Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 271-280

  Wang, Gang ^a,b   Wang, Jun Jie ^a   Yang, Guang Yi ^a   Du, Shi Ming ^a   Zeng, Nan ^b   Li, Dong Sheng ^c   Li, Rui Ming ^c   Chen, Ji Yan ^a   Feng, Jin Bo ^c   Yuan, Shen Hao ^a   Ye, Fang ^a  

^a HUBEI UNIVERSITY OF MEDICINE   (China)

^b Department of Pharmacy   (China)

^c Hubei Provincial Key Laboratory of Embryo Stem Cells   (China)

Author keywords

ATP; C6 glioma cells; Liposome; Mitochondria; Quercetin; Reactive oxygen species; Type III programmed cell death

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 9; CYTOCHROME C; LACTATE DEHYDROGENASE; LIPOSOME; NANOLIPOSOME; QUERCETIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CASPASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG FORMULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; FLOW CYTOMETRY; GLIOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; WESTERN BLOTTING; CANCER SURVIVAL; CONCENTRATION (PARAMETERS); DRUG EFFECT; DRUG MECHANISM; LIPOSOMAL DELIVERY; NANOANALYSIS; NERVE CELL NECROSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL SHAPE; CELL SURVIVAL; CYTOCHROMES C; GLIOMA; L-LACTATE DEHYDROGENASE; LIPOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; NANOPARTICLES; NECROSIS; QUERCETIN; RATS; REACTIVE OXYGEN SPECIES;

EID: 84863012010     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Clarke PG. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl). 1990;181:195-213.
2. Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004;23:2891-2906.
3. Arends MJ, Wyllie AH. Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol. 1991;32:223-254.
4. Jaattela M, Tschopp J. Caspase-independent cell death in T lymphocytes. Nat Immunol. 2003;4:416-423.
5. Okada H, Mak T W. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer. 2004;4:592-603.
6. Castro MG, Cowen R, Williamson IK, et al. Current and future strategies for the treatment of malignant brain tumors. Pharmacol Ther. 2003;98: 71-108.
7. Xavier C P, Lima CF, Rohde M, Pereira-Wilson C. Quercetin enhances 5-fuorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation. Cancer Chemother Pharmacol. 2011;68:1449-1457.
8. Siegelin MD, Reuss DE, Habel A, Rami A, von Deimling A. Quercetin promotes degradation of surviving and thereby enhances death-receptor-mediated apoptosis in glioma cells. Neuro Oncol. 2009;6:123-129.
9. Ong CS, Tran E, Nguyen TT, et al. Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions. Oncol Rep. 2004;11:727-733.
10. Gupta K, Panda D. Perturbation of microtubule polymerization by quercetin through tubulin binding: a novel mechanism of its antipro-liferative activity. Biochemistry. 2002;41:13029-13038.
11. Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related favonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer. 1999;35:1517-1525.
12. Yuan Z P, Chen LJ, Fan LY, et al. Liposomal quercetin effciently suppresses growth of solid tumors in murine models. Clin Cancer Res. 2006;12:3193-3199.
13. Li L, Han W, Gu Y, et al. Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore. Cancer Res. 2007;67:4894-4903.
14. Lee JH, Li YC, Ip S W, et al. The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway. Anticancer Res. 2008;28:1701-1711.
15. Lin CC, Yang JS, Chen JT, et al. Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway. Anticancer Res. 2007;27:3371-3378.
16. Lu HF, Hsueh SC, Ho YT, et al. ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial dependent pathway. Anticancer Res. 2007;27:117-125.
17. Huan SK, Lee HH, Liu DZ, Wu CC, Wang CC. Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. Toxicology. 2006;223:136-143.
18. Liu TZ, Chen CY, Yiin SJ, et al. Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). Food Chem Toxicol. 2006;44:227-235.
19. Dodo K, Katoh M, Shimizu T, Takahashi M, Sodeoka M. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolyl-maleimide derivatives. Bioorg Med Chem Lett. 2005;15:3114-3118.
20. Dive C, Gregory CD, Phipps DJ, et al. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter fow cytometry. Biochim Biophys Acta. 1992;1133:275-285.
21. Miyoshi N, Watanabe E, Osawa T, et al. ATP depletion alters the mode of cell death induced by benzyl isothiocyanate. Biochim Biophys Acta. 2008;1782:566-573.
22. Amaravadi RK, Thompson CB. The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res. 2007;13: 7271-7279.
23. Lim SC, Choi JE, Kim CH, et al. Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. Int J Mol Med. 2007;20: 187-192.
24. Lemasters, JJ. V Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol. 1999;276:G1-G6.
25. Heijnen CG, Haenen GR, van Acker FA, van der Vijgh WJ, Bast A. Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. Toxicol in Vitro. 2001;15:3-6.
26. Boots AW, Balk JM, Bast A, Haenen GR. The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity. Biochem Biophys Res Commun. 2005;338:923-929.
27. Boots AW, Li H, Schins R P, et al. The quercetin paradox. Toxicol Appl Pharmacol. 2007; 222:89-96.
28. Ferraresi R, Troiano L, Roat E, et al. Essential requirement of reduced glutathione (GSH) for the anti-oxidant effect of the favonoid quercetin. Free Radic Res. 2005;39:1249-1258.
29. Kim GN, Jang HD. Protective mechanism of quercetin and rutin using glutathione metabolism on HO induced oxidative stress in HepG2 cells. Ann N Y Acad Sci. 2009;1171:530-537.
30. Juan ME, Wenzel U, Daniel H, Planas JM. Erythrodiol, a natural triterpenoid from olives, has antiproliferative and apoptotic activity in HT-29 human adenocarcinoma cells. Mol Nutr Food Res. 2008;52: 595-599.
31. Oh JI, Chun KH, Joo SH, Oh YT, Lee SK. Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. Cancer Lett. 2005;230:228-238.
32. Yu S W, Wang H, Poitras M F, et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002;297:259-263.
33. Waring P. Redox active calcium ion channels and cell death. Arch Biochem Biophys. 2005;434:33-42.
34. Lemasters JJ, Qian T, He L, et al. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal. 2002;4:769-781.
35. Baigi MG, Brault L, Neguesque A, et al. Apoptosis/necrosis switch in two different cancer cell lines: infuence of benzoquinone- and hydrogen peroxide-induced oxidative stress intensity, and glutathione. Toxicol In Vitro. 2008;22:1547-1554.
36. Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med. 1997;185:1481-1486.
37. Nishikawa K, Satoh H, Hirai A, et al. Alpha-tocopheryloxybutyric acid enhances necrotic cell death in breast cancer cells treated with chemotherapy agent. Cancer Lett. 2003;201:51-56.