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Volumn 18, Issue 4, 2013, Pages 3641-3673

A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2011

Author keywords

Anticancer molecules; Cancer; Marine origin; Synthetic derivatives

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT;

EID: 84876767778     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18043641     Document Type: Review
Times cited : (65)

References (138)
  • 1
    • 78651486094 scopus 로고    scopus 로고
    • IARC. International Agency for Research on Cancer: Lyon, France
    • IARC. Cancer Incidence and Mortality Worlwide; International Agency for Research on Cancer: Lyon, France, 2011.
    • (2011) Cancer Incidence and Mortality Worlwide
  • 4
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012, 75, 311-335.
    • (2012) J. Nat. Prod. , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 6
    • 4344650390 scopus 로고    scopus 로고
    • Marine natural products and related compounds in clinical and advanced preclinical trials
    • Newman, D.J.; Cragg, G.M. Marine natural products and related compounds in clinical and advanced preclinical trials. J. Nat. Prod. 2004, 67, 1216-1238.
    • (2004) J. Nat. Prod. , vol.67 , pp. 1216-1238
    • Newman, D.J.1    Cragg, G.M.2
  • 7
    • 78650377362 scopus 로고    scopus 로고
    • Molluscan biological and chemical diversity: Secondary metabolites and medicinal resources produced by marine molluscs
    • Benkendorff, K. Molluscan biological and chemical diversity: Secondary metabolites and medicinal resources produced by marine molluscs. Biol. Rev. 2010, 85, 757-775.
    • (2010) Biol. Rev. , vol.85 , pp. 757-775
    • Benkendorff, K.1
  • 9
    • 79960812511 scopus 로고    scopus 로고
    • A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2010
    • Schumacher, M.; Kelkel, M.; Dicato, M.; Diederich, M. A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2010. Molecules 2011, 16, 5629-5646.
    • (2011) Molecules , vol.16 , pp. 5629-5646
    • Schumacher, M.1    Kelkel, M.2    Dicato, M.3    Diederich, M.4
  • 10
    • 0000114293 scopus 로고
    • Agelasine-A, -B, -C and -D, novel bicyclic diterpenoids with a 9-methyladeninium unit possessing inhibitory effects on na,K-atpase from the okinawa sea sponge Agelas sp.1)
    • Nakamura, H.; Wu, H.; Ohizumi, Y.; Hirata, Y. Agelasine-A, -B, -C and -D, novel bicyclic diterpenoids with a 9-methyladeninium unit possessing inhibitory effects on na,K-atpase from the okinawa sea sponge Agelas sp.1). Tetrahedron Lett. 1984, 25, 2989-2992.
    • (1984) Tetrahedron Lett. , vol.25 , pp. 2989-2992
    • Nakamura, H.1    Wu, H.2    Ohizumi, Y.3    Hirata, Y.4
  • 12
    • 79959619770 scopus 로고    scopus 로고
    • Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice model
    • Yan, X.; Chen, H.; Lu, X.; Wang, F.; Xu, W.; Jin, H.; Zhu, P. Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice model. Eur. J. Pharm. Sci. 2011, 43, 251-259.
    • (2011) Eur. J. Pharm. Sci. , vol.43 , pp. 251-259
    • Yan, X.1    Chen, H.2    Lu, X.3    Wang, F.4    Xu, W.5    Jin, H.6    Zhu, P.7
  • 13
  • 15
    • 33846269340 scopus 로고    scopus 로고
    • Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo
    • Lin, J.; Yan, X.J.; Chen, H.M. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo. Cancer Chemother. Pharmacol. 2007, 59, 439-445.
    • (2007) Cancer Chemother. Pharmacol. , vol.59 , pp. 439-445
    • Lin, J.1    Yan, X.J.2    Chen, H.M.3
  • 16
    • 77956878953 scopus 로고    scopus 로고
    • Direct effects of fascaplysin on human umbilical vein endothelial cells attributing the anti-angiogenesis activity
    • Zheng, Y.L.; Lu, X.L.; Lin, J.; Chen, H.M.; Yan, X.J.; Wang, F.; Xu, W.F. Direct effects of fascaplysin on human umbilical vein endothelial cells attributing the anti-angiogenesis activity. Biomed. Pharmacother. 2010, 64, 527-533.
    • (2010) Biomed. Pharmacother. , vol.64 , pp. 527-533
    • Zheng, Y.L.1    Lu, X.L.2    Lin, J.3    Chen, H.M.4    Yan, X.J.5    Wang, F.6    Xu, W.F.7
  • 17
    • 0035039381 scopus 로고    scopus 로고
    • DNA binding properties of the marine sponge pigment fascaplysin
    • Hormann, A.; Chaudhuri, B.; Fretz, H. DNA binding properties of the marine sponge pigment fascaplysin. Bioorg. Med. Chem. 2001, 9, 917-921.
    • (2001) Bioorg. Med. Chem. , vol.9 , pp. 917-921
    • Hormann, A.1    Chaudhuri, B.2    Fretz, H.3
  • 18
    • 71049132728 scopus 로고    scopus 로고
    • Anti-proliferation of human cervical cancer HeLa cell line by fascaplysin through apoptosis induction
    • Lu, X.L.; Zheng, Y.L.; Chen, H.M.; Yan, X.J.; Wang, F.; Xu, W.F. Anti-proliferation of human cervical cancer HeLa cell line by fascaplysin through apoptosis induction. Yao Xue Xue Bao 2009, 44, 980-986.
    • (2009) Yao Xue Xue Bao , vol.44 , pp. 980-986
    • Lu, X.L.1    Zheng, Y.L.2    Chen, H.M.3    Yan, X.J.4    Wang, F.5    Xu, W.F.6
  • 19
    • 84865057198 scopus 로고    scopus 로고
    • Fascaplysin as a specific inhibitor for CDK4: Insights from molecular modelling
    • Shafiq, M.I.; Steinbrecher, T.; Schmid, R. Fascaplysin as a specific inhibitor for CDK4: Insights from molecular modelling. PLoS One 2012, 7, e42612.
    • (2012) PLoS One , vol.7
    • Shafiq, M.I.1    Steinbrecher, T.2    Schmid, R.3
  • 20
  • 21
    • 40749112696 scopus 로고    scopus 로고
    • Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines
    • Shinkre, B.A.; Raisch, K.P.; Fan, L.; Velu, S.E. Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines. Bioorg. Med. Chem. 2008, 16, 2541-2549.
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 2541-2549
    • Shinkre, B.A.1    Raisch, K.P.2    Fan, L.3    Velu, S.E.4
  • 22
    • 79958124181 scopus 로고    scopus 로고
    • Experimental therapy of ovarian cancer with synthetic makaluvamine analog: In vitro and in vivo anticancer activity and molecular mechanisms of action
    • Chen, T.; Xu, Y.; Guo, H.; Liu, Y.; Hu, P.; Yang, X.; Li, X.; Ge, S.; Velu, S.E.; Nadkarni, D.H.; et al. Experimental therapy of ovarian cancer with synthetic makaluvamine analog: In vitro and in vivo anticancer activity and molecular mechanisms of action. PLoS One 2011, 6, e20729.
    • (2011) PLoS One , vol.6
    • Chen, T.1    Xu, Y.2    Guo, H.3    Liu, Y.4    Hu, P.5    Yang, X.6    Li, X.7    Ge, S.8    Velu, S.E.9    Nadkarni, D.H.10
  • 23
  • 26
    • 84879100388 scopus 로고    scopus 로고
    • Phase i study of PM00104 (Zalypsis ®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors
    • doi:10.1007/s10637-012-9843-5
    • Massard, C.; Margetts, J.; Amellal, N.; Drew, Y.; Bahleda, R.; Stevens, P.; Armand, J.P.; Calvert, H.; Soria, J.C.; Coronado, C.; et al. Phase I study of PM00104 (Zalypsis ®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors. Invest. New Drugs 2012, doi:10.1007/s10637-012-9843-5.
    • (2012) Invest. New Drugs
    • Massard, C.1    Margetts, J.2    Amellal, N.3    Drew, Y.4    Bahleda, R.5    Stevens, P.6    Armand, J.P.7    Calvert, H.8    Soria, J.C.9    Coronado, C.10
  • 27
    • 84859651995 scopus 로고    scopus 로고
    • First-in-man phase i trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours
    • Yap, T.A.; Cortes-Funes, H.; Shaw, H.; Rodriguez, R.; Olmos, D.; Lal, R.; Fong, P.C.; Tan, D.S.; Harris, D.; Capdevila, J.; et al. First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours. Br. J. Cancer 2012, 106, 1379-1385.
    • (2012) Br. J. Cancer , vol.106 , pp. 1379-1385
    • Yap, T.A.1    Cortes-Funes, H.2    Shaw, H.3    Rodriguez, R.4    Olmos, D.5    Lal, R.6    Fong, P.C.7    Tan, D.S.8    Harris, D.9    Capdevila, J.10
  • 30
    • 77952580649 scopus 로고    scopus 로고
    • Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi
    • Zhang, J.Y.; Tao, L.Y.; Liang, Y.J.; Chen, L.M.; Mi, Y.J.; Zheng, L.S.; Wang, F.; She, Z.G.; Lin, Y.C.; To, K.K.; et al. Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi. Mar. Drugs 2010, 8, 1469-1481.
    • (2010) Mar. Drugs , vol.8 , pp. 1469-1481
    • Zhang, J.Y.1    Tao, L.Y.2    Liang, Y.J.3    Chen, L.M.4    Mi, Y.J.5    Zheng, L.S.6    Wang, F.7    She, Z.G.8    Lin, Y.C.9    To, K.K.10
  • 31
    • 79551708802 scopus 로고    scopus 로고
    • A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells
    • Yuan, J.; He, Z.; Wu, J.; Lin, Y.; Zhu, X. A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells. Mol. Med. Report. 2011, 4, 261-265.
    • (2011) Mol. Med. Report. , vol.4 , pp. 261-265
    • Yuan, J.1    He, Z.2    Wu, J.3    Lin, Y.4    Zhu, X.5
  • 32
    • 4043132339 scopus 로고    scopus 로고
    • Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways
    • Chin, P.C.; D'Mello, S.R. Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways. Mol. Brain Res. 2004, 127, 140-145.
    • (2004) Mol. Brain Res. , vol.127 , pp. 140-145
    • Chin, P.C.1    D'Mello, S.R.2
  • 33
    • 15544369937 scopus 로고    scopus 로고
    • Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line
    • Lee, S.; Choi, E.J.; Jin, C.; Kim, D.H. Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line. Gynecol. Oncol. 2005, 97, 26-34.
    • (2005) Gynecol. Oncol. , vol.97 , pp. 26-34
    • Lee, S.1    Choi, E.J.2    Jin, C.3    Kim, D.H.4
  • 34
    • 29644442524 scopus 로고    scopus 로고
    • Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner
    • Fujiwara, Y.; Kawada, K.; Takano, D.; Tanimura, S.; Ozaki, K.-I.; Kohno, M. Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner. Biochem. Biophys. Res. Commun. 2006, 340, 560-566.
    • (2006) Biochem. Biophys. Res. Commun. , vol.340 , pp. 560-566
    • Fujiwara, Y.1    Kawada, K.2    Takano, D.3    Tanimura, S.4    Ozaki, K.-I.5    Kohno, M.6
  • 35
    • 0036968347 scopus 로고    scopus 로고
    • Activation of the PI3K/Akt pathway and chemotherapeutic resistance
    • West, K.A.; Sianna Castillo, S.; Dennis, P.A. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist. Updat. 2002, 5, 234-248.
    • (2002) Drug Resist. Updat. , vol.5 , pp. 234-248
    • West, K.A.1    Sianna Castillo, S.2    Dennis, P.A.3
  • 36
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
    • LoPiccolo, J.; Blumenthal, G.M.; Bernstein, W.B.; Dennis, P.A. Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations. Drug Resist. Updat. 2008, 11, 32-50.
    • (2008) Drug Resist. Updat. , vol.11 , pp. 32-50
    • Lopiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 37
    • 79551687167 scopus 로고    scopus 로고
    • Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway
    • doi:10.1186/1756-9966-30-17
    • Chen, W.S.; Hou, J.N.; Guo, Y.B.; Yang, H.L.; Xie, C.M.; Lin, Y.C.; She, Z.G. Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway. J. Exp. Clin. Cancer Res. 2011, 30, doi:10.1186/1756-9966-30-17.
    • (2011) J. Exp. Clin. Cancer Res. , pp. 30
    • Chen, W.S.1    Hou, J.N.2    Guo, Y.B.3    Yang, H.L.4    Xie, C.M.5    Lin, Y.C.6    She, Z.G.7
  • 38
    • 84055219449 scopus 로고    scopus 로고
    • Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp
    • Hu, Y.; MacMillan, J.B. Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp. Org. Lett. 2011, 13, 6580-6583.
    • (2011) Org. Lett. , vol.13 , pp. 6580-6583
    • Hu, Y.1    MacMillan, J.B.2
  • 39
    • 80955122677 scopus 로고    scopus 로고
    • Systematic chemical mutagenesis identifies a potent novel apratoxin A/E hybrid with improved in vivo antitumor activity
    • Chen, Q.Y.; Liu, Y.; Luesch, H. Systematic chemical mutagenesis identifies a potent novel apratoxin A/E hybrid with improved in vivo antitumor activity. ACS Med. Chem. Lett. 2011, 2, 861-865.
    • (2011) ACS Med. Chem. Lett. , vol.2 , pp. 861-865
    • Chen, Q.Y.1    Liu, Y.2    Luesch, H.3
  • 40
    • 33744493376 scopus 로고    scopus 로고
    • Targeting tyrosine kinases in cancer: The second wave
    • Baselga, J. Targeting tyrosine kinases in cancer: The second wave. Science 2006, 312, 1175-1178.
    • (2006) Science , vol.312 , pp. 1175-1178
    • Baselga, J.1
  • 41
    • 0034092011 scopus 로고    scopus 로고
    • Tumor angiogenesis: Past, present and the near future
    • Kerbel, R.S. Tumor angiogenesis: Past, present and the near future. Carcinogenesis 2000, 21, 505-515.
    • (2000) Carcinogenesis , vol.21 , pp. 505-515
    • Kerbel, R.S.1
  • 42
    • 47549102471 scopus 로고    scopus 로고
    • Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii
    • Matthew, S.; Schupp, P.J.; Luesch, H. Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. J. Nat. Prod. 2008, 71, 1113-1116.
    • (2008) J. Nat. Prod. , vol.71 , pp. 1113-1116
    • Matthew, S.1    Schupp, P.J.2    Luesch, H.3
  • 43
    • 33750012824 scopus 로고    scopus 로고
    • Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities
    • Ma, D.; Zou, B.; Cai, G.; Hu, X.; Liu, J.O. Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities. Chemistry 2006, 12, 7615-7626.
    • (2006) Chemistry , vol.12 , pp. 7615-7626
    • Ma, D.1    Zou, B.2    Cai, G.3    Hu, X.4    Liu, J.O.5
  • 44
    • 78650781428 scopus 로고    scopus 로고
    • Solid-phase total synthesis of (-)-apratoxin A and its analogues and their biological evaluation
    • Doi, T.; Numajiri, Y.; Takahashi, T.; Takagi, M.; Shin-ya, K. Solid-phase total synthesis of (-)-apratoxin A and its analogues and their biological evaluation. Chem. Asian J. 2011, 6, 180-188.
    • (2011) Chem. Asian J. , vol.6 , pp. 180-188
    • Doi, T.1    Numajiri, Y.2    Takahashi, T.3    Takagi, M.4    Shin-Ya, K.5
  • 45
    • 38749104725 scopus 로고    scopus 로고
    • New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus
    • Kito, K.; Ookura, R.; Yoshida, S.; Namikoshi, M.; Ooi, T.; Kusumi, T. New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus. Org. Lett. 2008, 10, 225-228.
    • (2008) Org. Lett. , vol.10 , pp. 225-228
    • Kito, K.1    Ookura, R.2    Yoshida, S.3    Namikoshi, M.4    Ooi, T.5    Kusumi, T.6
  • 46
    • 78651256756 scopus 로고    scopus 로고
    • Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B
    • Diaz-Oltra, S.; Angulo-Pachon, C.A.; Murga, J.; Falomir, E.; Carda, M.; Marco, J.A. Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B. Chemistry 2011, 17, 675-688.
    • (2011) Chemistry , vol.17 , pp. 675-688
    • Diaz-Oltra, S.1    Angulo-Pachon, C.A.2    Murga, J.3    Falomir, E.4    Carda, M.5    Marco, J.A.6
  • 48
    • 17944386473 scopus 로고    scopus 로고
    • Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: Analysis of the gene cluster and rational design of novel chromomycin analogs
    • Menendez, N.; Nur-e-Alam, M.; Brana, A.F.; Rohr, J.; Salas, J.A.; Mendez, C. Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. Chem. Biol. 2004, 11, 21-32.
    • (2004) Chem. Biol. , vol.11 , pp. 21-32
    • Menendez, N.1    Nur-E-Alam, M.2    Brana, A.F.3    Rohr, J.4    Salas, J.A.5    Mendez, C.6
  • 49
    • 79953229556 scopus 로고    scopus 로고
    • Lobophorin C and D, new kijanimicin derivatives from a marine sponge-associated actinomycetal strain AZS17
    • Wei, R.B.; Xi, T.; Li, J.; Wang, P.; Li, F.C.; Lin, Y.C.; Qin, S. Lobophorin C and D, new kijanimicin derivatives from a marine sponge-associated actinomycetal strain AZS17. Mar. Drugs 2011, 9, 359-368.
    • (2011) Mar. Drugs , vol.9 , pp. 359-368
    • Wei, R.B.1    Xi, T.2    Li, J.3    Wang, P.4    Li, F.C.5    Lin, Y.C.6    Qin, S.7
  • 50
    • 77957374632 scopus 로고    scopus 로고
    • Chapter 8 Total synthesis of spongistatin 1 (altohyrtin a): A tale of ten aldols
    • Michael, H., Ed.; Academic Press: Oxford, UK
    • Paterson, I.; Coster, M.J. Chapter 8 Total synthesis of spongistatin 1 (altohyrtin a): A tale of ten aldols. In Strategies and Tactics in Organic Synthesis; Michael, H., Ed.; Academic Press: Oxford, UK, 2004; Volume 4, pp. 211-245.
    • (2004) Strategies and Tactics in Organic Synthesis , vol.4 , pp. 211-245
    • Paterson, I.1    Coster, M.J.2
  • 52
    • 0027482896 scopus 로고
    • Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin
    • Bai, R.; Cichacz, Z.A.; Herald, C.L.; Pettit, G.R.; Hamel, E. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin. Mol. Pharmacol. 1993, 44, 757-766.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 757-766
    • Bai, R.1    Cichacz, Z.A.2    Herald, C.L.3    Pettit, G.R.4    Hamel, E.5
  • 53
    • 22744452190 scopus 로고    scopus 로고
    • The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation
    • Paterson, I.; Chen, D.Y.; Coster, M.J.; Acena, J.L.; Bach, J.; Wallace, D.J. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation. Org. Biomol. Chem. 2005, 3, 2431-2440.
    • (2005) Org. Biomol. Chem. , vol.3 , pp. 2431-2440
    • Paterson, I.1    Chen, D.Y.2    Coster, M.J.3    Acena, J.L.4    Bach, J.5    Wallace, D.J.6
  • 55
    • 70350212784 scopus 로고    scopus 로고
    • BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells
    • Schneiders, U.M.; Schyschka, L.; Rudy, A.; Vollmar, A.M. BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells. Mol. Cancer Ther. 2009, 8, 2914-2925.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2914-2925
    • Schneiders, U.M.1    Schyschka, L.2    Rudy, A.3    Vollmar, A.M.4
  • 56
    • 51649114209 scopus 로고    scopus 로고
    • Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP
    • Schyschka, L.; Rudy, A.; Jeremias, I.; Barth, N.; Pettit, G.R.; Vollmar, A.M. Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP. Leukemia 2008, 22, 1737-1745.
    • (2008) Leukemia , vol.22 , pp. 1737-1745
    • Schyschka, L.1    Rudy, A.2    Jeremias, I.3    Barth, N.4    Pettit, G.R.5    Vollmar, A.M.6
  • 58
    • 78650099214 scopus 로고    scopus 로고
    • Apoptosisinducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines
    • Choi, E.J.; Park, J.S.; Kim, Y.J.; Jung, J.H.; Lee, J.K.; Kwon, H.C.; Yang, H.O. Apoptosisinducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines. J. Appl. Microbiol. 2011, 110, 304-313.
    • (2011) J. Appl. Microbiol. , vol.110 , pp. 304-313
    • Choi, E.J.1    Park, J.S.2    Kim, Y.J.3    Jung, J.H.4    Lee, J.K.5    Kwon, H.C.6    Yang, H.O.7
  • 59
    • 17644412298 scopus 로고    scopus 로고
    • The epipolythiodioxopiperazine (ETP) class of fungal toxins: Distribution, mode of action, functions and biosynthesis
    • Gardiner, D.M.; Waring, P.; Howlett, B.J. The epipolythiodioxopiperazine (ETP) class of fungal toxins: Distribution, mode of action, functions and biosynthesis. Microbiology 2005, 151, 1021-1032.
    • (2005) Microbiology , vol.151 , pp. 1021-1032
    • Gardiner, D.M.1    Waring, P.2    Howlett, B.J.3
  • 60
    • 40949090477 scopus 로고    scopus 로고
    • Intravesical chemotherapy of high-grade bladder cancer with HTI-286, a synthetic analogue of the marine sponge product hemiasterlin
    • Hadaschik, B.A.; Adomat, H.; Fazli, L.; Fradet, Y.; Andersen, R.J.; Gleave, M.E.; So, A.I. Intravesical chemotherapy of high-grade bladder cancer with HTI-286, a synthetic analogue of the marine sponge product hemiasterlin. Clin. Cancer Res. 2008, 14, 1510-1518.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 1510-1518
    • Hadaschik, B.A.1    Adomat, H.2    Fazli, L.3    Fradet, Y.4    Andersen, R.J.5    Gleave, M.E.6    So, A.I.7
  • 61
    • 0037447174 scopus 로고    scopus 로고
    • HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo
    • Loganzo, F.; Discafani, C.M.; Annable, T.; Beyer, C.; Musto, S.; Hari, M.; Tan, X.; Hardy, C.; Hernandez, R.; Baxter, M.; et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003, 63, 1838-1845.
    • (2003) Cancer Res. , vol.63 , pp. 1838-1845
    • Loganzo, F.1    Discafani, C.M.2    Annable, T.3    Beyer, C.4    Musto, S.5    Hari, M.6    Tan, X.7    Hardy, C.8    Hernandez, R.9    Baxter, M.10
  • 63
    • 84866737041 scopus 로고    scopus 로고
    • Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor
    • Hsu, L.C.; Durrant, D.E.; Huang, C.C.; Chi, N.W.; Baruchello, R.; Rondanin, R.; Rullo, C.; Marchetti, P.; Grisolia, G.; Simoni, D.; et al. Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor. Invest. New Drugs 2012, 30, 1379-1388.
    • (2012) Invest. New Drugs , vol.30 , pp. 1379-1388
    • Hsu, L.C.1    Durrant, D.E.2    Huang, C.C.3    Chi, N.W.4    Baruchello, R.5    Rondanin, R.6    Rullo, C.7    Marchetti, P.8    Grisolia, G.9    Simoni, D.10
  • 65
    • 77949391413 scopus 로고    scopus 로고
    • Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin
    • Tannert, R.; Milroy, L.G.; Ellinger, B.; Hu, T.S.; Arndt, H.D.; Waldmann, H. Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin. J. Am. Chem. Soc. 2010, 132, 3063-3077.
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 3063-3077
    • Tannert, R.1    Milroy, L.G.2    Ellinger, B.3    Hu, T.S.4    Arndt, H.D.5    Waldmann, H.6
  • 66
    • 45649084241 scopus 로고    scopus 로고
    • Besarhanamides A and B from the marine cyanobacterium Lyngbya majuscula
    • Tan, L.T.; Chang, Y.Y.; Ashootosh, T. Besarhanamides A and B from the marine cyanobacterium Lyngbya majuscula. Phytochemistry 2008, 69, 2067-2069.
    • (2008) Phytochemistry , vol.69 , pp. 2067-2069
    • Tan, L.T.1    Chang, Y.Y.2    Ashootosh, T.3
  • 67
  • 68
    • 84865458429 scopus 로고    scopus 로고
    • Discovery of anticancer drugs from antimalarial natural products: A MEDLINE literature review
    • Duffy, R.; Wade, C.; Chang, R. Discovery of anticancer drugs from antimalarial natural products: a MEDLINE literature review. Drug Discov. Today 2012, 17, 942-953.
    • (2012) Drug Discov. Today , vol.17 , pp. 942-953
    • Duffy, R.1    Wade, C.2    Chang, R.3
  • 70
    • 80051599485 scopus 로고    scopus 로고
    • Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases
    • Cole, K.E.; Dowling, D.P.; Boone, M.A.; Phillips, A.J.; Christianson, D.W. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. J. Am. Chem. Soc. 2011, 133, 12474-12477.
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 12474-12477
    • Cole, K.E.1    Dowling, D.P.2    Boone, M.A.3    Phillips, A.J.4    Christianson, D.W.5
  • 71
    • 79951632653 scopus 로고    scopus 로고
    • Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: Application of N-heterocyclic carbene mediated acylations in complex molecule synthesis
    • Wang, B.; Huang, P.H.; Chen, C.S.; Forsyth, C.J. Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis. J. Org. Chem. 2011, 76, 1140-1150.
    • (2011) J. Org. Chem. , vol.76 , pp. 1140-1150
    • Wang, B.1    Huang, P.H.2    Chen, C.S.3    Forsyth, C.J.4
  • 73
    • 80455162618 scopus 로고    scopus 로고
    • Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: Synthesis and biological evaluation
    • Bhansali, P.; Hanigan, C.L.; Casero, R.A.; Tillekeratne, L.M. Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: Synthesis and biological evaluation. J. Med. Chem. 2011, 54, 7453-7463.
    • (2011) J. Med. Chem. , vol.54 , pp. 7453-7463
    • Bhansali, P.1    Hanigan, C.L.2    Casero, R.A.3    Tillekeratne, L.M.4
  • 75
    • 79956075028 scopus 로고    scopus 로고
    • Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein
    • Raju, R.; Piggott, A.M.; Huang, X.C.; Capon, R.J. Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein. Org. Lett. 2011, 13, 2770-2773.
    • (2011) Org. Lett. , vol.13 , pp. 2770-2773
    • Raju, R.1    Piggott, A.M.2    Huang, X.C.3    Capon, R.J.4
  • 76
    • 80054881646 scopus 로고    scopus 로고
    • Pardaxin an antimicrobial peptide, triggers caspase-dependent and ROS-mediated apoptosis in HT-1080 cells
    • Huang, T.C.; Lee, J.F.; Chen, J.Y. Pardaxin, an antimicrobial peptide, triggers caspase-dependent and ROS-mediated apoptosis in HT-1080 cells. Mar. Drugs 2011, 9, 1995-2009.
    • (2011) Mar. Drugs , vol.9 , pp. 1995-2009
    • Huang, T.C.1    Lee, J.F.2    Chen, J.Y.3
  • 77
    • 79957981259 scopus 로고    scopus 로고
    • Pardaxin-induced apoptosis enhances antitumor activity in HeLa cells
    • Hsu, J.C.; Lin, L.C.; Tzen, J.T.; Chen, J.Y. Pardaxin-induced apoptosis enhances antitumor activity in HeLa cells. Peptides 2011, 32, 1110-1116.
    • (2011) Peptides , vol.32 , pp. 1110-1116
    • Hsu, J.C.1    Lin, L.C.2    Tzen, J.T.3    Chen, J.Y.4
  • 79
    • 80053522700 scopus 로고    scopus 로고
    • Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells
    • Khanal, P.; Kang, B.S.; Yun, H.J.; Cho, H.G.; Makarieva, T.N.; Choi, H.S. Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells. Biol. Pharm. Bull. 2011, 34, 1553-1558.
    • (2011) Biol. Pharm. Bull. , vol.34 , pp. 1553-1558
    • Khanal, P.1    Kang, B.S.2    Yun, H.J.3    Cho, H.G.4    Makarieva, T.N.5    Choi, H.S.6
  • 80
    • 70349257239 scopus 로고    scopus 로고
    • Marine two-headed sphingolipid-like compound rhizochalin inhibits EGF-induced transformation of JB6 P+ Cl41 cells
    • Fedorov, S.N.; Makarieva, T.N.; Guzii, A.G.; Shubina, L.K.; Kwak, J.Y.; Stonik, V.A. Marine two-headed sphingolipid-like compound rhizochalin inhibits EGF-induced transformation of JB6 P+ Cl41 cells. Lipids 2009, 44, 777-785.
    • (2009) Lipids , vol.44 , pp. 777-785
    • Fedorov, S.N.1    Makarieva, T.N.2    Guzii, A.G.3    Shubina, L.K.4    Kwak, J.Y.5    Stonik, V.A.6
  • 81
    • 66549122868 scopus 로고    scopus 로고
    • Differential induction of apoptosis of leukemic cells by rhizochalin, two headed sphingolipids from sponge and its derivatives
    • Jin, J.O.; Shastina, V.; Park, J.I.; Han, J.Y.; Makarieva, T.; Fedorov, S.; Rasskazov, V.; Stonik, V.; Kwak, J.Y. Differential induction of apoptosis of leukemic cells by rhizochalin, two headed sphingolipids from sponge and its derivatives. Biol. Pharm. Bull. 2009, 32, 955-962.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 955-962
    • Jin, J.O.1    Shastina, V.2    Park, J.I.3    Han, J.Y.4    Makarieva, T.5    Fedorov, S.6    Rasskazov, V.7    Stonik, V.8    Kwak, J.Y.9
  • 83
    • 77949916262 scopus 로고    scopus 로고
    • AP-1 - The Jun proteins: Oncogenes or tumor suppressors in disguise?
    • Shaulian, E. AP-1 - The Jun proteins: Oncogenes or tumor suppressors in disguise? Cell. Signal. 2010, 22, 894-899.
    • (2010) Cell. Signal. , vol.22 , pp. 894-899
    • Shaulian, E.1
  • 84
    • 79960694150 scopus 로고    scopus 로고
    • Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction
    • Jiang, Y.; Miao, Z.H.; Xu, L.; Yu, B.; Gong, J.X.; Tong, L.J.; Chen, Y.; Zhou, Z.L.; Liu, H.C.; Wang, Y.; et al. Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction. J. Biol. Chem. 2011, 286, 26461-26469.
    • (2011) J. Biol. Chem. , vol.286 , pp. 26461-26469
    • Jiang, Y.1    Miao, Z.H.2    Xu, L.3    Yu, B.4    Gong, J.X.5    Tong, L.J.6    Chen, Y.7    Zhou, Z.L.8    Liu, H.C.9    Wang, Y.10
  • 85
    • 77955306935 scopus 로고    scopus 로고
    • Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review
    • Papatheodoridis, G.V.; Lampertico, P.; Manolakopoulos, S.; Lok, A. Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review. J. Hepatol. 2010, 53, 348-356.
    • (2010) J. Hepatol. , vol.53 , pp. 348-356
    • Papatheodoridis, G.V.1    Lampertico, P.2    Manolakopoulos, S.3    Lok, A.4
  • 86
    • 58849136702 scopus 로고    scopus 로고
    • Molecular targeted therapy for hepatocellular carcinoma
    • Thomas, M. Molecular targeted therapy for hepatocellular carcinoma. J. Gastroenterol. 2009, 44, 136-141.
    • (2009) J. Gastroenterol. , vol.44 , pp. 136-141
    • Thomas, M.1
  • 87
    • 38849199799 scopus 로고    scopus 로고
    • STAT3 as a target for inducing apoptosis in solid and hematological tumors
    • Al Zaid Siddiquee, K.; Turkson, J. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res. 2008, 18, 254-267.
    • (2008) Cell Res. , vol.18 , pp. 254-267
    • Al Zaid Siddiquee, K.1    Turkson, J.2
  • 88
    • 77950391697 scopus 로고    scopus 로고
    • Stat3 orchestrates tumor development and progression: The Achilles' heel of head and neck cancers?
    • Masuda, M.; Wakasaki, T.; Suzui, M.; Toh, S.; Joe, A.K.; Weinstein, I.B. Stat3 orchestrates tumor development and progression: The Achilles' heel of head and neck cancers? Curr. Cancer Drug Targets 2010, 10, 117-126.
    • (2010) Curr. Cancer Drug Targets , vol.10 , pp. 117-126
    • Masuda, M.1    Wakasaki, T.2    Suzui, M.3    Toh, S.4    Joe, A.K.5    Weinstein, I.B.6
  • 89
    • 80053469046 scopus 로고    scopus 로고
    • Dieckol from ecklonia cava regulates invasion of human fibrosarcoma cells and modulates MMP-2 and MMP-9 expression via NF-kappaB pathway
    • Zhang, C.; Li, Y.; Qian, Z.J.; Lee, S.H.; Li, Y.X.; Kim, S.K. Dieckol from ecklonia cava regulates invasion of human fibrosarcoma cells and modulates MMP-2 and MMP-9 expression via NF-kappaB pathway. Evid. Based Complement. Alternat. Med. 2011, 2011, 140462.
    • (2011) Evid. Based Complement. Alternat. Med. , vol.2011 , pp. 140462
    • Zhang, C.1    Li, Y.2    Qian, Z.J.3    Lee, S.H.4    Li, Y.X.5    Kim, S.K.6
  • 90
    • 39149084984 scopus 로고    scopus 로고
    • Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium
    • Das, S.; Banerji, A.; Frei, E.; Chatterjee, A. Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium. Life Sci. 2008, 82, 467-476.
    • (2008) Life Sci. , vol.82 , pp. 467-476
    • Das, S.1    Banerji, A.2    Frei, E.3    Chatterjee, A.4
  • 91
    • 0036800192 scopus 로고    scopus 로고
    • Metalloproteinase inhibitors: Biological actions and therapeutic opportunities
    • Baker, A.H.; Edwards, D.R.; Murphy, G. Metalloproteinase inhibitors: Biological actions and therapeutic opportunities. J. Cell. Sci. 2002, 115, 3719-3727.
    • (2002) J. Cell. Sci. , vol.115 , pp. 3719-3727
    • Baker, A.H.1    Edwards, D.R.2    Murphy, G.3
  • 92
    • 17044412494 scopus 로고    scopus 로고
    • Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity
    • Tanimura, S.; Kadomoto, R.; Tanaka, T.; Zhang, Y.J.; Kouno, I.; Kohno, M. Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity. Biochem. Biophys. Res. Commun. 2005, 330, 1306-1313.
    • (2005) Biochem. Biophys. Res. Commun. , vol.330 , pp. 1306-1313
    • Tanimura, S.1    Kadomoto, R.2    Tanaka, T.3    Zhang, Y.J.4    Kouno, I.5    Kohno, M.6
  • 93
    • 84863433452 scopus 로고    scopus 로고
    • Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling
    • Park, S.J.; Jeon, Y.J. Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling. Mol. Cells 2012, 33, 141-149.
    • (2012) Mol. Cells , vol.33 , pp. 141-149
    • Park, S.J.1    Jeon, Y.J.2
  • 94
    • 33751276236 scopus 로고    scopus 로고
    • Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1)
    • Lee, J.; Jung, E.; Lee, J.; Huh, S.; Hwang, C.H.; Lee, H.Y.; Kim, E.J.; Cheon, J.M.; Hyun, C.G.; Kim, Y.S.; et al. Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1). Life Sci. 2006, 79, 2480-2485.
    • (2006) Life Sci. , vol.79 , pp. 2480-2485
    • Lee, J.1    Jung, E.2    Lee, J.3    Huh, S.4    Hwang, C.H.5    Lee, H.Y.6    Kim, E.J.7    Cheon, J.M.8    Hyun, C.G.9    Kim, Y.S.10
  • 95
    • 79953212580 scopus 로고    scopus 로고
    • Astaxanthin: A potential therapeutic agent in cardiovascular disease
    • Fassett, R.G.; Coombes, J.S. Astaxanthin: A potential therapeutic agent in cardiovascular disease. Mar. Drugs 2011, 9, 447-465.
    • (2011) Mar. Drugs , vol.9 , pp. 447-465
    • Fassett, R.G.1    Coombes, J.S.2
  • 96
    • 82155183286 scopus 로고    scopus 로고
    • Effects of astaxanthin on oxidative stress in overweight and obese adults
    • Choi, H.D.; Kim, J.H.; Chang, M.J.; Kyu-Youn, Y.; Shin, W.G. Effects of astaxanthin on oxidative stress in overweight and obese adults. Phytother. Res. 2011, 25, 1813-1818.
    • (2011) Phytother. Res. , vol.25 , pp. 1813-1818
    • Choi, H.D.1    Kim, J.H.2    Chang, M.J.3    Kyu-Youn, Y.4    Shin, W.G.5
  • 97
    • 67650450196 scopus 로고    scopus 로고
    • Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells
    • Palozza, P.; Torelli, C.; Boninsegna, A.; Simone, R.; Catalano, A.; Mele, M.C.; Picci, N. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett. 2009, 283, 108-117.
    • (2009) Cancer Lett. , vol.283 , pp. 108-117
    • Palozza, P.1    Torelli, C.2    Boninsegna, A.3    Simone, R.4    Catalano, A.5    Mele, M.C.6    Picci, N.7
  • 98
    • 77951497956 scopus 로고    scopus 로고
    • Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress
    • Wolf, A.M.; Asoh, S.; Hiranuma, H.; Ohsawa, I.; Iio, K.; Satou, A.; Ishikura, M.; Ohta, S. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J. Nutr. Biochem. 2010, 21, 381-389.
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 381-389
    • Wolf, A.M.1    Asoh, S.2    Hiranuma, H.3    Ohsawa, I.4    Iio, K.5    Satou, A.6    Ishikura, M.7    Ohta, S.8
  • 99
    • 79956080227 scopus 로고    scopus 로고
    • Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2
    • Nagendraprabhu, P.; Sudhandiran, G. Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Invest. New Drugs 2011, 29, 207-224.
    • (2011) Invest. New Drugs , vol.29 , pp. 207-224
    • Nagendraprabhu, P.1    Sudhandiran, G.2
  • 100
    • 62849123061 scopus 로고    scopus 로고
    • Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis
    • Prabhu, P.N.; Ashokkumar, P.; Sudhandiran, G. Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis. Fundam. Clin. Pharmacol. 2009, 23, 225-234.
    • (2009) Fundam. Clin. Pharmacol. , vol.23 , pp. 225-234
    • Prabhu, P.N.1    Ashokkumar, P.2    Sudhandiran, G.3
  • 101
    • 79959945798 scopus 로고    scopus 로고
    • Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines
    • Yasui, Y.; Hosokawa, M.; Mikami, N.; Miyashita, K.; Tanaka, T. Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines. Chem. Biol. Interact. 2011, 193, 79-87.
    • (2011) Chem. Biol. Interact. , vol.193 , pp. 79-87
    • Yasui, Y.1    Hosokawa, M.2    Mikami, N.3    Miyashita, K.4    Tanaka, T.5
  • 102
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl, H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18, 6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 103
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: Linking inflammation and immunity to cancer development and progression
    • Karin, M.; Greten, F.R. NF-kappaB: Linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 2005, 5, 749-759.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 104
    • 84855246261 scopus 로고    scopus 로고
    • Tetrahydrofuran cembranoids from the cultured soft coral Lobophytum crassum
    • Lee, N.L.; Su, J.H. Tetrahydrofuran cembranoids from the cultured soft coral Lobophytum crassum. Mar. Drugs 2011, 9, 2526-2536.
    • (2011) Mar. Drugs , vol.9 , pp. 2526-2536
    • Lee, N.L.1    Su, J.H.2
  • 105
    • 77649213543 scopus 로고    scopus 로고
    • Bioactive sesterterpenes and triterpenes from marine sponges: Occurrence and pharmacological significance
    • Ebada, S.S.; Lin, W.; Proksch, P. Bioactive sesterterpenes and triterpenes from marine sponges: Occurrence and pharmacological significance. Mar. Drugs 2010, 8, 313-346.
    • (2010) Mar. Drugs , vol.8 , pp. 313-346
    • Ebada, S.S.1    Lin, W.2    Proksch, P.3
  • 106
    • 79957801058 scopus 로고    scopus 로고
    • Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne
    • Piao, S.J.; Zhang, H.J.; Lu, H.Y.; Yang, F.; Jiao, W.H.; Yi, Y.H.; Chen, W.S.; Lin, H.W. Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne. J. Nat. Prod. 2011, 74, 1248-1254.
    • (2011) J. Nat. Prod. , vol.74 , pp. 1248-1254
    • Piao, S.J.1    Zhang, H.J.2    Lu, H.Y.3    Yang, F.4    Jiao, W.H.5    Yi, Y.H.6    Chen, W.S.7    Lin, H.W.8
  • 108
    • 80053213572 scopus 로고    scopus 로고
    • Cytotoxic C21 and C22 terpenoid-derived metabolites from the sponge Ircinia sp
    • Su, J.H.; Tseng, S.W.; Lu, M.C.; Liu, L.L.; Chou, Y.; Sung, P.J. Cytotoxic C21 and C22 terpenoid-derived metabolites from the sponge Ircinia sp. J. Nat. Prod. 2011, 74, 2005-2009.
    • (2011) J. Nat. Prod. , vol.74 , pp. 2005-2009
    • Su, J.H.1    Tseng, S.W.2    Lu, M.C.3    Liu, L.L.4    Chou, Y.5    Sung, P.J.6
  • 110
    • 0035866625 scopus 로고    scopus 로고
    • Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges
    • Wright, A.D.; Wang, H.; Gurrath, M.; Konig, G.M.; Kocak, G.; Neumann, G.; Loria, P.; Foley, M.; Tilley, L. Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges. J. Med. Chem. 2001, 44, 873-885.
    • (2001) J. Med. Chem. , vol.44 , pp. 873-885
    • Wright, A.D.1    Wang, H.2    Gurrath, M.3    Konig, G.M.4    Kocak, G.5    Neumann, G.6    Loria, P.7    Foley, M.8    Tilley, L.9
  • 111
    • 80055078414 scopus 로고    scopus 로고
    • Evaluation of the antiproliferative activity of diterpene isonitriles from the sponge Pseudoaxinella flava in apoptosis-sensitive and apoptosis-resistant cancer cell lines
    • Lamoral-Theys, D.; Fattorusso, E.; Mangoni, A.; Perinu, C.; Kiss, R.; Costantino, V. Evaluation of the antiproliferative activity of diterpene isonitriles from the sponge Pseudoaxinella flava in apoptosis-sensitive and apoptosis-resistant cancer cell lines. J. Nat. Prod. 2011, 74, 2299-2303.
    • (2011) J. Nat. Prod. , vol.74 , pp. 2299-2303
    • Lamoral-Theys, D.1    Fattorusso, E.2    Mangoni, A.3    Perinu, C.4    Kiss, R.5    Costantino, V.6
  • 112
    • 79959750983 scopus 로고    scopus 로고
    • Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule
    • Lin, W.Y.; Lu, Y.; Su, J.H.; Wen, Z.H.; Dai, C.F.; Kuo, Y.H.; Sheu, J.H. Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule. Mar. Drugs 2011, 9, 994-1006.
    • (2011) Mar. Drugs , vol.9 , pp. 994-1006
    • Lin, W.Y.1    Lu, Y.2    Su, J.H.3    Wen, Z.H.4    Dai, C.F.5    Kuo, Y.H.6    Sheu, J.H.7
  • 113
    • 79961166820 scopus 로고    scopus 로고
    • Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors
    • Hassan, H.M.; Sallam, A.A.; Mohammed, R.; Hifnawy, M.S.; Youssef, D.T.; El Sayed, K.A. Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors. Bioorg. Med. Chem. 2011, 19, 4928-4934.
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 4928-4934
    • Hassan, H.M.1    Sallam, A.A.2    Mohammed, R.3    Hifnawy, M.S.4    Youssef, D.T.5    El Sayed, K.A.6
  • 114
    • 79952697175 scopus 로고    scopus 로고
    • Siphonaxanthin a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells
    • Ganesan, P.; Noda, K.; Manabe, Y.; Ohkubo, T.; Tanaka, Y.; Maoka, T.; Sugawara, T.; Hirata, T. Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells. Biochim. Biophys. Acta 2011, 1810, 497-503.
    • (2011) Biochim. Biophys. Acta , vol.1810 , pp. 497-503
    • Ganesan, P.1    Noda, K.2    Manabe, Y.3    Ohkubo, T.4    Tanaka, Y.5    Maoka, T.6    Sugawara, T.7    Hirata, T.8
  • 116
    • 53349096248 scopus 로고    scopus 로고
    • Smenospongine a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells
    • Kong, D.; Aoki, S.; Sowa, Y.; Sakai, T.; Kobayashi, M. Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells. Mar. Drugs 2008, 6, 480-488.
    • (2008) Mar. Drugs , vol.6 , pp. 480-488
    • Kong, D.1    Aoki, S.2    Sowa, Y.3    Sakai, T.4    Kobayashi, M.5
  • 117
    • 1942421216 scopus 로고    scopus 로고
    • Smenospongine a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells
    • Aoki, S.; Kong, D.; Matsui, K.; Kobayashi, M. Smenospongine, a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells. Anticancer Drug 2004, 15, 363-369.
    • (2004) Anticancer Drug , vol.15 , pp. 363-369
    • Aoki, S.1    Kong, D.2    Matsui, K.3    Kobayashi, M.4
  • 118
    • 79851499458 scopus 로고    scopus 로고
    • Antiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene aminoquinone
    • Kong, D.; Yamori, T.; Kobayashi, M.; Duan, H. Antiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene aminoquinone. Mar. Drugs 2011, 9, 154-161.
    • (2011) Mar. Drugs , vol.9 , pp. 154-161
    • Kong, D.1    Yamori, T.2    Kobayashi, M.3    Duan, H.4
  • 119
    • 15444357498 scopus 로고
    • Two new xenicin diterpenoids from the octocoral anthelia edmondsoni
    • Coval, S.J.; Scheuer, P.J.; Matsumoto, G.K.; Clardy, J. Two new xenicin diterpenoids from the octocoral anthelia edmondsoni. Tetrahedron 1984, 40, 3823-3828.
    • (1984) Tetrahedron , vol.40 , pp. 3823-3828
    • Coval, S.J.1    Scheuer, P.J.2    Matsumoto, G.K.3    Clardy, J.4
  • 120
    • 80655144731 scopus 로고    scopus 로고
    • Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels
    • Zierler, S.; Yao, G.; Zhang, Z.; Kuo, W.C.; Porzgen, P.; Penner, R.; Horgen, F.D.; Fleig, A. Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. J. Biol. Chem. 2011, 286, 39328-39335.
    • (2011) J. Biol. Chem. , vol.286 , pp. 39328-39335
    • Zierler, S.1    Yao, G.2    Zhang, Z.3    Kuo, W.C.4    Porzgen, P.5    Penner, R.6    Horgen, F.D.7    Fleig, A.8
  • 123
    • 36348964907 scopus 로고    scopus 로고
    • Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: Role in cell proliferation
    • Jiang, J.; Li, M.H.; Inoue, K.; Chu, X.P.; Seeds, J.; Xiong, Z.G. Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: Role in cell proliferation. Cancer Res. 2007, 67, 10929-10938.
    • (2007) Cancer Res. , vol.67 , pp. 10929-10938
    • Jiang, J.1    Li, M.H.2    Inoue, K.3    Chu, X.P.4    Seeds, J.5    Xiong, Z.G.6
  • 124
    • 57349188508 scopus 로고    scopus 로고
    • Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer
    • Kim, B.J.; Park, E.J.; Lee, J.H.; Jeon, J.H.; Kim, S.J.; So, I. Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Sci. 2008, 99, 2502-2509.
    • (2008) Cancer Sci. , vol.99 , pp. 2502-2509
    • Kim, B.J.1    Park, E.J.2    Lee, J.H.3    Jeon, J.H.4    Kim, S.J.5    So, I.6
  • 126
    • 34548498843 scopus 로고    scopus 로고
    • Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7
    • Li, M.; Du, J.; Jiang, J.; Ratzan, W.; Su, L.T.; Runnels, L.W.; Yue, L. Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7. J. Biol. Chem. 2007, 282, 25817-25830.
    • (2007) J. Biol. Chem. , vol.282 , pp. 25817-25830
    • Li, M.1    Du, J.2    Jiang, J.3    Ratzan, W.4    Su, L.T.5    Runnels, L.W.6    Yue, L.7
  • 127
    • 33646140352 scopus 로고    scopus 로고
    • Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7
    • Li, M.; Jiang, J.; Yue, L. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J. Gen. Physiol. 2006, 127, 525-537.
    • (2006) J. Gen. Physiol. , vol.127 , pp. 525-537
    • Li, M.1    Jiang, J.2    Yue, L.3
  • 130
    • 1942501853 scopus 로고    scopus 로고
    • Dual-function ion channel/protein kinases: Novel components of vertebrate magnesium regulatory mechanisms
    • Schmitz, C.; Perraud, A.L.; Fleig, A.; Scharenberg, A.M. Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms. Pediatr. Res. 2004, 55, 734-737.
    • (2004) Pediatr. Res. , vol.55 , pp. 734-737
    • Schmitz, C.1    Perraud, A.L.2    Fleig, A.3    Scharenberg, A.M.4
  • 131
    • 84868158166 scopus 로고    scopus 로고
    • Intracellular magnesium content decreases during mitochondria-mediated apoptosis induced by a new indole-derivative in human colon cancer cells
    • Cappadone, C.; Merolle, L.; Marraccini, C.; Farruggia, G.; Sargenti, A.; Locatelli, A.; Morigi, R.; Iotti, S. Intracellular magnesium content decreases during mitochondria-mediated apoptosis induced by a new indole-derivative in human colon cancer cells. Magnes. Res. 2012, 25, 104-111.
    • (2012) Magnes. Res. , vol.25 , pp. 104-111
    • Cappadone, C.1    Merolle, L.2    Marraccini, C.3    Farruggia, G.4    Sargenti, A.5    Locatelli, A.6    Morigi, R.7    Iotti, S.8
  • 132
    • 84864021130 scopus 로고    scopus 로고
    • Magnesium and its transporters in cancer: A novel paradigm in tumour development
    • Wolf, F.I.; Trapani, V. Magnesium and its transporters in cancer: A novel paradigm in tumour development. Clin. Sci. 2012, 123, 417-427.
    • (2012) Clin. Sci. , vol.123 , pp. 417-427
    • Wolf, F.I.1    Trapani, V.2
  • 133
    • 77952958037 scopus 로고    scopus 로고
    • TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca2+ influx
    • Chen, J.P.; Luan, Y.; You, C.X.; Chen, X.H.; Luo, R.C.; Li, R. TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca2+ influx. Cell Calcium 2010, 47, 425-432.
    • (2010) Cell Calcium , vol.47 , pp. 425-432
    • Chen, J.P.1    Luan, Y.2    You, C.X.3    Chen, X.H.4    Luo, R.C.5    Li, R.6
  • 135
    • 82655173826 scopus 로고    scopus 로고
    • Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling
    • Dia, V.P.; Gonzalez de Mejia, E. Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling. Cancer Lett. 2011, 313, 167-180.
    • (2011) Cancer Lett. , vol.313 , pp. 167-180
    • Dia, V.P.1    Gonzalez De Mejia, E.2
  • 137
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski, C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 2000, 44, 235-249.
    • (2000) J. Pharmacol. Toxicol. Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 138
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 2001, 46, 3-26.
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4


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