Cucurbitacin I Inhibits cell motility by indirectly interfering with actin dynamics

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Knecht, David A ^a   LaFleur, Rebecca A ^a   Kahsai, Alem W ^a,b   Argueta, Christian E ^a   Beshir, Anwar B ^a   Fenteany, Gabriel ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; COFILIN; CUCURBITACIN; CUCURBITACIN A; CUCURBITACIN B; CUCURBITACIN C; CUCURBITACIN I; CYTOSKELETON PROTEIN; F ACTIN; G ACTIN; GELSOLIN; JANUS KINASE 2; JASPAMIDE; PHALLACIDIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; ACTIN DEPOLYMERIZING FACTOR; ANTINEOPLASTIC AGENT; CYCLOPEPTIDE; DEPSIPEPTIDE; TRITERPENE;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BIOACCUMULATION; CELL ADHESION; CELL AGGREGATION; CELL MIGRATION; CELL MOTILITY; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; DEPOLYMERIZATION; DICTYOSTELIUM DISCOIDEUM; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; IN VITRO STUDY; KIDNEY CELL; MASS SPECTROMETRY; MELANOMA B16; MELANOMA CELL; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; WOUND CLOSURE; ANIMAL; CELL LINE; CELL MOTION; CHEMICAL STRUCTURE; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; DICTYOSTELIUM; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; MICROFILAMENT; POLYMERIZATION; TUMOR CELL LINE; ULTRASTRUCTURE;

DICTYOSTELIUM DISCOIDEUM;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CYTOSKELETON; DEPSIPEPTIDES; DICTYOSTELIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GELSOLIN; MICROFILAMENTS; MICROSCOPY, CONFOCAL; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; POLYMERIZATION; TRITERPENES;

EID: 78649674867     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014039     Document Type: Article

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