Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences

Journal of Experimental Medicine

Volumn 207, Issue 1, 2010, Pages 61-75

  Berger, Christoph T ^a   Carlson, Jonathan M ^b   Brumme, Chanson J ^a   Hartman, Kari L ^a   Brumme, Zabrina L ^a,c,d   Henry, Leah M ^a   Rosato, Pamela C ^a   Piechocka Trocha, Alicja ^a   Brockman, Mark A ^a,c,d   Harrigan, P Richard ^c,e   Heckerman, David ^b   Kaufmann, Daniel E ^a   Brander, Christian ^a,f,g  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MICROSOFT RESEARCH   (United States)

^c BRITISH COLUMBIA CENTRE FOR EXCELLENCE IN HIV AIDS   (Canada)

^d SIMON FRASER UNIVERSITY   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^g HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAG PROTEIN; HLA A3 ANTIGEN; HLA ANTIGEN CLASS 1; NEF PROTEIN; POL PROTEIN;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EVOLUTION; EX VIVO STUDY; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HOST; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; IMMUNE RESPONSE; IN VITRO STUDY; MAJOR CLINICAL STUDY; OPEN READING FRAME; PRIORITY JOURNAL; RIBOSOMAL FRAMESHIFTING; START CODON; VIRUS IMMUNITY; VIRUS REPLICATION; WILD TYPE;

CD8-POSITIVE T-LYMPHOCYTES; CODON, INITIATOR; EPITOPES, T-LYMPHOCYTE; EVOLUTION, MOLECULAR; FEMALE; FRAMESHIFT MUTATION; HIV; HIV INFECTIONS; HLA-A ANTIGENS; HUMANS; IMMUNITY, CELLULAR; MALE; PEPTIDES; POLYMORPHISM, GENETIC; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 76149099253     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20091808     Document Type: Article

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