Cancer Res 2010, 16:5679-5691.
    • (2010) Clin Cancer Res , vol.16 , pp. 5679-5691
    • Cheng, S.1    Gao, N.2    Zhang, Z.3    Chen, G.4    Budhraja, A.5    Ke, Z.6
  • 35
    • 84857794915 scopus 로고    scopus 로고
    • A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer
    • Chiappori A.A., Schreeder M.T., Moezi M.M., Stephenson J.J., Blakely J., Salgia R., et al. A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer. Br J Cancer 2012, 106:839-845.
    • (2012) Br J Cancer , vol.106 , pp. 839-845
    • Chiappori, A.A.1    Schreeder, M.T.2    Moezi, M.M.3    Stephenson, J.J.4    Blakely, J.5    Salgia, R.6
  • 36
    • 84877767143 scopus 로고    scopus 로고
    • Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin
    • Choudhury D., Ganguli A., Dastidar D.G., Acharya B.R., Das A., Chakrabarti G. Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin. Biochimie 2013, 95:1297-1309.
    • (2013) Biochimie , vol.95 , pp. 1297-1309
    • Choudhury, D.1    Ganguli, A.2    Dastidar, D.G.3    Acharya, B.R.4    Das, A.5    Chakrabarti, G.6
  • 38
    • 33646846666 scopus 로고    scopus 로고
    • Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis
    • Clohessy J.G., Zhuang J., de Boer J., Gil-Gomez G., Brady H.J. Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis. J Biol Chem 2006, 281:5750-5759.
    • (2006) J Biol Chem , vol.281 , pp. 5750-5759
    • Clohessy, J.G.1    Zhuang, J.2    de Boer, J.3    Gil-Gomez, G.4    Brady, H.J.5
  • 40
    • 69349104331 scopus 로고    scopus 로고
    • Structural basis for bivalent Smac-mimetics recognition in the IAP protein family
    • Cossu F., Milani M., Mastrangelo E., Vachette P., Servida F., Lecis D., et al. Structural basis for bivalent Smac-mimetics recognition in the IAP protein family. J Mol Biol 2009, 392:630-644.
    • (2009) J Mol Biol , vol.392 , pp. 630-644
    • Cossu, F.1    Milani, M.2    Mastrangelo, E.3    Vachette, P.4    Servida, F.5    Lecis, D.6
  • 41
    • 37549069901 scopus 로고    scopus 로고
    • BCL-2 family proteins: critical checkpoints of apoptotic cell death
    • Danial N.N. BCL-2 family proteins: critical checkpoints of apoptotic cell death. Clin Cancer Res 2007, 13:7254-7263.
    • (2007) Clin Cancer Res , vol.13 , pp. 7254-7263
    • Danial, N.N.1
  • 42
    • 84865736998 scopus 로고    scopus 로고
    • Targeting the B-cell lymphoma/leukemia 2 family in cancer
    • Davids M.S., Letai A. Targeting the B-cell lymphoma/leukemia 2 family in cancer. J Clin Oncol 2012, 30:3127-3135.
    • (2012) J Clin Oncol , vol.30 , pp. 3127-3135
    • Davids, M.S.1    Letai, A.2
  • 43
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K., Mathew R., Beaudoin B., Bray K., Anderson D., Chen G., et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006, 10:51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5    Chen, G.6
  • 44
  • 45
    • 0033082995 scopus 로고    scopus 로고
    • IAP family proteins-suppressors of apoptosis
    • Deveraux Q.L., Reed J.C. IAP family proteins-suppressors of apoptosis. Genes Dev 1999, 13:239-252.
    • (1999) Genes Dev , vol.13 , pp. 239-252
    • Deveraux, Q.L.1    Reed, J.C.2
  • 46
    • 84858957737 scopus 로고    scopus 로고
    • Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation
    • Doi K., Li R., Sung S.S., Wu H., Liu Y., Manieri W., et al. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem 2012, 287:10224-10235.
    • (2012) J Biol Chem , vol.287 , pp. 10224-10235
    • Doi, K.1    Li, R.2    Sung, S.S.3    Wu, H.4    Liu, Y.5    Manieri, W.6
  • 47
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du C., Fang M., Li Y., Li L., Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000, 102:33-42.
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 48
    • 0030915587 scopus 로고    scopus 로고
    • Intracellular ATP levels determine cell death fate by apoptosis or necrosis
    • Eguchi Y., Shimizu S., Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 1997, 57:1835-1840.
    • (1997) Cancer Res , vol.57 , pp. 1835-1840
    • Eguchi, Y.1    Shimizu, S.2    Tsujimoto, Y.3
  • 49
    • 79960922705 scopus 로고    scopus 로고
    • CIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
    • Feoktistova M., Geserick P., Kellert B., Dimitrova D.P., Langlais C., Hupe M., et al. cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 2011, 43:449-463.
    • (2011) Mol Cell , vol.43 , pp. 449-463
    • Feoktistova, M.1    Geserick, P.2    Kellert, B.3    Dimitrova, D.P.4    Langlais, C.5    Hupe, M.6
  • 50
    • 79958700761 scopus 로고    scopus 로고
    • Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells
    • Filippi-Chiela E.C., Villodre E.S., Zamin L.L., Lenz G. Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells. PloS One 2011, 6:e20849.
    • (2011) PloS One , vol.6
    • Filippi-Chiela, E.C.1    Villodre, E.S.2    Zamin, L.L.3    Lenz, G.4
  • 51
    • 84872184195 scopus 로고    scopus 로고
    • Phosphorylation network dynamics in the control of cell cycle transitions
    • Fisher D., Krasinska L., Coudreuse D., Novak B. Phosphorylation network dynamics in the control of cell cycle transitions. J Cell Sci 2012, 125:4703-4711.
    • (2012) J Cell Sci , vol.125 , pp. 4703-4711
    • Fisher, D.1    Krasinska, L.2    Coudreuse, D.3    Novak, B.4
  • 53
    • 84864532318 scopus 로고    scopus 로고
    • From the deepest sea shelf to the uppermost kitchen cabinet shelf: the quest for novel TNF-alpha inhibitors
    • Folmer F., Dicato M., Diederich M. From the deepest sea shelf to the uppermost kitchen cabinet shelf: the quest for novel TNF-alpha inhibitors. Curr Top Med Chem 2012, 12:1392-1407.
    • (2012) Curr Top Med Chem , vol.12 , pp. 1392-1407
    • Folmer, F.1    Dicato, M.2    Diederich, M.3
  • 54
    • 33747469017 scopus 로고    scopus 로고
    • Modulation of apoptosis signaling for cancer therapy
    • Fulda S., Debatin K.M. Modulation of apoptosis signaling for cancer therapy. Arch Immunol Ther Exp (Warsz) 2006, 54:173-175.
    • (2006) Arch Immunol Ther Exp (Warsz) , vol.54 , pp. 173-175
    • Fulda, S.1    Debatin, K.M.2
  • 55
  • 56
  • 57
    • 77954930632 scopus 로고    scopus 로고
    • IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
    • Gyrd-Hansen M., Meier P. IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 2010, 10:561-574.
    • (2010) Nat Rev Cancer , vol.10 , pp. 561-574
    • Gyrd-Hansen, M.1    Meier, P.2
  • 58
    • 34548439451 scopus 로고    scopus 로고
    • Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties
    • Hadi S.M., Bhat S.H., Azmi A.S., Hanif S., Shamim U., Ullah M.F. Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties. Semin Cancer Biol 2007, 17:370-376.
    • (2007) Semin Cancer Biol , vol.17 , pp. 370-376
    • Hadi, S.M.1    Bhat, S.H.2    Azmi, A.S.3    Hanif, S.4    Shamim, U.5    Ullah, M.F.6
  • 59
    • 77952941515 scopus 로고    scopus 로고
    • Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products
    • Harikumar K.B., Sung B., Tharakan S.T., Pandey M.K., Joy B., Guha S., et al. Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products. Mol Cancer Res 2010, 8:751-761.
    • (2010) Mol Cancer Res , vol.8 , pp. 751-761
    • Harikumar, K.B.1    Sung, B.2    Tharakan, S.T.3    Pandey, M.K.4    Joy, B.5    Guha, S.6
  • 60
    • 77954884045 scopus 로고    scopus 로고
    • Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
    • Harley M.E., Allan L.A., Sanderson H.S., Clarke P.R. Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO J 2010, 29:2407-2420.
    • (2010) EMBO J , vol.29 , pp. 2407-2420
    • Harley, M.E.1    Allan, L.A.2    Sanderson, H.S.3    Clarke, P.R.4
  • 61
    • 77951237303 scopus 로고    scopus 로고
    • The Beclin 1 interactome
    • He C., Levine B. The Beclin 1 interactome. Curr Opin Cell Biol 2010, 22:140-149.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 140-149
    • He, C.1    Levine, B.2
  • 62
    • 84883387793 scopus 로고    scopus 로고
    • Targeting the unfolded protein response in disease
    • Hetz C., Chevet E., Harding H.P. Targeting the unfolded protein response in disease. Nat Rev Drug Discov 2013, 12:703-719.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 703-719
    • Hetz, C.1    Chevet, E.2    Harding, H.P.3
  • 63
    • 5944233768 scopus 로고    scopus 로고
    • Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    • Holler N., Zaru R., Micheau O., Thome M., Attinger A., Valitutti S., et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 2000, 1:489-495.
    • (2000) Nat Immunol , vol.1 , pp. 489-495
    • Holler, N.1    Zaru, R.2    Micheau, O.3    Thome, M.4    Attinger, A.5    Valitutti, S.6
  • 64
    • 29244484434 scopus 로고    scopus 로고
    • Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin
    • Hosono T., Fukao T., Ogihara J., Ito Y., Shiba H., Seki T., et al. Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin. J Biol Chem 2005, 280:41487-41493.
    • (2005) J Biol Chem , vol.280 , pp. 41487-41493
    • Hosono, T.1    Fukao, T.2    Ogihara, J.3    Ito, Y.4    Shiba, H.5    Seki, T.6
  • 66
    • 84882770181 scopus 로고    scopus 로고
    • Tributyltin-induced endoplasmic reticulum stress and its Ca(2+)-mediated mechanism
    • Isomura M., Kotake Y., Masuda K., Miyara M., Okuda K., Samizo S., et al. Tributyltin-induced endoplasmic reticulum stress and its Ca(2+)-mediated mechanism. Toxicol Appl Pharmacol 2013, 272:137-146.
    • (2013) Toxicol Appl Pharmacol , vol.272 , pp. 137-146
    • Isomura, M.1    Kotake, Y.2    Masuda, K.3    Miyara, M.4    Okuda, K.5    Samizo, S.6
  • 67
    • 18044393290 scopus 로고    scopus 로고
    • Resveratrol-induced apoptotic death in human U251 glioma cells
    • Jiang H., Zhang L., Kuo J., Kuo K., Gautam S.C., Groc L., et al. Resveratrol-induced apoptotic death in human U251 glioma cells. Mol Cancer Ther 2005, 4:554-561.
    • (2005) Mol Cancer Ther , vol.4 , pp. 554-561
    • Jiang, H.1    Zhang, L.2    Kuo, J.3    Kuo, K.4    Gautam, S.C.5    Groc, L.6
  • 68
    • 78549284246 scopus 로고    scopus 로고
    • UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells
    • Juncker T., Cerella C., Teiten M.H., Morceau F., Schumacher M., Ghelfi J., et al. UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells. Biochem Pharmacol 2011, 81:13-23.
    • (2011) Biochem Pharmacol , vol.81 , pp. 13-23
    • Juncker, T.1    Cerella, C.2    Teiten, M.H.3    Morceau, F.4    Schumacher, M.5    Ghelfi, J.6
  • 69
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: linking inflammation and immunity to cancer development and progression
    • Karin M., Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005, 5:749-759.
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 70
    • 0036009115 scopus 로고    scopus 로고
    • NF-kappaB at the crossroads of life and death
    • Karin M., Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002, 3:221-227.
    • (2002) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 71
  • 72
    • 77649191871 scopus 로고    scopus 로고
    • Microtubules and resistance to tubulin-binding agents
    • Kavallaris M. Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer 2010, 10:194-204.
    • (2010) Nat Rev Cancer , vol.10 , pp. 194-204
    • Kavallaris, M.1
  • 73
    • 84868629206 scopus 로고    scopus 로고
    • ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis
    • Kelkel M., Cerella C., Mack F., Schneider T., Jacob C., Schumacher M., et al. ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis. Carcinogenesis 2012, 33:2162-2171.
    • (2012) Carcinogenesis , vol.33 , pp. 2162-2171
    • Kelkel, M.1    Cerella, C.2    Mack, F.3    Schneider, T.4    Jacob, C.5    Schumacher, M.6
  • 74
    • 0015383455 scopus 로고
    • Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26:239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 75
  • 76
    • 0141569444 scopus 로고    scopus 로고
    • Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
    • Kitada S., Leone M., Sareth S., Zhai D., Reed J.C., Pellecchia M. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem 2003, 46:4259-4264.
    • (2003) J Med Chem , vol.46 , pp. 4259-4264
    • Kitada, S.1    Leone, M.2    Sareth, S.3    Zhai, D.4    Reed, J.C.5    Pellecchia, M.6
  • 78
    • 13944277343 scopus 로고    scopus 로고
    • BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
    • Kuwana T., Bouchier-Hayes L., Chipuk J.E., Bonzon C., Sullivan B.A., Green D.R., et al. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 2005, 17:525-535.
    • (2005) Mol Cell , vol.17 , pp. 525-535
    • Kuwana, T.1    Bouchier-Hayes, L.2    Chipuk, J.E.3    Bonzon, C.4    Sullivan, B.A.5    Green, D.R.6
  • 79
    • 77956178353 scopus 로고    scopus 로고
    • The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention
    • Lambert J.D., Elias R.J. The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys 2010, 501:65-72.
    • (2010) Arch Biochem Biophys , vol.501 , pp. 65-72
    • Lambert, J.D.1    Elias, R.J.2
  • 80
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane D.P. Cancer. p53, guardian of the genome. Nature 1992, 358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 81
    • 57149087269 scopus 로고    scopus 로고
    • Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue
    • Leamon C.P., Reddy J.A., Vetzel M., Dorton R., Westrick E., Parker N., et al. Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue. Cancer Res 2008, 68:9839-9844.
    • (2008) Cancer Res , vol.68 , pp. 9839-9844
    • Leamon, C.P.1    Reddy, J.A.2    Vetzel, M.3    Dorton, R.4    Westrick, E.5    Parker, N.6
  • 82
    • 70449529788 scopus 로고    scopus 로고
    • FLIP-mediated autophagy regulation in cell death control
    • Lee J.S., Li Q., Lee J.Y., Lee S.H., Jeong J.H., Lee H.R., et al. FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol 2009, 11:1355-1362.
    • (2009) Nat Cell Biol , vol.11 , pp. 1355-1362
    • Lee, J.S.1    Li, Q.2    Lee, J.Y.3    Lee, S.H.4    Jeong, J.H.5    Lee, H.R.6
  • 83
    • 0347626109 scopus 로고    scopus 로고
    • Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins
    • Leone M., Zhai D., Sareth S., Kitada S., Reed J.C., Pellecchia M. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Res 2003, 63:8118-8121.
    • (2003) Cancer Res , vol.63 , pp. 8118-8121
    • Leone, M.1    Zhai, D.2    Sareth, S.3    Kitada, S.4    Reed, J.C.5    Pellecchia, M.6
  • 85
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • Letai A., Bassik M.C., Walensky L.D., Sorcinelli M.D., Weiler S., Korsmeyer S.J. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2002, 2:183-192.
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3    Sorcinelli, M.D.4    Weiler, S.5    Korsmeyer, S.J.6
  • 86
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 87
    • 48249092267 scopus 로고    scopus 로고
    • Bcl-2 family members: dual regulators of apoptosis and autophagy
    • Levine B., Sinha S., Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008, 4:600-606.
    • (2008) Autophagy , vol.4 , pp. 600-606
    • Levine, B.1    Sinha, S.2    Kroemer, G.3
  • 88
    • 68449083829 scopus 로고    scopus 로고
    • The prosurvival role of autophagy in resveratrol-induced cytotoxicity in human U251 glioma cells
    • Li J., Qin Z., Liang Z. The prosurvival role of autophagy in resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer 2009, 9:215.
    • (2009) BMC Cancer , vol.9 , pp. 215
    • Li, J.1    Qin, Z.2    Liang, Z.3
  • 89
    • 78649308481 scopus 로고    scopus 로고
    • The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells
    • Lian J., Karnak D., Xu L. The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells. Autophagy 2010, 6:1201-1203.
    • (2010) Autophagy , vol.6 , pp. 1201-1203
    • Lian, J.1    Karnak, D.2    Xu, L.3
  • 90
    • 0033214236 scopus 로고    scopus 로고
    • Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
    • Lin Y., Devin A., Rodriguez Y., Liu Z.G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 1999, 13:2514-2526.
    • (1999) Genes Dev , vol.13 , pp. 2514-2526
    • Lin, Y.1    Devin, A.2    Rodriguez, Y.3    Liu, Z.G.4
  • 91
    • 84869748202 scopus 로고    scopus 로고
    • Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors
    • Liu Q., Wang H.G. Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors. Commun Integr Biol 2012, 5:557-565.
    • (2012) Commun Integr Biol , vol.5 , pp. 557-565
    • Liu, Q.1    Wang, H.G.2
  • 92
    • 84870850140 scopus 로고    scopus 로고
    • New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
    • Long J.S., Ryan K.M. New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy. Oncogene 2012, 31:5045-5060.
    • (2012) Oncogene , vol.31 , pp. 5045-5060
    • Long, J.S.1    Ryan, K.M.2
  • 93
    • 33845936028 scopus 로고    scopus 로고
    • The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway
    • Lopez-Anton N., Rudy A., Barth N., Schmitz M.L., Pettit G.R., Schulze-Osthoff K., et al. The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. J Biol Chem 2006, 281:33078-33086.
    • (2006) J Biol Chem , vol.281 , pp. 33078-33086
    • Lopez-Anton, N.1    Rudy, A.2    Barth, N.3    Schmitz, M.L.4    Pettit, G.R.5    Schulze-Osthoff, K.6
  • 95
    • 0037138678 scopus 로고    scopus 로고
    • A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors
    • Lugovskoy A.A., Degterev A.I., Fahmy A.F., Zhou P., Gross J.D., Yuan J., et al. A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J Am Chem Soc 2002, 124:1234-1240.
    • (2002) J Am Chem Soc , vol.124 , pp. 1234-1240
    • Lugovskoy, A.A.1    Degterev, A.I.2    Fahmy, A.F.3    Zhou, P.4    Gross, J.D.5    Yuan, J.6
  • 96
    • 34250894388 scopus 로고    scopus 로고
    • BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
    • Maiuri M.C., Criollo A., Tasdemir E., Vicencio J.M., Tajeddine N., Hickman J.A., et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007, 3:374-376.
    • (2007) Autophagy , vol.3 , pp. 374-376
    • Maiuri, M.C.1    Criollo, A.2    Tasdemir, E.3    Vicencio, J.M.4    Tajeddine, N.5    Hickman, J.A.6
  • 97
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: crosstalk between autophagy and apoptosis
    • Maiuri M.C., Zalckvar E., Kimchi A., Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007, 8:741-752.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 98
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R., Karp C.M., Beaudoin B., Vuong N., Chen G., Chen H.Y., et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009, 137:1062-1075.
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3    Vuong, N.4    Chen, G.5    Chen, H.Y.6
  • 99
    • 80755132118 scopus 로고    scopus 로고
    • Boosting and suppressing mitotic phosphorylation
    • Medema R.H., Lindqvist A. Boosting and suppressing mitotic phosphorylation. Trends Biochem Sci 2011, 36:578-584.
    • (2011) Trends Biochem Sci , vol.36 , pp. 578-584
    • Medema, R.H.1    Lindqvist, A.2
  • 100
    • 77955708390 scopus 로고    scopus 로고
    • Overview of macroautophagy regulation in mammalian cells
    • Mehrpour M., Esclatine A., Beau I., Codogno P. Overview of macroautophagy regulation in mammalian cells. Cell Res 2010, 20:748-762.
    • (2010) Cell Res , vol.20 , pp. 748-762
    • Mehrpour, M.1    Esclatine, A.2    Beau, I.3    Codogno, P.4
  • 101
    • 51049106854 scopus 로고    scopus 로고
    • Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa
    • Meng Y., Tang W., Dai Y., Wu X., Liu M., Ji Q., et al. Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. Mol Cancer Ther 2008, 7:2192-2202.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2192-2202
    • Meng, Y.1    Tang, W.2    Dai, Y.3    Wu, X.4    Liu, M.5    Ji, Q.6
  • 102
    • 82755163093 scopus 로고    scopus 로고
    • Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H)
    • Misra J., Chanda D., Kim D.K., Li T., Koo S.H., Back S.H., et al. Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H). J Biol Chem 2011, 286:41972-41984.
    • (2011) J Biol Chem , vol.286 , pp. 41972-41984
    • Misra, J.1    Chanda, D.2    Kim, D.K.3    Li, T.4    Koo, S.H.5    Back, S.H.6
  • 103
    • 74849083369 scopus 로고    scopus 로고
    • Rosmarinic acid sensitizes cell death through suppression of TNF-alpha-induced NF-kappaB activation and ROS generation in human leukemia U937 cells
    • Moon D.O., Kim M.O., Lee J.D., Choi Y.H., Kim G.Y. Rosmarinic acid sensitizes cell death through suppression of TNF-alpha-induced NF-kappaB activation and ROS generation in human leukemia U937 cells. Cancer Lett 2010, 288:183-191.
    • (2010) Cancer Lett , vol.288 , pp. 183-191
    • Moon, D.O.1    Kim, M.O.2    Lee, J.D.3    Choi, Y.H.4    Kim, G.Y.5
  • 104
    • 77951878281 scopus 로고    scopus 로고
    • AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer
    • Moretti L., Li B., Kim K.W., Chen H., Lu B. AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer. J Thorac Oncol 2010, 5:680-687.
    • (2010) J Thorac Oncol , vol.5 , pp. 680-687
    • Moretti, L.1    Li, B.2    Kim, K.W.3    Chen, H.4    Lu, B.5
  • 106
    • 0142026431 scopus 로고    scopus 로고
    • Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1
    • Nakashima S., Hiraku Y., Tada-Oikawa S., Hishita T., Gabazza E.C., Tamaki S., et al. Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1. J Biochem 2003, 134:359-364.
    • (2003) J Biochem , vol.134 , pp. 359-364
    • Nakashima, S.1    Hiraku, Y.2    Tada-Oikawa, S.3    Hishita, T.4    Gabazza, E.C.5    Tamaki, S.6
  • 107
    • 2342448582 scopus 로고    scopus 로고
    • Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database
    • Nikolovska-Coleska Z., Xu L., Hu Z., Tomita Y., Li P., Roller P.P., et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem 2004, 47:2430-2440.
    • (2004) J Med Chem , vol.47 , pp. 2430-2440
    • Nikolovska-Coleska, Z.1    Xu, L.2    Hu, Z.3    Tomita, Y.4    Li, P.5    Roller, P.P.6
  • 109
    • 84860652885 scopus 로고    scopus 로고
    • Power from the garden: plant compounds as inhibitors of the hallmarks of cancer
    • Orlikova B., Diederich M. Power from the garden: plant compounds as inhibitors of the hallmarks of cancer. Curr Med Chem 2012, 19:2061-2087.
    • (2012) Curr Med Chem , vol.19 , pp. 2061-2087
    • Orlikova, B.1    Diederich, M.2
  • 110
    • 80051549637 scopus 로고    scopus 로고
    • The aromatic ketone 4'-hydroxychalcone inhibits TNFalpha-induced NF-kappaB activation via proteasome inhibition
    • Orlikova B., Tasdemir D., Golais F., Dicato M., Diederich M. The aromatic ketone 4'-hydroxychalcone inhibits TNFalpha-induced NF-kappaB activation via proteasome inhibition. Biochem Pharmacol 2011, 82:620-631.
    • (2011) Biochem Pharmacol , vol.82 , pp. 620-631
    • Orlikova, B.1    Tasdemir, D.2    Golais, F.3    Dicato, M.4    Diederich, M.5
  • 111
    • 79956360137 scopus 로고    scopus 로고
    • Dietary chalcones with chemopreventive and chemotherapeutic potential
    • Orlikova B., Tasdemir D., Golais F., Dicato M., Diederich M. Dietary chalcones with chemopreventive and chemotherapeutic potential. Genes Nutr 2011, 6:125-147.
    • (2011) Genes Nutr , vol.6 , pp. 125-147
    • Orlikova, B.1    Tasdemir, D.2    Golais, F.3    Dicato, M.4    Diederich, M.5
  • 112
    • 29644436953 scopus 로고    scopus 로고
    • P73, a sophisticated p53 family member in the cancer world
    • Ozaki T., Nakagawara A. p73, a sophisticated p53 family member in the cancer world. Cancer Sci 2005, 96:729-737.
    • (2005) Cancer Sci , vol.96 , pp. 729-737
    • Ozaki, T.1    Nakagawara, A.2
  • 113
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18:6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 114
    • 0034790052 scopus 로고    scopus 로고
    • Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity
    • Park J.W., Choi Y.J., Suh S.I., Baek W.K., Suh M.H., Jin I.N., et al. Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity. Carcinogenesis 2001, 22:1633-1639.
    • (2001) Carcinogenesis , vol.22 , pp. 1633-1639
    • Park, J.W.1    Choi, Y.J.2    Suh, S.I.3    Baek, W.K.4    Suh, M.H.5    Jin, I.N.6
  • 115
    • 80051519147 scopus 로고    scopus 로고
    • Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1
    • Polier G., Ding J., Konkimalla B.V., Eick D., Ribeiro N., Kohler R., et al. Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. Cell Death Dis 2011, 2:e182.
    • (2011) Cell Death Dis , vol.2
    • Polier, G.1    Ding, J.2    Konkimalla, B.V.3    Eick, D.4    Ribeiro, N.5    Kohler, R.6
  • 117
  • 118
    • 0024317851 scopus 로고
    • Strand scission in DNA induced by quercetin and Cu(II): role of Cu(I) and oxygen free radicals
    • Rahman A., Shahabuddin, Hadi S.M., Parish J.H., Ainley K. Strand scission in DNA induced by quercetin and Cu(II): role of Cu(I) and oxygen free radicals. Carcinogenesis 1989, 10:1833-1839.
    • (1989) Carcinogenesis , vol.10 , pp. 1833-1839
    • Rahman, A.1    Shahabuddin2    Hadi, S.M.3    Parish, J.H.4    Ainley, K.5
  • 119
    • 79953025265 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer
    • Ready N., Karaseva N.A., Orlov S.V., Luft A.V., Popovych O., Holmlund J.T., et al. Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer. J Thorac Oncol 2011, 6:781-785.
    • (2011) J Thorac Oncol , vol.6 , pp. 781-785
    • Ready, N.1    Karaseva, N.A.2    Orlov, S.V.3    Luft, A.V.4    Popovych, O.5    Holmlund, J.T.6
  • 120
    • 0028972616 scopus 로고
    • Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance
    • Reed J.C. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol 1995, 7:541-546.
    • (1995) Curr Opin Oncol , vol.7 , pp. 541-546
    • Reed, J.C.1
  • 121
    • 33745863017 scopus 로고    scopus 로고
    • Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms
    • Reed J.C. Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms. Nat Clin Pract Oncol 2006, 3:388-398.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 388-398
    • Reed, J.C.1
  • 122
    • 55949095821 scopus 로고    scopus 로고
    • Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells
    • Reuter S., Eifes S., Dicato M., Aggarwal B.B., Diederich M. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem Pharmacol 2008, 76:1340-1351.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1340-1351
    • Reuter, S.1    Eifes, S.2    Dicato, M.3    Aggarwal, B.B.4    Diederich, M.5
  • 123
    • 69149111441 scopus 로고    scopus 로고
    • Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells
    • Reuter S., Charlet J., Juncker T., Teiten M.H., Dicato M., Diederich M. Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells. Ann N Y Acad Sci 2009, 1171:436-447.
    • (2009) Ann N Y Acad Sci , vol.1171 , pp. 436-447
    • Reuter, S.1    Charlet, J.2    Juncker, T.3    Teiten, M.H.4    Dicato, M.5    Diederich, M.6
  • 124
    • 7744233719 scopus 로고    scopus 로고
    • Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint
    • Rieder C.L., Maiato H. Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev Cell 2004, 7:637-651.
    • (2004) Dev Cell , vol.7 , pp. 637-651
    • Rieder, C.L.1    Maiato, H.2
  • 125
    • 77952872240 scopus 로고    scopus 로고
    • Rationally simplified bistramide analog reversibly targets actin polymerization and inhibits cancer progression in vitro and in vivo
    • Rizvi S.A., Liu S., Chen Z., Skau C., Pytynia M., Kovar D.R., et al. Rationally simplified bistramide analog reversibly targets actin polymerization and inhibits cancer progression in vitro and in vivo. J Am Chem Soc 2010, 132:7288-7290.
    • (2010) J Am Chem Soc , vol.132 , pp. 7288-7290
    • Rizvi, S.A.1    Liu, S.2    Chen, Z.3    Skau, C.4    Pytynia, M.5    Kovar, D.R.6
  • 126
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • Roos W.P., Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol Med 2006, 12:440-450.
    • (2006) Trends Mol Med , vol.12 , pp. 440-450
    • Roos, W.P.1    Kaina, B.2
  • 127
    • 83455225635 scopus 로고    scopus 로고
    • The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis
    • Rubinstein A.D., Eisenstein M., Ber Y., Bialik S., Kimchi A. The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis. Mol Cell 2011, 44:698-709.
    • (2011) Mol Cell , vol.44 , pp. 698-709
    • Rubinstein, A.D.1    Eisenstein, M.2    Ber, Y.3    Bialik, S.4    Kimchi, A.5
  • 128
    • 0035073292 scopus 로고    scopus 로고
    • Phosphorylation of Bcl2 and regulation of apoptosis
    • Ruvolo P.P., Deng X., May W.S. Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia 2001, 15:515-522.
    • (2001) Leukemia , vol.15 , pp. 515-522
    • Ruvolo, P.P.1    Deng, X.2    May, W.S.3
  • 129
    • 0026594634 scopus 로고
    • Activities of flavonoids for the cleavage of DNA in the presence of Cu(II): correlation with generation of active oxygen species
    • Said Ahmad M., Fazal F., Rahman A., Hadi S.M., Parish J.H. Activities of flavonoids for the cleavage of DNA in the presence of Cu(II): correlation with generation of active oxygen species. Carcinogenesis 1992, 13:605-608.
    • (1992) Carcinogenesis , vol.13 , pp. 605-608
    • Said Ahmad, M.1    Fazal, F.2    Rahman, A.3    Hadi, S.M.4    Parish, J.H.5
  • 130
    • 84883203751 scopus 로고    scopus 로고
    • Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells
    • Saidu N.E., Abu Asali I., Czepukojc B., Seitz B., Jacob C., Montenarh M. Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells. Biochim Biophys Acta 2013, 1830:5267-5276.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 5267-5276
    • Saidu, N.E.1    Abu Asali, I.2    Czepukojc, B.3    Seitz, B.4    Jacob, C.5    Montenarh, M.6
  • 131
    • 53049107046 scopus 로고    scopus 로고
    • Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential
    • Salminen A., Lehtonen M., Suuronen T., Kaarniranta K., Huuskonen J. Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential. Cell Mol Life Sci 2008, 65:2979-2999.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2979-2999
    • Salminen, A.1    Lehtonen, M.2    Suuronen, T.3    Kaarniranta, K.4    Huuskonen, J.5
  • 132
    • 0036088471 scopus 로고    scopus 로고
    • IAP proteins: blocking the road to death's door
    • Salvesen G.S., Duckett C.S. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 2002, 3:401-410.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 401-410
    • Salvesen, G.S.1    Duckett, C.S.2
  • 134
    • 0033779074 scopus 로고    scopus 로고
    • Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties
    • Sasse F., Steinmetz H., Heil J., Hofle G., Reichenbach H. Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J Antibiot 2000, 53:879-885.
    • (2000) J Antibiot , vol.53 , pp. 879-885
    • Sasse, F.1    Steinmetz, H.2    Heil, J.3    Hofle, G.4    Reichenbach, H.5
  • 135
    • 84876767778 scopus 로고    scopus 로고
    • A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2011
    • Sawadogo W.R., Schumacher M., Teiten M.H., Cerella C., Dicato M., Diederich M. A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2011. Molecules 2013, 18:3641-3673.
    • (2013) Molecules , vol.18 , pp. 3641-3673
    • Sawadogo, W.R.1    Schumacher, M.2    Teiten, M.H.3    Cerella, C.4    Dicato, M.5    Diederich, M.6
  • 136
    • 71349086366 scopus 로고    scopus 로고
    • Heteronemin, a spongean sesterterpene, inhibits TNF alpha-induced NF-kappa B activation through proteasome inhibition and induces apoptotic cell death
    • Schumacher M., Cerella C., Eifes S., Chateauvieux S., Morceau F., Jaspars M., et al. Heteronemin, a spongean sesterterpene, inhibits TNF alpha-induced NF-kappa B activation through proteasome inhibition and induces apoptotic cell death. Biochem Pharmacol 2010, 79:610-622.
    • (2010) Biochem Pharmacol , vol.79 , pp. 610-622
    • Schumacher, M.1    Cerella, C.2    Eifes, S.3    Chateauvieux, S.4    Morceau, F.5    Jaspars, M.6
  • 137
    • 79956354307 scopus 로고    scopus 로고
    • Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-kappaB pathway
    • Schumacher M., Cerella C., Reuter S., Dicato M., Diederich M. Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-kappaB pathway. Genes Nutr 2011, 6:149-160.
    • (2011) Genes Nutr , vol.6 , pp. 149-160
    • Schumacher, M.1    Cerella, C.2    Reuter, S.3    Dicato, M.4    Diederich, M.5
  • 139
    • 0036163042 scopus 로고    scopus 로고
    • A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding
    • Shi Y. A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding. Cell Death Differ 2002, 9:93-95.
    • (2002) Cell Death Differ , vol.9 , pp. 93-95
    • Shi, Y.1
  • 140
    • 10344262564 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
    • Shimizu S., Kanaseki T., Mizushima N., Mizuta T., Arakawa-Kobayashi S., Thompson C.B., et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 2004, 6:1221-1228.
    • (2004) Nat Cell Biol , vol.6 , pp. 1221-1228
    • Shimizu, S.1    Kanaseki, T.2    Mizushima, N.3    Mizuta, T.4    Arakawa-Kobayashi, S.5    Thompson, C.B.6
  • 141
    • 35848938724 scopus 로고    scopus 로고
    • Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy
    • Shinojima N., Yokoyama T., Kondo Y., Kondo S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy 2007, 3:635-637.
    • (2007) Autophagy , vol.3 , pp. 635-637
    • Shinojima, N.1    Yokoyama, T.2    Kondo, Y.3    Kondo, S.4
  • 142
    • 80051621155 scopus 로고    scopus 로고
    • Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells
    • Singh M., Singh R., Bhui K., Tyagi S., Mahmood Z., Shukla Y. Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells. Oncol Res 2011, 19:245-257.
    • (2011) Oncol Res , vol.19 , pp. 245-257
    • Singh, M.1    Singh, R.2    Bhui, K.3    Tyagi, S.4    Mahmood, Z.5    Shukla, Y.6
  • 143
    • 71749096160 scopus 로고    scopus 로고
    • Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies
    • Solomon V.R., Lee H. Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol 2009, 625:220-233.
    • (2009) Eur J Pharmacol , vol.625 , pp. 220-233
    • Solomon, V.R.1    Lee, H.2
  • 144
    • 84863001577 scopus 로고    scopus 로고
    • Prime, repair, restore: the active role of chromatin in the DNA damage response
    • Soria G., Polo S.E., Almouzni G. Prime, repair, restore: the active role of chromatin in the DNA damage response. Mol Cell 2012, 46:722-734.
    • (2012) Mol Cell , vol.46 , pp. 722-734
    • Soria, G.1    Polo, S.E.2    Almouzni, G.3
  • 147
    • 75549087583 scopus 로고    scopus 로고
    • Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents
    • Stengel C., Newman S.P., Leese M.P., Potter B.V., Reed M.J., Purohit A. Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents. Br J Cancer 2010, 102:316-324.
    • (2010) Br J Cancer , vol.102 , pp. 316-324
    • Stengel, C.1    Newman, S.P.2    Leese, M.P.3    Potter, B.V.4    Reed, M.J.5    Purohit, A.6
  • 148
    • 84882450932 scopus 로고    scopus 로고
    • Various modes of cell death induced by DNA damage
    • Surova O., Zhivotovsky B. Various modes of cell death induced by DNA damage. Oncogene 2013, 32:3789-3797.
    • (2013) Oncogene , vol.32 , pp. 3789-3797
    • Surova, O.1    Zhivotovsky, B.2
  • 149
    • 79952264011 scopus 로고    scopus 로고
    • Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
    • Tabas I., Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 2011, 13:184-190.
    • (2011) Nat Cell Biol , vol.13 , pp. 184-190
    • Tabas, I.1    Ron, D.2
  • 150
    • 0037468160 scopus 로고    scopus 로고
    • In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis
    • Tanigaki K., Sasaki S., Ohkuma S. In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis. FEBS Lett 2003, 537:79-84.
    • (2003) FEBS Lett , vol.537 , pp. 79-84
    • Tanigaki, K.1    Sasaki, S.2    Ohkuma, S.3
  • 151
    • 67349266285 scopus 로고    scopus 로고
    • Induction of heat shock response by curcumin in human leukemia cells
    • Teiten M.H., Reuter S., Schumacher M., Dicato M., Diederich M. Induction of heat shock response by curcumin in human leukemia cells. Cancer Lett 2009, 279(2):145-154.
    • (2009) Cancer Lett , vol.279 , Issue.2 , pp. 145-154
    • Teiten, M.H.1    Reuter, S.2    Schumacher, M.3    Dicato, M.4    Diederich, M.5
  • 152
    • 79952025567 scopus 로고    scopus 로고
    • Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment
    • Teiten M.H., Eifes S., Dicato M., Diederich M. Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment. Toxins 2010, 2:128-162.
    • (2010) Toxins , vol.2 , pp. 128-162
    • Teiten, M.H.1    Eifes, S.2    Dicato, M.3    Diederich, M.4
  • 154
    • 84878600634 scopus 로고    scopus 로고
    • Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-kappaB activity
    • Teiten M.H., Mack F., Debbab A., Aly A.H., Dicato M., Proksch P., et al. Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-kappaB activity. Bioorg Med Chem 2013, 21:3850-3858.
    • (2013) Bioorg Med Chem , vol.21 , pp. 3850-3858
    • Teiten, M.H.1    Mack, F.2    Debbab, A.3    Aly, A.H.4    Dicato, M.5    Proksch, P.6
  • 155
    • 79960921946 scopus 로고    scopus 로고
    • The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
    • Tenev T., Bianchi K., Darding M., Broemer M., Langlais C., Wallberg F., et al. The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 2011, 43:432-448.
    • (2011) Mol Cell , vol.43 , pp. 432-448
    • Tenev, T.1    Bianchi, K.2    Darding, M.3    Broemer, M.4    Langlais, C.5    Wallberg, F.6
  • 156
    • 77954175674 scopus 로고    scopus 로고
    • Mcl-1; the molecular regulation of protein function
    • Thomas L.W., Lam C., Edwards S.W. Mcl-1; the molecular regulation of protein function. FEBS Lett 2010, 584:2981-2989.
    • (2010) FEBS Lett , vol.584 , pp. 2981-2989
    • Thomas, L.W.1    Lam, C.2    Edwards, S.W.3
  • 157
    • 40549085336 scopus 로고    scopus 로고
    • Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes
    • Trincheri N.F., Follo C., Nicotra G., Peracchio C., Castino R., Isidoro C. Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes. Carcinogenesis 2008, 29:381-389.
    • (2008) Carcinogenesis , vol.29 , pp. 381-389
    • Trincheri, N.F.1    Follo, C.2    Nicotra, G.3    Peracchio, C.4    Castino, R.5    Isidoro, C.6
  • 158
    • 34249982915 scopus 로고    scopus 로고
    • Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
    • Trudel S., Li Z.H., Rauw J., Tiedemann R.E., Wen X.Y., Stewart A.K. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood 2007, 109:5430-5438.
    • (2007) Blood , vol.109 , pp. 5430-5438
    • Trudel, S.1    Li, Z.H.2    Rauw, J.3    Tiedemann, R.E.4    Wen, X.Y.5    Stewart, A.K.6
  • 159
    • 77955432889 scopus 로고    scopus 로고
    • The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma
    • Voss V., Senft C., Lang V., Ronellenfitsch M.W., Steinbach J.P., Seifert V., et al. The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma. Mol Cancer Res 2010, 8:1002-1016.
    • (2010) Mol Cancer Res , vol.8 , pp. 1002-1016
    • Voss, V.1    Senft, C.2    Lang, V.3    Ronellenfitsch, M.W.4    Steinbach, J.P.5    Seifert, V.6
  • 160
    • 0034630161 scopus 로고    scopus 로고
    • The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems
    • Walczak H., Krammer P.H. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp Cell Res 2000, 256:58-66.
    • (2000) Exp Cell Res , vol.256 , pp. 58-66
    • Walczak, H.1    Krammer, P.H.2
  • 161
    • 74849132892 scopus 로고    scopus 로고
    • Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL
    • Wan K.F., Wang S., Brown C.J., Yu V.C., Entzeroth M., Lane D.P., et al. Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL. Cell Cycle 2009, 8:3943-3952.
    • (2009) Cell Cycle , vol.8 , pp. 3943-3952
    • Wan, K.F.1    Wang, S.2    Brown, C.J.3    Yu, V.C.4    Entzeroth, M.5    Lane, D.P.6
  • 162
    • 84863012010 scopus 로고    scopus 로고
    • Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death
    • Wang G., Wang J.J., Yang G.Y., Du S.M., Zeng N., Li D.S., et al. Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death. Int J Nanomedicine 2012, 7:271-280.
    • (2012) Int J Nanomedicine , vol.7 , pp. 271-280
    • Wang, G.1    Wang, J.J.2    Yang, G.Y.3    Du, S.M.4    Zeng, N.5    Li, D.S.6
  • 163
    • 84867368272 scopus 로고    scopus 로고
    • Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression
    • Wang H.C., Pao J., Lin S.Y., Sheen L.Y. Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Ann N Y Acad Sci 2012, 1271:44-52.
    • (2012) Ann N Y Acad Sci , vol.1271 , pp. 44-52
    • Wang, H.C.1    Pao, J.2    Lin, S.Y.3    Sheen, L.Y.4
  • 164
    • 84864213132 scopus 로고    scopus 로고
    • Role of autophagy in quercetin-induced apoptosis in human bladder carcinoma BIU-87 cells
    • [Chinese journal of oncology]
    • Wei L., Liu J.J., Cao J., Du N.C., Ji L.N., Yang X.L. Role of autophagy in quercetin-induced apoptosis in human bladder carcinoma BIU-87 cells. Zhonghua Zhong Liu Za Zhi 2012, 34:414-418. [Chinese journal of oncology].
    • (2012) Zhonghua Zhong Liu Za Zhi , vol.34 , pp. 414-418
    • Wei, L.1    Liu, J.J.2    Cao, J.3    Du, N.C.4    Ji, L.N.5    Yang, X.L.6
  • 165
    • 78649636176 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
    • Wirawan E., Vande Walle L., Kersse K., Cornelis S., Claerhout S., Vanoverberghe I., et al. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis 2010, 1:e18.
    • (2010) Cell Death Dis , vol.1
    • Wirawan, E.1    Vande Walle, L.2    Kersse, K.3    Cornelis, S.4    Claerhout, S.5    Vanoverberghe, I.6
  • 166
    • 58149316018 scopus 로고    scopus 로고
    • Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases cascade and mitochondrial-dependent pathways
    • Yang J.S., Chen G.W., Hsia T.C., Ho H.C., Ho C.C., Lin M.W., et al. Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases cascade and mitochondrial-dependent pathways. Food Chem Toxicol 2009, 47:171-179.
    • (2009) Food Chem Toxicol , vol.47 , pp. 171-179
    • Yang, J.S.1    Chen, G.W.2    Hsia, T.C.3    Ho, H.C.4    Ho, C.C.5    Lin, M.W.6
  • 168
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • Yu L., Alva A., Su H., Dutt P., Freundt E., Welsh S., et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004, 304:1500-1502.
    • (2004) Science , vol.304 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3    Dutt, P.4    Freundt, E.5    Welsh, S.6
  • 169
    • 48249140222 scopus 로고    scopus 로고
    • The selectivity of autophagy and its role in cell death and survival
    • Yu L., Strandberg L., Lenardo M.J. The selectivity of autophagy and its role in cell death and survival. Autophagy 2008, 4:567-573.
    • (2008) Autophagy , vol.4 , pp. 567-573
    • Yu, L.1    Strandberg, L.2    Lenardo, M.J.3
  • 170
    • 33750806817 scopus 로고    scopus 로고
    • Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft
    • Zhang Y.H., Bhunia A., Wan K.F., Lee M.C., Chan S.L., Yu V.C., et al. Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft. J Mol Biol 2006, 364:536-549.
    • (2006) J Mol Biol , vol.364 , pp. 536-549
    • Zhang, Y.H.1    Bhunia, A.2    Wan, K.F.3    Lee, M.C.4    Chan, S.L.5    Yu, V.C.6
  • 171
    • 67651160513 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo
    • Zhang D., Qiu L., Jin X., Guo Z., Guo C. Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo. Mol Cancer Res 2009, 7:1139-1149.
    • (2009) Mol Cancer Res , vol.7 , pp. 1139-1149
    • Zhang, D.1    Qiu, L.2    Jin, X.3    Guo, Z.4    Guo, C.5
  • 172
    • 79952780505 scopus 로고    scopus 로고
    • Functional complementation between FADD and RIP1 in embryos and lymphocytes
    • Zhang H., Zhou X., McQuade T., Li J., Chan F.K., Zhang J. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 2011, 471:373-376.
    • (2011) Nature , vol.471 , pp. 373-376
    • Zhang, H.1    Zhou, X.2    McQuade, T.3    Li, J.4    Chan, F.K.5    Zhang, J.6
  • 173
    • 33751509078 scopus 로고    scopus 로고
    • DNA damage induced by resveratrol and its synthetic analogues in the presence of Cu (II) ions: mechanism and structure-activity relationship
    • Zheng L.F., Wei Q.Y., Cai Y.J., Fang J.G., Zhou B., Yang L., et al. DNA damage induced by resveratrol and its synthetic analogues in the presence of Cu (II) ions: mechanism and structure-activity relationship. Free Radic Biol Med 2006, 41:1807-1816.
    • (2006) Free Radic Biol Med , vol.41 , pp. 1807-1816
    • Zheng, L.F.1    Wei, Q.Y.2    Cai, Y.J.3    Fang, J.G.4    Zhou, B.5    Yang, L.6
  • 174
    • 36849028123 scopus 로고    scopus 로고
    • Prooxidant activity of hydroxycinnamic acids on DNA damage in the presence of Cu(II) ions: mechanism and structure-activity relationship
    • Zheng L.F., Dai F., Zhou B., Yang L., Liu Z.L. Prooxidant activity of hydroxycinnamic acids on DNA damage in the presence of Cu(II) ions: mechanism and structure-activity relationship. Food Chem Toxicol 2008, 46:149-156.
    • (2008) Food Chem Toxicol , vol.46 , pp. 149-156
    • Zheng, L.F.1    Dai, F.2    Zhou, B.3    Yang, L.4    Liu, Z.L.5
  • 175
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H., Henzel W.J., Liu X., Lutschg A., Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997, 90:405-413.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 176
    • 84879621492 scopus 로고    scopus 로고
    • Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants
    • Zubair H., Khan H.Y., Sohail A., Azim S., Ullah M.F., Ahmad A., et al. Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants. Cell Death Dis 2013, 4:e660.
    • (2013) Cell Death Dis , vol.4
    • Zubair, H.1    Khan, H.Y.2    Sohail, A.3    Azim, S.4    Ullah, M.F.5    Ahmad, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.