Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation

Toxicological Sciences

Volumn 123, Issue 2, 2011, Pages 523-541

  Castino, Roberta ^a   Fiorentino, Ilaria ^a   Cagnin, Monica ^a   Giovia, Antonino ^a   Isidoro, Ciro ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Autophagy; Cell death; Deferoxamine; Lysosomes; Oxidative stress

Indexed keywords

3 METHYLADENINE; BECLIN 1; DEFEROXAMINE; HYDROGEN PEROXIDE; IRON; LIPOCORTIN 5; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BAX; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

ARTICLE; AUTOPHAGY; CELL DEATH; CELL STRESS; CHELATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; GENE SILENCING; HUMAN; HUMAN CELL; LYSOSOME; MITOCHONDRION; NEUROBLASTOMA; NEUROPROTECTION; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; TOXICITY TESTING;

ADENINE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; DEFEROXAMINE; FREE RADICALS; GENE SILENCING; HUMANS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LYSOSOMES; MEMBRANE PROTEINS; MITOCHONDRIA; NEUROBLASTOMA; ONCOGENE PROTEIN V-AKT; OXIDANTS; PHOSPHORYLATION; RNA, SMALL INTERFERING; SIDEROPHORES;

MAMMALIA;

EID: 80053450324     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr179     Document Type: Article

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