Dissecting the multifactorial causes of immunodominance in class I- restricted T cell responses to viruses

Immunity

Volumn 12, Issue 1, 2000, Pages 83-93

  Chen, Weisan ^b   Antón, Luis C ^b   Bennink, Jack R ^a   Yewdell, Jonathan W ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; GENE OVEREXPRESSION; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOGENICITY; INFLUENZA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VACCINE PRODUCTION;

EID: 0002866386     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80161-2     Document Type: Article

References (22)

1. Antón, L.C., Yewdell, J.W., and Bennink, J.R. (1997). MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies. J. Immunol. 158, 2535-2542.
2. Bennink, J.R., and Doherty, P.C. (1981). The response to H-2-different virus-infected cells is mediated by long-lived T lymphocytes and is diminished by prior virus priming in a syngeneic environment. Cell Immunol. 61, 220-224.
3. Bousso, P., Levraud, J.P., Kourilsky, P., and Abastado, J.P. (1999). The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones. J. Exp. Med. 189, 1591-1600.
4. Burrows, S.R., Silins, S.L., Moss, D.J., Khanna, R., Misko, I.S., and Argaet, V.P. (1995). T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen. J. Exp. Med. 182, 1703-1715.
5. Busch, D.H., Pilip, I.M., Vijh, S., and Pamer, E.G. (1998). Coordinate regulation of complex T cell populations responding to bacterial infection. Immunity. 8, 353-362.
6. Chen, W., Yewdell, J.W., Levine, R.L., and Bennink, J.R. (1999). Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants. J. Exp. Med. 189, 1757-1764.
7. + memory T cells specific for a subdominant epitope following Sendai virus infection. J. Immunol. 158, 4301-4309.
8. Deng, Y., Yewdell, J.W., Eisenlohr, L.C., and Bennink, J.R. (1997). MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL. J. Immunol. 158, 1507-1515.
9. Falk, K., Rötzschke, O., Deres, K., Metzger, J., Jung, G., and Rammensee, H.-G. (1991). Identification of naturally processed viral non-apeptides allows their quantitation in infected cells and suggests an allele-specific T cell epitope forecast. J. Exp. Med. 174, 425-434.
10. Flynn, K.J., Belz, G.T., Altman, J.D., Ahmed, R., Woodland, D.L., and Doherty, P.C. (1998). Virus-specific CD8+ T cells in primary and secondary influenza pneumonia. Immunity 8, 683-691.
11. Jamieson, B.D., and Ahmed, R. (1989). T cell memory. Long-term persistence of virus-specific cytotoxic T cells. J. Exp. Med. 169, 1993-2005.
12. Jones, C.M., Cose, S.C., and Carbone, F.R. (1997). Evidence for cooperation between TCR V region and junctional sequences in determining a dominant cytotoxic T lymphocyte response to herpes simplex virus glycoprotein B. Int. Immunol. 9, 1319-1328.
13. Jung, T., Schauer, U., Heusser, C., Neumann, C., and Rieger, C. (1993). Detection of intracellular cytokines by flow cytometry. J. Immunol. Methods 159, 197-207.
14. McMichael, A.J., and O'Callaghan, C.A. (1998). A new look at T cells. J. Exp. Med. 187, 1367-1371.
15. Restifo, N.P., Bacík, I., Irvine, K.R., Yewdell, J.W., McCabe, B., Anderson, R.W., Eisenlohr, L.C., Rosenberg, S.A., and Bennink, J.R. (1995). Antigen processing in vivo and the elicitation of primary CTL responses. J. Immunol. 154, 4414-4422.
16. Sercarz, E.E., Lehmann, P.V., Ametani, A., Benichou, G., Miller, A., and Moudgil, K. (1993). Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol. 11, 729-766.
17. Sourdive, D.J., Murali-Krishna, K., Altman, J.D., Zajac, A.J., Whitmire, J.K., Pannetier, C., Kourilsky, P., Evavold, B., Sette, A., and Ahmed, R. (1998). Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J. Exp. Med. 188, 71-82.
18. van der Burg, S.H., Visseren, M.J., Brandt, R.M., Kast, W.M., and Melief, C.J. (1996). Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability. J. Immunol. 156, 3308-3314.
19. Wallace, M.E., Keating, R., Heath, W.R., and Carbone, F.R. (1999). The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant. J. Virol. 73, 7619-7626.
20. + T cell epitopes, virus load, and kinetics of primary antiviral CTL response. J. Immunol. 160, 2923-2931.
21. Yewdell, J.W., and Bennink, J.R. (1999). Immunodominance in MHC class I restricted responses. Annu. Rev. Immunol. 17, 51-88.
22. Zinkernagel, R.M., and Doherty, P.C. (1979). MHC-restriced cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv. Immunol. 27, 52-180.