-
1
-
-
84893344365
-
Residues 240-250 in the C-terminus of the Pirh2 protein complement the function of the RING domain in self-ubiquitination of the Pirh2 protein
-
Abou Zeinab, R., Wu, H., Sergi, C., and Leng, R. P. (2013). Residues 240-250 in the C-terminus of the Pirh2 protein complement the function of the RING domain in self-ubiquitination of the Pirh2 protein. PLoS ONE 8:e82803. doi: 10.1371/journal.pone.0082803.
-
(2013)
PLoS ONE
, vol.8
-
-
Abou Zeinab, R.1
Wu, H.2
Sergi, C.3
Leng, R.P.4
-
2
-
-
82955233157
-
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks
-
Acs, K., Luijsterburg, M. S., Ackermann, L., Salomons, F. A., Hoppe, T., and Dantuma, N. P. (2011). The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat. Struct. Mol. Biol. 18, 1345-1350. doi: 10.1038/nsmb.2188.
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 1345-1350
-
-
Acs, K.1
Luijsterburg, M.S.2
Ackermann, L.3
Salomons, F.A.4
Hoppe, T.5
Dantuma, N.P.6
-
3
-
-
0032575688
-
The Bcl-2 protein family: arbiters of cell survival
-
Adams, J. M., and Cory, S. (1998). The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322-1326. doi: 10.1126/science.281.5381.1322.
-
(1998)
Science
, vol.281
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
4
-
-
33847328289
-
The Bcl-2 apoptotic switch in cancer development and therapy
-
Adams, J. M., and Cory, S. (2007). The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26, 1324-1337. doi: 10.1038/sj.onc.1210220.
-
(2007)
Oncogene
, vol.26
, pp. 1324-1337
-
-
Adams, J.M.1
Cory, S.2
-
5
-
-
10744232926
-
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim
-
Akiyama, T., Bouillet, P., Miyazaki, T., Kadono, Y., Chikuda, H., Chung, U. I., et al. (2003). Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J. 22, 6653-6664. doi: 10.1093/emboj/cdg635.
-
(2003)
EMBO J
, vol.22
, pp. 6653-6664
-
-
Akiyama, T.1
Bouillet, P.2
Miyazaki, T.3
Kadono, Y.4
Chikuda, H.5
Chung, U.I.6
-
6
-
-
78649492271
-
The ubiquitous role of ubiquitin in the DNA damage response
-
Al-Hakim, A., Escribano-Diaz, C., Landry, M. C., O'Donnell, L., Panier, S., Szilard, R. K., et al. (2010). The ubiquitous role of ubiquitin in the DNA damage response. DNA Repair (Amst). 9, 1229-1240. doi: 10.1016/j.dnarep.2010.09.011.
-
(2010)
DNA Repair (Amst)
, vol.9
, pp. 1229-1240
-
-
Al-Hakim, A.1
Escribano-Diaz, C.2
Landry, M.C.3
O'Donnell, L.4
Panier, S.5
Szilard, R.K.6
-
7
-
-
75149174149
-
MdmX is a substrate for the deubiquitinating enzyme USP2a
-
Allende-Vega, N., Sparks, A., Lane, D. P., and Saville, M. K. (2010). MdmX is a substrate for the deubiquitinating enzyme USP2a. Oncogene 29, 432-441. doi: 10.1038/onc.2009.330.
-
(2010)
Oncogene
, vol.29
, pp. 432-441
-
-
Allende-Vega, N.1
Sparks, A.2
Lane, D.P.3
Saville, M.K.4
-
8
-
-
68049123430
-
Differentiation-related gene-1 decreases Bim stability by proteasome-mediated degradation
-
Ambrosini, G., Seelman, S. L., and Schwartz, G. K. (2009). Differentiation-related gene-1 decreases Bim stability by proteasome-mediated degradation. Cancer Res. 69, 6115-6121. doi: 10.1158/0008-5472.CAN-08-3024.
-
(2009)
Cancer Res
, vol.69
, pp. 6115-6121
-
-
Ambrosini, G.1
Seelman, S.L.2
Schwartz, G.K.3
-
9
-
-
34547935761
-
Living with p53, dying of p53
-
Aylon, Y., and Oren, M. (2007). Living with p53, dying of p53. Cell 130, 597-600. doi: 10.1016/j.cell.2007.08.005.
-
(2007)
Cell
, vol.130
, pp. 597-600
-
-
Aylon, Y.1
Oren, M.2
-
10
-
-
33845932083
-
S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis
-
Azad, N., Vallyathan, V., Wang, L., Tantishaiyakul, V., Stehlik, C., Leonard, S. S., et al. (2006). S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis. J. Biol. Chem. 281, 34124-34134. doi: 10.1074/jbc. M602551200.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 34124-34134
-
-
Azad, N.1
Vallyathan, V.2
Wang, L.3
Tantishaiyakul, V.4
Stehlik, C.5
Leonard, S.S.6
-
11
-
-
76349086181
-
The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid
-
Azakir, B. A., Desrochers, G., and Angers, A. (2010). The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid. FEBS J. 277, 1319-1330. doi: 10.1111/j.1742-4658.2010.07562.x.
-
(2010)
FEBS J
, vol.277
, pp. 1319-1330
-
-
Azakir, B.A.1
Desrochers, G.2
Angers, A.3
-
12
-
-
0037147143
-
MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination
-
Badciong, J. C., and Haas, A. L. (2002). MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. J. Biol. Chem. 277, 49668-49675. doi: 10.1074/jbc. M208593200.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 49668-49675
-
-
Badciong, J.C.1
Haas, A.L.2
-
13
-
-
0033536230
-
Mdm2 binds p73 alpha without targeting degradation
-
Balint, E., Bates, S., and Vousden, K. H. (1999). Mdm2 binds p73 alpha without targeting degradation. Oncogene 18, 3923-3929. doi: 10.1038/sj.onc.1202781.
-
(1999)
Oncogene
, vol.18
, pp. 3923-3929
-
-
Balint, E.1
Bates, S.2
Vousden, K.H.3
-
14
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin, S., Moyal, L., Shieh, S., Taya, Y., Anderson, C. W., Chessa, L., et al. (1998). Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 1674-1677. doi: 10.1126/science.281.5383.1674.
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
Moyal, L.2
Shieh, S.3
Taya, Y.4
Anderson, C.W.5
Chessa, L.6
-
15
-
-
77956863324
-
Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells
-
Baou, M., Kohlhaas, S. L., Butterworth, M., Vogler, M., Dinsdale, D., Walewska, R., et al. (2010). Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells. Haematologica 95, 1510-1518. doi: 10.3324/haematol.2010.022368.
-
(2010)
Haematologica
, vol.95
, pp. 1510-1518
-
-
Baou, M.1
Kohlhaas, S.L.2
Butterworth, M.3
Vogler, M.4
Dinsdale, D.5
Walewska, R.6
-
16
-
-
0036655060
-
Alternative and aberrant splicing of MDM2 mRNA in human cancer
-
Bartel, F., Taubert, H., and Harris, L. C. (2002). Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell 2, 9-15. doi: 10.1016/S1535-6108(02)00091-0.
-
(2002)
Cancer Cell
, vol.2
, pp. 9-15
-
-
Bartel, F.1
Taubert, H.2
Harris, L.C.3
-
17
-
-
0036726532
-
Signal-induced site specific phosphorylation targets Bcl2 to the proteasome pathway
-
Basu, A., and Haldar, S. (2002). Signal-induced site specific phosphorylation targets Bcl2 to the proteasome pathway. Int. J. Oncol. 21, 597-601. doi: 10.3892/ijo.21.3.597.
-
(2002)
Int. J. Oncol
, vol.21
, pp. 597-601
-
-
Basu, A.1
Haldar, S.2
-
18
-
-
84855258476
-
Role of histone tails in structural stability of the nucleosome
-
Biswas, M., Voltz, K., Smith, J. C., and Langowski, J. (2011). Role of histone tails in structural stability of the nucleosome. PLoS Comput. Biol. 7:e1002279. doi: 10.1371/journal.pcbi.1002279.
-
(2011)
PLoS Comput. Biol
, vol.7
-
-
Biswas, M.1
Voltz, K.2
Smith, J.C.3
Langowski, J.4
-
19
-
-
84877578269
-
The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover
-
Bohgaki, M., Hakem, A., Halaby, M. J., Bohgaki, T., Li, Q., Bissey, P. A., et al. (2013). The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover. Cell Death Differ. 20, 812-822. doi: 10.1038/cdd.2013.7.
-
(2013)
Cell Death Differ
, vol.20
, pp. 812-822
-
-
Bohgaki, M.1
Hakem, A.2
Halaby, M.J.3
Bohgaki, T.4
Li, Q.5
Bissey, P.A.6
-
20
-
-
0032531925
-
A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein
-
Breitschopf, K., Bengal, E., Ziv, T., Admon, A., and Ciechanover, A. (1998). A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. EMBO J. 17, 5964-5973. doi: 10.1093/emboj/17.20.5964.
-
(1998)
EMBO J
, vol.17
, pp. 5964-5973
-
-
Breitschopf, K.1
Bengal, E.2
Ziv, T.3
Admon, A.4
Ciechanover, A.5
-
21
-
-
0033974063
-
Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway
-
Breitschopf, K., Haendeler, J., Malchow, P., Zeiher, A. M., and Dimmeler, S. (2000a). Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway. Mol. Cell. Biol. 20, 1886-1896. doi: 10.1128/MCB.20.5.1886-1896.2000.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 1886-1896
-
-
Breitschopf, K.1
Haendeler, J.2
Malchow, P.3
Zeiher, A.M.4
Dimmeler, S.5
-
22
-
-
0034647563
-
Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction
-
Breitschopf, K., Zeiher, A. M., and Dimmeler, S. (2000b). Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction. J. Biol. Chem. 275, 21648-21652. doi: 10.1074/jbc. M001083200.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 21648-21652
-
-
Breitschopf, K.1
Zeiher, A.M.2
Dimmeler, S.3
-
23
-
-
84897387048
-
Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?
-
Brinkmann, K., and Kashkar, H. (2014). Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies? Cell Death Dis. 5:e1098. doi: 10.1038/cddis.2014.61.
-
(2014)
Cell Death Dis
, vol.5
-
-
Brinkmann, K.1
Kashkar, H.2
-
24
-
-
84875808231
-
Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA
-
Brinkmann, K., Zigrino, P., Witt, A., Schell, M., Ackermann, L., Broxtermann, P., et al. (2013). Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA. Cell Rep. 3, 881-891. doi: 10.1016/j.celrep.2013.02.014.
-
(2013)
Cell Rep
, vol.3
, pp. 881-891
-
-
Brinkmann, K.1
Zigrino, P.2
Witt, A.3
Schell, M.4
Ackermann, L.5
Broxtermann, P.6
-
25
-
-
0030053794
-
Abnormal expression of MDM-2 in breast carcinomas
-
Bueso-Ramos, C. E., Manshouri, T., Haidar, M. A., Yang, Y., McCown, P., Ordonez, N., et al. (1996). Abnormal expression of MDM-2 in breast carcinomas. Breast Cancer Res. Treat. 37, 179-188. doi: 10.1007/BF01806499.
-
(1996)
Breast Cancer Res. Treat
, vol.37
, pp. 179-188
-
-
Bueso-Ramos, C.E.1
Manshouri, T.2
Haidar, M.A.3
Yang, Y.4
McCown, P.5
Ordonez, N.6
-
26
-
-
0027368879
-
The human MDM-2 oncogene is overexpressed in leukemias
-
Bueso-Ramos, C. E., Yang, Y., deLeon, E., McCown, P., Stass, S. A., and Albitar, M. (1993). The human MDM-2 oncogene is overexpressed in leukemias. Blood 82, 2617-2623.
-
(1993)
Blood
, vol.82
, pp. 2617-2623
-
-
Bueso-Ramos, C.E.1
Yang, Y.2
deLeon, E.3
McCown, P.4
Stass, S.A.5
Albitar, M.6
-
27
-
-
84881101184
-
End-joining, translocations and cancer
-
Bunting, S. F., and Nussenzweig, A. (2013). End-joining, translocations and cancer. Nat. Rev. Cancer 13, 443-454. doi: 10.1038/nrc3537.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 443-454
-
-
Bunting, S.F.1
Nussenzweig, A.2
-
28
-
-
0031985007
-
mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway
-
Chang, Y. C., Lee, Y. S., Tejima, T., Tanaka, K., Omura, S., Heintz, N. H., et al. (1998). mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway. Cell Growth Differ. 9, 79-84.
-
(1998)
Cell Growth Differ
, vol.9
, pp. 79-84
-
-
Chang, Y.C.1
Lee, Y.S.2
Tejima, T.3
Tanaka, K.4
Omura, S.5
Heintz, N.H.6
-
29
-
-
33745685863
-
Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination
-
Chanvorachote, P., Nimmannit, U., Stehlik, C., Wang, L., Jiang, B. H., Ongpipatanakul, B., et al. (2006). Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination. Cancer Res. 66, 6353-6360. doi: 10.1158/0008-5472.CAN-05-4533.
-
(2006)
Cancer Res
, vol.66
, pp. 6353-6360
-
-
Chanvorachote, P.1
Nimmannit, U.2
Stehlik, C.3
Wang, L.4
Jiang, B.H.5
Ongpipatanakul, B.6
-
30
-
-
84865364870
-
Playing the end game: DNA double-strand break repair pathway choice
-
Chapman, J. R., Taylor, M. R., and Boulton, S. J. (2012). Playing the end game: DNA double-strand break repair pathway choice. Mol. Cell 47, 497-510. doi: 10.1016/j.molcel.2012.07.029.
-
(2012)
Mol. Cell
, vol.47
, pp. 497-510
-
-
Chapman, J.R.1
Taylor, M.R.2
Boulton, S.J.3
-
31
-
-
21244451434
-
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
-
Chen, D., Kon, N., Li, M., Zhang, W., Qin, J., and Gu, W. (2005b). ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell 121, 1071-1083. doi: 10.1016/j.cell.2005.03.037.
-
(2005)
Cell
, vol.121
, pp. 1071-1083
-
-
Chen, D.1
Kon, N.2
Li, M.3
Zhang, W.4
Qin, J.5
Gu, W.6
-
32
-
-
27144448514
-
The RING finger ATPase Rad5p of Saccharomyces cerevisiae contributes to DNA double-strand break repair in a ubiquitin-independent manner
-
Chen, S., Davies, A. A., Sagan, D., and Ulrich, H. D. (2005a). The RING finger ATPase Rad5p of Saccharomyces cerevisiae contributes to DNA double-strand break repair in a ubiquitin-independent manner. Nucleic Acids Res. 33, 5878-5886. doi: 10.1093/nar/gki902.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 5878-5886
-
-
Chen, S.1
Davies, A.A.2
Sagan, D.3
Ulrich, H.D.4
-
33
-
-
77951935474
-
Mechanism of p53 stabilization by ATM after DNA damage
-
Cheng, Q., and Chen, J. (2010). Mechanism of p53 stabilization by ATM after DNA damage. Cell Cycle 9, 472-478. doi: 10.4161/cc.9.3.10556.
-
(2010)
Cell Cycle
, vol.9
, pp. 472-478
-
-
Cheng, Q.1
Chen, J.2
-
34
-
-
23644441130
-
Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation
-
Cheung, H. W., Ching, Y. P., Nicholls, J. M., Ling, M. T., Wong, Y. C., Hui, N., et al. (2005). Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation. Mol. Carcinog. 43, 237-245. doi: 10.1002/mc.20106.
-
(2005)
Mol. Carcinog
, vol.43
, pp. 237-245
-
-
Cheung, H.W.1
Ching, Y.P.2
Nicholls, J.M.3
Ling, M.T.4
Wong, Y.C.5
Hui, N.6
-
35
-
-
0021140995
-
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85
-
Ciechanover, A., Finley, D., and Varshavsky, A. (1984). Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell 37, 57-66. doi: 10.1016/0092-8674(84)90300-3.
-
(1984)
Cell
, vol.37
, pp. 57-66
-
-
Ciechanover, A.1
Finley, D.2
Varshavsky, A.3
-
36
-
-
0021780519
-
Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation
-
Ciechanover, A., Finley, D., and Varshavsky, A. (1985). Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation. Prog. Clin. Biol. Res. 180, 17-31.
-
(1985)
Prog. Clin. Biol. Res
, vol.180
, pp. 17-31
-
-
Ciechanover, A.1
Finley, D.2
Varshavsky, A.3
-
37
-
-
0027258466
-
Thymocyte apoptosis induced by p53-dependent and independent pathways
-
Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., et al. (1993). Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852. doi: 10.1038/362849a0.
-
(1993)
Nature
, vol.362
, pp. 849-852
-
-
Clarke, A.R.1
Purdie, C.A.2
Harrison, D.J.3
Morris, R.G.4
Bird, C.C.5
Hooper, M.L.6
-
38
-
-
33746420647
-
Developmental modulation of nonhomologous end joining in Caenorhabditis elegans
-
Clejan, I., Boerckel, J., and Ahmed, S. (2006). Developmental modulation of nonhomologous end joining in Caenorhabditis elegans. Genetics 173, 1301-1317. doi: 10.1534/genetics.106.058628.
-
(2006)
Genetics
, vol.173
, pp. 1301-1317
-
-
Clejan, I.1
Boerckel, J.2
Ahmed, S.3
-
39
-
-
0036716281
-
The Bcl2 family: regulators of the cellular life-or-death switch
-
Cory, S., and Adams, J. M. (2002). The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647-656. doi: 10.1038/nrc883.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
40
-
-
84865200787
-
NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1
-
Craxton, A., Butterworth, M., Harper, N., Fairall, L., Schwabe, J., Ciechanover, A., et al. (2012). NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. Cell Death Differ. 19, 1424-1434. doi: 10.1038/cdd.2012.16.
-
(2012)
Cell Death Differ
, vol.19
, pp. 1424-1434
-
-
Craxton, A.1
Butterworth, M.2
Harper, N.3
Fairall, L.4
Schwabe, J.5
Ciechanover, A.6
-
41
-
-
3242774545
-
HAUSP is required for p53 destabilization
-
Cummins, J. M., and Vogelstein, B. (2004). HAUSP is required for p53 destabilization. Cell Cycle 3, 689-692. doi: 10.4161/cc.3.6.924.
-
(2004)
Cell Cycle
, vol.3
, pp. 689-692
-
-
Cummins, J.M.1
Vogelstein, B.2
-
42
-
-
14944342130
-
Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53
-
Dahm-Daphi, J., Hubbe, P., Horvath, F., El-Awady, R. A., Bouffard, K. E., Powell, S. N., et al. (2005). Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53. Oncogene 24, 1663-1672. doi: 10.1038/sj.onc.1208396.
-
(2005)
Oncogene
, vol.24
, pp. 1663-1672
-
-
Dahm-Daphi, J.1
Hubbe, P.2
Horvath, F.3
El-Awady, R.A.4
Bouffard, K.E.5
Powell, S.N.6
-
43
-
-
77953694683
-
Ubiquitin-dependent DNA damage bypass is separable from genome replication
-
Daigaku, Y., Davies, A. A., and Ulrich, H. D. (2010). Ubiquitin-dependent DNA damage bypass is separable from genome replication. Nature 465, 951-955. doi: 10.1038/nature09097.
-
(2010)
Nature
, vol.465
, pp. 951-955
-
-
Daigaku, Y.1
Davies, A.A.2
Ulrich, H.D.3
-
44
-
-
84865602944
-
Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin
-
Dantuma, N. P., and Hoppe, T. (2012). Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin. Trends Cell Biol. 22, 483-491. doi: 10.1016/j.tcb.2012.06.003.
-
(2012)
Trends Cell Biol
, vol.22
, pp. 483-491
-
-
Dantuma, N.P.1
Hoppe, T.2
-
45
-
-
0141866880
-
Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2
-
de Graaf, P., Little, N. A., Ramos, Y. F., Meulmeester, E., Letteboer, S. J., and Jochemsen, A. G. (2003). Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2. J. Biol. Chem. 278, 38315-38324. doi: 10.1074/jbc. M213034200.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 38315-38324
-
-
de Graaf, P.1
Little, N.A.2
Ramos, Y.F.3
Meulmeester, E.4
Letteboer, S.J.5
Jochemsen, A.G.6
-
46
-
-
58149312710
-
BetaTrCP-and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
-
Dehan, E., Bassermann, F., Guardavaccaro, D., Vasiliver-Shamis, G., Cohen, M., Lowes, K. N., et al. (2009). BetaTrCP-and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol. Cell 33, 109-116. doi: 10.1016/j.molcel.2008.12.020.
-
(2009)
Mol. Cell
, vol.33
, pp. 109-116
-
-
Dehan, E.1
Bassermann, F.2
Guardavaccaro, D.3
Vasiliver-Shamis, G.4
Cohen, M.5
Lowes, K.N.6
-
47
-
-
84906911103
-
Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma
-
Dengler, M. A., Weilbacher, A., Gutekunst, M., Staiger, A. M., Vohringer, M. C., Horn, H., et al. (2014). Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma. Cell Death Dis. 5, e1013. doi: 10.1038/cddis.2013.552.
-
(2014)
Cell Death Dis
, vol.5
-
-
Dengler, M.A.1
Weilbacher, A.2
Gutekunst, M.3
Staiger, A.M.4
Vohringer, M.C.5
Horn, H.6
-
48
-
-
84857490009
-
MDM4 enhances p53 stability by promoting an active conformation of the protein upon DNA damage
-
Di Conza, G., Mancini, F., Buttarelli, M., Pontecorvi, A., Trimarchi, F., and Moretti, F. (2012). MDM4 enhances p53 stability by promoting an active conformation of the protein upon DNA damage. Cell Cycle 11, 749-760. doi: 10.4161/cc.11.4.19208.
-
(2012)
Cell Cycle
, vol.11
, pp. 749-760
-
-
Di Conza, G.1
Mancini, F.2
Buttarelli, M.3
Pontecorvi, A.4
Trimarchi, F.5
Moretti, F.6
-
49
-
-
0033532543
-
Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway
-
Dimmeler, S., Breitschopf, K., Haendeler, J., and Zeiher, A. M. (1999). Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway. J. Exp. Med. 189, 1815-1822. doi: 10.1084/jem.189.11.1815.
-
(1999)
J. Exp. Med
, vol.189
, pp. 1815-1822
-
-
Dimmeler, S.1
Breitschopf, K.2
Haendeler, J.3
Zeiher, A.M.4
-
50
-
-
34347350211
-
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
-
Ding, Q., He, X., Hsu, J. M., Xia, W., Chen, C. T., Li, L. Y., et al. (2007). Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol. Cell. Biol. 27, 4006-4017. doi: 10.1128/MCB.00620-06.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 4006-4017
-
-
Ding, Q.1
He, X.2
Hsu, J.M.3
Xia, W.4
Chen, C.T.5
Li, L.Y.6
-
51
-
-
59049091728
-
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
-
Doil, C., Mailand, N., Bekker-Jensen, S., Menard, P., Larsen, D. H., Pepperkok, R., et al. (2009). RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 136, 435-446. doi: 10.1016/j.cell.2008.12.041.
-
(2009)
Cell
, vol.136
, pp. 435-446
-
-
Doil, C.1
Mailand, N.2
Bekker-Jensen, S.3
Menard, P.4
Larsen, D.H.5
Pepperkok, R.6
-
52
-
-
5644302246
-
COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas
-
Dornan, D., Bheddah, S., Newton, K., Ince, W., Frantz, G. D., Dowd, P., et al. (2004b). COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas. Cancer Res. 64, 7226-7230. doi: 10.1158/0008-5472.CAN-04-2601.
-
(2004)
Cancer Res
, vol.64
, pp. 7226-7230
-
-
Dornan, D.1
Bheddah, S.2
Newton, K.3
Ince, W.4
Frantz, G.D.5
Dowd, P.6
-
53
-
-
33748054298
-
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
-
Dornan, D., Shimizu, H., Mah, A., Dudhela, T., Eby, M., O'Rourke, K., et al. (2006). ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science 313, 1122-1126. doi: 10.1126/science.1127335.
-
(2006)
Science
, vol.313
, pp. 1122-1126
-
-
Dornan, D.1
Shimizu, H.2
Mah, A.3
Dudhela, T.4
Eby, M.5
O'Rourke, K.6
-
54
-
-
2342447397
-
The ubiquitin ligase COP1 is a critical negative regulator of p53
-
Dornan, D., Wertz, I., Shimizu, H., Arnott, D., Frantz, G. D., Dowd, P., et al. (2004a). The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 429, 86-92. doi: 10.1038/nature02514.
-
(2004)
Nature
, vol.429
, pp. 86-92
-
-
Dornan, D.1
Wertz, I.2
Shimizu, H.3
Arnott, D.4
Frantz, G.D.5
Dowd, P.6
-
55
-
-
34447308810
-
Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53
-
Duan, S., Yao, Z., Hou, D., Wu, Z., Zhu, W. G., and Wu, M. (2007). Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO J. 26, 3062-3074. doi: 10.1038/sj.emboj.7601749.
-
(2007)
EMBO J
, vol.26
, pp. 3062-3074
-
-
Duan, S.1
Yao, Z.2
Hou, D.3
Wu, Z.4
Zhu, W.G.5
Wu, M.6
-
56
-
-
9744227111
-
Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer
-
Duan, W., Gao, L., Druhan, L. J., Zhu, W. G., Morrison, C., Otterson, G. A., et al. (2004). Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. J. Natl. Cancer Inst. 96, 1718-1721. doi: 10.1093/jnci/djh292.
-
(2004)
J. Natl. Cancer Inst
, vol.96
, pp. 1718-1721
-
-
Duan, W.1
Gao, L.2
Druhan, L.J.3
Zhu, W.G.4
Morrison, C.5
Otterson, G.A.6
-
57
-
-
10744230829
-
MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC)
-
Dworakowska, D., Jassem, E., Jassem, J., Peters, B., Dziadziuszko, R., Zylicz, M., et al. (2004). MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC). Lung Cancer 43, 285-295. doi: 10.1016/j.lungcan.2003.09.010.
-
(2004)
Lung Cancer
, vol.43
, pp. 285-295
-
-
Dworakowska, D.1
Jassem, E.2
Jassem, J.3
Peters, B.4
Dziadziuszko, R.5
Zylicz, M.6
-
58
-
-
0347988069
-
CHFR-associated early G2/M checkpoint defects in breast cancer cells
-
Erson, A. E., and Petty, E. M. (2004). CHFR-associated early G2/M checkpoint defects in breast cancer cells. Mol. Carcinog. 39, 26-33. doi: 10.1002/mc.10161.
-
(2004)
Mol. Carcinog
, vol.39
, pp. 26-33
-
-
Erson, A.E.1
Petty, E.M.2
-
59
-
-
84862777619
-
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair
-
Feng, L., and Chen, J. (2012). The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat. Struct. Mol. Biol. 19, 201-206. doi: 10.1038/nsmb.2211.
-
(2012)
Nat. Struct. Mol. Biol
, vol.19
, pp. 201-206
-
-
Feng, L.1
Chen, J.2
-
60
-
-
80053301716
-
Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction
-
Gomez-Bougie, P., Menoret, E., Juin, P., Dousset, C., Pellat-Deceunynck, C., and Amiot, M. (2011). Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction. Biochem. Biophys. Res. Commun. 413, 460-464. doi: 10.1016/j.bbrc.2011.08.118.
-
(2011)
Biochem. Biophys. Res. Commun
, vol.413
, pp. 460-464
-
-
Gomez-Bougie, P.1
Menoret, E.2
Juin, P.3
Dousset, C.4
Pellat-Deceunynck, C.5
Amiot, M.6
-
61
-
-
27144529182
-
Ubiquitylation and cell signaling
-
Haglund, K., and Dikic, I. (2005). Ubiquitylation and cell signaling. EMBO J. 24, 3353-3359. doi: 10.1038/sj.emboj.7600808.
-
(2005)
EMBO J
, vol.24
, pp. 3353-3359
-
-
Haglund, K.1
Dikic, I.2
-
62
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan, D., and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674. doi: 10.1016/j.cell.2011.02.013.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
63
-
-
77954884045
-
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
-
Harley, M. E., Allan, L. A., Sanderson, H. S., and Clarke, P. R. (2010). Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO J. 29, 2407-2420. doi: 10.1038/emboj.2010.112.
-
(2010)
EMBO J
, vol.29
, pp. 2407-2420
-
-
Harley, M.E.1
Allan, L.A.2
Sanderson, H.S.3
Clarke, P.R.4
-
64
-
-
0031657807
-
The ubiquitin system
-
Hershko, A., and Ciechanover, A. (1998). The ubiquitin system. Annu. Rev. Biochem. 67, 425-479. doi: 10.1146/annurev.biochem.67.1.425.
-
(1998)
Annu. Rev. Biochem
, vol.67
, pp. 425-479
-
-
Hershko, A.1
Ciechanover, A.2
-
65
-
-
0021099710
-
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown
-
Hershko, A., Heller, H., Elias, S., and Ciechanover, A. (1983). Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J. Biol. Chem. 258, 8206-8214.
-
(1983)
J. Biol. Chem
, vol.258
, pp. 8206-8214
-
-
Hershko, A.1
Heller, H.2
Elias, S.3
Ciechanover, A.4
-
66
-
-
83555162507
-
Regulation of p53 stability and function by the deubiquitinating enzyme USP42
-
Hock, A. K., Vigneron, A. M., Carter, S., Ludwig, R. L., and Vousden, K. H. (2011). Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J. 30, 4921-4930. doi: 10.1038/emboj.2011.419.
-
(2011)
EMBO J
, vol.30
, pp. 4921-4930
-
-
Hock, A.K.1
Vigneron, A.M.2
Carter, S.3
Ludwig, R.L.4
Vousden, K.H.5
-
67
-
-
0037068455
-
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
-
Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G., and Jentsch, S. (2002). RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-141. doi: 10.1038/nature00991.
-
(2002)
Nature
, vol.419
, pp. 135-141
-
-
Hoege, C.1
Pfander, B.2
Moldovan, G.L.3
Pyrowolakis, G.4
Jentsch, S.5
-
68
-
-
0028108985
-
Database of p53 gene somatic mutations in human tumors and cell lines
-
Hollstein, M., Rice, K., Greenblatt, M. S., Soussi, T., Fuchs, R., Sorlie, T., et al. (1994). Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res. 22, 3551-3555.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 3551-3555
-
-
Hollstein, M.1
Rice, K.2
Greenblatt, M.S.3
Soussi, T.4
Fuchs, R.5
Sorlie, T.6
-
69
-
-
16244373679
-
Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all
-
Hoppe, T. (2005). Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all. Trends Biochem. Sci. 30, 183-187. doi: 10.1016/j.tibs.2005.02.004.
-
(2005)
Trends Biochem. Sci
, vol.30
, pp. 183-187
-
-
Hoppe, T.1
-
70
-
-
27944506944
-
UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination
-
Hosoda, M., Ozaki, T., Miyazaki, K., Hayashi, S., Furuya, K., Watanabe, K., et al. (2005). UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination. Oncogene 24, 7156-7169. doi: 10.1038/sj.onc.1208872.
-
(2005)
Oncogene
, vol.24
, pp. 7156-7169
-
-
Hosoda, M.1
Ozaki, T.2
Miyazaki, K.3
Hayashi, S.4
Furuya, K.5
Watanabe, K.6
-
71
-
-
84865326385
-
SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor-suppressive function in the development of hepatocellular carcinoma
-
Hu, L., Liu, M., Chen, L., Chan, T. H., Wang, J., Huo, K. K., et al. (2012). SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor-suppressive function in the development of hepatocellular carcinoma. Carcinogenesis 33, 1581-1588. doi: 10.1093/carcin/bgs162.
-
(2012)
Carcinogenesis
, vol.33
, pp. 1581-1588
-
-
Hu, L.1
Liu, M.2
Chen, L.3
Chan, T.H.4
Wang, J.5
Huo, K.K.6
-
72
-
-
1442330469
-
The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis
-
Hur, J., Chesnes, J., Coser, K. R., Lee, R. S., Geck, P., Isselbacher, K. J., et al. (2004). The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis. Proc. Natl. Acad. Sci. U.S.A. 101, 2351-2356. doi: 10.1073/pnas.0307337101.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 2351-2356
-
-
Hur, J.1
Chesnes, J.2
Coser, K.R.3
Lee, R.S.4
Geck, P.5
Isselbacher, K.J.6
-
73
-
-
84878154617
-
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15
-
Inoue, S., Hao, Z., Elia, A. J., Cescon, D., Zhou, L., Silvester, J., et al. (2013). Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev. 27, 1101-1114. doi: 10.1101/gad.214577.113.
-
(2013)
Genes Dev
, vol.27
, pp. 1101-1114
-
-
Inoue, S.1
Hao, Z.2
Elia, A.J.3
Cescon, D.4
Zhou, L.5
Silvester, J.6
-
74
-
-
79952261405
-
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
-
Inuzuka, H., Shaik, S., Onoyama, I., Gao, D., Tseng, A., Maser, R. S., et al. (2011). SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 471, 104-109. doi: 10.1038/nature09732.
-
(2011)
Nature
, vol.471
, pp. 104-109
-
-
Inuzuka, H.1
Shaik, S.2
Onoyama, I.3
Gao, D.4
Tseng, A.5
Maser, R.S.6
-
75
-
-
33646355987
-
Is there more to BARD1 than BRCA1?
-
Irminger-Finger, I., and Jefford, C. E. (2006). Is there more to BARD1 than BRCA1? Nat. Rev. Cancer 6, 382-391. doi: 10.1038/nrc1878.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 382-391
-
-
Irminger-Finger, I.1
Jefford, C.E.2
-
76
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva, N., Bozko, P., Enge, M., Protopopova, M., Verhoef, L. G., Masucci, M., et al. (2004). Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat. Med. 10, 1321-1328. doi: 10.1038/nm1146.
-
(2004)
Nat. Med
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
Bozko, P.2
Enge, M.3
Protopopova, M.4
Verhoef, L.G.5
Masucci, M.6
-
77
-
-
84876886904
-
Regulation of DNA damage responses by ubiquitin and SUMO
-
Jackson, S. P., and Durocher, D. (2013). Regulation of DNA damage responses by ubiquitin and SUMO. Mol. Cell 49, 795-807. doi: 10.1016/j.molcel.2013.01.017.
-
(2013)
Mol. Cell
, vol.49
, pp. 795-807
-
-
Jackson, S.P.1
Durocher, D.2
-
78
-
-
79960927023
-
Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination
-
Jia, L., Gorman, G. S., Coward, L. U., Noker, P. E., McCormick, D., Horn, T. L., et al. (2011). Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination. Cancer Chemother. Pharmacol. 68, 513-524. doi: 10.1007/s00280-010-1518-3.
-
(2011)
Cancer Chemother. Pharmacol
, vol.68
, pp. 513-524
-
-
Jia, L.1
Gorman, G.S.2
Coward, L.U.3
Noker, P.E.4
McCormick, D.5
Horn, T.L.6
-
79
-
-
84879386947
-
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells
-
Jiang, N., Shen, Y., Fei, X., Sheng, K., Sun, P., Qiu, Y., et al. (2013). Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. Cell Death Dis. 4, e647. doi: 10.1038/cddis.2013.171.
-
(2013)
Cell Death Dis
, vol.4
-
-
Jiang, N.1
Shen, Y.2
Fei, X.3
Sheng, K.4
Sun, P.5
Qiu, Y.6
-
80
-
-
80053927313
-
The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation
-
Jung, Y. S., Qian, Y., and Chen, X. (2011). The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation. J. Biol. Chem. 286, 35388-35395. doi: 10.1074/jbc. M111.261537.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 35388-35395
-
-
Jung, Y.S.1
Qian, Y.2
Chen, X.3
-
81
-
-
0034921151
-
Regulation of p63 function by Mdm2 and MdmX
-
Kadakia, M., Slader, C., and Berberich, S. J. (2001). Regulation of p63 function by Mdm2 and MdmX. DNA Cell Biol. 20, 321-330. doi: 10.1089/10445490152122433.
-
(2001)
DNA Cell Biol
, vol.20
, pp. 321-330
-
-
Kadakia, M.1
Slader, C.2
Berberich, S.J.3
-
82
-
-
0242580250
-
DNA damage-induced MDMX degradation is mediated by MDM2
-
Kawai, H., Wiederschain, D., Kitao, H., Stuart, J., Tsai, K. K., and Yuan, Z. M. (2003). DNA damage-induced MDMX degradation is mediated by MDM2. J. Biol. Chem. 278, 45946-45953. doi: 10.1074/jbc. M308295200.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 45946-45953
-
-
Kawai, H.1
Wiederschain, D.2
Kitao, H.3
Stuart, J.4
Tsai, K.K.5
Yuan, Z.M.6
-
83
-
-
84873696103
-
USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair
-
Khoronenkova, S. V., and Dianov, G. L. (2013). USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. Nucleic Acids Res. 41, 1750-1756. doi: 10.1093/nar/gks1359.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 1750-1756
-
-
Khoronenkova, S.V.1
Dianov, G.L.2
-
84
-
-
0033592868
-
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
-
Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y., and Shkedy, D. (1999). Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc. Natl. Acad. Sci. U.S.A. 96, 14973-14977. doi: 10.1073/pnas.96.26.14973.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A
, vol.96
, pp. 14973-14977
-
-
Khosravi, R.1
Maya, R.2
Gottlieb, T.3
Oren, M.4
Shiloh, Y.5
Shkedy, D.6
-
85
-
-
0033621392
-
Substrate specificities and identification of putative substrates of ATM kinase family members
-
Kim, S. T., Lim, D. S., Canman, C. E., and Kastan, M. B. (1999). Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 274, 37538-37543. doi: 10.1074/jbc.274.53.37538.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 37538-37543
-
-
Kim, S.T.1
Lim, D.S.2
Canman, C.E.3
Kastan, M.B.4
-
86
-
-
0033525589
-
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
-
Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H. D., Mayer, T. U., and Jentsch, S. (1999). A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 96, 635-644. doi: 10.1016/S0092-8674(00)80574-7.
-
(1999)
Cell
, vol.96
, pp. 635-644
-
-
Koegl, M.1
Hoppe, T.2
Schlenker, S.3
Ulrich, H.D.4
Mayer, T.U.5
Jentsch, S.6
-
87
-
-
84861877407
-
The ubiquitin code
-
Komander, D., and Rape, M. (2012). The ubiquitin code. Annu. Rev. Biochem. 81, 203-229. doi: 10.1146/annurev-biochem-060310-170328.
-
(2012)
Annu. Rev. Biochem
, vol.81
, pp. 203-229
-
-
Komander, D.1
Rape, M.2
-
88
-
-
30744449974
-
NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro
-
Krajewski, M., Ozdowy, P., D'Silva, L., Rothweiler, U., and Holak, T. A. (2005). NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nat. Med. 11, 1135-1136. doi: 10.1038/nm1105-1135.
-
(2005)
Nat. Med
, vol.11
, pp. 1135-1136
-
-
Krajewski, M.1
Ozdowy, P.2
D'Silva, L.3
Rothweiler, U.4
Holak, T.A.5
-
89
-
-
22344436226
-
Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor
-
Kucharczak, J. F., Simmons, M. J., Duckett, C. S., and Gelinas, C. (2005). Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. Cell Death Differ. 12, 1225-1239. doi: 10.1038/sj.cdd.4401684.
-
(2005)
Cell Death Differ
, vol.12
, pp. 1225-1239
-
-
Kucharczak, J.F.1
Simmons, M.J.2
Duckett, C.S.3
Gelinas, C.4
-
90
-
-
0035903157
-
Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization
-
Lai, Z., Ferry, K. V., Diamond, M. A., Wee, K. E., Kim, Y. B., Ma, J., et al. (2001). Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization. J. Biol. Chem. 276, 31357-31367. doi: 10.1074/jbc. M011517200.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 31357-31367
-
-
Lai, Z.1
Ferry, K.V.2
Diamond, M.A.3
Wee, K.E.4
Kim, Y.B.5
Ma, J.6
-
91
-
-
33646807491
-
Transcriptional regulation by p53: one protein, many possibilities
-
Laptenko, O., and Prives, C. (2006). Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13, 951-961. doi: 10.1038/sj.cdd.4401916.
-
(2006)
Cell Death Differ
, vol.13
, pp. 951-961
-
-
Laptenko, O.1
Prives, C.2
-
92
-
-
78449283414
-
Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma
-
Lee, Y. H., Andersen, J. B., Song, H. T., Judge, A. D., Seo, D., Ishikawa, T., et al. (2010). Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma. Cancer Res. 70, 8264-8269. doi: 10.1158/0008-5472.CAN-10-0749.
-
(2010)
Cancer Res
, vol.70
, pp. 8264-8269
-
-
Lee, Y.H.1
Andersen, J.B.2
Song, H.T.3
Judge, A.D.4
Seo, D.5
Ishikawa, T.6
-
93
-
-
79952452312
-
DNA double-strand break repair in Caenorhabditis elegans
-
Lemmens, B. B., and Tijsterman, M. (2010). DNA double-strand break repair in Caenorhabditis elegans. Chromosoma 120, 1-21. doi: 10.1007/s00412-010-0296-3.
-
(2010)
Chromosoma
, vol.120
, pp. 1-21
-
-
Lemmens, B.B.1
Tijsterman, M.2
-
94
-
-
0037459377
-
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
-
Leng, R. P., Lin, Y., Ma, W., Wu, H., Lemmers, B., Chung, S., et al. (2003). Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell 112, 779-791. doi: 10.1016/S0092-8674(03)00193-4.
-
(2003)
Cell
, vol.112
, pp. 779-791
-
-
Leng, R.P.1
Lin, Y.2
Ma, W.3
Wu, H.4
Lemmers, B.5
Chung, S.6
-
95
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai, A., Bassik, M. C., Walensky, L. D., Sorcinelli, M. D., Weiler, S., and Korsmeyer, S. J. (2002). Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2, 183-192. doi: 10.1016/S1535-6108(02)00127-7.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
-
96
-
-
0030665658
-
Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells
-
Levine, J. S., Koh, J. S., Triaca, V., and Lieberthal, W. (1997). Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells. Am. J. Physiol. 273, F575-F585.
-
(1997)
Am. J. Physiol
, vol.273
, pp. F575-F585
-
-
Levine, J.S.1
Koh, J.S.2
Triaca, V.3
Lieberthal, W.4
-
97
-
-
0019023314
-
High-resolution fractionation of nucleosomes: minor particles, "whiskers" and separation of mononucleosomes containing and lacking A24 semihistone
-
Levinger, L., and Varshavsky, A. (1980). High-resolution fractionation of nucleosomes: minor particles, "whiskers" and separation of mononucleosomes containing and lacking A24 semihistone. Proc. Natl. Acad. Sci. U.S.A. 77, 3244-3248. doi: 10.1073/pnas.77.6.3244.
-
(1980)
Proc. Natl. Acad. Sci. U.S.A
, vol.77
, pp. 3244-3248
-
-
Levinger, L.1
Varshavsky, A.2
-
98
-
-
0038482050
-
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
-
Ley, R., Balmanno, K., Hadfield, K., Weston, C., and Cook, S. J. (2003). Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J. Biol. Chem. 278, 18811-18816. doi: 10.1074/jbc. M301010200.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 18811-18816
-
-
Ley, R.1
Balmanno, K.2
Hadfield, K.3
Weston, C.4
Cook, S.J.5
-
99
-
-
0034635952
-
Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression
-
Li, B., and Dou, Q. P. (2000). Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression. Proc. Natl. Acad. Sci. U.S.A. 97, 3850-3855. doi: 10.1073/pnas.070047997.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A
, vol.97
, pp. 3850-3855
-
-
Li, B.1
Dou, Q.P.2
-
100
-
-
84893828038
-
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
-
Li, H., Tan, M., Jia, L., Wei, D., Zhao, Y., Chen, G., et al. (2014). Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. J. Clin. Invest. 124, 835-846. doi: 10.1172/JCI70297.
-
(2014)
J. Clin. Invest
, vol.124
, pp. 835-846
-
-
Li, H.1
Tan, M.2
Jia, L.3
Wei, D.4
Zhao, Y.5
Chen, G.6
-
101
-
-
77953099661
-
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma
-
Li, L., Tao, Q., Jin, H., van Hasselt, A., Poon, F. F., Wang, X., et al. (2010). The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma. Clin. Cancer Res. 16, 2949-2958. doi: 10.1158/1078-0432.CCR-09-3178.
-
(2010)
Clin. Cancer Res
, vol.16
, pp. 2949-2958
-
-
Li, L.1
Tao, Q.2
Jin, H.3
van Hasselt, A.4
Poon, F.F.5
Wang, X.6
-
102
-
-
1842421376
-
A dynamic role of HAUSP in the p53-Mdm2 pathway
-
Li, M., Brooks, C. L., Kon, N., and Gu, W. (2004). A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol. Cell 13, 879-886. doi: 10.1016/S1097-2765(04)00157-1.
-
(2004)
Mol. Cell
, vol.13
, pp. 879-886
-
-
Li, M.1
Brooks, C.L.2
Kon, N.3
Gu, W.4
-
103
-
-
0037061508
-
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
-
Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J., et al. (2002). Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416, 648-653. doi: 10.1038/nature737.
-
(2002)
Nature
, vol.416
, pp. 648-653
-
-
Li, M.1
Chen, D.2
Shiloh, A.3
Luo, J.4
Nikolaev, A.Y.5
Qin, J.6
-
104
-
-
0027716843
-
Effects of histone acetylation, ubiquitination and variants on nucleosome stability
-
Li, W., Nagaraja, S., Delcuve, G. P., Hendzel, M. J., and Davie, J. R. (1993). Effects of histone acetylation, ubiquitination and variants on nucleosome stability. Biochem. J. 296(Pt 3), 737-744.
-
(1993)
Biochem. J
, vol.296
, pp. 737-744
-
-
Li, W.1
Nagaraja, S.2
Delcuve, G.P.3
Hendzel, M.J.4
Davie, J.R.5
-
105
-
-
84867545561
-
High level of COP1 expression is associated with poor prognosis in primary gastric cancer
-
Li, Y. F., Wang, D. D., Zhao, B. W., Wang, W., Huang, C. Y., Chen, Y. M., et al. (2012). High level of COP1 expression is associated with poor prognosis in primary gastric cancer. Int. J. Biol. Sci. 8, 1168-1177. doi: 10.7150/ijbs.4778.
-
(2012)
Int. J. Biol. Sci
, vol.8
, pp. 1168-1177
-
-
Li, Y.F.1
Wang, D.D.2
Zhao, B.W.3
Wang, W.4
Huang, C.Y.5
Chen, Y.M.6
-
106
-
-
42149105590
-
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
-
Linke, K., Mace, P. D., Smith, C. A., Vaux, D. L., Silke, J., and Day, C. L. (2008). Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ. 15, 841-848. doi: 10.1038/sj.cdd.4402309.
-
(2008)
Cell Death Differ
, vol.15
, pp. 841-848
-
-
Linke, K.1
Mace, P.D.2
Smith, C.A.3
Vaux, D.L.4
Silke, J.5
Day, C.L.6
-
107
-
-
84873631924
-
CHFR is important for the first wave of ubiquitination at DNA damage sites
-
Liu, C., Wu, J., Paudyal, S. C., You, Z., and Yu, X. (2013). CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Res. 41, 1698-1710. doi: 10.1093/nar/gks1278.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 1698-1710
-
-
Liu, C.1
Wu, J.2
Paudyal, S.C.3
You, Z.4
Yu, X.5
-
108
-
-
79952282523
-
JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress
-
Liu, J., Chung, H. J., Vogt, M., Jin, Y., Malide, D., He, L., et al. (2011). JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress. EMBO J. 30, 846-858. doi: 10.1038/emboj.2011.11.
-
(2011)
EMBO J
, vol.30
, pp. 846-858
-
-
Liu, J.1
Chung, H.J.2
Vogt, M.3
Jin, Y.4
Malide, D.5
He, L.6
-
109
-
-
33747780741
-
Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer
-
Logan, I. R., Gaughan, L., McCracken, S. R., Sapountzi, V., Leung, H. Y., and Robson, C. N. (2006). Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer. Mol. Cell. Biol. 26, 6502-6510. doi: 10.1128/MCB.00147-06.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 6502-6510
-
-
Logan, I.R.1
Gaughan, L.2
McCracken, S.R.3
Sapountzi, V.4
Leung, H.Y.5
Robson, C.N.6
-
110
-
-
1642523726
-
Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome
-
Logan, I. R., Sapountzi, V., Gaughan, L., Neal, D. E., and Robson, C. N. (2004). Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome. J. Biol. Chem. 279, 11696-11704. doi: 10.1074/jbc. M312712200.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 11696-11704
-
-
Logan, I.R.1
Sapountzi, V.2
Gaughan, L.3
Neal, D.E.4
Robson, C.N.5
-
111
-
-
82955164827
-
Differential regulation of RNF8-mediated Lys48-and Lys63-based poly-ubiquitylation
-
Lok, G. T., Sy, S. M., Dong, S. S., Ching, Y. P., Tsao, S. W., Thomson, T. M., et al. (2012). Differential regulation of RNF8-mediated Lys48-and Lys63-based poly-ubiquitylation. Nucleic Acids Res. 40, 196-205. doi: 10.1093/nar/gkr655.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 196-205
-
-
Lok, G.T.1
Sy, S.M.2
Dong, S.S.3
Ching, Y.P.4
Tsao, S.W.5
Thomson, T.M.6
-
112
-
-
84856019858
-
The DNA damage response and cancer therapy
-
Lord, C. J., and Ashworth, A. (2012). The DNA damage response and cancer therapy. Nature 481, 287-294. doi: 10.1038/nature10760.
-
(2012)
Nature
, vol.481
, pp. 287-294
-
-
Lord, C.J.1
Ashworth, A.2
-
113
-
-
0027319521
-
p53 is required for radiation-induced apoptosis in mouse thymocytes
-
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. (1993). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849. doi: 10.1038/362847a0.
-
(1993)
Nature
, vol.362
, pp. 847-849
-
-
Lowe, S.W.1
Schmitt, E.M.2
Smith, S.W.3
Osborne, B.A.4
Jacks, T.5
-
114
-
-
35148893194
-
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
-
Lu, X., Ma, O., Nguyen, T. A., Jones, S. N., Oren, M., and Donehower, L. A. (2007). The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell 12, 342-354. doi: 10.1016/j.ccr.2007.08.033.
-
(2007)
Cancer Cell
, vol.12
, pp. 342-354
-
-
Lu, X.1
Ma, O.2
Nguyen, T.A.3
Jones, S.N.4
Oren, M.5
Donehower, L.A.6
-
115
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X. (1998). Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481-490. doi: 10.1016/S0092-8674(00)81589-5.
-
(1998)
Cell
, vol.94
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
116
-
-
84872288551
-
Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons
-
Magiera, M. M., Mora, S., Mojsa, B., Robbins, I., Lassot, I., and Desagher, S. (2013). Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons. Cell Death Differ. 20, 281-292. doi: 10.1038/cdd.2012.124.
-
(2013)
Cell Death Differ
, vol.20
, pp. 281-292
-
-
Magiera, M.M.1
Mora, S.2
Mojsa, B.3
Robbins, I.4
Lassot, I.5
Desagher, S.6
-
117
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
-
Mailand, N., Bekker-Jensen, S., Faustrup, H., Melander, F., Bartek, J., Lukas, C., et al. (2007). RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 131, 887-900. doi: 10.1016/j.cell.2007.09.040.
-
(2007)
Cell
, vol.131
, pp. 887-900
-
-
Mailand, N.1
Bekker-Jensen, S.2
Faustrup, H.3
Melander, F.4
Bartek, J.5
Lukas, C.6
-
118
-
-
84884902595
-
The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity
-
Malatesta, M., Peschiaroli, A., Memmi, E. M., Zhang, J., Antonov, A., Green, D. R., et al. (2013). The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity. Oncogene 32, 4721-4726. doi: 10.1038/onc.2012.463.
-
(2013)
Oncogene
, vol.32
, pp. 4721-4726
-
-
Malatesta, M.1
Peschiaroli, A.2
Memmi, E.M.3
Zhang, J.4
Antonov, A.5
Green, D.R.6
-
119
-
-
84859895529
-
RNF8-and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites
-
Mallette, F. A., Mattiroli, F., Cui, G., Young, L. C., Hendzel, M. J., Mer, G., et al. (2012). RNF8-and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J. 31, 1865-1878. doi: 10.1038/emboj.2012.47.
-
(2012)
EMBO J
, vol.31
, pp. 1865-1878
-
-
Mallette, F.A.1
Mattiroli, F.2
Cui, G.3
Young, L.C.4
Hendzel, M.J.5
Mer, G.6
-
120
-
-
0035284812
-
Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells
-
Marshansky, V., Wang, X., Bertrand, R., Luo, H., Duguid, W., Chinnadurai, G., et al. (2001). Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells. J. Immunol. 166, 3130-3142. doi: 10.4049/jimmunol.166.5.3130.
-
(2001)
J. Immunol
, vol.166
, pp. 3130-3142
-
-
Marshansky, V.1
Wang, X.2
Bertrand, R.3
Luo, H.4
Duguid, W.5
Chinnadurai, G.6
-
121
-
-
80455145246
-
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
-
Meerang, M., Ritz, D., Paliwal, S., Garajova, Z., Bosshard, M., Mailand, N., et al. (2011). The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat. Cell Biol. 13, 1376-1382. doi: 10.1038/ncb2367.
-
(2011)
Nat. Cell Biol
, vol.13
, pp. 1376-1382
-
-
Meerang, M.1
Ritz, D.2
Paliwal, S.3
Garajova, Z.4
Bosshard, M.5
Mailand, N.6
-
122
-
-
25444478027
-
ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation
-
Meulmeester, E., Pereg, Y., Shiloh, Y., and Jochemsen, A. G. (2005). ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. Cell Cycle 4, 1166-1170. doi: 10.4161/cc.4.9.1981.
-
(2005)
Cell Cycle
, vol.4
, pp. 1166-1170
-
-
Meulmeester, E.1
Pereg, Y.2
Shiloh, Y.3
Jochemsen, A.G.4
-
123
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
-
Miyashita, T., and Reed, J. C. (1995). Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299. doi: 10.1016/0092-8674(95)90412-3.
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
124
-
-
85047695475
-
Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers
-
Mizuno, K., Osada, H., Konishi, H., Tatematsu, Y., Yatabe, Y., Mitsudomi, T., et al. (2002). Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers. Oncogene 21, 2328-2333. doi: 10.1038/sj.onc.1205402.
-
(2002)
Oncogene
, vol.21
, pp. 2328-2333
-
-
Mizuno, K.1
Osada, H.2
Konishi, H.3
Tatematsu, Y.4
Yatabe, Y.5
Mitsudomi, T.6
-
125
-
-
0032145989
-
The MDM2 gene amplification database
-
Momand, J., Jung, D., Wilczynski, S., and Niland, J. (1998). The MDM2 gene amplification database. Nucleic Acids Res. 26, 3453-3459. doi: 10.1093/nar/26.15.3453.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 3453-3459
-
-
Momand, J.1
Jung, D.2
Wilczynski, S.3
Niland, J.4
-
126
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand, J., Zambetti, G. P., Olson, D. C., George, D., and Levine, A. J. (1992). The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69, 1237-1245. doi: 10.1016/0092-8674(92)90644-R.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
127
-
-
77649131406
-
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
-
Moynahan, M. E., and Jasin, M. (2010). Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat. Rev. Mol. Cell Biol. 11, 196-207. doi: 10.1038/nrm2851.
-
(2010)
Nat. Rev. Mol. Cell Biol
, vol.11
, pp. 196-207
-
-
Moynahan, M.E.1
Jasin, M.2
-
128
-
-
8544264616
-
Cul4A physically associates with MDM2 and participates in the proteolysis of p53
-
Nag, A., Bagchi, S., and Raychaudhuri, P. (2004). Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res. 64, 8152-8155. doi: 10.1158/0008-5472.CAN-04-2598.
-
(2004)
Cancer Res
, vol.64
, pp. 8152-8155
-
-
Nag, A.1
Bagchi, S.2
Raychaudhuri, P.3
-
129
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano, K., and Vousden, K. H. (2001). PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7, 683-694. doi: 10.1016/S1097-2765(01)00214-3.
-
(2001)
Mol. Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
130
-
-
68149112387
-
Mimicking the BH3 domain to kill cancer cells
-
Ni Chonghaile, T., and Letai, A. (2008). Mimicking the BH3 domain to kill cancer cells. Oncogene 27, S149-S157. doi: 10.1038/onc.2009.52.
-
(2008)
Oncogene
, vol.27
, pp. S149-S157
-
-
Ni Chonghaile, T.1
Letai, A.2
-
131
-
-
28344456279
-
A genomic and functional inventory of deubiquitinating enzymes
-
Nijman, S. M., Luna-Vargas, M. P., Velds, A., Brummelkamp, T. R., Dirac, A. M., Sixma, T. K., et al. (2005). A genomic and functional inventory of deubiquitinating enzymes. Cell 123, 773-786. doi: 10.1016/j.cell.2005.11.007.
-
(2005)
Cell
, vol.123
, pp. 773-786
-
-
Nijman, S.M.1
Luna-Vargas, M.P.2
Velds, A.3
Brummelkamp, T.R.4
Dirac, A.M.5
Sixma, T.K.6
-
132
-
-
15944387964
-
The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim
-
Nikrad, M., Johnson, T., Puthalalath, H., Coultas, L., Adams, J., and Kraft, A. S. (2005). The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. Mol. Cancer Ther. 4, 443-449. doi: 10.1158/1535-7163.MCT-04-0260.
-
(2005)
Mol. Cancer Ther
, vol.4
, pp. 443-449
-
-
Nikrad, M.1
Johnson, T.2
Puthalalath, H.3
Coultas, L.4
Adams, J.5
Kraft, A.S.6
-
133
-
-
2342459790
-
DNA damage-induced apoptosis
-
Norbury, C. J., and Zhivotovsky, B. (2004). DNA damage-induced apoptosis. Oncogene 23, 2797-2808. doi: 10.1038/sj.onc.1207532.
-
(2004)
Oncogene
, vol.23
, pp. 2797-2808
-
-
Norbury, C.J.1
Zhivotovsky, B.2
-
134
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., et al. (2000). Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288, 1053-1058. doi: 10.1126/science.288.5468.1053.
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
Nemoto, J.4
Shibue, T.5
Yamashita, T.6
-
135
-
-
41549133200
-
Proteasome inhibitors in cancer therapy: lessons from the first decade
-
Orlowski, R. Z., and Kuhn, D. J. (2008). Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin. Cancer Res. 14, 1649-1657. doi: 10.1158/1078-0432.CCR-07-2218.
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 1649-1657
-
-
Orlowski, R.Z.1
Kuhn, D.J.2
-
136
-
-
80051494784
-
Monoubiquitination of H2AX protein regulates DNA damage response signaling
-
Pan, M. R., Peng, G., Hung, W. C., and Lin, S. Y. (2011). Monoubiquitination of H2AX protein regulates DNA damage response signaling. J. Biol. Chem. 286, 28599-28607. doi: 10.1074/jbc. M111.256297.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 28599-28607
-
-
Pan, M.R.1
Peng, G.2
Hung, W.C.3
Lin, S.Y.4
-
137
-
-
0042592947
-
MDM2 promotes ubiquitination and degradation of MDMX
-
Pan, Y., and Chen, J. (2003). MDM2 promotes ubiquitination and degradation of MDMX. Mol. Cell. Biol. 23, 5113-5121. doi: 10.1128/MCB.23.15.5113-5121.2003.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 5113-5121
-
-
Pan, Y.1
Chen, J.2
-
138
-
-
79951997444
-
USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase beta
-
Parsons, J. L., Dianova, II, Khoronenkova, S. V., Edelmann, M. J., Kessler, B. M., and Dianov, G. L. (2011). USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase beta. Mol. Cell 41, 609-615. doi: 10.1016/j.molcel.2011.02.016.
-
(2011)
Mol. Cell
, vol.41
, pp. 609-615
-
-
Parsons, J.L.1
Dianova, I.I.2
Khoronenkova, S.V.3
Edelmann, M.J.4
Kessler, B.M.5
Dianov, G.L.6
-
139
-
-
70350340291
-
Ubiquitin ligase ARF-BP1/Mule modulates base excision repair
-
Parsons, J. L., Tait, P. S., Finch, D., Dianova, I. I., Edelmann, M. J., Khoronenkova, S. V., et al. (2009). Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. EMBO J. 28, 3207-3215. doi: 10.1038/emboj.2009.243.
-
(2009)
EMBO J
, vol.28
, pp. 3207-3215
-
-
Parsons, J.L.1
Tait, P.S.2
Finch, D.3
Dianova, I.I.4
Edelmann, M.J.5
Khoronenkova, S.V.6
-
140
-
-
0041706156
-
A proteomics approach to understanding protein ubiquitination
-
Peng, J., Schwartz, D., Elias, J. E., Thoreen, C. C., Cheng, D., Marsischky, G., et al. (2003). A proteomics approach to understanding protein ubiquitination. Nat. Biotechnol. 21, 921-926. doi: 10.1038/nbt849.
-
(2003)
Nat. Biotechnol
, vol.21
, pp. 921-926
-
-
Peng, J.1
Schwartz, D.2
Elias, J.E.3
Thoreen, C.C.4
Cheng, D.5
Marsischky, G.6
-
141
-
-
20144387944
-
Phosphorylation of Hdmx mediates its Hdm2-and ATM-dependent degradation in response to DNA damage
-
Pereg, Y., Shkedy, D., de Graaf, P., Meulmeester, E., Edelson-Averbukh, M., Salek, M., et al. (2005). Phosphorylation of Hdmx mediates its Hdm2-and ATM-dependent degradation in response to DNA damage. Proc. Natl. Acad. Sci. U.S.A. 102, 5056-5061. doi: 10.1073/pnas.0408595102.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A
, vol.102
, pp. 5056-5061
-
-
Pereg, Y.1
Shkedy, D.2
de Graaf, P.3
Meulmeester, E.4
Edelson-Averbukh, M.5
Salek, M.6
-
142
-
-
0034915764
-
Mechanisms underlying ubiquitination
-
Pickart, C. M. (2001). Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533. doi: 10.1146/annurev.biochem.70.1.503.
-
(2001)
Annu. Rev. Biochem
, vol.70
, pp. 503-533
-
-
Pickart, C.M.1
-
143
-
-
84922393807
-
Ubiquitination in disease pathogenesis and treatment
-
Popovic, D., Vucic, D., and Dikic, I. (2014). Ubiquitination in disease pathogenesis and treatment. Nat. Med. 20, 1242-1253. doi: 10.1038/nm.3739.
-
(2014)
Nat. Med
, vol.20
, pp. 1242-1253
-
-
Popovic, D.1
Vucic, D.2
Dikic, I.3
-
144
-
-
84861548210
-
Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms
-
Qi, C. F., Kim, Y. S., Xiang, S., Abdullaev, Z., Torrey, T. A., Janz, S., et al. (2012). Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms. Int. J. Mol. Sci. 13, 6204-6219. doi: 10.3390/ijms13056204.
-
(2012)
Int. J. Mol. Sci
, vol.13
, pp. 6204-6219
-
-
Qi, C.F.1
Kim, Y.S.2
Xiang, S.3
Abdullaev, Z.4
Torrey, T.A.5
Janz, S.6
-
145
-
-
22244452016
-
Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells
-
Qin, J. Z., Ziffra, J., Stennett, L., Bodner, B., Bonish, B. K., Chaturvedi, V., et al. (2005). Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res. 65, 6282-6293. doi: 10.1158/0008-5472.CAN-05-0676.
-
(2005)
Cancer Res
, vol.65
, pp. 6282-6293
-
-
Qin, J.Z.1
Ziffra, J.2
Stennett, L.3
Bodner, B.4
Bonish, B.K.5
Chaturvedi, V.6
-
146
-
-
80052781403
-
Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: new perspectives for anti-cancer therapy
-
Ramadan, K., and Meerang, M. (2011). Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: new perspectives for anti-cancer therapy. FEBS Lett. 585, 2868-2875. doi: 10.1016/j.febslet.2011.04.046.
-
(2011)
FEBS Lett
, vol.585
, pp. 2868-2875
-
-
Ramadan, K.1
Meerang, M.2
-
147
-
-
53249137795
-
TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2
-
Ramesh, S., Qi, X. J., Wildey, G. M., Robinson, J., Molkentin, J., Letterio, J., et al. (2008). TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. EMBO Rep. 9, 990-997. doi: 10.1038/embor.2008.158.
-
(2008)
EMBO Rep
, vol.9
, pp. 990-997
-
-
Ramesh, S.1
Qi, X.J.2
Wildey, G.M.3
Robinson, J.4
Molkentin, J.5
Letterio, J.6
-
148
-
-
33748065322
-
The E3 ubiquitin ligase Itch controls the protein stability of p63
-
Rossi, M., Aqeilan, R. I., Neale, M., Candi, E., Salomoni, P., Knight, R. A., et al. (2006). The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc. Natl. Acad. Sci. U.S.A. 103, 12753-12758. doi: 10.1073/pnas.0603449103.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 12753-12758
-
-
Rossi, M.1
Aqeilan, R.I.2
Neale, M.3
Candi, E.4
Salomoni, P.5
Knight, R.A.6
-
149
-
-
15444367709
-
The ubiquitin-protein ligase Itch regulates p73 stability
-
Rossi, M., De Laurenzi, V., Munarriz, E., Green, D. R., Liu, Y. C., Vousden, K. H., et al. (2005). The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 24, 836-848. doi: 10.1038/sj.emboj.7600444.
-
(2005)
EMBO J
, vol.24
, pp. 836-848
-
-
Rossi, M.1
De Laurenzi, V.2
Munarriz, E.3
Green, D.R.4
Liu, Y.C.5
Vousden, K.H.6
-
150
-
-
28544448219
-
Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma
-
Sakai, M., Hibi, K., Kanazumi, N., Nomoto, S., Inoue, S., Takeda, S., et al. (2005). Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma. Hepatogastroenterology. 52, 1854-1857.
-
(2005)
Hepatogastroenterology
, vol.52
, pp. 1854-1857
-
-
Sakai, M.1
Hibi, K.2
Kanazumi, N.3
Nomoto, S.4
Inoue, S.5
Takeda, S.6
-
151
-
-
84870508724
-
USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis
-
Santin, I., Moore, F., Grieco, F. A., Marchetti, P., Brancolini, C., and Eizirik, D. L. (2012). USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis. Cell Death Dis. 3, e419. doi: 10.1038/cddis.2012.158.
-
(2012)
Cell Death Dis
, vol.3
-
-
Santin, I.1
Moore, F.2
Grieco, F.A.3
Marchetti, P.4
Brancolini, C.5
Eizirik, D.L.6
-
152
-
-
35148842829
-
p53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo: new hope for treating aggressive viral lymphomas
-
Sarek, G., and Ojala, P. M. (2007). p53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo: new hope for treating aggressive viral lymphomas. Cell Cycle 6, 2205-2209. doi: 10.4161/cc.6.18.4730.
-
(2007)
Cell Cycle
, vol.6
, pp. 2205-2209
-
-
Sarek, G.1
Ojala, P.M.2
-
153
-
-
9144239265
-
Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer
-
Satoh, A., Toyota, M., Itoh, F., Sasaki, Y., Suzuki, H., Ogi, K., et al. (2003). Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer. Cancer Res. 63, 8606-8613.
-
(2003)
Cancer Res
, vol.63
, pp. 8606-8613
-
-
Satoh, A.1
Toyota, M.2
Itoh, F.3
Sasaki, Y.4
Suzuki, H.5
Ogi, K.6
-
154
-
-
84882599178
-
Loss of COP1 expression determines poor prognosisin patients with gastric cancer
-
Sawada, G., Ueo, H., Matsumura, T., Uchi, R., Ishibashi, M., Mima, K., et al. (2013). Loss of COP1 expression determines poor prognosisin patients with gastric cancer. Oncol. Rep. 30, 1971-1975. doi: 10.3892/or.2013.2664.
-
(2013)
Oncol. Rep
, vol.30
, pp. 1971-1975
-
-
Sawada, G.1
Ueo, H.2
Matsumura, T.3
Uchi, R.4
Ishibashi, M.5
Mima, K.6
-
155
-
-
0027358723
-
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
-
Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. (1993). The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75, 495-505. doi: 10.1016/0092-8674(93)90384-3.
-
(1993)
Cell
, vol.75
, pp. 495-505
-
-
Scheffner, M.1
Huibregtse, J.M.2
Vierstra, R.D.3
Howley, P.M.4
-
156
-
-
0028898424
-
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade
-
Scheffner, M., Nuber, U., and Huibregtse, J. M. (1995). Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 373, 81-83. doi: 10.1038/373081a0.
-
(1995)
Nature
, vol.373
, pp. 81-83
-
-
Scheffner, M.1
Nuber, U.2
Huibregtse, J.M.3
-
157
-
-
0016798328
-
The complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells
-
Schlesinger, D. H., Goldstein, G., and Niall, H. D. (1975). The complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells. Biochemistry 14, 2214-2218. doi: 10.1021/bi00681a026.
-
(1975)
Biochemistry
, vol.14
, pp. 2214-2218
-
-
Schlesinger, D.H.1
Goldstein, G.2
Niall, H.D.3
-
158
-
-
73849083434
-
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
-
Schwickart, M., Huang, X., Lill, J. R., Liu, J., Ferrando, R., French, D. M., et al. (2010). Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 463, 103-107. doi: 10.1038/nature08646.
-
(2010)
Nature
, vol.463
, pp. 103-107
-
-
Schwickart, M.1
Huang, X.2
Lill, J.R.3
Liu, J.4
Ferrando, R.5
French, D.M.6
-
159
-
-
41649102468
-
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
-
Shangary, S., Qin, D., McEachern, D., Liu, M., Miller, R. S., Qiu, S., et al. (2008). Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc. Natl. Acad. Sci. U.S.A. 105, 3933-3938. doi: 10.1073/pnas.0708917105.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A
, vol.105
, pp. 3933-3938
-
-
Shangary, S.1
Qin, D.2
McEachern, D.3
Liu, M.4
Miller, R.S.5
Qiu, S.6
-
160
-
-
57149120085
-
Molecular basis of Pirh2-mediated p53 ubiquitylation
-
Sheng, Y., Laister, R. C., Lemak, A., Wu, B., Tai, E., Duan, S., et al. (2008). Molecular basis of Pirh2-mediated p53 ubiquitylation. Nat. Struct. Mol. Biol. 15, 1334-1342. doi: 10.1038/nsmb.1521.
-
(2008)
Nat. Struct. Mol. Biol
, vol.15
, pp. 1334-1342
-
-
Sheng, Y.1
Laister, R.C.2
Lemak, A.3
Wu, B.4
Tai, E.5
Duan, S.6
-
161
-
-
33644808087
-
Molecular recognition of p53 and MDM2 by USP7/HAUSP
-
Sheng, Y., Saridakis, V., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C. H., et al. (2006). Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nat. Struct. Mol. Biol. 13, 285-291. doi: 10.1038/nsmb1067.
-
(2006)
Nat. Struct. Mol. Biol
, vol.13
, pp. 285-291
-
-
Sheng, Y.1
Saridakis, V.2
Sarkari, F.3
Duan, S.4
Wu, T.5
Arrowsmith, C.H.6
-
162
-
-
70349488818
-
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53
-
Shi, D., Pop, M. S., Kulikov, R., Love, I. M., Kung, A. L., and Grossman, S. R. (2009). CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. Proc. Natl. Acad. Sci. U.S.A. 106, 16275-16280. doi: 10.1073/pnas.0904305106.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A
, vol.106
, pp. 16275-16280
-
-
Shi, D.1
Pop, M.S.2
Kulikov, R.3
Love, I.M.4
Kung, A.L.5
Grossman, S.R.6
-
163
-
-
0036799843
-
Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer
-
Shibata, Y., Haruki, N., Kuwabara, Y., Ishiguro, H., Shinoda, N., Sato, A., et al. (2002). Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer. Carcinogenesis 23, 1695-1699. doi: 10.1093/carcin/23.10.1695.
-
(2002)
Carcinogenesis
, vol.23
, pp. 1695-1699
-
-
Shibata, Y.1
Haruki, N.2
Kuwabara, Y.3
Ishiguro, H.4
Shinoda, N.5
Sato, A.6
-
164
-
-
0037365789
-
ATM and related protein kinases: safeguarding genome integrity
-
Shiloh, Y. (2003). ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168. doi: 10.1038/nrc1011.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
165
-
-
84875423827
-
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
-
Shiloh, Y., and Ziv, Y. (2013). The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 14, 197-210. doi: 10.1038/nrm3546.
-
(2013)
Nat. Rev. Mol. Cell Biol
, vol.14
, pp. 197-210
-
-
Shiloh, Y.1
Ziv, Y.2
-
166
-
-
65349157682
-
High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers
-
Shimada, M., Kitagawa, K., Dobashi, Y., Isobe, T., Hattori, T., Uchida, C., et al. (2009). High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers. Cancer Sci. 100, 866-872. doi: 10.1111/j.1349-7006.2009.01122.x.
-
(2009)
Cancer Sci
, vol.100
, pp. 866-872
-
-
Shimada, M.1
Kitagawa, K.2
Dobashi, Y.3
Isobe, T.4
Hattori, T.5
Uchida, C.6
-
167
-
-
33847212425
-
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
-
Stevenson, L. F., Sparks, A., Allende-Vega, N., Xirodimas, D. P., Lane, D. P., and Saville, M. K. (2007). The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J. 26, 976-986. doi: 10.1038/sj.emboj.7601567.
-
(2007)
EMBO J
, vol.26
, pp. 976-986
-
-
Stevenson, L.F.1
Sparks, A.2
Allende-Vega, N.3
Xirodimas, D.P.4
Lane, D.P.5
Saville, M.K.6
-
168
-
-
0028072523
-
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
-
Strasser, A., Harris, A. W., Jacks, T., and Cory, S. (1994). DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 79, 329-339. doi: 10.1016/0092-8674(94)90201-1.
-
(1994)
Cell
, vol.79
, pp. 329-339
-
-
Strasser, A.1
Harris, A.W.2
Jacks, T.3
Cory, S.4
-
169
-
-
84856415004
-
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
-
Sun, X. X., Challagundla, K. B., and Dai, M. S. (2012). Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J. 31, 576-592. doi: 10.1038/emboj.2011.434.
-
(2012)
EMBO J
, vol.31
, pp. 576-592
-
-
Sun, X.X.1
Challagundla, K.B.2
Dai, M.S.3
-
170
-
-
84902068582
-
RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway
-
Surget, S., Descamps, G., Brosseau, C., Normant, V., Maiga, S., Gomez-Bougie, P., et al. (2014). RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway. BMC Cancer 14:437. doi: 10.1186/1471-2407-14-437.
-
(2014)
BMC Cancer
, vol.14
, pp. 437
-
-
Surget, S.1
Descamps, G.2
Brosseau, C.3
Normant, V.4
Maiga, S.5
Gomez-Bougie, P.6
-
171
-
-
38049059937
-
Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment
-
Tait, S. W., de Vries, E., Maas, C., Keller, A. M., D'Santos, C. S., and Borst, J. (2007). Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment. J. Cell Biol. 179, 1453-1466. doi: 10.1083/jcb.200707063.
-
(2007)
J. Cell Biol
, vol.179
, pp. 1453-1466
-
-
Tait, S.W.1
de Vries, E.2
Maas, C.3
Keller, A.M.4
D'Santos, C.S.5
Borst, J.6
-
172
-
-
77956095537
-
Mitochondria and cell death: outer membrane permeabilization and beyond
-
Tait, S. W., and Green, D. R. (2010). Mitochondria and cell death: outer membrane permeabilization and beyond. Nat. Rev. Mol. Cell Biol. 11, 621-632. doi: 10.1038/nrm2952.
-
(2010)
Nat. Rev. Mol. Cell Biol
, vol.11
, pp. 621-632
-
-
Tait, S.W.1
Green, D.R.2
-
173
-
-
84898877848
-
E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation
-
Thirunavukarasou, A., Singh, P., Govindarajalu, G., Bandi, V., and Baluchamy, S. (2014). E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation. Mol. Cell. Biochem. 390, 93-100. doi: 10.1007/s11010-014-1960-3.
-
(2014)
Mol. Cell. Biochem
, vol.390
, pp. 93-100
-
-
Thirunavukarasou, A.1
Singh, P.2
Govindarajalu, G.3
Bandi, V.4
Baluchamy, S.5
-
174
-
-
79957598477
-
Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection
-
Thompson, S., Pearson, A. N., Ashley, M. D., Jessick, V., Murphy, B. M., Gafken, P., et al. (2011). Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. J. Biol. Chem. 286, 19331-19339. doi: 10.1074/jbc. M110.197707.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 19331-19339
-
-
Thompson, S.1
Pearson, A.N.2
Ashley, M.D.3
Jessick, V.4
Murphy, B.M.5
Gafken, P.6
-
175
-
-
0034602845
-
Recognition of the polyubiquitin proteolytic signal
-
Thrower, J. S., Hoffman, L., Rechsteiner, M., and Pickart, C. M. (2000). Recognition of the polyubiquitin proteolytic signal. EMBO J. 19, 94-102. doi: 10.1093/emboj/19.1.94.
-
(2000)
EMBO J
, vol.19
, pp. 94-102
-
-
Thrower, J.S.1
Hoffman, L.2
Rechsteiner, M.3
Pickart, C.M.4
-
176
-
-
32444449180
-
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
-
Tovar, C., Rosinski, J., Filipovic, Z., Higgins, B., Kolinsky, K., Hilton, H., et al. (2006). Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc. Natl. Acad. Sci. U.S.A. 103, 1888-1893. doi: 10.1073/pnas.0507493103.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 1888-1893
-
-
Tovar, C.1
Rosinski, J.2
Filipovic, Z.3
Higgins, B.4
Kolinsky, K.5
Hilton, H.6
-
177
-
-
0037934421
-
Epigenetic inactivation of CHFR in human tumors
-
Toyota, M., Sasaki, Y., Satoh, A., Ogi, K., Kikuchi, T., Suzuki, H., et al. (2003). Epigenetic inactivation of CHFR in human tumors. Proc. Natl. Acad. Sci. U.S.A. 100, 7818-7823. doi: 10.1073/pnas.1337066100.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 7818-7823
-
-
Toyota, M.1
Sasaki, Y.2
Satoh, A.3
Ogi, K.4
Kikuchi, T.5
Suzuki, H.6
-
178
-
-
84889082367
-
Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B
-
van de Kooij, B., Rooswinkel, R. W., Kok, F., Herrebout, M., de Vries, E., Paauwe, M., et al. (2013). Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B. Oncogene 32, 5439-5448. doi: 10.1038/onc.2013.99.
-
(2013)
Oncogene
, vol.32
, pp. 5439-5448
-
-
van de Kooij, B.1
Rooswinkel, R.W.2
Kok, F.3
Herrebout, M.4
de Vries, E.5
Paauwe, M.6
-
179
-
-
21244458051
-
Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73
-
van Doorn, R., Zoutman, W. H., Dijkman, R., de Menezes, R. X., Commandeur, S., Mulder, A. A., et al. (2005). Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. J. Clin. Oncol. 23, 3886-3896. doi: 10.1200/JCO.2005.11.353.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 3886-3896
-
-
van Doorn, R.1
Zoutman, W.H.2
Dijkman, R.3
de Menezes, R.X.4
Commandeur, S.5
Mulder, A.A.6
-
180
-
-
4344610526
-
Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics
-
Vassilev, L. T. (2004). Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics. Cell Cycle 3, 419-421. doi: 10.4161/cc.3.4.801.
-
(2004)
Cell Cycle
, vol.3
, pp. 419-421
-
-
Vassilev, L.T.1
-
181
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., et al. (2004). In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848. doi: 10.1126/science.1092472.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
-
182
-
-
0032867676
-
The 26S proteasome: a molecular machine designed for controlled proteolysis
-
Voges, D., Zwickl, P., and Baumeister, W. (1999). The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu. Rev. Biochem. 68, 1015-1068. doi: 10.1146/annurev.biochem.68.1.1015.
-
(1999)
Annu. Rev. Biochem
, vol.68
, pp. 1015-1068
-
-
Voges, D.1
Zwickl, P.2
Baumeister, W.3
-
183
-
-
84869093164
-
Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells
-
Wade, M., Li, Y. C., Matani, A. S., Braun, S. M., Milanesi, F., Rodewald, L. W., et al. (2012). Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene 31, 4789-4797. doi: 10.1038/onc.2011.625.
-
(2012)
Oncogene
, vol.31
, pp. 4789-4797
-
-
Wade, M.1
Li, Y.C.2
Matani, A.S.3
Braun, S.M.4
Milanesi, F.5
Rodewald, L.W.6
-
184
-
-
84882987840
-
A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1
-
Wang, P., Wu, Y., Li, Y., Zheng, J., and Tang, J. (2013). A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1. Cell. Signal. 25, 2320-2333. doi: 10.1016/j.cellsig.2013.07.016.
-
(2013)
Cell. Signal
, vol.25
, pp. 2320-2333
-
-
Wang, P.1
Wu, Y.2
Li, Y.3
Zheng, J.4
Tang, J.5
-
185
-
-
79959881127
-
MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination
-
Wang, X., Wang, J., and Jiang, X. (2011). MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination. J. Biol. Chem. 286, 23725-23734. doi: 10.1074/jbc. M110.213868.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 23725-23734
-
-
Wang, X.1
Wang, J.2
Jiang, X.3
-
186
-
-
70349280704
-
p53-induced RING-H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection
-
Wang, X. M., Yang, L. Y., Guo, L., Fan, C., and Wu, F. (2009). p53-induced RING-H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection. Cancer 115, 4554-4563. doi: 10.1002/cncr.24494.
-
(2009)
Cancer
, vol.115
, pp. 4554-4563
-
-
Wang, X.M.1
Yang, L.Y.2
Guo, L.3
Fan, C.4
Wu, F.5
-
187
-
-
79952271269
-
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
-
Wertz, I. E., Kusam, S., Lam, C., Okamoto, T., Sandoval, W., Anderson, D. J., et al. (2011). Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471, 110-114. doi: 10.1038/nature09779.
-
(2011)
Nature
, vol.471
, pp. 110-114
-
-
Wertz, I.E.1
Kusam, S.2
Lam, C.3
Okamoto, T.4
Sandoval, W.5
Anderson, D.J.6
-
188
-
-
77951921275
-
Refining the minimal sequence required for ERK1/2-dependent poly-ubiquitination and proteasome-dependent turnover of BIM
-
Wiggins, C. M., Johnson, M., and Cook, S. J. (2010). Refining the minimal sequence required for ERK1/2-dependent poly-ubiquitination and proteasome-dependent turnover of BIM. Cell. Signal. 22, 801-808. doi: 10.1016/j.cellsig.2010.01.004.
-
(2010)
Cell. Signal
, vol.22
, pp. 801-808
-
-
Wiggins, C.M.1
Johnson, M.2
Cook, S.J.3
-
189
-
-
79959217794
-
UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation
-
Wu, H., and Leng, R. P. (2011). UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation. Cell Cycle 10, 1912-1915. doi: 10.4161/cc.10.12.15882.
-
(2011)
Cell Cycle
, vol.10
, pp. 1912-1915
-
-
Wu, H.1
Leng, R.P.2
-
190
-
-
79952453180
-
UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53
-
Wu, H., Pomeroy, S. L., Ferreira, M., Teider, N., Mariani, J., Nakayama, K. I., et al. (2011b). UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. Nat. Med. 17, 347-355. doi: 10.1038/nm.2283.
-
(2011)
Nat. Med
, vol.17
, pp. 347-355
-
-
Wu, H.1
Pomeroy, S.L.2
Ferreira, M.3
Teider, N.4
Mariani, J.5
Nakayama, K.I.6
-
191
-
-
84055216930
-
Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination
-
Wu, H., Zeinab, R. A., Flores, E. R., and Leng, R. P. (2011c). Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination. Mol. Cancer Res. 9, 1780-1790. doi: 10.1158/1541-7786.MCR-11-0157.
-
(2011)
Mol. Cancer Res
, vol.9
, pp. 1780-1790
-
-
Wu, H.1
Zeinab, R.A.2
Flores, E.R.3
Leng, R.P.4
-
192
-
-
79960034248
-
Chfr and RNF8 synergistically regulate ATM activation
-
Wu, J., Chen, Y., Lu, L. Y., Wu, Y., Paulsen, M. T., Ljungman, M., et al. (2011a). Chfr and RNF8 synergistically regulate ATM activation. Nat. Struct. Mol. Biol. 18, 761-768. doi: 10.1038/nsmb.2078.
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 761-768
-
-
Wu, J.1
Chen, Y.2
Lu, L.Y.3
Wu, Y.4
Paulsen, M.T.5
Ljungman, M.6
-
193
-
-
84870886194
-
High expression of P53-induced Ring-h2 protein is associated with poor prognosis in clear cell renal cell carcinoma
-
Wu, X. R., Sha, J. J., Liu, D. M., Chen, Y. H., Yang, G. L., Zhang, J., et al. (2013). High expression of P53-induced Ring-h2 protein is associated with poor prognosis in clear cell renal cell carcinoma. Eur. J. Surg. Oncol. 39, 100-106. doi: 10.1016/j.ejso.2012.10.004.
-
(2013)
Eur. J. Surg. Oncol
, vol.39
, pp. 100-106
-
-
Wu, X.R.1
Sha, J.J.2
Liu, D.M.3
Chen, Y.H.4
Yang, G.L.5
Zhang, J.6
-
194
-
-
0042317328
-
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
-
Wu-Baer, F., Lagrazon, K., Yuan, W., and Baer, R. (2003). The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. J. Biol. Chem. 278, 34743-34746. doi: 10.1074/jbc. C300249200.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 34743-34746
-
-
Wu-Baer, F.1
Lagrazon, K.2
Yuan, W.3
Baer, R.4
-
195
-
-
45849116513
-
Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation
-
Xia, M., Knezevic, D., Tovar, C., Huang, B., Heimbrook, D. C., and Vassilev, L. T. (2008). Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation. Cell Cycle 7, 1604-1612. doi: 10.4161/cc.7.11.5929.
-
(2008)
Cell Cycle
, vol.7
, pp. 1604-1612
-
-
Xia, M.1
Knezevic, D.2
Tovar, C.3
Huang, B.4
Heimbrook, D.C.5
Vassilev, L.T.6
-
196
-
-
84862921850
-
The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer
-
Xiang, T., Li, L., Yin, X., Yuan, C., Tan, C., Su, X., et al. (2012). The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer. PLoS ONE 7:e29783. doi: 10.1371/journal.pone.0029783.
-
(2012)
PLoS ONE
, vol.7
-
-
Xiang, T.1
Li, L.2
Yin, X.3
Yuan, C.4
Tan, C.5
Su, X.6
-
197
-
-
0036726569
-
Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization
-
Xie, D., Jauch, A., Miller, C. W., Bartram, C. R., and Koeffler, H. P. (2002). Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization. Int. J. Oncol. 21, 499-507. doi: 10.3892/ijo.21.3.499.
-
(2002)
Int. J. Oncol
, vol.21
, pp. 499-507
-
-
Xie, D.1
Jauch, A.2
Miller, C.W.3
Bartram, C.R.4
Koeffler, H.P.5
-
198
-
-
84879689690
-
p28, a first in class peptide inhibitor of cop1 binding to p53
-
Yamada, T., Christov, K., Shilkaitis, A., Bratescu, L., Green, A., Santini, S., et al. (2013a). p28, a first in class peptide inhibitor of cop1 binding to p53. Br. J. Cancer 108, 2495-2504. doi: 10.1038/bjc.2013.266.
-
(2013)
Br. J. Cancer
, vol.108
, pp. 2495-2504
-
-
Yamada, T.1
Christov, K.2
Shilkaitis, A.3
Bratescu, L.4
Green, A.5
Santini, S.6
-
199
-
-
84883585808
-
p28, an anionic cell-penetrating peptide, increases the activity of wild type and mutated p53 without altering its conformation
-
Yamada, T., Das Gupta, T. K., and Beattie, C. W. (2013b). p28, an anionic cell-penetrating peptide, increases the activity of wild type and mutated p53 without altering its conformation. Mol. Pharm. 10, 3375-3383. doi: 10.1021/mp400221r.
-
(2013)
Mol. Pharm
, vol.10
, pp. 3375-3383
-
-
Yamada, T.1
Das Gupta, T.K.2
Beattie, C.W.3
-
200
-
-
75749132016
-
USP10 regulates p53 localization and stability by deubiquitinating p53
-
Yuan, J., Luo, K., Zhang, L., Cheville, J. C., and Lou, Z. (2010). USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 140, 384-396. doi: 10.1016/j.cell.2009.12.032.
-
(2010)
Cell
, vol.140
, pp. 384-396
-
-
Yuan, J.1
Luo, K.2
Zhang, L.3
Cheville, J.C.4
Lou, Z.5
-
201
-
-
67349246802
-
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
-
Yun, M. H., and Hiom, K. (2009). CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 459, 460-463. doi: 10.1038/nature07955.
-
(2009)
Nature
, vol.459
, pp. 460-463
-
-
Yun, M.H.1
Hiom, K.2
-
202
-
-
77956628160
-
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
-
Zhang, H., Zhai, Y., Hu, Z., Wu, C., Qian, J., Jia, W., et al. (2010). Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat. Genet. 42, 755-758. doi: 10.1038/ng.638.
-
(2010)
Nat. Genet
, vol.42
, pp. 755-758
-
-
Zhang, H.1
Zhai, Y.2
Hu, Z.3
Wu, C.4
Qian, J.5
Jia, W.6
-
203
-
-
55849111846
-
PCNA is ubiquitinated by RNF8
-
Zhang, S., Chea, J., Meng, X., Zhou, Y., Lee, E. Y., and Lee, M. Y. (2008). PCNA is ubiquitinated by RNF8. Cell Cycle 7, 3399-3404. doi: 10.4161/cc.7.21.6949.
-
(2008)
Cell Cycle
, vol.7
, pp. 3399-3404
-
-
Zhang, S.1
Chea, J.2
Meng, X.3
Zhou, Y.4
Lee, E.Y.5
Lee, M.Y.6
-
204
-
-
79957900145
-
USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1
-
Zhang, X., Berger, F. G., Yang, J., and Lu, X. (2011). USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J. 30, 2177-2189. doi: 10.1038/emboj.2011.125.
-
(2011)
EMBO J
, vol.30
, pp. 2177-2189
-
-
Zhang, X.1
Berger, F.G.2
Yang, J.3
Lu, X.4
-
205
-
-
84889578101
-
Small molecule inhibitors of MDM2-p53 and MDMX-p53 interactions as new cancer therapeutics
-
Zhao, Y., Bernard, D., and Wang, S. (2013). Small molecule inhibitors of MDM2-p53 and MDMX-p53 interactions as new cancer therapeutics. Biodiscovery 8:4. doi: 10.7750/BioDiscovery.2013.8.4.
-
(2013)
Biodiscovery
, vol.8
, pp. 4
-
-
Zhao, Y.1
Bernard, D.2
Wang, S.3
-
206
-
-
21244472965
-
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
-
Zhong, Q., Gao, W., Du, F., and Wang, X. (2005). Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121, 1085-1095. doi: 10.1016/j.cell.2005.06.009.
-
(2005)
Cell
, vol.121
, pp. 1085-1095
-
-
Zhong, Q.1
Gao, W.2
Du, F.3
Wang, X.4
-
207
-
-
38149098408
-
Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation
-
Zhou, W., Zhu, P., Wang, J., Pascual, G., Ohgi, K. A., Lozach, J., et al. (2008). Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol. Cell 29, 69-80. doi: 10.1016/j.molcel.2007.11.002.
-
(2008)
Mol. Cell
, vol.29
, pp. 69-80
-
-
Zhou, W.1
Zhu, P.2
Wang, J.3
Pascual, G.4
Ohgi, K.A.5
Lozach, J.6
|