-
1
-
-
78651486094
-
-
IARC. International Agency for Research on Cancer: Lyon, France
-
IARC. Cancer Incidence and Mortality Worlwide; International Agency for Research on Cancer: Lyon, France, 2011.
-
(2011)
Cancer Incidence and Mortality Worlwide
-
-
-
3
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Ferlay, J.; Shin, H.R.; Bray, F.; Forman, D.; Mathers, C.; Parkin, D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 2010, 127, 2893-2917.
-
(2010)
Int. J. Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
Parkin, D.M.6
-
4
-
-
84858308226
-
Natural products as sources of new drugs over the 30 years from 1981 to 2010
-
Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012, 75, 311-335.
-
(2012)
J. Nat. Prod.
, vol.75
, pp. 311-335
-
-
Newman, D.J.1
Cragg, G.M.2
-
5
-
-
84865321509
-
Marine natural products: A lead for anti-cancer
-
Sarfaraj, H.M.; Sheeba, F.; Saba, A.; Mohd, S.K. Marine natural products: A lead for anti-cancer. Indian J. Mar. Sci. 2012, 41, 27-39.
-
(2012)
Indian J. Mar. Sci.
, vol.41
, pp. 27-39
-
-
Sarfaraj, H.M.1
Sheeba, F.2
Saba, A.3
Mohd, S.K.4
-
6
-
-
4344650390
-
Marine natural products and related compounds in clinical and advanced preclinical trials
-
Newman, D.J.; Cragg, G.M. Marine natural products and related compounds in clinical and advanced preclinical trials. J. Nat. Prod. 2004, 67, 1216-1238.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 1216-1238
-
-
Newman, D.J.1
Cragg, G.M.2
-
7
-
-
78650377362
-
Molluscan biological and chemical diversity: Secondary metabolites and medicinal resources produced by marine molluscs
-
Benkendorff, K. Molluscan biological and chemical diversity: Secondary metabolites and medicinal resources produced by marine molluscs. Biol. Rev. 2010, 85, 757-775.
-
(2010)
Biol. Rev.
, vol.85
, pp. 757-775
-
-
Benkendorff, K.1
-
8
-
-
84860287730
-
Anticancer drug discovery from the marine environment
-
Nastrucci, C.; Cesario, A.; Russo, P. Anticancer drug discovery from the marine environment. Recent Pat. Anticancer Drug Discov. 2012, 7, 218-232.
-
(2012)
Recent Pat. Anticancer Drug Discov.
, vol.7
, pp. 218-232
-
-
Nastrucci, C.1
Cesario, A.2
Russo, P.3
-
9
-
-
79960812511
-
A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2010
-
Schumacher, M.; Kelkel, M.; Dicato, M.; Diederich, M. A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2010. Molecules 2011, 16, 5629-5646.
-
(2011)
Molecules
, vol.16
, pp. 5629-5646
-
-
Schumacher, M.1
Kelkel, M.2
Dicato, M.3
Diederich, M.4
-
10
-
-
0000114293
-
Agelasine-A, -B, -C and -D, novel bicyclic diterpenoids with a 9-methyladeninium unit possessing inhibitory effects on na,K-atpase from the okinawa sea sponge Agelas sp.1)
-
Nakamura, H.; Wu, H.; Ohizumi, Y.; Hirata, Y. Agelasine-A, -B, -C and -D, novel bicyclic diterpenoids with a 9-methyladeninium unit possessing inhibitory effects on na,K-atpase from the okinawa sea sponge Agelas sp.1). Tetrahedron Lett. 1984, 25, 2989-2992.
-
(1984)
Tetrahedron Lett.
, vol.25
, pp. 2989-2992
-
-
Nakamura, H.1
Wu, H.2
Ohizumi, Y.3
Hirata, Y.4
-
11
-
-
78651307725
-
Antimicrobial and antineoplastic activities of agelasine analogs modified in the purine 2-position
-
Roggen, H.; Charnock, C.; Burman, R.; Felth, J.; Larsson, R.; Bohlin, L.; Gundersen, L.L. Antimicrobial and antineoplastic activities of agelasine analogs modified in the purine 2-position. Arch. Pharm. (Weinheim) 2011, 344, 50-55.
-
(2011)
Arch. Pharm. (Weinheim)
, vol.344
, pp. 50-55
-
-
Roggen, H.1
Charnock, C.2
Burman, R.3
Felth, J.4
Larsson, R.5
Bohlin, L.6
Gundersen, L.L.7
-
12
-
-
79959619770
-
Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice model
-
Yan, X.; Chen, H.; Lu, X.; Wang, F.; Xu, W.; Jin, H.; Zhu, P. Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice model. Eur. J. Pharm. Sci. 2011, 43, 251-259.
-
(2011)
Eur. J. Pharm. Sci.
, vol.43
, pp. 251-259
-
-
Yan, X.1
Chen, H.2
Lu, X.3
Wang, F.4
Xu, W.5
Jin, H.6
Zhu, P.7
-
13
-
-
0037459866
-
Structures and cytotoxicities of fascaplysin and related alkaloids from two marine phyla - Fascaplysinopsis sponges and Didemnum tunicates
-
Segraves, N.L.; Lopez, S.; Johnson, T.A.; Said, S.A.; Fu, X.; Schmitz, F.J.; Pietraszkiewicz, H.; Valeriote, F.A.; Crews, P. Structures and cytotoxicities of fascaplysin and related alkaloids from two marine phyla - Fascaplysinopsis sponges and Didemnum tunicates. Tetrahedron Lett. 2003, 44, 3471-3475.
-
(2003)
Tetrahedron Lett.
, vol.44
, pp. 3471-3475
-
-
Segraves, N.L.1
Lopez, S.2
Johnson, T.A.3
Said, S.A.4
Fu, X.5
Schmitz, F.J.6
Pietraszkiewicz, H.7
Valeriote, F.A.8
Crews, P.9
-
14
-
-
2542511641
-
Comparison of fascaplysin and related alkaloids: A study of structures, cytotoxicities, and sources
-
Segraves, N.L.; Robinson, S.J.; Garcia, D.; Said, S.A.; Fu, X.; Schmitz, F.J.; Pietraszkiewicz, H.; Valeriote, F.A.; Crews, P. Comparison of fascaplysin and related alkaloids: A study of structures, cytotoxicities, and sources. J. Nat. Prod. 2004, 67, 783-792.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 783-792
-
-
Segraves, N.L.1
Robinson, S.J.2
Garcia, D.3
Said, S.A.4
Fu, X.5
Schmitz, F.J.6
Pietraszkiewicz, H.7
Valeriote, F.A.8
Crews, P.9
-
15
-
-
33846269340
-
Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo
-
Lin, J.; Yan, X.J.; Chen, H.M. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo. Cancer Chemother. Pharmacol. 2007, 59, 439-445.
-
(2007)
Cancer Chemother. Pharmacol.
, vol.59
, pp. 439-445
-
-
Lin, J.1
Yan, X.J.2
Chen, H.M.3
-
16
-
-
77956878953
-
Direct effects of fascaplysin on human umbilical vein endothelial cells attributing the anti-angiogenesis activity
-
Zheng, Y.L.; Lu, X.L.; Lin, J.; Chen, H.M.; Yan, X.J.; Wang, F.; Xu, W.F. Direct effects of fascaplysin on human umbilical vein endothelial cells attributing the anti-angiogenesis activity. Biomed. Pharmacother. 2010, 64, 527-533.
-
(2010)
Biomed. Pharmacother.
, vol.64
, pp. 527-533
-
-
Zheng, Y.L.1
Lu, X.L.2
Lin, J.3
Chen, H.M.4
Yan, X.J.5
Wang, F.6
Xu, W.F.7
-
17
-
-
0035039381
-
DNA binding properties of the marine sponge pigment fascaplysin
-
Hormann, A.; Chaudhuri, B.; Fretz, H. DNA binding properties of the marine sponge pigment fascaplysin. Bioorg. Med. Chem. 2001, 9, 917-921.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 917-921
-
-
Hormann, A.1
Chaudhuri, B.2
Fretz, H.3
-
18
-
-
71049132728
-
Anti-proliferation of human cervical cancer HeLa cell line by fascaplysin through apoptosis induction
-
Lu, X.L.; Zheng, Y.L.; Chen, H.M.; Yan, X.J.; Wang, F.; Xu, W.F. Anti-proliferation of human cervical cancer HeLa cell line by fascaplysin through apoptosis induction. Yao Xue Xue Bao 2009, 44, 980-986.
-
(2009)
Yao Xue Xue Bao
, vol.44
, pp. 980-986
-
-
Lu, X.L.1
Zheng, Y.L.2
Chen, H.M.3
Yan, X.J.4
Wang, F.5
Xu, W.F.6
-
19
-
-
84865057198
-
Fascaplysin as a specific inhibitor for CDK4: Insights from molecular modelling
-
Shafiq, M.I.; Steinbrecher, T.; Schmid, R. Fascaplysin as a specific inhibitor for CDK4: Insights from molecular modelling. PLoS One 2012, 7, e42612.
-
(2012)
PLoS One
, vol.7
-
-
Shafiq, M.I.1
Steinbrecher, T.2
Schmid, R.3
-
20
-
-
66149180566
-
In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues
-
Wang, W.; Rayburn, E.R.; Velu, S.E.; Nadkarni, D.H.; Murugesan, S.; Zhang, R. In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues. Clin. Cancer Res. 2009, 15, 3511-3518.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 3511-3518
-
-
Wang, W.1
Rayburn, E.R.2
Velu, S.E.3
Nadkarni, D.H.4
Murugesan, S.5
Zhang, R.6
-
21
-
-
40749112696
-
Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines
-
Shinkre, B.A.; Raisch, K.P.; Fan, L.; Velu, S.E. Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines. Bioorg. Med. Chem. 2008, 16, 2541-2549.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 2541-2549
-
-
Shinkre, B.A.1
Raisch, K.P.2
Fan, L.3
Velu, S.E.4
-
22
-
-
79958124181
-
Experimental therapy of ovarian cancer with synthetic makaluvamine analog: In vitro and in vivo anticancer activity and molecular mechanisms of action
-
Chen, T.; Xu, Y.; Guo, H.; Liu, Y.; Hu, P.; Yang, X.; Li, X.; Ge, S.; Velu, S.E.; Nadkarni, D.H.; et al. Experimental therapy of ovarian cancer with synthetic makaluvamine analog: In vitro and in vivo anticancer activity and molecular mechanisms of action. PLoS One 2011, 6, e20729.
-
(2011)
PLoS One
, vol.6
-
-
Chen, T.1
Xu, Y.2
Guo, H.3
Liu, Y.4
Hu, P.5
Yang, X.6
Li, X.7
Ge, S.8
Velu, S.E.9
Nadkarni, D.H.10
-
23
-
-
65549099309
-
Zalypsis: A novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks
-
Ocio, E.M.; Maiso, P.; Chen, X.; Garayoa, M.; Alvarez-Fernandez, S.; San-Segundo, L.; Vilanova, D.; Lopez-Corral, L.; Montero, J.C.; Hernandez-Iglesias, T.; et al. Zalypsis: A novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks. Blood 2009, 113, 3781-3791.
-
(2009)
Blood
, vol.113
, pp. 3781-3791
-
-
Ocio, E.M.1
Maiso, P.2
Chen, X.3
Garayoa, M.4
Alvarez-Fernandez, S.5
San-Segundo, L.6
Vilanova, D.7
Lopez-Corral, L.8
Montero, J.C.9
Hernandez-Iglesias, T.10
-
24
-
-
65649141676
-
Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines
-
Leal, J.F.; Garcia-Hernandez, V.; Moneo, V.; Domingo, A.; Bueren-Calabuig, J.A.; Negri, A.; Gago, F.; Guillen-Navarro, M.J.; Aviles, P.; Cuevas, C.; et al. Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines. Biochem. Pharmacol. 2009, 78, 162-170.
-
(2009)
Biochem. Pharmacol.
, vol.78
, pp. 162-170
-
-
Leal, J.F.1
Garcia-Hernandez, V.2
Moneo, V.3
Domingo, A.4
Bueren-Calabuig, J.A.5
Negri, A.6
Gago, F.7
Guillen-Navarro, M.J.8
Aviles, P.9
Cuevas, C.10
-
25
-
-
79955733795
-
Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response
-
Colado, E.; Paino, T.; Maiso, P.; Ocio, E.M.; Chen, X.; Alvarez-Fernandez, S.; Gutierrez, N.C.; Martin-Sanchez, J.; Flores-Montero, J.; San Segundo, L.; et al. Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response. Haematologica 2011, 96, 687-695.
-
(2011)
Haematologica
, vol.96
, pp. 687-695
-
-
Colado, E.1
Paino, T.2
Maiso, P.3
Ocio, E.M.4
Chen, X.5
Alvarez-Fernandez, S.6
Gutierrez, N.C.7
Martin-Sanchez, J.8
Flores-Montero, J.9
San Segundo, L.10
-
26
-
-
84879100388
-
Phase i study of PM00104 (Zalypsis ®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors
-
doi:10.1007/s10637-012-9843-5
-
Massard, C.; Margetts, J.; Amellal, N.; Drew, Y.; Bahleda, R.; Stevens, P.; Armand, J.P.; Calvert, H.; Soria, J.C.; Coronado, C.; et al. Phase I study of PM00104 (Zalypsis ®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors. Invest. New Drugs 2012, doi:10.1007/s10637-012-9843-5.
-
(2012)
Invest. New Drugs
-
-
Massard, C.1
Margetts, J.2
Amellal, N.3
Drew, Y.4
Bahleda, R.5
Stevens, P.6
Armand, J.P.7
Calvert, H.8
Soria, J.C.9
Coronado, C.10
-
27
-
-
84859651995
-
First-in-man phase i trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours
-
Yap, T.A.; Cortes-Funes, H.; Shaw, H.; Rodriguez, R.; Olmos, D.; Lal, R.; Fong, P.C.; Tan, D.S.; Harris, D.; Capdevila, J.; et al. First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours. Br. J. Cancer 2012, 106, 1379-1385.
-
(2012)
Br. J. Cancer
, vol.106
, pp. 1379-1385
-
-
Yap, T.A.1
Cortes-Funes, H.2
Shaw, H.3
Rodriguez, R.4
Olmos, D.5
Lal, R.6
Fong, P.C.7
Tan, D.S.8
Harris, D.9
Capdevila, J.10
-
28
-
-
84856713795
-
Population pharmacokinetics of PM00104 (Zalypsis((R))) in cancer patients
-
Perez-Ruixo, C.; Valenzuela, B.; Fernandez Teruel, C.; Gonzalez-Sales, M.; Miguel-Lillo, B.; Soto-Matos, A.; Perez-Ruixo, J.J. Population pharmacokinetics of PM00104 (Zalypsis((R))) in cancer patients. Cancer Chemother. Pharmacol. 2012, 69, 15-24.
-
(2012)
Cancer Chemother. Pharmacol.
, vol.69
, pp. 15-24
-
-
Perez-Ruixo, C.1
Valenzuela, B.2
Fernandez Teruel, C.3
Gonzalez-Sales, M.4
Miguel-Lillo, B.5
Soto-Matos, A.6
Perez-Ruixo, J.J.7
-
29
-
-
3242731082
-
Study on the secondary metabolites of mangrove fungus N° 1403 from the South China Sea
-
Jiang, G.C.; Lin, Y.C.; Zhou, S.N.; Vrumoed, I.I.P.; Jones, E.B.G. Study on the secondary metabolites of mangrove fungus N° 1403 from the South China Sea. Acta Sci. Natur. Univ. Sunyatseni 2000, 39, 68-72.
-
(2000)
Acta Sci. Natur. Univ. Sunyatseni
, vol.39
, pp. 68-72
-
-
Jiang, G.C.1
Lin, Y.C.2
Zhou, S.N.3
Vrumoed, I.I.P.4
Jones, E.B.G.5
-
30
-
-
77952580649
-
Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi
-
Zhang, J.Y.; Tao, L.Y.; Liang, Y.J.; Chen, L.M.; Mi, Y.J.; Zheng, L.S.; Wang, F.; She, Z.G.; Lin, Y.C.; To, K.K.; et al. Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi. Mar. Drugs 2010, 8, 1469-1481.
-
(2010)
Mar. Drugs
, vol.8
, pp. 1469-1481
-
-
Zhang, J.Y.1
Tao, L.Y.2
Liang, Y.J.3
Chen, L.M.4
Mi, Y.J.5
Zheng, L.S.6
Wang, F.7
She, Z.G.8
Lin, Y.C.9
To, K.K.10
-
31
-
-
79551708802
-
A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells
-
Yuan, J.; He, Z.; Wu, J.; Lin, Y.; Zhu, X. A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells. Mol. Med. Report. 2011, 4, 261-265.
-
(2011)
Mol. Med. Report.
, vol.4
, pp. 261-265
-
-
Yuan, J.1
He, Z.2
Wu, J.3
Lin, Y.4
Zhu, X.5
-
32
-
-
4043132339
-
Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways
-
Chin, P.C.; D'Mello, S.R. Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways. Mol. Brain Res. 2004, 127, 140-145.
-
(2004)
Mol. Brain Res.
, vol.127
, pp. 140-145
-
-
Chin, P.C.1
D'Mello, S.R.2
-
33
-
-
15544369937
-
Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line
-
Lee, S.; Choi, E.J.; Jin, C.; Kim, D.H. Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line. Gynecol. Oncol. 2005, 97, 26-34.
-
(2005)
Gynecol. Oncol.
, vol.97
, pp. 26-34
-
-
Lee, S.1
Choi, E.J.2
Jin, C.3
Kim, D.H.4
-
34
-
-
29644442524
-
Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner
-
Fujiwara, Y.; Kawada, K.; Takano, D.; Tanimura, S.; Ozaki, K.-I.; Kohno, M. Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner. Biochem. Biophys. Res. Commun. 2006, 340, 560-566.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.340
, pp. 560-566
-
-
Fujiwara, Y.1
Kawada, K.2
Takano, D.3
Tanimura, S.4
Ozaki, K.-I.5
Kohno, M.6
-
35
-
-
0036968347
-
Activation of the PI3K/Akt pathway and chemotherapeutic resistance
-
West, K.A.; Sianna Castillo, S.; Dennis, P.A. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist. Updat. 2002, 5, 234-248.
-
(2002)
Drug Resist. Updat.
, vol.5
, pp. 234-248
-
-
West, K.A.1
Sianna Castillo, S.2
Dennis, P.A.3
-
36
-
-
43049131769
-
Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
-
LoPiccolo, J.; Blumenthal, G.M.; Bernstein, W.B.; Dennis, P.A. Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations. Drug Resist. Updat. 2008, 11, 32-50.
-
(2008)
Drug Resist. Updat.
, vol.11
, pp. 32-50
-
-
Lopiccolo, J.1
Blumenthal, G.M.2
Bernstein, W.B.3
Dennis, P.A.4
-
37
-
-
79551687167
-
Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway
-
doi:10.1186/1756-9966-30-17
-
Chen, W.S.; Hou, J.N.; Guo, Y.B.; Yang, H.L.; Xie, C.M.; Lin, Y.C.; She, Z.G. Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway. J. Exp. Clin. Cancer Res. 2011, 30, doi:10.1186/1756-9966-30-17.
-
(2011)
J. Exp. Clin. Cancer Res.
, pp. 30
-
-
Chen, W.S.1
Hou, J.N.2
Guo, Y.B.3
Yang, H.L.4
Xie, C.M.5
Lin, Y.C.6
She, Z.G.7
-
38
-
-
84055219449
-
Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp
-
Hu, Y.; MacMillan, J.B. Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp. Org. Lett. 2011, 13, 6580-6583.
-
(2011)
Org. Lett.
, vol.13
, pp. 6580-6583
-
-
Hu, Y.1
MacMillan, J.B.2
-
39
-
-
80955122677
-
Systematic chemical mutagenesis identifies a potent novel apratoxin A/E hybrid with improved in vivo antitumor activity
-
Chen, Q.Y.; Liu, Y.; Luesch, H. Systematic chemical mutagenesis identifies a potent novel apratoxin A/E hybrid with improved in vivo antitumor activity. ACS Med. Chem. Lett. 2011, 2, 861-865.
-
(2011)
ACS Med. Chem. Lett.
, vol.2
, pp. 861-865
-
-
Chen, Q.Y.1
Liu, Y.2
Luesch, H.3
-
40
-
-
33744493376
-
Targeting tyrosine kinases in cancer: The second wave
-
Baselga, J. Targeting tyrosine kinases in cancer: The second wave. Science 2006, 312, 1175-1178.
-
(2006)
Science
, vol.312
, pp. 1175-1178
-
-
Baselga, J.1
-
41
-
-
0034092011
-
Tumor angiogenesis: Past, present and the near future
-
Kerbel, R.S. Tumor angiogenesis: Past, present and the near future. Carcinogenesis 2000, 21, 505-515.
-
(2000)
Carcinogenesis
, vol.21
, pp. 505-515
-
-
Kerbel, R.S.1
-
42
-
-
47549102471
-
Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii
-
Matthew, S.; Schupp, P.J.; Luesch, H. Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. J. Nat. Prod. 2008, 71, 1113-1116.
-
(2008)
J. Nat. Prod.
, vol.71
, pp. 1113-1116
-
-
Matthew, S.1
Schupp, P.J.2
Luesch, H.3
-
43
-
-
33750012824
-
Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities
-
Ma, D.; Zou, B.; Cai, G.; Hu, X.; Liu, J.O. Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities. Chemistry 2006, 12, 7615-7626.
-
(2006)
Chemistry
, vol.12
, pp. 7615-7626
-
-
Ma, D.1
Zou, B.2
Cai, G.3
Hu, X.4
Liu, J.O.5
-
44
-
-
78650781428
-
Solid-phase total synthesis of (-)-apratoxin A and its analogues and their biological evaluation
-
Doi, T.; Numajiri, Y.; Takahashi, T.; Takagi, M.; Shin-ya, K. Solid-phase total synthesis of (-)-apratoxin A and its analogues and their biological evaluation. Chem. Asian J. 2011, 6, 180-188.
-
(2011)
Chem. Asian J.
, vol.6
, pp. 180-188
-
-
Doi, T.1
Numajiri, Y.2
Takahashi, T.3
Takagi, M.4
Shin-Ya, K.5
-
45
-
-
38749104725
-
New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus
-
Kito, K.; Ookura, R.; Yoshida, S.; Namikoshi, M.; Ooi, T.; Kusumi, T. New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus. Org. Lett. 2008, 10, 225-228.
-
(2008)
Org. Lett.
, vol.10
, pp. 225-228
-
-
Kito, K.1
Ookura, R.2
Yoshida, S.3
Namikoshi, M.4
Ooi, T.5
Kusumi, T.6
-
46
-
-
78651256756
-
Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B
-
Diaz-Oltra, S.; Angulo-Pachon, C.A.; Murga, J.; Falomir, E.; Carda, M.; Marco, J.A. Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B. Chemistry 2011, 17, 675-688.
-
(2011)
Chemistry
, vol.17
, pp. 675-688
-
-
Diaz-Oltra, S.1
Angulo-Pachon, C.A.2
Murga, J.3
Falomir, E.4
Carda, M.5
Marco, J.A.6
-
47
-
-
84860388802
-
Chromomycin SA analogs from a marine-derived Streptomyces sp
-
Hu, Y.; Espindola, A.P.; Stewart, N.A.; Wei, S.; Posner, B.A.; MacMillan, J.B. Chromomycin SA analogs from a marine-derived Streptomyces sp. Bioorg. Med. Chem. 2011, 19, 5183-5189.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 5183-5189
-
-
Hu, Y.1
Espindola, A.P.2
Stewart, N.A.3
Wei, S.4
Posner, B.A.5
MacMillan, J.B.6
-
48
-
-
17944386473
-
Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: Analysis of the gene cluster and rational design of novel chromomycin analogs
-
Menendez, N.; Nur-e-Alam, M.; Brana, A.F.; Rohr, J.; Salas, J.A.; Mendez, C. Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. Chem. Biol. 2004, 11, 21-32.
-
(2004)
Chem. Biol.
, vol.11
, pp. 21-32
-
-
Menendez, N.1
Nur-E-Alam, M.2
Brana, A.F.3
Rohr, J.4
Salas, J.A.5
Mendez, C.6
-
49
-
-
79953229556
-
Lobophorin C and D, new kijanimicin derivatives from a marine sponge-associated actinomycetal strain AZS17
-
Wei, R.B.; Xi, T.; Li, J.; Wang, P.; Li, F.C.; Lin, Y.C.; Qin, S. Lobophorin C and D, new kijanimicin derivatives from a marine sponge-associated actinomycetal strain AZS17. Mar. Drugs 2011, 9, 359-368.
-
(2011)
Mar. Drugs
, vol.9
, pp. 359-368
-
-
Wei, R.B.1
Xi, T.2
Li, J.3
Wang, P.4
Li, F.C.5
Lin, Y.C.6
Qin, S.7
-
50
-
-
77957374632
-
Chapter 8 Total synthesis of spongistatin 1 (altohyrtin a): A tale of ten aldols
-
Michael, H., Ed.; Academic Press: Oxford, UK
-
Paterson, I.; Coster, M.J. Chapter 8 Total synthesis of spongistatin 1 (altohyrtin a): A tale of ten aldols. In Strategies and Tactics in Organic Synthesis; Michael, H., Ed.; Academic Press: Oxford, UK, 2004; Volume 4, pp. 211-245.
-
(2004)
Strategies and Tactics in Organic Synthesis
, vol.4
, pp. 211-245
-
-
Paterson, I.1
Coster, M.J.2
-
51
-
-
67650266670
-
Spongipyran synthetic studies. Evolution of a scalable total synthesis of (+)-spongistatin 1
-
Smith Iii, A.B.; Sfouggatakis, C.; Risatti, C.A.; Sperry, J.B.; Zhu, W.; Doughty, V.A.; Tomioka, T.; Gotchev, D.B.; Bennett, C.S.; Sakamoto, S.; et al. Spongipyran synthetic studies. Evolution of a scalable total synthesis of (+)-spongistatin 1. Tetrahedron 2009, 65, 6489-6509.
-
(2009)
Tetrahedron
, vol.65
, pp. 6489-6509
-
-
Smith Iii, A.B.1
Sfouggatakis, C.2
Risatti, C.A.3
Sperry, J.B.4
Zhu, W.5
Doughty, V.A.6
Tomioka, T.7
Gotchev, D.B.8
Bennett, C.S.9
Sakamoto, S.10
-
52
-
-
0027482896
-
Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin
-
Bai, R.; Cichacz, Z.A.; Herald, C.L.; Pettit, G.R.; Hamel, E. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin. Mol. Pharmacol. 1993, 44, 757-766.
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 757-766
-
-
Bai, R.1
Cichacz, Z.A.2
Herald, C.L.3
Pettit, G.R.4
Hamel, E.5
-
53
-
-
22744452190
-
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation
-
Paterson, I.; Chen, D.Y.; Coster, M.J.; Acena, J.L.; Bach, J.; Wallace, D.J. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation. Org. Biomol. Chem. 2005, 3, 2431-2440.
-
(2005)
Org. Biomol. Chem.
, vol.3
, pp. 2431-2440
-
-
Paterson, I.1
Chen, D.Y.2
Coster, M.J.3
Acena, J.L.4
Bach, J.5
Wallace, D.J.6
-
54
-
-
77955488063
-
The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis
-
Rothmeier, A.S.; Schneiders, U.M.; Wiedmann, R.M.; Ischenko, I.; Bruns, C.J.; Rudy, A.; Zahler, S.; Vollmar, A.M. The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis. Int. J. Cancer 2010, 127, 1096-1105.
-
(2010)
Int. J. Cancer
, vol.127
, pp. 1096-1105
-
-
Rothmeier, A.S.1
Schneiders, U.M.2
Wiedmann, R.M.3
Ischenko, I.4
Bruns, C.J.5
Rudy, A.6
Zahler, S.7
Vollmar, A.M.8
-
55
-
-
70350212784
-
BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells
-
Schneiders, U.M.; Schyschka, L.; Rudy, A.; Vollmar, A.M. BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells. Mol. Cancer Ther. 2009, 8, 2914-2925.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2914-2925
-
-
Schneiders, U.M.1
Schyschka, L.2
Rudy, A.3
Vollmar, A.M.4
-
56
-
-
51649114209
-
Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP
-
Schyschka, L.; Rudy, A.; Jeremias, I.; Barth, N.; Pettit, G.R.; Vollmar, A.M. Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP. Leukemia 2008, 22, 1737-1745.
-
(2008)
Leukemia
, vol.22
, pp. 1737-1745
-
-
Schyschka, L.1
Rudy, A.2
Jeremias, I.3
Barth, N.4
Pettit, G.R.5
Vollmar, A.M.6
-
57
-
-
80051643517
-
In vitro and in vivo anticancer activity of (+)-spongistatin 1
-
Xu, Q.; Huang, K.C.; Tendyke, K.; Marsh, J.; Liu, J.; Qiu, D.; Littlefield, B.A.; Nomoto, K.; Atasoylu, O.; Risatti, C.A.; et al. In vitro and in vivo anticancer activity of (+)-spongistatin 1. Anticancer Res. 2011, 31, 2773-2779.
-
(2011)
Anticancer Res.
, vol.31
, pp. 2773-2779
-
-
Xu, Q.1
Huang, K.C.2
Tendyke, K.3
Marsh, J.4
Liu, J.5
Qiu, D.6
Littlefield, B.A.7
Nomoto, K.8
Atasoylu, O.9
Risatti, C.A.10
-
58
-
-
78650099214
-
Apoptosisinducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines
-
Choi, E.J.; Park, J.S.; Kim, Y.J.; Jung, J.H.; Lee, J.K.; Kwon, H.C.; Yang, H.O. Apoptosisinducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines. J. Appl. Microbiol. 2011, 110, 304-313.
-
(2011)
J. Appl. Microbiol.
, vol.110
, pp. 304-313
-
-
Choi, E.J.1
Park, J.S.2
Kim, Y.J.3
Jung, J.H.4
Lee, J.K.5
Kwon, H.C.6
Yang, H.O.7
-
59
-
-
17644412298
-
The epipolythiodioxopiperazine (ETP) class of fungal toxins: Distribution, mode of action, functions and biosynthesis
-
Gardiner, D.M.; Waring, P.; Howlett, B.J. The epipolythiodioxopiperazine (ETP) class of fungal toxins: Distribution, mode of action, functions and biosynthesis. Microbiology 2005, 151, 1021-1032.
-
(2005)
Microbiology
, vol.151
, pp. 1021-1032
-
-
Gardiner, D.M.1
Waring, P.2
Howlett, B.J.3
-
60
-
-
40949090477
-
Intravesical chemotherapy of high-grade bladder cancer with HTI-286, a synthetic analogue of the marine sponge product hemiasterlin
-
Hadaschik, B.A.; Adomat, H.; Fazli, L.; Fradet, Y.; Andersen, R.J.; Gleave, M.E.; So, A.I. Intravesical chemotherapy of high-grade bladder cancer with HTI-286, a synthetic analogue of the marine sponge product hemiasterlin. Clin. Cancer Res. 2008, 14, 1510-1518.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 1510-1518
-
-
Hadaschik, B.A.1
Adomat, H.2
Fazli, L.3
Fradet, Y.4
Andersen, R.J.5
Gleave, M.E.6
So, A.I.7
-
61
-
-
0037447174
-
HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo
-
Loganzo, F.; Discafani, C.M.; Annable, T.; Beyer, C.; Musto, S.; Hari, M.; Tan, X.; Hardy, C.; Hernandez, R.; Baxter, M.; et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003, 63, 1838-1845.
-
(2003)
Cancer Res.
, vol.63
, pp. 1838-1845
-
-
Loganzo, F.1
Discafani, C.M.2
Annable, T.3
Beyer, C.4
Musto, S.5
Hari, M.6
Tan, X.7
Hardy, C.8
Hernandez, R.9
Baxter, M.10
-
62
-
-
70350231755
-
Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin
-
Kuznetsov, G.; TenDyke, K.; Towle, M.J.; Cheng, H.; Liu, J.; Marsh, J.P.; Schiller, S.E.; Spyvee, M.R.; Yang, H.; Seletsky, B.M.; et al. Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin. Mol. Cancer Ther. 2009, 8, 2852-2860.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2852-2860
-
-
Kuznetsov, G.1
Tendyke, K.2
Towle, M.J.3
Cheng, H.4
Liu, J.5
Marsh, J.P.6
Schiller, S.E.7
Spyvee, M.R.8
Yang, H.9
Seletsky, B.M.10
-
63
-
-
84866737041
-
Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor
-
Hsu, L.C.; Durrant, D.E.; Huang, C.C.; Chi, N.W.; Baruchello, R.; Rondanin, R.; Rullo, C.; Marchetti, P.; Grisolia, G.; Simoni, D.; et al. Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor. Invest. New Drugs 2012, 30, 1379-1388.
-
(2012)
Invest. New Drugs
, vol.30
, pp. 1379-1388
-
-
Hsu, L.C.1
Durrant, D.E.2
Huang, C.C.3
Chi, N.W.4
Baruchello, R.5
Rondanin, R.6
Rullo, C.7
Marchetti, P.8
Grisolia, G.9
Simoni, D.10
-
64
-
-
79953234852
-
Biostructural features of additional jasplakinolide (jaspamide) analogues
-
Watts, K.R.; Morinaka, B.I.; Amagata, T.; Robinson, S.J.; Tenney, K.; Bray, W.M.; Gassner, N.C.; Lokey, R.S.; Media, J.; Valeriote, F.A.; et al. Biostructural features of additional jasplakinolide (jaspamide) analogues. J. Nat. Prod. 2011, 74, 341-351.
-
(2011)
J. Nat. Prod.
, vol.74
, pp. 341-351
-
-
Watts, K.R.1
Morinaka, B.I.2
Amagata, T.3
Robinson, S.J.4
Tenney, K.5
Bray, W.M.6
Gassner, N.C.7
Lokey, R.S.8
Media, J.9
Valeriote, F.A.10
-
65
-
-
77949391413
-
Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin
-
Tannert, R.; Milroy, L.G.; Ellinger, B.; Hu, T.S.; Arndt, H.D.; Waldmann, H. Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin. J. Am. Chem. Soc. 2010, 132, 3063-3077.
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 3063-3077
-
-
Tannert, R.1
Milroy, L.G.2
Ellinger, B.3
Hu, T.S.4
Arndt, H.D.5
Waldmann, H.6
-
66
-
-
45649084241
-
Besarhanamides A and B from the marine cyanobacterium Lyngbya majuscula
-
Tan, L.T.; Chang, Y.Y.; Ashootosh, T. Besarhanamides A and B from the marine cyanobacterium Lyngbya majuscula. Phytochemistry 2008, 69, 2067-2069.
-
(2008)
Phytochemistry
, vol.69
, pp. 2067-2069
-
-
Tan, L.T.1
Chang, Y.Y.2
Ashootosh, T.3
-
67
-
-
80054925331
-
Lagunamide C a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula
-
Tripathi, A.; Puddick, J.; Prinsep, M.R.; Rottmann, M.; Chan, K.P.; Chen, D.Y.; Tan, L.T. Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula. Phytochemistry 2011, 72, 2369-2375.
-
(2011)
Phytochemistry
, vol.72
, pp. 2369-2375
-
-
Tripathi, A.1
Puddick, J.2
Prinsep, M.R.3
Rottmann, M.4
Chan, K.P.5
Chen, D.Y.6
Tan, L.T.7
-
68
-
-
84865458429
-
Discovery of anticancer drugs from antimalarial natural products: A MEDLINE literature review
-
Duffy, R.; Wade, C.; Chang, R. Discovery of anticancer drugs from antimalarial natural products: a MEDLINE literature review. Drug Discov. Today 2012, 17, 942-953.
-
(2012)
Drug Discov. Today
, vol.17
, pp. 942-953
-
-
Duffy, R.1
Wade, C.2
Chang, R.3
-
69
-
-
78650280205
-
Direct observation of local atomic order in a metallic glass
-
Hirata, A.; Guan, P.; Fujita, T.; Hirotsu, Y.; Inoue, A.; Yavari, A.R.; Sakurai, T.; Chen, M. Direct observation of local atomic order in a metallic glass. Nat. Mater. 2011, 10, 28-33.
-
(2011)
Nat. Mater.
, vol.10
, pp. 28-33
-
-
Hirata, A.1
Guan, P.2
Fujita, T.3
Hirotsu, Y.4
Inoue, A.5
Yavari, A.R.6
Sakurai, T.7
Chen, M.8
-
70
-
-
80051599485
-
Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases
-
Cole, K.E.; Dowling, D.P.; Boone, M.A.; Phillips, A.J.; Christianson, D.W. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. J. Am. Chem. Soc. 2011, 133, 12474-12477.
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 12474-12477
-
-
Cole, K.E.1
Dowling, D.P.2
Boone, M.A.3
Phillips, A.J.4
Christianson, D.W.5
-
71
-
-
79951632653
-
Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: Application of N-heterocyclic carbene mediated acylations in complex molecule synthesis
-
Wang, B.; Huang, P.H.; Chen, C.S.; Forsyth, C.J. Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis. J. Org. Chem. 2011, 76, 1140-1150.
-
(2011)
J. Org. Chem.
, vol.76
, pp. 1140-1150
-
-
Wang, B.1
Huang, P.H.2
Chen, C.S.3
Forsyth, C.J.4
-
72
-
-
79958264627
-
Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability
-
Benelkebir, H.; Marie, S.; Hayden, A.L.; Lyle, J.; Loadman, P.M.; Crabb, S.J.; Packham, G.; Ganesan, A. Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability. Bioorg. Med. Chem. 2011, 19, 3650-3658.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 3650-3658
-
-
Benelkebir, H.1
Marie, S.2
Hayden, A.L.3
Lyle, J.4
Loadman, P.M.5
Crabb, S.J.6
Packham, G.7
Ganesan, A.8
-
73
-
-
80455162618
-
Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: Synthesis and biological evaluation
-
Bhansali, P.; Hanigan, C.L.; Casero, R.A.; Tillekeratne, L.M. Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: Synthesis and biological evaluation. J. Med. Chem. 2011, 54, 7453-7463.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 7453-7463
-
-
Bhansali, P.1
Hanigan, C.L.2
Casero, R.A.3
Tillekeratne, L.M.4
-
74
-
-
77955646151
-
Macrocyclic histone deacetylase inhibitors
-
Mwakwari, S.C.; Patil, V.; Guerrant, W.; Oyelere, A.K. Macrocyclic histone deacetylase inhibitors. Curr. Top. Med. Chem. 2010, 10, 1423-1440.
-
(2010)
Curr. Top. Med. Chem.
, vol.10
, pp. 1423-1440
-
-
Mwakwari, S.C.1
Patil, V.2
Guerrant, W.3
Oyelere, A.K.4
-
75
-
-
79956075028
-
Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein
-
Raju, R.; Piggott, A.M.; Huang, X.C.; Capon, R.J. Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein. Org. Lett. 2011, 13, 2770-2773.
-
(2011)
Org. Lett.
, vol.13
, pp. 2770-2773
-
-
Raju, R.1
Piggott, A.M.2
Huang, X.C.3
Capon, R.J.4
-
76
-
-
80054881646
-
Pardaxin an antimicrobial peptide, triggers caspase-dependent and ROS-mediated apoptosis in HT-1080 cells
-
Huang, T.C.; Lee, J.F.; Chen, J.Y. Pardaxin, an antimicrobial peptide, triggers caspase-dependent and ROS-mediated apoptosis in HT-1080 cells. Mar. Drugs 2011, 9, 1995-2009.
-
(2011)
Mar. Drugs
, vol.9
, pp. 1995-2009
-
-
Huang, T.C.1
Lee, J.F.2
Chen, J.Y.3
-
77
-
-
79957981259
-
Pardaxin-induced apoptosis enhances antitumor activity in HeLa cells
-
Hsu, J.C.; Lin, L.C.; Tzen, J.T.; Chen, J.Y. Pardaxin-induced apoptosis enhances antitumor activity in HeLa cells. Peptides 2011, 32, 1110-1116.
-
(2011)
Peptides
, vol.32
, pp. 1110-1116
-
-
Hsu, J.C.1
Lin, L.C.2
Tzen, J.T.3
Chen, J.Y.4
-
78
-
-
14544301506
-
Rhizochalin A a novel two-headed sphingolipid from the sponge Rhizochalina incrustata
-
Makarieva, T.N.; Guzii, A.G.; Denisenko, V.A.; Dmitrenok, P.S.; Santalova, E.A.; Pokanevich, E.V.; Molinski, T.F.; Stonik, V.A. Rhizochalin A, a novel two-headed sphingolipid from the sponge Rhizochalina incrustata. J. Nat. Prod. 2005, 68, 255-257.
-
(2005)
J. Nat. Prod.
, vol.68
, pp. 255-257
-
-
Makarieva, T.N.1
Guzii, A.G.2
Denisenko, V.A.3
Dmitrenok, P.S.4
Santalova, E.A.5
Pokanevich, E.V.6
Molinski, T.F.7
Stonik, V.A.8
-
79
-
-
80053522700
-
Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells
-
Khanal, P.; Kang, B.S.; Yun, H.J.; Cho, H.G.; Makarieva, T.N.; Choi, H.S. Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells. Biol. Pharm. Bull. 2011, 34, 1553-1558.
-
(2011)
Biol. Pharm. Bull.
, vol.34
, pp. 1553-1558
-
-
Khanal, P.1
Kang, B.S.2
Yun, H.J.3
Cho, H.G.4
Makarieva, T.N.5
Choi, H.S.6
-
80
-
-
70349257239
-
Marine two-headed sphingolipid-like compound rhizochalin inhibits EGF-induced transformation of JB6 P+ Cl41 cells
-
Fedorov, S.N.; Makarieva, T.N.; Guzii, A.G.; Shubina, L.K.; Kwak, J.Y.; Stonik, V.A. Marine two-headed sphingolipid-like compound rhizochalin inhibits EGF-induced transformation of JB6 P+ Cl41 cells. Lipids 2009, 44, 777-785.
-
(2009)
Lipids
, vol.44
, pp. 777-785
-
-
Fedorov, S.N.1
Makarieva, T.N.2
Guzii, A.G.3
Shubina, L.K.4
Kwak, J.Y.5
Stonik, V.A.6
-
81
-
-
66549122868
-
Differential induction of apoptosis of leukemic cells by rhizochalin, two headed sphingolipids from sponge and its derivatives
-
Jin, J.O.; Shastina, V.; Park, J.I.; Han, J.Y.; Makarieva, T.; Fedorov, S.; Rasskazov, V.; Stonik, V.; Kwak, J.Y. Differential induction of apoptosis of leukemic cells by rhizochalin, two headed sphingolipids from sponge and its derivatives. Biol. Pharm. Bull. 2009, 32, 955-962.
-
(2009)
Biol. Pharm. Bull.
, vol.32
, pp. 955-962
-
-
Jin, J.O.1
Shastina, V.2
Park, J.I.3
Han, J.Y.4
Makarieva, T.5
Fedorov, S.6
Rasskazov, V.7
Stonik, V.8
Kwak, J.Y.9
-
82
-
-
23444437971
-
Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis
-
Lerdrup, M.; Holmberg, C.; Dietrich, N.; Shaulian, E.; Herdegen, T.; Jäättelä, M.; Kallunki, T. Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. Biochim. Biophys. Acta 2005, 1745, 29-37.
-
(2005)
Biochim. Biophys. Acta
, vol.1745
, pp. 29-37
-
-
Lerdrup, M.1
Holmberg, C.2
Dietrich, N.3
Shaulian, E.4
Herdegen, T.5
Jäättelä, M.6
Kallunki, T.7
-
83
-
-
77949916262
-
AP-1 - The Jun proteins: Oncogenes or tumor suppressors in disguise?
-
Shaulian, E. AP-1 - The Jun proteins: Oncogenes or tumor suppressors in disguise? Cell. Signal. 2010, 22, 894-899.
-
(2010)
Cell. Signal.
, vol.22
, pp. 894-899
-
-
Shaulian, E.1
-
84
-
-
79960694150
-
Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction
-
Jiang, Y.; Miao, Z.H.; Xu, L.; Yu, B.; Gong, J.X.; Tong, L.J.; Chen, Y.; Zhou, Z.L.; Liu, H.C.; Wang, Y.; et al. Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction. J. Biol. Chem. 2011, 286, 26461-26469.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 26461-26469
-
-
Jiang, Y.1
Miao, Z.H.2
Xu, L.3
Yu, B.4
Gong, J.X.5
Tong, L.J.6
Chen, Y.7
Zhou, Z.L.8
Liu, H.C.9
Wang, Y.10
-
85
-
-
77955306935
-
Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review
-
Papatheodoridis, G.V.; Lampertico, P.; Manolakopoulos, S.; Lok, A. Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review. J. Hepatol. 2010, 53, 348-356.
-
(2010)
J. Hepatol.
, vol.53
, pp. 348-356
-
-
Papatheodoridis, G.V.1
Lampertico, P.2
Manolakopoulos, S.3
Lok, A.4
-
86
-
-
58849136702
-
Molecular targeted therapy for hepatocellular carcinoma
-
Thomas, M. Molecular targeted therapy for hepatocellular carcinoma. J. Gastroenterol. 2009, 44, 136-141.
-
(2009)
J. Gastroenterol.
, vol.44
, pp. 136-141
-
-
Thomas, M.1
-
87
-
-
38849199799
-
STAT3 as a target for inducing apoptosis in solid and hematological tumors
-
Al Zaid Siddiquee, K.; Turkson, J. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res. 2008, 18, 254-267.
-
(2008)
Cell Res.
, vol.18
, pp. 254-267
-
-
Al Zaid Siddiquee, K.1
Turkson, J.2
-
88
-
-
77950391697
-
Stat3 orchestrates tumor development and progression: The Achilles' heel of head and neck cancers?
-
Masuda, M.; Wakasaki, T.; Suzui, M.; Toh, S.; Joe, A.K.; Weinstein, I.B. Stat3 orchestrates tumor development and progression: The Achilles' heel of head and neck cancers? Curr. Cancer Drug Targets 2010, 10, 117-126.
-
(2010)
Curr. Cancer Drug Targets
, vol.10
, pp. 117-126
-
-
Masuda, M.1
Wakasaki, T.2
Suzui, M.3
Toh, S.4
Joe, A.K.5
Weinstein, I.B.6
-
89
-
-
80053469046
-
Dieckol from ecklonia cava regulates invasion of human fibrosarcoma cells and modulates MMP-2 and MMP-9 expression via NF-kappaB pathway
-
Zhang, C.; Li, Y.; Qian, Z.J.; Lee, S.H.; Li, Y.X.; Kim, S.K. Dieckol from ecklonia cava regulates invasion of human fibrosarcoma cells and modulates MMP-2 and MMP-9 expression via NF-kappaB pathway. Evid. Based Complement. Alternat. Med. 2011, 2011, 140462.
-
(2011)
Evid. Based Complement. Alternat. Med.
, vol.2011
, pp. 140462
-
-
Zhang, C.1
Li, Y.2
Qian, Z.J.3
Lee, S.H.4
Li, Y.X.5
Kim, S.K.6
-
90
-
-
39149084984
-
Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium
-
Das, S.; Banerji, A.; Frei, E.; Chatterjee, A. Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium. Life Sci. 2008, 82, 467-476.
-
(2008)
Life Sci.
, vol.82
, pp. 467-476
-
-
Das, S.1
Banerji, A.2
Frei, E.3
Chatterjee, A.4
-
91
-
-
0036800192
-
Metalloproteinase inhibitors: Biological actions and therapeutic opportunities
-
Baker, A.H.; Edwards, D.R.; Murphy, G. Metalloproteinase inhibitors: Biological actions and therapeutic opportunities. J. Cell. Sci. 2002, 115, 3719-3727.
-
(2002)
J. Cell. Sci.
, vol.115
, pp. 3719-3727
-
-
Baker, A.H.1
Edwards, D.R.2
Murphy, G.3
-
92
-
-
17044412494
-
Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity
-
Tanimura, S.; Kadomoto, R.; Tanaka, T.; Zhang, Y.J.; Kouno, I.; Kohno, M. Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity. Biochem. Biophys. Res. Commun. 2005, 330, 1306-1313.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.330
, pp. 1306-1313
-
-
Tanimura, S.1
Kadomoto, R.2
Tanaka, T.3
Zhang, Y.J.4
Kouno, I.5
Kohno, M.6
-
93
-
-
84863433452
-
Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling
-
Park, S.J.; Jeon, Y.J. Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling. Mol. Cells 2012, 33, 141-149.
-
(2012)
Mol. Cells
, vol.33
, pp. 141-149
-
-
Park, S.J.1
Jeon, Y.J.2
-
94
-
-
33751276236
-
Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1)
-
Lee, J.; Jung, E.; Lee, J.; Huh, S.; Hwang, C.H.; Lee, H.Y.; Kim, E.J.; Cheon, J.M.; Hyun, C.G.; Kim, Y.S.; et al. Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1). Life Sci. 2006, 79, 2480-2485.
-
(2006)
Life Sci.
, vol.79
, pp. 2480-2485
-
-
Lee, J.1
Jung, E.2
Lee, J.3
Huh, S.4
Hwang, C.H.5
Lee, H.Y.6
Kim, E.J.7
Cheon, J.M.8
Hyun, C.G.9
Kim, Y.S.10
-
95
-
-
79953212580
-
Astaxanthin: A potential therapeutic agent in cardiovascular disease
-
Fassett, R.G.; Coombes, J.S. Astaxanthin: A potential therapeutic agent in cardiovascular disease. Mar. Drugs 2011, 9, 447-465.
-
(2011)
Mar. Drugs
, vol.9
, pp. 447-465
-
-
Fassett, R.G.1
Coombes, J.S.2
-
96
-
-
82155183286
-
Effects of astaxanthin on oxidative stress in overweight and obese adults
-
Choi, H.D.; Kim, J.H.; Chang, M.J.; Kyu-Youn, Y.; Shin, W.G. Effects of astaxanthin on oxidative stress in overweight and obese adults. Phytother. Res. 2011, 25, 1813-1818.
-
(2011)
Phytother. Res.
, vol.25
, pp. 1813-1818
-
-
Choi, H.D.1
Kim, J.H.2
Chang, M.J.3
Kyu-Youn, Y.4
Shin, W.G.5
-
97
-
-
67650450196
-
Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells
-
Palozza, P.; Torelli, C.; Boninsegna, A.; Simone, R.; Catalano, A.; Mele, M.C.; Picci, N. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett. 2009, 283, 108-117.
-
(2009)
Cancer Lett.
, vol.283
, pp. 108-117
-
-
Palozza, P.1
Torelli, C.2
Boninsegna, A.3
Simone, R.4
Catalano, A.5
Mele, M.C.6
Picci, N.7
-
98
-
-
77951497956
-
Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress
-
Wolf, A.M.; Asoh, S.; Hiranuma, H.; Ohsawa, I.; Iio, K.; Satou, A.; Ishikura, M.; Ohta, S. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J. Nutr. Biochem. 2010, 21, 381-389.
-
(2010)
J. Nutr. Biochem.
, vol.21
, pp. 381-389
-
-
Wolf, A.M.1
Asoh, S.2
Hiranuma, H.3
Ohsawa, I.4
Iio, K.5
Satou, A.6
Ishikura, M.7
Ohta, S.8
-
99
-
-
79956080227
-
Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2
-
Nagendraprabhu, P.; Sudhandiran, G. Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Invest. New Drugs 2011, 29, 207-224.
-
(2011)
Invest. New Drugs
, vol.29
, pp. 207-224
-
-
Nagendraprabhu, P.1
Sudhandiran, G.2
-
100
-
-
62849123061
-
Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis
-
Prabhu, P.N.; Ashokkumar, P.; Sudhandiran, G. Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis. Fundam. Clin. Pharmacol. 2009, 23, 225-234.
-
(2009)
Fundam. Clin. Pharmacol.
, vol.23
, pp. 225-234
-
-
Prabhu, P.N.1
Ashokkumar, P.2
Sudhandiran, G.3
-
101
-
-
79959945798
-
Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines
-
Yasui, Y.; Hosokawa, M.; Mikami, N.; Miyashita, K.; Tanaka, T. Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines. Chem. Biol. Interact. 2011, 193, 79-87.
-
(2011)
Chem. Biol. Interact.
, vol.193
, pp. 79-87
-
-
Yasui, Y.1
Hosokawa, M.2
Mikami, N.3
Miyashita, K.4
Tanaka, T.5
-
102
-
-
0033596121
-
Activators and target genes of Rel/NF-kappaB transcription factors
-
Pahl, H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18, 6853-6866.
-
(1999)
Oncogene
, vol.18
, pp. 6853-6866
-
-
Pahl, H.L.1
-
103
-
-
25844459154
-
NF-kappaB: Linking inflammation and immunity to cancer development and progression
-
Karin, M.; Greten, F.R. NF-kappaB: Linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 2005, 5, 749-759.
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
104
-
-
84855246261
-
Tetrahydrofuran cembranoids from the cultured soft coral Lobophytum crassum
-
Lee, N.L.; Su, J.H. Tetrahydrofuran cembranoids from the cultured soft coral Lobophytum crassum. Mar. Drugs 2011, 9, 2526-2536.
-
(2011)
Mar. Drugs
, vol.9
, pp. 2526-2536
-
-
Lee, N.L.1
Su, J.H.2
-
105
-
-
77649213543
-
Bioactive sesterterpenes and triterpenes from marine sponges: Occurrence and pharmacological significance
-
Ebada, S.S.; Lin, W.; Proksch, P. Bioactive sesterterpenes and triterpenes from marine sponges: Occurrence and pharmacological significance. Mar. Drugs 2010, 8, 313-346.
-
(2010)
Mar. Drugs
, vol.8
, pp. 313-346
-
-
Ebada, S.S.1
Lin, W.2
Proksch, P.3
-
106
-
-
79957801058
-
Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne
-
Piao, S.J.; Zhang, H.J.; Lu, H.Y.; Yang, F.; Jiao, W.H.; Yi, Y.H.; Chen, W.S.; Lin, H.W. Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne. J. Nat. Prod. 2011, 74, 1248-1254.
-
(2011)
J. Nat. Prod.
, vol.74
, pp. 1248-1254
-
-
Piao, S.J.1
Zhang, H.J.2
Lu, H.Y.3
Yang, F.4
Jiao, W.H.5
Yi, Y.H.6
Chen, W.S.7
Lin, H.W.8
-
107
-
-
33646337639
-
Novel linear C22-sesterterpenoids from sponge Ircinia formosana
-
Shen, Y.-C.; Lo, K.-L.; Lin, Y.-C.; Khalil, A.T.; Kuo, Y.-H.; Shih, P.-S. Novel linear C22-sesterterpenoids from sponge Ircinia formosana. Tetrahedron Lett. 2006, 47, 4007-4010.
-
(2006)
Tetrahedron Lett.
, vol.47
, pp. 4007-4010
-
-
Shen, Y.-C.1
Lo, K.-L.2
Lin, Y.-C.3
Khalil, A.T.4
Kuo, Y.-H.5
Shih, P.-S.6
-
108
-
-
80053213572
-
Cytotoxic C21 and C22 terpenoid-derived metabolites from the sponge Ircinia sp
-
Su, J.H.; Tseng, S.W.; Lu, M.C.; Liu, L.L.; Chou, Y.; Sung, P.J. Cytotoxic C21 and C22 terpenoid-derived metabolites from the sponge Ircinia sp. J. Nat. Prod. 2011, 74, 2005-2009.
-
(2011)
J. Nat. Prod.
, vol.74
, pp. 2005-2009
-
-
Su, J.H.1
Tseng, S.W.2
Lu, M.C.3
Liu, L.L.4
Chou, Y.5
Sung, P.J.6
-
109
-
-
84868140756
-
10-acetylirciformonin B, a sponge furanoterpenoid, induces DNA damage and apoptosis in leukemia cells
-
Su, J.H.; Chang, W.B.; Chen, H.M.; El-Shazly, M.; Du, Y.C.; Kung, T.H.; Chen, Y.C.; Sung, P.J.; Ho, Y.S.; Kuo, F.W.; et al. 10-acetylirciformonin B, a sponge furanoterpenoid, induces DNA damage and apoptosis in leukemia cells. Molecules 2012, 17, 11839-11848.
-
(2012)
Molecules
, vol.17
, pp. 11839-11848
-
-
Su, J.H.1
Chang, W.B.2
Chen, H.M.3
El-Shazly, M.4
Du, Y.C.5
Kung, T.H.6
Chen, Y.C.7
Sung, P.J.8
Ho, Y.S.9
Kuo, F.W.10
-
110
-
-
0035866625
-
Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges
-
Wright, A.D.; Wang, H.; Gurrath, M.; Konig, G.M.; Kocak, G.; Neumann, G.; Loria, P.; Foley, M.; Tilley, L. Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges. J. Med. Chem. 2001, 44, 873-885.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 873-885
-
-
Wright, A.D.1
Wang, H.2
Gurrath, M.3
Konig, G.M.4
Kocak, G.5
Neumann, G.6
Loria, P.7
Foley, M.8
Tilley, L.9
-
111
-
-
80055078414
-
Evaluation of the antiproliferative activity of diterpene isonitriles from the sponge Pseudoaxinella flava in apoptosis-sensitive and apoptosis-resistant cancer cell lines
-
Lamoral-Theys, D.; Fattorusso, E.; Mangoni, A.; Perinu, C.; Kiss, R.; Costantino, V. Evaluation of the antiproliferative activity of diterpene isonitriles from the sponge Pseudoaxinella flava in apoptosis-sensitive and apoptosis-resistant cancer cell lines. J. Nat. Prod. 2011, 74, 2299-2303.
-
(2011)
J. Nat. Prod.
, vol.74
, pp. 2299-2303
-
-
Lamoral-Theys, D.1
Fattorusso, E.2
Mangoni, A.3
Perinu, C.4
Kiss, R.5
Costantino, V.6
-
112
-
-
79959750983
-
Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule
-
Lin, W.Y.; Lu, Y.; Su, J.H.; Wen, Z.H.; Dai, C.F.; Kuo, Y.H.; Sheu, J.H. Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule. Mar. Drugs 2011, 9, 994-1006.
-
(2011)
Mar. Drugs
, vol.9
, pp. 994-1006
-
-
Lin, W.Y.1
Lu, Y.2
Su, J.H.3
Wen, Z.H.4
Dai, C.F.5
Kuo, Y.H.6
Sheu, J.H.7
-
113
-
-
79961166820
-
Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors
-
Hassan, H.M.; Sallam, A.A.; Mohammed, R.; Hifnawy, M.S.; Youssef, D.T.; El Sayed, K.A. Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors. Bioorg. Med. Chem. 2011, 19, 4928-4934.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 4928-4934
-
-
Hassan, H.M.1
Sallam, A.A.2
Mohammed, R.3
Hifnawy, M.S.4
Youssef, D.T.5
El Sayed, K.A.6
-
114
-
-
79952697175
-
Siphonaxanthin a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells
-
Ganesan, P.; Noda, K.; Manabe, Y.; Ohkubo, T.; Tanaka, Y.; Maoka, T.; Sugawara, T.; Hirata, T. Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells. Biochim. Biophys. Acta 2011, 1810, 497-503.
-
(2011)
Biochim. Biophys. Acta
, vol.1810
, pp. 497-503
-
-
Ganesan, P.1
Noda, K.2
Manabe, Y.3
Ohkubo, T.4
Tanaka, Y.5
Maoka, T.6
Sugawara, T.7
Hirata, T.8
-
115
-
-
78149410116
-
Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile
-
Ganesan, P.; Matsubara, K.; Ohkubo, T.; Tanaka, Y.; Noda, K.; Sugawara, T.; Hirata, T. Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile. Phytomedicine 2010, 17, 1140-1144.
-
(2010)
Phytomedicine
, vol.17
, pp. 1140-1144
-
-
Ganesan, P.1
Matsubara, K.2
Ohkubo, T.3
Tanaka, Y.4
Noda, K.5
Sugawara, T.6
Hirata, T.7
-
116
-
-
53349096248
-
Smenospongine a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells
-
Kong, D.; Aoki, S.; Sowa, Y.; Sakai, T.; Kobayashi, M. Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells. Mar. Drugs 2008, 6, 480-488.
-
(2008)
Mar. Drugs
, vol.6
, pp. 480-488
-
-
Kong, D.1
Aoki, S.2
Sowa, Y.3
Sakai, T.4
Kobayashi, M.5
-
117
-
-
1942421216
-
Smenospongine a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells
-
Aoki, S.; Kong, D.; Matsui, K.; Kobayashi, M. Smenospongine, a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells. Anticancer Drug 2004, 15, 363-369.
-
(2004)
Anticancer Drug
, vol.15
, pp. 363-369
-
-
Aoki, S.1
Kong, D.2
Matsui, K.3
Kobayashi, M.4
-
118
-
-
79851499458
-
Antiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene aminoquinone
-
Kong, D.; Yamori, T.; Kobayashi, M.; Duan, H. Antiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene aminoquinone. Mar. Drugs 2011, 9, 154-161.
-
(2011)
Mar. Drugs
, vol.9
, pp. 154-161
-
-
Kong, D.1
Yamori, T.2
Kobayashi, M.3
Duan, H.4
-
119
-
-
15444357498
-
Two new xenicin diterpenoids from the octocoral anthelia edmondsoni
-
Coval, S.J.; Scheuer, P.J.; Matsumoto, G.K.; Clardy, J. Two new xenicin diterpenoids from the octocoral anthelia edmondsoni. Tetrahedron 1984, 40, 3823-3828.
-
(1984)
Tetrahedron
, vol.40
, pp. 3823-3828
-
-
Coval, S.J.1
Scheuer, P.J.2
Matsumoto, G.K.3
Clardy, J.4
-
120
-
-
80655144731
-
Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels
-
Zierler, S.; Yao, G.; Zhang, Z.; Kuo, W.C.; Porzgen, P.; Penner, R.; Horgen, F.D.; Fleig, A. Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. J. Biol. Chem. 2011, 286, 39328-39335.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 39328-39335
-
-
Zierler, S.1
Yao, G.2
Zhang, Z.3
Kuo, W.C.4
Porzgen, P.5
Penner, R.6
Horgen, F.D.7
Fleig, A.8
-
121
-
-
70349253981
-
Evidence that TRPM7 is required for breast cancer cell proliferation
-
Guilbert, A.; Gautier, M.; Dhennin-Duthille, I.; Haren, N.; Sevestre, H.; Ouadid-Ahidouch, H. Evidence that TRPM7 is required for breast cancer cell proliferation. Am. J. Physiol. Cell. Physiol. 2009, 297, C493-C502.
-
(2009)
Am. J. Physiol. Cell. Physiol.
, vol.297
-
-
Guilbert, A.1
Gautier, M.2
Dhennin-Duthille, I.3
Haren, N.4
Sevestre, H.5
Ouadid-Ahidouch, H.6
-
122
-
-
83755207524
-
High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: Correlation with pathological parameters
-
Dhennin-Duthille, I.; Gautier, M.; Faouzi, M.; Guilbert, A.; Brevet, M.; Vaudry, D.; Ahidouch, A.; Sevestre, H.; Ouadid-Ahidouch, H. High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: Correlation with pathological parameters. Cell. Physiol. Biochem. 2011, 28, 813-822.
-
(2011)
Cell. Physiol. Biochem.
, vol.28
, pp. 813-822
-
-
Dhennin-Duthille, I.1
Gautier, M.2
Faouzi, M.3
Guilbert, A.4
Brevet, M.5
Vaudry, D.6
Ahidouch, A.7
Sevestre, H.8
Ouadid-Ahidouch, H.9
-
123
-
-
36348964907
-
Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: Role in cell proliferation
-
Jiang, J.; Li, M.H.; Inoue, K.; Chu, X.P.; Seeds, J.; Xiong, Z.G. Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: Role in cell proliferation. Cancer Res. 2007, 67, 10929-10938.
-
(2007)
Cancer Res.
, vol.67
, pp. 10929-10938
-
-
Jiang, J.1
Li, M.H.2
Inoue, K.3
Chu, X.P.4
Seeds, J.5
Xiong, Z.G.6
-
124
-
-
57349188508
-
Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer
-
Kim, B.J.; Park, E.J.; Lee, J.H.; Jeon, J.H.; Kim, S.J.; So, I. Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Sci. 2008, 99, 2502-2509.
-
(2008)
Cancer Sci.
, vol.99
, pp. 2502-2509
-
-
Kim, B.J.1
Park, E.J.2
Lee, J.H.3
Jeon, J.H.4
Kim, S.J.5
So, I.6
-
125
-
-
84861927907
-
TRPM7: A unique channel involved in magnesium homeostasis
-
Paravicini, T.M.; Chubanov, V.; Gudermann, T. TRPM7: A unique channel involved in magnesium homeostasis. Int. J. Biochem. Cell. Biol. 2012, 44, 1381-1384.
-
(2012)
Int. J. Biochem. Cell. Biol.
, vol.44
, pp. 1381-1384
-
-
Paravicini, T.M.1
Chubanov, V.2
Gudermann, T.3
-
126
-
-
34548498843
-
Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7
-
Li, M.; Du, J.; Jiang, J.; Ratzan, W.; Su, L.T.; Runnels, L.W.; Yue, L. Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7. J. Biol. Chem. 2007, 282, 25817-25830.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 25817-25830
-
-
Li, M.1
Du, J.2
Jiang, J.3
Ratzan, W.4
Su, L.T.5
Runnels, L.W.6
Yue, L.7
-
127
-
-
33646140352
-
Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7
-
Li, M.; Jiang, J.; Yue, L. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J. Gen. Physiol. 2006, 127, 525-537.
-
(2006)
J. Gen. Physiol.
, vol.127
, pp. 525-537
-
-
Li, M.1
Jiang, J.2
Yue, L.3
-
128
-
-
78650069888
-
TRPM7 is essential for Mg2+ homeostasis in mammals
-
doi:10.1038/ncomms1108
-
Ryazanova, L.V.; Rondon, L.J.; Zierler, S.; Hu, Z.; Galli, J.; Yamaguchi, T.P.; Mazur, A.; Fleig, A.; Ryazanov, A.G. TRPM7 is essential for Mg2+ homeostasis in mammals. Nat. Commun. 2010, 1, doi:10.1038/ncomms1108.
-
(2010)
Nat. Commun.
, pp. 1
-
-
Ryazanova, L.V.1
Rondon, L.J.2
Zierler, S.3
Hu, Z.4
Galli, J.5
Yamaguchi, T.P.6
Mazur, A.7
Fleig, A.8
Ryazanov, A.G.9
-
129
-
-
0042197392
-
Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7
-
Schmitz, C.; Perraud, A.L.; Johnson, C.O.; Inabe, K.; Smith, M.K.; Penner, R.; Kurosaki, T.; Fleig, A.; Scharenberg, A.M. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell 2003, 114, 191-200.
-
(2003)
Cell
, vol.114
, pp. 191-200
-
-
Schmitz, C.1
Perraud, A.L.2
Johnson, C.O.3
Inabe, K.4
Smith, M.K.5
Penner, R.6
Kurosaki, T.7
Fleig, A.8
Scharenberg, A.M.9
-
130
-
-
1942501853
-
Dual-function ion channel/protein kinases: Novel components of vertebrate magnesium regulatory mechanisms
-
Schmitz, C.; Perraud, A.L.; Fleig, A.; Scharenberg, A.M. Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms. Pediatr. Res. 2004, 55, 734-737.
-
(2004)
Pediatr. Res.
, vol.55
, pp. 734-737
-
-
Schmitz, C.1
Perraud, A.L.2
Fleig, A.3
Scharenberg, A.M.4
-
131
-
-
84868158166
-
Intracellular magnesium content decreases during mitochondria-mediated apoptosis induced by a new indole-derivative in human colon cancer cells
-
Cappadone, C.; Merolle, L.; Marraccini, C.; Farruggia, G.; Sargenti, A.; Locatelli, A.; Morigi, R.; Iotti, S. Intracellular magnesium content decreases during mitochondria-mediated apoptosis induced by a new indole-derivative in human colon cancer cells. Magnes. Res. 2012, 25, 104-111.
-
(2012)
Magnes. Res.
, vol.25
, pp. 104-111
-
-
Cappadone, C.1
Merolle, L.2
Marraccini, C.3
Farruggia, G.4
Sargenti, A.5
Locatelli, A.6
Morigi, R.7
Iotti, S.8
-
132
-
-
84864021130
-
Magnesium and its transporters in cancer: A novel paradigm in tumour development
-
Wolf, F.I.; Trapani, V. Magnesium and its transporters in cancer: A novel paradigm in tumour development. Clin. Sci. 2012, 123, 417-427.
-
(2012)
Clin. Sci.
, vol.123
, pp. 417-427
-
-
Wolf, F.I.1
Trapani, V.2
-
133
-
-
77952958037
-
TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca2+ influx
-
Chen, J.P.; Luan, Y.; You, C.X.; Chen, X.H.; Luo, R.C.; Li, R. TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca2+ influx. Cell Calcium 2010, 47, 425-432.
-
(2010)
Cell Calcium
, vol.47
, pp. 425-432
-
-
Chen, J.P.1
Luan, Y.2
You, C.X.3
Chen, X.H.4
Luo, R.C.5
Li, R.6
-
134
-
-
72149130530
-
Human cancer cell antiproliferative and antioxidant activities of Juglans regia L
-
Carvalho, M.; Ferreira, P.J.; Mendes, V.S.; Silva, R.; Pereira, J.A.; Jerónimo, C.; Silva, B.M. Human cancer cell antiproliferative and antioxidant activities of Juglans regia L. Food Chem. Toxicol. 2010, 48, 441-447.
-
(2010)
Food Chem. Toxicol.
, vol.48
, pp. 441-447
-
-
Carvalho, M.1
Ferreira, P.J.2
Mendes, V.S.3
Silva, R.4
Pereira, J.A.5
Jerónimo, C.6
Silva, B.M.7
-
135
-
-
82655173826
-
Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling
-
Dia, V.P.; Gonzalez de Mejia, E. Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling. Cancer Lett. 2011, 313, 167-180.
-
(2011)
Cancer Lett.
, vol.313
, pp. 167-180
-
-
Dia, V.P.1
Gonzalez De Mejia, E.2
-
136
-
-
79959637805
-
Integrated plant biotechnologies applied to safer and healthier food production: The Nutra-Snack manufacturing chain
-
Rea, G.; Antonacci, A.; Lambreva, M.; Pastorelli, S.; Tibuzzi, A.; Ferrari, S.; Fischer, D.; Johanningmeier, U.; Oleszek, W.; Doroszewska, T.; et al. Integrated plant biotechnologies applied to safer and healthier food production: The Nutra-Snack manufacturing chain. Trends Food Sci. Technol. 2011, 22, 353-366.
-
(2011)
Trends Food Sci. Technol.
, vol.22
, pp. 353-366
-
-
Rea, G.1
Antonacci, A.2
Lambreva, M.3
Pastorelli, S.4
Tibuzzi, A.5
Ferrari, S.6
Fischer, D.7
Johanningmeier, U.8
Oleszek, W.9
Doroszewska, T.10
-
137
-
-
0034461768
-
Drug-like properties and the causes of poor solubility and poor permeability
-
Lipinski, C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 2000, 44, 235-249.
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.44
, pp. 235-249
-
-
Lipinski, C.A.1
-
138
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 2001, 46, 3-26.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
|