The RING finger ATPase Rad5p of Saccharomyces cerevisiae contributes to DNA double-strand break repair in a ubiquitin-independent manner

Nucleic Acids Research

Volumn 33, Issue 18, 2005, Pages 5878-5886

  Chen, S Shuhua ^a,b   Davies, Adelina A ^b   Sagan, Daniel ^a   Ulrich, Helle D ^a,b  

^a MAX PLANCK INSTITUTE FOR TERRESTRIAL MICROBIOLOGY   (Germany)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CYCLINE; KU ANTIGEN; MRE11 PROTEIN; PROTEIN RAD5P; PROTEIN XRS2; RAD50 PROTEIN; RAD52 PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SINGLE STRANDED DNA; UBIQUITIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; DEOXYRIBONUCLEASE; DNA BINDING PROTEIN; EXODEOXYRIBONUCLEASE; MRE11 PROTEIN, S CEREVISIAE; RAD5 PROTEIN, S CEREVISIAE; RAD50 PROTEIN, S CEREVISIAE; UBIQUITIN PROTEIN LIGASE; XRS2 PROTEIN, S CEREVISIAE;

ARTICLE; CONJUGATION; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; IN VIVO STUDY; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; CHEMISTRY; DNA DAMAGE; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

SACCHAROMYCES CEREVISIAE;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; DNA DAMAGE; DNA REPAIR; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EID: 27144448514     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki902     Document Type: Article

References (45)

1. Aylon,Y. and Kupiec,M. (2004) DSB repair: The yeast paradigm. DNA Repair, 3, 797-815.
2. Haber,J.E. (2000) Partners and pathways: Repairing a double-strand break. Trends Genet., 16, 259-264.
3. Downs,J.A. and Jackson,S.P. (2004) A means to a DNA end: The many roles of Ku. Nature Rev. Mol. Cell Biol., 5, 367-378.
4. Haber,J.E. (1999) DNA recombination: The replication connection. Trends Biochem. Sci., 24, 271-275.
5. D'Amours,D. and Jackson,S.P. (2002) The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling. Nature Rev. Mol. Cell Biol., 3, 317-327.
6. Hopfner,K.P., Putnam,C.D. and Tainer,J.A. (2002) DNA double-strand break repair from head to tail. Curr. Opin. Struct. Biol., 12, 115-122.
7. Krogh,B.O. and Symington,L.S. (2004) Recombination proteins in yeast. Annu. Rev. Genet., 38, 233-271.
8. Ulrich,H.D. (2002) Degradation or maintenance: Actions of the ubiquitin system on eukaryotic chromatin. Eukaryot. Cell, 1, 1-10.
9. Lawrence,C. (1994) The RAD6 DNA repair pathway in Saccharomyces cerevisiae: What does it do, and how does it do it? Bioessays, 16, 253-258.
10. Broomfield,S., Hryciw,T. and Xiao,W. (2001) DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae. Mutat. Res., 486, 167-184.
11. Hoege,C., Pfander,B., Moldovan,G.L., Pyrowolakis,G. and Jentsch,S. (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature, 419, 135-141.
12. Stelter,P. and Ulrich,H.D. (2003) Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature, 425, 188-191.
13. Kannouche,P.L., Wing,J. and Lehmann,A.R. (2004) Interaction of human DNA polymerase η with monoubiquitinated PCNA: A possible mechanism for the polymerase switch in response to DNA damage. Mol. Cell, 14, 491-500.
14. Watanabe,K., Tateishi,S., Kawasuji,M., Tsurimoto,T., Inoue,H. and Yamaizumi,M. (2004) Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J., 23, 3886-3896.
15. Ulrich,H.D. and Jentsch,S. (2000) Two RING finger proteins mediate cooperation between ubiquitiin-conjugating enzymes in DNA repair. EMBO J., 19, 3388-3397.
16. Friedl,A.A., Liefshitz,B., Steinlauf R. and Kupiec,M. (2001) Deletion of the SRS2 gene suppresses elevated recombination and DNA damage sensitivity in rad5 and rad18 mutants of Saccharomyces cerevisiae. Mutat. Res., 486, 137-146.
17. Liefshitz,B., Steinlauf,R., Friedl,A., Eckardt-Schupp,F. and Kupiec,M. (1998) Genetic interactions between mutants of the 'error-prone' repair group of Saccharomyces cerevisiae and their effect on recombination and mutagenesis. Mutat. Res., 407, 135-145.
18. Smith,S., Hwang,J.Y., Banerjee,S., Majeed,A., Gupta,A. and Myung,K. (2004) Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 101, 9039-9044.
19. Johnson,R.E., Henderson,S.T., Petes,T.D., Prakash,S., Bankmann,M. and Prakash,L. (1992) Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome. Mol. Cell. Biol., 12, 3807-3818.
20. Ahne,F., Jha,B. and Eckardt-Schupp,F. (1997) The RAD5 gene product is involved in the avoidance of non-homologous end joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae. Nucleic Acids Res., 25, 743-749.
21. Lewis,L.K., Westmoreland,J.W. and Resnick,M.A. (1999) Repair of endonuclease-induced double-strand breaks in Saccharomyces cerevisiae: essential role for genes associated with nonhomologous end-joining. Genetics, 152, 1513-1529.
22. Ulrich,H.D. (2003) Protein-protein interactions within an E2-RING finger complex. Implications for ubiquitin-dependent DNA damage repair. J. Biol. Chem., 278, 7051-7058.
23. Eisen,J.A., Sweder,K.S. and Hanawalt,P.C. (1995) Evolution of the SNF2 family of proteins: Subfamilies with distinct sequences and functions. Nucleic Acids Res., 23, 2715-2723.
24. Johnson,R.E., Prakash,S. and Prakash,L. (1994) Yeast DNA repair protein RAD5 that promotes instability of simple repetitive sequences is a DNA-dependent ATPase. J. Biol. Chem., 269, 28259-28262.
25. Barnes,G. and Rine,J. (1985) Regulated expression of endonuclease EcoRI in Saccharomyces cerevisiae: Nuclear entry and biological consequences. Proc. Natl Acad. Sci. USA, 82, 1354-1358.
26. Hecht,A, and Grunstein,M. (1999) Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction. Methods Enzymol., 304, 399-414.
27. Davies,G.P., Powell,L.M., Webb,J.L., Cooper,L.P. and Murray,N.E. (1998) EcoKI with an amino acid substitution in any one of seven DEAD-box motifs has impaired ATPase and endonuclease activities. Nucleic Acids Res., 26, 4828-4836.
28. Pause,A. and Sonenberg,N. (1992) Mutational analysis of a DEAD box RNA helicase: The mammalian translation initiation factor eIF-4A. EMBO J., 11, 2643-2654.
29. Richmond,E. and Peterson,C.L. (1996) Functional analysis of the DNA-stimulated ATPase domain of yeast SWI2/SNF2. Nucleic Acids Res., 24, 3685-3692.
30. Siede,W., Friedl,A.A., Dianova,I., Eckardt-Schupp,F. and Friedberg,E.C. (1996) The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics, 142, 91-102.
31. Ma,J.L., Kim,E.M., Haber,J.E. and Lee,S.E. (2003) Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol. Cell. Biol., 23, 8820-8828.
32. Boulton,S.J. and Jaekson,S.P. (1996) Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J., 15, 5093-5103.
33. Hegde,V. and Klein,H. (2000) Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast. Nucleic Acids Res., 28, 2779-2783.
34. Orlando,V. (2000) Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation. Trends Biochem. Sci., 25, 99-104.
35. Wolner,B., van Komen,S., Sung,P. and Peterson,C.L. (2003) Recruitment of the recombinational repair machinery to a DNA double-strand break in yeast. Mol. Cell, 12, 221-232.
36. Frank-Vaillant,M. and Marcand,S. (2002) Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. Mol. Cell, 10, 1189-1199.
37. 2/M arrest after DNA damage. Cell, 94, 399-409.
38. Bailly,V., Lauder,S., Prakash,S. and Prakash,L. (1997) Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J. Biol. Chem., 272, 23360-23365.
39. Costanzo,V., Robertson,K., Bibikova,M., Kim,E., Grieco,D., Gottesman,M., Carroll,D. and Gautier,J. (2001) Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol. Cell, 8, 137-147.
40. Franchitto,A. and Pichierri,P. (2004) Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery. Cell Cycle, 3, 1331-1339.
41. Singleton,M.R. and Wigley,D.B. (2002) Modularity and specialization in superfamily 1 and 2 helicases. J. Bacteriol., 184, 1819-1826.
42. Langst,G. and Becker,P.B. (2004) Nucleosome remodeling: One mechanism, many phenomena? Biochim. Biophys. Acta, 1677, 58-63.
43. Chilton,B.S. and Hewetson,A. (1998) Zinc finger proteins RUSH in where others fear to tread. Biol. Reprod., 58, 285-294.
44. Ramsey,K.L., Smith,J.J., Dasgupta,A., Magani,N., Grant,P. and Auble,D.T. (2004) The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repair. Mol. Cell. Biol., 24, 6362-6378.
45. Yu,S., Owen-Hughes,T., Friedberg,E.C., Waters,R. and Reed,S.H. (2004) The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair. DNA Repair, 3, 277-287.