메뉴 건너뛰기




Volumn 1271, Issue 1, 2012, Pages 44-52

Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression

Author keywords

Allyl sulfides; Apoptosis; ER stress; Garlic; ROS; Skin cancer

Indexed keywords

AJOENE; ALLYL SULFIDE; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BENZO[A]PYRENE; CASPASE 3; CASPASE 4; CASPASE 9; CROTON OIL; DIMETHYLBENZ[A]ANTHRACENE; GARLIC OIL; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SURVIVIN;

EID: 84867368272     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06743.x     Document Type: Article
Times cited : (93)

References (71)
  • 1
    • 68849096515 scopus 로고    scopus 로고
    • Skin cancer trends among Asians living in Singapore from 1968 to 2006
    • Sng, J. et al. 2009. Skin cancer trends among Asians living in Singapore from 1968 to 2006. J. Am. Acad. Dermatol. 61: 426-432.
    • (2009) J. Am. Acad. Dermatol , vol.61 , pp. 426-432
    • Sng, J.1
  • 2
    • 78650063265 scopus 로고    scopus 로고
    • A content analysis of news coverage of skin cancer in China newspapers
    • Liu, Y. et al. 2010. A content analysis of news coverage of skin cancer in China newspapers. Health Commun. 25: 647-649.
    • (2010) Health Commun. , vol.25 , pp. 647-649
    • Liu, Y.1
  • 3
    • 17244376894 scopus 로고    scopus 로고
    • Changing trends in the number of deaths from nonmelanoma skin cancer in Japan, 1955-2000
    • Ohtsuka, H. & S. Nagamatsu. 2005. Changing trends in the number of deaths from nonmelanoma skin cancer in Japan, 1955-2000. Dermatology 210: 206-210.
    • (2005) Dermatology , vol.210 , pp. 206-210
    • Ohtsuka, H.1    Nagamatsu, S.2
  • 4
    • 82455220844 scopus 로고    scopus 로고
    • Nonmelanoma skin cancer
    • ix.
    • Kim, R.H. & A.W. Armstrong. 2012. Nonmelanoma skin cancer. Dermatol. Clin. 30: 125-139, ix.
    • (2012) Dermatol. Clin. , vol.30 , pp. 125-139
    • Kim, R.H.1    Armstrong, A.W.2
  • 5
    • 84857053657 scopus 로고    scopus 로고
    • Melanoma: new insights and new therapies
    • Nikolaou, V.A. et al. 2012. Melanoma: new insights and new therapies. J. Invest. Dermatol. 132: 854-863.
    • (2012) J. Invest. Dermatol. , vol.132 , pp. 854-863
    • Nikolaou, V.A.1
  • 6
    • 84255176375 scopus 로고    scopus 로고
    • UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
    • Pfeifer, G.P. & A. Besaratinia. 2012. UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer. Photochem. Photobiol. Sci. 11: 90-97.
    • (2012) Photochem. Photobiol. Sci. , vol.11 , pp. 90-97
    • Pfeifer, G.P.1    Besaratinia, A.2
  • 7
    • 78651091810 scopus 로고    scopus 로고
    • Food intake and risk of basal cell carcinoma in an 11-year prospective study of Australian adults
    • van der Pols, J.C. et al. 2010. Food intake and risk of basal cell carcinoma in an 11-year prospective study of Australian adults. Eur. J. Clin. Nutr. 65: 39-46.
    • (2010) Eur. J. Clin. Nutr. , vol.65 , pp. 39-46
    • van der Pols, J.C.1
  • 8
    • 77951079764 scopus 로고    scopus 로고
    • Common links among the pathways leading to UV-induced immunosuppression
    • Halliday, G.M. 2010. Common links among the pathways leading to UV-induced immunosuppression. J. Invest. Dermatol. 130: 1209-1212.
    • (2010) J. Invest. Dermatol. , vol.130 , pp. 1209-1212
    • Halliday, G.M.1
  • 9
    • 34547689211 scopus 로고    scopus 로고
    • UV-induced immune suppression and photocarcinogenesis: chemoprevention by dietary botanical agents
    • Katiyar, S.K. 2007. UV-induced immune suppression and photocarcinogenesis: chemoprevention by dietary botanical agents. Cancer Lett. 255: 1-11.
    • (2007) Cancer Lett. , vol.255 , pp. 1-11
    • Katiyar, S.K.1
  • 10
    • 77449147298 scopus 로고    scopus 로고
    • Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms
    • Nichols, J.A. & S.K. Katiyar. 2010. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Arch. Dermatol. Res. 302: 71-83.
    • (2010) Arch. Dermatol. Res. , vol.302 , pp. 71-83
    • Nichols, J.A.1    Katiyar, S.K.2
  • 11
    • 31444433637 scopus 로고    scopus 로고
    • A population-based case-control study of diet and melanoma risk in northern Italy
    • Vinceti, M. et al. 2005. A population-based case-control study of diet and melanoma risk in northern Italy. Public Health Nutr. 8: 1307-1314.
    • (2005) Public Health Nutr. , vol.8 , pp. 1307-1314
    • Vinceti, M.1
  • 12
    • 0030411296 scopus 로고    scopus 로고
    • Vegetables, fruit, and cancer prevention: a review
    • Steinmetz, K.A. & J.D. Potter. 1996. Vegetables, fruit, and cancer prevention: a review. J. Am.Diet. Assoc. 96: 1027-1039.
    • (1996) J. Am.Diet. Assoc. , vol.96 , pp. 1027-1039
    • Steinmetz, K.A.1    Potter, J.D.2
  • 13
    • 0022039421 scopus 로고
    • The chemistry of garlic and onions
    • Block, E. 1985. The chemistry of garlic and onions. Sci. Am. 252: 114-119.
    • (1985) Sci. Am. , vol.252 , pp. 114-119
    • Block, E.1
  • 14
    • 1842789950 scopus 로고    scopus 로고
    • Solid-phase microextraction-gas chromatographic-mass spectrometric analysis of garlic oil obtained by hydrodistillation
    • Calvo-Gomez, O., J. Morales-Lopez & M.G. Lopez. 2004. Solid-phase microextraction-gas chromatographic-mass spectrometric analysis of garlic oil obtained by hydrodistillation. J. Chromatogr. A. 1036: 91-93.
    • (2004) J. Chromatogr. A. , vol.1036 , pp. 91-93
    • Calvo-Gomez, O.1    Morales-Lopez, J.2    Lopez, M.G.3
  • 15
    • 84867393701 scopus 로고
    • Preparation of spray-dried microcapsules with various amounts of basil, garlic and ginger essential oils and changes in oil signal transduction pathways
    • Sheen, L.Y., S.Y. Lin & S-J. Tsai. 1991. Preparation of spray-dried microcapsules with various amounts of basil, garlic and ginger essential oils and changes in oil signal transduction pathways. Biochem. Pharmacol. 64: 765-770.
    • (1991) Biochem. Pharmacol. , vol.64 , pp. 765-770
    • Sheen, L.Y.1    Lin, S.Y.2    Tsai, S.-J.3
  • 16
    • 0025788904 scopus 로고
    • Identification and HPLC quantitation of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products
    • Lawson, L.D., Z.J. Wang & B.G. Hughes. 1991. Identification and HPLC quantitation of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products. Planta Med. 57: 363-370.
    • (1991) Planta Med. , vol.57 , pp. 363-370
    • Lawson, L.D.1    Wang, Z.J.2    Hughes, B.G.3
  • 17
    • 51349109112 scopus 로고    scopus 로고
    • Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds
    • Powolny, A.A. & S.V. Singh. 2008. Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds. Cancer Lett. 269: 305-314.
    • (2008) Cancer Lett. , vol.269 , pp. 305-314
    • Powolny, A.A.1    Singh, S.V.2
  • 18
    • 84865614239 scopus 로고    scopus 로고
    • Recent research progress on garlic as a potential anticarcinogenic agent against major digestive cancers
    • Raghu, R. et al. 2012. Recent research progress on garlic as a potential anticarcinogenic agent against major digestive cancers. J. Trad. Complement. Med. 2: 192-201.
    • (2012) J. Trad. Complement. Med. , vol.2 , pp. 192-201
    • Raghu, R.1
  • 19
    • 32444433056 scopus 로고    scopus 로고
    • Cellular aspects of photocarcinogenesis
    • Nishigori, C. 2006. Cellular aspects of photocarcinogenesis. Photochem. Photobiol. Sci. 5: 208-214.
    • (2006) Photochem. Photobiol. Sci. , vol.5 , pp. 208-214
    • Nishigori, C.1
  • 20
    • 70249123827 scopus 로고    scopus 로고
    • Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications
    • Abel, E.L. et al. 2009. Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat. Protoc. 4: 1350-1362.
    • (2009) Nat. Protoc. , vol.4 , pp. 1350-1362
    • Abel, E.L.1
  • 22
    • 0020964874 scopus 로고
    • Onion and garlic oils inhibit tumor promotion
    • Belman, S. 1983. Onion and garlic oils inhibit tumor promotion. Carcinogenesis. 4: 1063-1065.
    • (1983) Carcinogenesis. , vol.4 , pp. 1063-1065
    • Belman, S.1
  • 23
    • 0023917734 scopus 로고
    • Inhibitory action of garlic oil on the initiation of benzo[a]pyrene-induced skin carcinogenesis in mice
    • Sadhana, A.S. et al. 1988. Inhibitory action of garlic oil on the initiation of benzo[a]pyrene-induced skin carcinogenesis in mice. Cancer Lett. 40: 193-197.
    • (1988) Cancer Lett. , vol.40 , pp. 193-197
    • Sadhana, A.S.1
  • 24
    • 0025242851 scopus 로고
    • Inhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oils
    • Perchellet, J.P., E.M. Perchellet & S. Belman. 1990. Inhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oils. Nutr. Cancer. 14: 183-193.
    • (1990) Nutr. Cancer. , vol.14 , pp. 183-193
    • Perchellet, J.P.1    Perchellet, E.M.2    Belman, S.3
  • 25
    • 0025056849 scopus 로고
    • Inhibition of benzoyl peroxide-mediated tumor promotion in 7,12-dimethylbenz(a) anthracene-initiated skin of Sencar mice by antioxidants nordihydroguaiaretic acid and diallyl sulfide
    • Athar, M. et al. 1990. Inhibition of benzoyl peroxide-mediated tumor promotion in 7, 12-dimethylbenz(a) anthracene-initiated skin of Sencar mice by antioxidants nordihydroguaiaretic acid and diallyl sulfide. J. Invest. Dermatol. 94: 162-165.
    • (1990) J. Invest. Dermatol. , vol.94 , pp. 162-165
    • Athar, M.1
  • 26
    • 0026564271 scopus 로고
    • Chemoprevention of chemically induced skin tumor development by diallyl sulfide and diallyl disulfide
    • Dwivedi, C. et al. 1992. Chemoprevention of chemically induced skin tumor development by diallyl sulfide and diallyl disulfide. Pharm. Res. 9: 1668-1670.
    • (1992) Pharm. Res. , vol.9 , pp. 1668-1670
    • Dwivedi, C.1
  • 27
    • 33749241471 scopus 로고    scopus 로고
    • Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin
    • Arora, A., N. Kalra & Y. Shukla. 2006. Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin. Cancer Lett. 242: 28-36.
    • (2006) Cancer Lett. , vol.242 , pp. 28-36
    • Arora, A.1    Kalra, N.2    Shukla, Y.3
  • 28
    • 60749085613 scopus 로고    scopus 로고
    • Effect of garlic on lipid peroxidation and antioxidation enzymes in DMBA-induced skin carcinoma
    • Das, I. & T. Saha. 2009. Effect of garlic on lipid peroxidation and antioxidation enzymes in DMBA-induced skin carcinoma. Nutrition 25: 459-471.
    • (2009) Nutrition , vol.25 , pp. 459-471
    • Das, I.1    Saha, T.2
  • 29
    • 36649010400 scopus 로고    scopus 로고
    • Preventive effects of diallyl sulfide on 7,12-dimethylbenz[a]anthracene induced DNA alkylation damage in mouse skin
    • Nigam, N. & Y. Shukla. 2007. Preventive effects of diallyl sulfide on 7, 12-dimethylbenz[a]anthracene induced DNA alkylation damage in mouse skin. Mol. Nutr. Food Res. 51: 1324-1328.
    • (2007) Mol. Nutr. Food Res. , vol.51 , pp. 1324-1328
    • Nigam, N.1    Shukla, Y.2
  • 30
    • 33947517318 scopus 로고    scopus 로고
    • Involvement of multiple signaling pathways in diallyl sulfide mediated apoptosis in mouse skin tumors
    • Kalra, N., A. Arora & Y. Shukla. 2006. Involvement of multiple signaling pathways in diallyl sulfide mediated apoptosis in mouse skin tumors. Asian Pac. J. Cancer Prev. 7: 556-562.
    • (2006) Asian Pac. J. Cancer Prev. , vol.7 , pp. 556-562
    • Kalra, N.1    Arora, A.2    Shukla, Y.3
  • 31
    • 0032151717 scopus 로고    scopus 로고
    • Antitumor activity of diallyl sulfide in two-stage mouse skin model of carcinogenesis
    • Singh, A. & Y. Shukla. 1998. Antitumor activity of diallyl sulfide in two-stage mouse skin model of carcinogenesis. Biomed. Environ. Sci. 11: 258-263.
    • (1998) Biomed. Environ. Sci. , vol.11 , pp. 258-263
    • Singh, A.1    Shukla, Y.2
  • 32
    • 0036949182 scopus 로고    scopus 로고
    • Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors
    • Arora, A. & Y. Shukla. 2002. Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors. Nutr. Cancer 44: 89-94.
    • (2002) Nutr. Cancer , vol.44 , pp. 89-94
    • Arora, A.1    Shukla, Y.2
  • 33
    • 9444241651 scopus 로고    scopus 로고
    • Modulation of p53 in 7,12-dimethylbenz[a]anthracene-induced skin tumors by diallyl sulfide in Swiss albino mice
    • Arora, A., I.A. Siddiqui & Y. Shukla. 2004. Modulation of p53 in 7, 12-dimethylbenz[a]anthracene-induced skin tumors by diallyl sulfide in Swiss albino mice. Mol. Cancer Ther. 3: 1459-1466.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1459-1466
    • Arora, A.1    Siddiqui, I.A.2    Shukla, Y.3
  • 34
    • 77950280661 scopus 로고    scopus 로고
    • Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling
    • Shrotriya, S. et al. 2010. Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling. Cancer Res. 70: 1932-1940.
    • (2010) Cancer Res. , vol.70 , pp. 1932-1940
    • Shrotriya, S.1
  • 35
    • 33749241471 scopus 로고    scopus 로고
    • Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin
    • Arora, A., N. Kalra & Y. Shukla. 2006. Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin. Cancer Lett. 242: 28-36.
    • (2006) Cancer Lett. , vol.242 , pp. 28-36
    • Arora, A.1    Kalra, N.2    Shukla, Y.3
  • 36
    • 0042336818 scopus 로고    scopus 로고
    • Inhibition by ajoene of skin-tumor promotion in mice
    • Nishikawa, T. et al. 2002. Inhibition by ajoene of skin-tumor promotion in mice. Biosci. Biotechnol. Biochem. 66: 2221-2223.
    • (2002) Biosci. Biotechnol. Biochem. , vol.66 , pp. 2221-2223
    • Nishikawa, T.1
  • 37
    • 77953148360 scopus 로고    scopus 로고
    • Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis
    • Wang, H.C. et al. 2010. Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis. J. Agric. Food Chem. 58: 7096-7103.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 7096-7103
    • Wang, H.C.1
  • 38
    • 84863646670 scopus 로고    scopus 로고
    • Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway
    • Wang, H.C. et al. 2012. Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway. Nutr. Cancer 64: 1-11.
    • (2012) Nutr. Cancer , vol.64 , pp. 1-11
    • Wang, H.C.1
  • 39
    • 34250747473 scopus 로고    scopus 로고
    • Polysulfides as biologically active ingredients of garlic
    • Munchberg, U. et al. 2007. Polysulfides as biologically active ingredients of garlic. Org. Biomol. Chem. 5: 1505-1518.
    • (2007) Org. Biomol. Chem. , vol.5 , pp. 1505-1518
    • Munchberg, U.1
  • 40
    • 79954459360 scopus 로고    scopus 로고
    • Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds
    • Cerella, C. et al. 2011. Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds. Anticancer Agents Med. Chem. 11: 267-271.
    • (2011) Anticancer Agents Med. Chem. , vol.11 , pp. 267-271
    • Cerella, C.1
  • 41
    • 33644844644 scopus 로고    scopus 로고
    • Redox-sensitive proteins are potential targets of garlic-derived mercaptocysteine derivatives
    • Pinto, J.T., B.F. Krasnikov & A.J. Cooper. 2006. Redox-sensitive proteins are potential targets of garlic-derived mercaptocysteine derivatives. J. Nutr. 136: 835S-841S.
    • (2006) J. Nutr. , vol.136
    • Pinto, J.T.1    Krasnikov, B.F.2    Cooper, A.J.3
  • 42
    • 0142188703 scopus 로고    scopus 로고
    • Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation
    • Xiao, D. et al. 2003. Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. Cancer Res. 63: 6825-6837.
    • (2003) Cancer Res. , vol.63 , pp. 6825-6837
    • Xiao, D.1
  • 43
    • 68249108128 scopus 로고    scopus 로고
    • Targeting the DNA damage response for cancer therapy
    • Powell, S.N. & R.S. Bindra. 2009. Targeting the DNA damage response for cancer therapy. DNA Repair 8: 1153-1165.
    • (2009) DNA Repair , vol.8 , pp. 1153-1165
    • Powell, S.N.1    Bindra, R.S.2
  • 44
    • 55949084077 scopus 로고    scopus 로고
    • Molecular transduction mechanisms of the redox network underlying the antiproliferative effects of allyl compounds from garlic
    • Filomeni, G., G. Rotilio & M.R. Ciriolo. 2008. Molecular transduction mechanisms of the redox network underlying the antiproliferative effects of allyl compounds from garlic. J. Nutr. 138: 2053-2057.
    • (2008) J. Nutr. , vol.138 , pp. 2053-2057
    • Filomeni, G.1    Rotilio, G.2    Ciriolo, M.R.3
  • 45
    • 84863253114 scopus 로고    scopus 로고
    • A garlic derivative, S-allylcysteine (SAC), suppresses proliferation and metastasis of hepatocellular carcinoma
    • Ng, K.T. et al. 2012. A garlic derivative, S-allylcysteine (SAC), suppresses proliferation and metastasis of hepatocellular carcinoma. PLoS One 7: e31655.
    • (2012) PLoS One , vol.7
    • Ng, K.T.1
  • 46
    • 70349286052 scopus 로고    scopus 로고
    • DNA damage-induced cell death is enhanced by progression through mitosis
    • Varmark, H. et al. 2009. DNA damage-induced cell death is enhanced by progression through mitosis. Cell Cycle 8: 2951-2963.
    • (2009) Cell Cycle , vol.8 , pp. 2951-2963
    • Varmark, H.1
  • 47
    • 7044263002 scopus 로고    scopus 로고
    • Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells
    • Wu, C.C. et al. 2004. Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells. Food Chem. Toxicol. 42: 1937-1947.
    • (2004) Food Chem. Toxicol , vol.42 , pp. 1937-1947
    • Wu, C.C.1
  • 48
    • 77953231700 scopus 로고    scopus 로고
    • Diallyl trisulfide-induced G2/M phase cell cycle arrest in DU145 cells is associated with delayed nuclear translocation of cyclin-dependent kinase 1
    • Herman-Antosiewicz, A. et al. 2010. Diallyl trisulfide-induced G2/M phase cell cycle arrest in DU145 cells is associated with delayed nuclear translocation of cyclin-dependent kinase 1. Pharm. Res. 27: 1072-1079.
    • (2010) Pharm. Res. , vol.27 , pp. 1072-1079
    • Herman-Antosiewicz, A.1
  • 49
    • 63049130448 scopus 로고    scopus 로고
    • Biological properties of garlic and garlic-derived organosulfur compounds
    • Iciek, M., I. Kwiecien & L. Wlodek. 2009. Biological properties of garlic and garlic-derived organosulfur compounds. Environ. Mol. Mutagen. 50: 247-265.
    • (2009) Environ. Mol. Mutagen. , vol.50 , pp. 247-265
    • Iciek, M.1    Kwiecien, I.2    Wlodek, L.3
  • 50
    • 28044435379 scopus 로고    scopus 로고
    • Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C
    • Xiao, D. et al. 2005. Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C. Oncogene 24: 6256-6268.
    • (2005) Oncogene , vol.24 , pp. 6256-6268
    • Xiao, D.1
  • 51
    • 28644436192 scopus 로고    scopus 로고
    • Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests
    • Stanford, J.S. & J.V. Ruderman. 2005. Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests. Mol. Biol. Cell 16: 5749-5760.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 5749-5760
    • Stanford, J.S.1    Ruderman, J.V.2
  • 52
    • 80355141492 scopus 로고    scopus 로고
    • Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide
    • Antony, M.L. & S.V. Singh. 2011. Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide. Indian J. Exp. Biol. 49: 805-816.
    • (2011) Indian J. Exp. Biol. , vol.49 , pp. 805-816
    • Antony, M.L.1    Singh, S.V.2
  • 53
    • 0029970362 scopus 로고    scopus 로고
    • Diallyl disulfide induces apoptosis of human colon tumor cells
    • Sundaram, S.G. & J.A. Milner. 1996. Diallyl disulfide induces apoptosis of human colon tumor cells. Carcinogenesis 17: 669-673.
    • (1996) Carcinogenesis , vol.17 , pp. 669-673
    • Sundaram, S.G.1    Milner, J.A.2
  • 54
    • 77949670442 scopus 로고    scopus 로고
    • Markers expression of cell proliferation and apoptosis in basal cell carcinoma
    • Correa Mde, P. et al. 2009. Markers expression of cell proliferation and apoptosis in basal cell carcinoma. An. Bras. Dermatol. 84: 606-614.
    • (2009) An. Bras. Dermatol. , vol.84 , pp. 606-614
    • Correa Mde, P.1
  • 55
    • 0042659566 scopus 로고    scopus 로고
    • The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis
    • Tilli, C.M. et al. 2003. The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis. Arch. Dermatol. Res. 295: 117-123.
    • (2003) Arch. Dermatol. Res. , vol.295 , pp. 117-123
    • Tilli, C.M.1
  • 56
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li, P. et al. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1
  • 59
    • 33644873086 scopus 로고    scopus 로고
    • Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo
    • Koblish, H.K. et al. 2006. Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo. Mol. Cancer Ther. 5: 160-169.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 160-169
    • Koblish, H.K.1
  • 60
    • 70349145859 scopus 로고    scopus 로고
    • Caspase-independent pathways of programmed cell death: the unraveling of new targets of cancer therapy
    • Constantinou, C., K.A. Papas & A.I. Constantinou. 2009. Caspase-independent pathways of programmed cell death: the unraveling of new targets of cancer therapy Curr. Cancer Drug. Targets. 9: 717-728.
    • (2009) Curr. Cancer Drug. Targets. , vol.9 , pp. 717-728
    • Constantinou, C.1    Papas, K.A.2    Constantinou, A.I.3
  • 61
    • 19644375921 scopus 로고    scopus 로고
    • Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G
    • Widlak, P. & W.T. Garrard. 2005. Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G. J. Cell Biochem. 94: 1078-1087.
    • (2005) J. Cell Biochem. , vol.94 , pp. 1078-1087
    • Widlak, P.1    Garrard, W.T.2
  • 62
    • 0037016686 scopus 로고    scopus 로고
    • HtrA(2) promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
    • Verhagen, A.M. et al. 2002. HtrA(2) promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277: 445-454.
    • (2002) J. Biol. Chem. , vol.277 , pp. 445-454
    • Verhagen, A.M.1
  • 64
    • 43249109174 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress responses
    • Schroder, M. 2008. Endoplasmic reticulum stress responses. Cell Mol. Life Sci. 65: 862-894.
    • (2008) Cell Mol. Life Sci , vol.65 , pp. 862-894
    • Schroder, M.1
  • 65
    • 34548152518 scopus 로고    scopus 로고
    • Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells
    • Das, A., N.L. Banik & S.K. Ray. 2007. Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells. Cancer 110: 1083-1095.
    • (2007) Cancer , vol.110 , pp. 1083-1095
    • Das, A.1    Banik, N.L.2    Ray, S.K.3
  • 66
    • 0030071542 scopus 로고    scopus 로고
    • Diallyl disulfide inhibits the proliferation of human tumor cells in culture
    • Sundaram, S.G. & J.A. Milner. 1996. Diallyl disulfide inhibits the proliferation of human tumor cells in culture. Biochim. Biophys. Acta. 1315: 15-20.
    • (1996) Biochim. Biophys. Acta. , vol.1315 , pp. 15-20
    • Sundaram, S.G.1    Milner, J.A.2
  • 67
    • 77749313046 scopus 로고    scopus 로고
    • Photoactivation of 9-hydroxyph eophorbide alpha triggers apoptosis through the reactive oxygen species-mediated mitochondrial pathway and endoplasmic reticulum stress in AMC-HN-3 laryngeal cancer cells
    • He, P. et al. 2010. Photoactivation of 9-hydroxyph eophorbide alpha triggers apoptosis through the reactive oxygen species-mediated mitochondrial pathway and endoplasmic reticulum stress in AMC-HN-3 laryngeal cancer cells. Int. J. Oncol. 36: 801-808.
    • (2010) Int. J. Oncol. , vol.36 , pp. 801-808
    • He, P.1
  • 68
    • 33645656552 scopus 로고    scopus 로고
    • Cutaneous malignant melanoma
    • Cummins, D.L. et al. 2006. Cutaneous malignant melanoma. Mayo. Clin. Proc. 81: 500-507.
    • (2006) Mayo. Clin. Proc. , vol.81 , pp. 500-507
    • Cummins, D.L.1
  • 69
    • 33745667762 scopus 로고    scopus 로고
    • Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice
    • Taylor, P. et al. 2006. Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice. Cancer Lett. 239: 298-304.
    • (2006) Cancer Lett. , vol.239 , pp. 298-304
    • Taylor, P.1
  • 71
    • 0345862188 scopus 로고    scopus 로고
    • Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling
    • Bowden, G.T. 2004. Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling. Nat. Rev. Cancer 4: 23-35.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 23-35
    • Bowden, G.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.