Amyloidogenic processing but not Amyloid Precursor Protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

Journal of Biological Chemistry

Volumn 283, Issue 12, 2008, Pages 7733-7744

  Kienlen Campard, Pascal ^a   Tasiaux, Bernadette ^a   Van Hees, Joanne ^b   Li, Mingli ^b   Huysseune, Sandra ^a   Sato, Takeshi ^d   Fei, Jeffrey Z ^c   Aimoto, Saburo ^d   Courtoy, Pierre J ^b   Smith, Steven O ^c   Constantinescu, Stefan N ^b,e   Octave, Jean Noël ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b DE DUVE INSTITUTE   (Belgium)

^c STONY BROOK UNIVERSITY   (United States)

^d OSAKA UNIVERSITY   (Japan)

^e FUND FOR SCIENTIFIC RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; CELL MEMBRANES; DIMERIZATION; ENZYME INHIBITION; GLYCOPROTEINS; PLANTS (BOTANY); PORT TERMINALS; TRANSCRIPTION;

ALZHEIMER DISEASES; AMYLOID PEPTIDES; AMYLOID PRECURSOR PROTEINS; GENE TRANSCRIPTIONS; JUXTAMEMBRANE; PRECISELY ORIENTED; SECRETASE; SECRETASES; SENILE PLAQUES; TERMINAL DOMAINS; TERMINAL FRAGMENTS; TRANSMEMBRANE;

PUMPING PLANTS;

ALANINE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; GLYCINE; ISOLEUCINE; LEUCINE; SECRETASE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; INHIBITION KINETICS; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN SECRETION; ANIMAL; CELL MEMBRANE; CHO CELL; CRICETULUS; GENETIC TRANSCRIPTION; GENETICS; HAMSTER; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; DIMERIZATION; HUMANS; MUTATION; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION, GENETIC;

EID: 43149088724     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707142200     Document Type: Article

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