Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex

Journal of Biological Chemistry

Volumn 290, Issue 11, 2015, Pages 7169-7184

  Marinangeli, Claudia ^a   Tasiaux, Bernadette ^a   Opsomer, Rémi ^a   Hage, Salim ^a   Sodero, Alejandro O ^a   Dewachter, Ilse ^a   Octave, Jean Noël ^a   Smith, Steven O ^c   Constantinescu, Stefan N ^b   Kienlen Campard, Pascal ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b DE DUVE INSTITUTE   (Belgium)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; BIOLOGICAL MEMBRANES; CONFORMATIONS; ENZYME ACTIVITY; NEURODEGENERATIVE DISEASES; PHYSIOLOGY; SUBSTRATES;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; FUNCTIONAL CONFORMATIONS; MOLECULAR MECHANISM; PEPTIDE PRODUCTION; PROTEOLYTIC ACTIVITIES; SUBSTRATE DOCKING; TRANS-MEMBRANE DOMAINS;

CATALYST ACTIVITY;

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; PRESENILIN 1; PRESENILIN 2; AMYLOID BETA PROTEIN; SECRETASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; ANIMAL; CELL LINE; CHEMISTRY; CHO CELL LINE; CRICETULUS; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; CHO CELLS; CONSERVED SEQUENCE; CRICETULUS; HEK293 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PRESENILIN-1; PRESENILIN-2; PROTEIN STRUCTURE, TERTIARY;

EID: 84924872553     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.601286     Document Type: Article

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