Mechanisms of HIV protein degradation into epitopes: Implications for vaccine design

Viruses

Volumn 6, Issue 8, 2014, Pages 3271-3292

  Rucevic, Marijana ^a   Boucau, Julie ^a   Dinter, Jens ^a   Kourjian, Georgio ^a   Le Gall, Sylvie ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aminopeptidase; Antigen processing; Dendritic cells; HIV; Immunogen; Peptidase; Proteasome; Protein degradation; T cells; Vaccine vector; Viral evolution

Indexed keywords

AMINOPEPTIDASE; CYTOSOL AMINOPEPTIDASE; EPITOPE; GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INSULINASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDASE; PROTEASOME; RITONAVIR; SAQUINAVIR; T LYMPHOCYTE RECEPTOR; THIMET OLIGOPEPTIDASE; UBIQUITIN PROTEIN LIGASE E3; VIRUS RNA; VIRUS VECTOR; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN;

ANTIGEN PRESENTATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL TRIAL (TOPIC); DENDRITIC CELL; DRUG DESIGN; EVOLUTION; GENE MUTATION; HLA SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVIEW; VACCINATION; VIRUS LOAD; VIRUS REPLICATION; IMMUNOLOGY; METABOLISM;

AIDS VACCINES; ANTIGEN PRESENTATION; EPITOPES; HIV; HIV ANTIGENS; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; HUMANS; PROTEOLYSIS;

EID: 84925883303     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v6083271     Document Type: Review

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