Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells

Cancer Letters

Volumn 288, Issue 2, 2010, Pages 183-191

  Moon, Dong Oh ^a,b   Kim, Mun Ock ^a,b   Lee, Jae Dong ^c   Choi, Yung Hyun ^d   Kim, Gi Young ^a,b  

^a Jeju National University   (South Korea)

^b Jeju National University   (South Korea)

^c Pusan National University   (South Korea)

^d Dong Eui University   (South Korea)

Author keywords

Apoptosis; NF B; ROS; Rosmarinic acid; TNF

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CYTOCHROME C; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; PROTEIN BCL 2; PROTEIN P50; REACTIVE OXYGEN METABOLITE; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; ROSMARINIC ACID; SYNAPTOTAGMIN I; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CELL DEATH; CELL STRAIN U937; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CASPASES; CELL SURVIVAL; CINNAMATES; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; DEPSIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEP G2 CELLS; HUMANS; I-KAPPA B PROTEINS; INHIBITOR OF APOPTOSIS PROTEINS; LEUKEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

EID: 74849083369     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.06.033     Document Type: Article

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