Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate

Journal of Biological Chemistry

Volumn 281, Issue 13, 2006, Pages 8582-8590

  Kisselev, Alexei F ^a,b   Callard, Alice ^a   Goldberg, Alfred L ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c Ellison Foundation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN; INHIBITORS; PROTEASOMES; PROTEOLYSIS;

BIODEGRADATION; CELLS; ENZYME INHIBITION; SUBSTRATES; TUMORS;

PROTEINS;

BORTEZOMIB; CALMODULIN; CASEIN; CASPASE; CHYMOTRYPSIN; EPOXOMICIN; HISTONE; OVALBUMIN; PROTEASOME; TRYPSIN; ADENOSINE TRIPHOSPHATASE; ATP DEPENDENT 26S PROTEASE; ENZYME INHIBITOR; FLUORESCENT DYE;

ARTICLE; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PURIFICATION; ANIMAL; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME SPECIFICITY; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN BINDING; RABBIT; TIME;

MAMMALIA;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BINDING SITES; CASPASES; CHYMOTRYPSIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLUORESCENT DYES; HELA CELLS; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RABBITS; SUBSTRATE SPECIFICITY; TIME FACTORS; TRYPSIN;

EID: 33646841837     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M509043200     Document Type: Article

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