Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP Protein Family

Journal of Molecular Biology

Volumn 392, Issue 3, 2009, Pages 630-644

  Cossu, Federica ^a   Milani, Mario ^a,b   Mastrangelo, Eloise ^a,b   Vachette, Patrice ^c   Servida, Federica ^a   Lecis, Daniele ^d   Canevari, Giulia ^a   Delia, Domenico ^d   Drago, Carmelo ^a   Rizzo, Vincenzo ^a   Manzoni, Leonardo ^a,e   Seneci, Pierfausto ^a   Scolastico, Carlo ^a   Bolognesi, Martino ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b CNR Consiglio Nazionale delle Ricerche   (Italy)

^c INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e CNR   (Italy)

Author keywords

cIAP; inhibition of apoptosis; pro apoptotic drugs; Smac DIABLO; XIAP

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 9; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE ACTIVATOR; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HL 60; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FAMILY; UBIQUITINATION;

AMINO ACID SEQUENCE; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MITOCHONDRIAL PROTEINS; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 69349104331     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.04.033     Document Type: Article

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