Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties

Journal of Antibiotics

Volumn 53, Issue 9, 2000, Pages 879-885

  Sasse, F ^a   Steinmetz, H ^a   Heil, J ^a   Hofle, G ^a   Reichenbach, H ^a  

^a Abteilung Naturstoffchemie   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; ACETIC ACID ETHYL ESTER; ACETONE; ALPHA TUBULIN; AMINO ACID; AMMONIUM ACETATE; CYTOSTATIC AGENT; DOLASTATIN 10; HYDROXYL GROUP; IMMUNOGLOBULIN G; METHANOL; MONOCLONAL ANTIBODY; PEPTIDE; POLACRILIN; RESIN; SODIUM CHLORIDE; TUBULYSIN A; TUBULYSIN B; TUBULYSIN D; TUBULYSIN E; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIUM CULTURE; CELL LINE; CELL POLARITY; CHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INCUBATION TIME; MAMMAL CELL; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; MOUSE; MYXOCOCCALES; NONHUMAN; PRIORITY JOURNAL; RAT;

ANGIOCOCCUS DISCIFORMIS; ARCHANGIUM GEPHYRA;

EID: 0033779074     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.879     Document Type: Article

References (11)

1. Tubulysins, new cytostatic peptides from myxobacteria
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7. The chondramides: Cytostatic agents from myxobacteria acting on the actin cytoskeleton
8. Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties
9. Effect of rhizopodin and latrunculin B on the morphology and on the actin cytoskeleton of mammalian cells
10. Dolastatin 10 and dolastatin 15: Effects of two natural peptides on growth and differentiation of leukemia cells
11. LU103793 (NSC D-669356): A synthetic peptide that interacts with microtubules and inhibits mitosis