MHC Affinity, Peptide Liberation, T Cell Repertoire, and Immunodominance All Contribute to the Paucity of MHC Class I-Restricted Peptides Recognized by Antiviral CTL

Journal of Immunology

Volumn 158, Issue 4, 1997, Pages 1507-1515

  Deng, Yuping ^a   Yewdell, Jonathan W ^a   Eisenlohr, Laurence C ^a   Bennink, Jack R ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; H2 ANTIGEN; PEPTIDE FRAGMENT;

ANIMAL; ANTIGEN PRESENTATION; ARTICLE; BAGG ALBINO MOUSE; CD8+ T LYMPHOCYTE; CYTOTOXICITY; IMMUNOLOGY; INFLUENZA VIRUS A; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN BINDING; SYNTHESIS; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; H-2 ANTIGENS; IMMUNODOMINANT EPITOPES; INFLUENZA A VIRUS; MICE; MICE, INBRED BALB C; PEPTIDE FRAGMENTS; PROTEIN BINDING; T-LYMPHOCYTE SUBSETS;

EID: 0031568653     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Zinkernagel, R. M., and P. C. Doherty. 1979. MHC-restriced cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv. Immunol. 27:52.
2. Townsend, A., and H. Bodmer. 1989. Antigen recognition by class I-restricted T lymphocytes. Annu. Rev. Immunol. 7:601.
3. Rammensee, H.-G., K. Falk, and O. Rötzschke. 1993. Peptides naturally presented by MHC class I molecules. Annu. Rev. Immunol. 11:213.
4. Yewdell, J. W., and J. R. Bennink. 1992. Cell biology of antigen processing and presentation to MHC class I molecule-restricted T lymphocytes. Adv. Immunol. 52:1.
5. Rock, K. L., C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, and A. L. Goldberg. 1994. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761.
6. Heemels, M.-T., and H. Ploegh. 1995. Generation, translocation, and presentation of MHC class I-restricted peptides. Annu. Rev. Biochem. 64:463.
7. Suh, W.-K., M. F. Cohen-Doyle, K. Fruh, K. Wang, P. A. Peterson, and D. B. Williams. 1994. Interaction of MHC class I molecules with the transporter associated with antigen processing. Science 264:1322.
8. 2-microglobulin complexes associate with TAP transporters before peptide binding. Nature 368:864.
9. Engelhard, V. H. 1994. Structures of peptides associated with class I and class II MHC molecules. Ann. Rev. Immunol. 12:181.
10. Bennink, J. R., and J. W. Yewdell. 1988. Murine cytotoxic T lymphocyte recognition of individual influenza virus proteins. High frequency of non-responder MHC class I alleles. J. Exp. Med. 168:1935.
11. Bennink, J. R., J. W. Yewdell, G. L. Smith, and B. Moss. 1987. Anti-influenza virus cytotoxic T lymphocytes recognize the three viral polymerases and a non-structural protein: responsiveness to individual viral antigens is major histocompatibility complex controlled. J. Virol. 61:1098.
12. b molecule. Nature 348:213.
13. Eisenlohr, L. C., J. W. Yewdell, and J. R. Bennink. 1992. Ranking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes. J. Exp. Med. 175:481.
14. del Val, M., H.-J. Schlicht, T. Ruppert, M. J. Reddehase, and U. H. Koszinowski. 1991. Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein. Cell 66: 1145.
15. Niedermann, G., S. Butz, H. G. Ihlenfeldt, R. Grimm, M. Lucchiari, H. Hoschützky, G. Jung, B. Maier, and K. Eichmann. 1995. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules. Immunity 2:289.
16. Momburg. F., J. Roelse, G. J. Hämmerling, and J. J. Neefjes. 1994. Peptide size selection by the major histocompatibility complex-encoded peptide transporter. J. Exp. Med. 179:1613.
17. Elliot, T., A. Willis, V. Cerundolo, and A. Townsend. 1995. Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum. J. Exp. Med. 181:1481.
18. Snyder, H. L., J. W. Yewdell, and J. R. Bennink. 1994. Trimming of antigenic peptides in an early secretory compartment. J. Exp. Med. 180:2389.
19. Chen, W., S. Khilko, J. Fecondo, D. H. Margulies, and J. McCluskey. 1994. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J. Exp. Med. 180:1471.
20. Khilko, S. N., M. Corr, L. F. Boyd, A. Lees, J. K. Inman, and D. H. Margulies. 1993. Direct detection of major histocompatibility complex class I binding to antigenic peptides using surface plasmon resonance: peptide immobilization and characterization of binding specificity. J. Biol. Chem. 268:15425.
21. Sette, A., A. Vitiello, B. Reherman, P. Fowler, R. Nayersina, W. A. Kast, C. J. M. Melief, C. Oseroff, L. Yuan, J. Ruppert, J. Sidney, M.-F. del Guercio, S. Southwood, R. T. Kubo, R. W. Chesnut, H. M. Grey, and F. V. Chisari. 1994. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. J. Immunol. 153:5586.
22. b cells. J. Immunol. 152:4843.
23. Oldstone, M. B. A., H. Lewicki, P. Borst, D. Hudrisier, and J. Gairin. 1995. Discriminated selection among viral peptides with the appropriate anchor residues: implication for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection. J. Virol. 69:7423.
24. Salter, R. D., and P. Cresswell. 1986. Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid. EMBO J. 5:943.
25. Bacik, I., J. H. Cox, R. Anderson, J. W. Yewdell, and J. R. Bennink. 1994. TAP-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino but not carboxyl terminus of the peptide. J. Immunol. 152:381.
26. Loken, M. R., and A. M. Stall. 1982. Flow cytometry as an analytical and preparative tool in immunology. J. Immunol. Methods 50:R85.
27. Maryanski, J. L., A. S. Verdini, P. C. Weber, F. R. Salemme, and G. Corradin. 1990. Competitor analogs for defined T cell antigens: peptides incorporating a putative binding motif and polyproline or polyglycine spacers. Cell 60:63.
28. Sweetser, M. T., V. L. Braciale, and T. J. Braciale. 1989. Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin: overlap between class I cytotoxic T lymphocytes and antibody sites. J. Exp. Med. 170:1357.
29. Bodmer, H. C., R. M. Pemberton, J. B. Rothbard, and B. A. Askonas. 1988. Enhanced recognition of a modified peptide antigen by cytotoxic T cells specific for influenza nucleoprotein. Cell 52:253.
30. Sherman, L. A., T. A. Burke, and J. A. Biggs. 1992. Extracellular processing of antigens that bind class I major histocompatibility molecules. J. Exp. Med. 175: 1221.
31. Anderson, K. S., J. Alexander, M. Wei, and P. Cresswell. 1993. Intracellular transport of class I MHC molecules in antigen processing mutant cell lines. J. Immunol. 151:3407.
32. Ljunggren, H.-G., N. J. Stam, C. Öhlen, J. J. Neefjes, P. Höglund, E. Heinen, J. Bastin, T. N. M. Schumacher, A. Townsend, K. Kärre, and H. L. Ploegh. 1990. Empty MHC class I molecules come out in the cold. Nature 346:476.
33. Nuchtern, J. G., J. S. Bonifacino, W. E. Biddison, and R. D. Klausner. 1989. Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation. Nature 339:223.
34. Yewdell, J. W., and J. R. Bennink. 1989. Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes. Science 244:1072.
35. Anderson, K., P. Cresswell, M. Gammon, J. Hermes, A. Williamson, and H. Zweerink. 1991. Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis. J. Exp. Med. 174:489.
36. Restifo, N. P., I. Bacik, K. R. Irvine, J. W. Yewdell, B. McCabe, R. W. Anderson, L. C. Eisenlohr, S. A. Rosenberg, and J. R. Bennink. 1995. Antigen processing in vivo and the elicitation of primary CTL responses. J. Immunol. 154:4414.
37. b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen. J. Virol. 69:6665.
38. Sadasivan, B., P. J. Lehner, B. Ortmann, T. Spies, and P. Cresswell. 1996. Roles of calreticulin and novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity 5:103.
39. Grandea, A. G., III, M. J. Androlewicz, R. S. Athwal, D. E. Geraghty, and T. Spies. 1995. Dependence of peptide binding by MHC class I molecules on their interaction with TAP. Science 270:105.
40. Peace-Brewer, A. L., L. G. Tussey, M. Matsui, G. Li, D. G. Quinn, and J. A. Frelinger. 1996. A point mutation in HLA-A*0201 results in failure to bind the TAP complex and to present virus-derived peptides to CTL. Immunity 4:505.
41. Lewis, J. W., A. Neisig, J. Neefjes, and T. Elliot. 1996. Point mutations in the α2 domain of HLA-A2.1 define a functionally relevant interaction with TAP. Curr. Biol. 6:873.
42. Dick, L. R., C. Aldrich, S. C. Jameson, C. R. Moomaw, B. C. Pramanik, C. K. Doyle, G. N. DeMartino, M. J. Bevan, J. M. Forman, and C. A. Slaughter. 1994. Proteolytic processing of ovalbumin and β-galactosidase by the proteasome to yield antigenic peptides. J. Immunol 152:3884.
43. Srivastava, P. K., H. Udono, N. E. Blachere, and Z. Li. 1994. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 39:93.
44. Gammon, G., N. Shastri, J. Cogswell, S. Wilbur, S. Sadegh-Nasseri, U. Krzych, A. Miller, and E. Sercarz. 1987. The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site. Immunol. Rev. 53.
45. Gegin, C., and F. Lehmann-Grubbe. 1992. Control of acute infection with lymphocytic choriomeningitis virus in mice that cannot present an immunodominant viral cytotoxic T lymphocyte epitope. J. Immunol. 149:3331.
46. Wysocka, M., and J. R. Bennink. 1988. Limiting dilution analysis of memory cytotoxic T lymphocytes specific for individual influenza virus gene products. Cell. Immunol. 112:425.