Modeling the MHC class I pathway by combining predictions of proteasomal cleavage, TAP transport and MHC class I binding

Cellular and Molecular Life Sciences

Volumn 62, Issue 9, 2005, Pages 1025-1037

  Tenzer, S ^a   Peters, B ^b,d   Bulik, S ^b   Schoor, O ^c   Lemmel, C ^c   Schatz, M M ^a   Kloetzel, P M ^b   Rammensee, H G ^c   Schild, H ^a   Holzhutter H G ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

Antigen processing; Epitope prediction; MHC; Proteasome; TAP

Indexed keywords

LYSINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE HYDROLASE; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; TRIPEPTIDYL PEPTIDASE II; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSOL; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MAJOR HISTOCOMPATIBILITY COMPLEX; MASS SPECTROMETRY; PEPTIDE SYNTHESIS; PREDICTION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN TRANSPORT;

ALGORITHMS; ANTIGEN PRESENTATION; AREA UNDER CURVE; ARTIFICIAL INTELLIGENCE; ATP-BINDING CASSETTE TRANSPORTERS; BINDING, COMPETITIVE; COMPUTER SIMULATION; EPITOPES, T-LYMPHOCYTE; GENE EXPRESSION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-A ANTIGENS; HLA-B ANTIGENS; HUMANS; LYSINE; MODELS, IMMUNOLOGICAL; MODELS, STATISTICAL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SUBUNITS; PROTEIN TRANSPORT; ROC CURVE;

EID: 20844434026     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-005-4528-2     Document Type: Article

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