Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 10, 2008, Pages 3933-3938

  Shangary, Sanjeev ^a   Qin, Dongguang ^a   McEachern, Donna ^a   Liu, Meilan ^a   Miller, Rebecca S ^a   Qiu, Su ^a   Nikolovska Coleska, Zaneta ^a   Ding, Ke ^a   Wang, Guoping ^a   Chen, Jianyong ^a   Bernard, Denzil ^a   Zhang, Jian ^a   Lu, Yipin ^a   Gu, Qingyang ^b   Shah, Rajal B ^c   Pienta, Kenneth J ^a,c   Ling, Xiaolan ^d   Kang, Sanmao ^d   Guo, Ming ^d   Sun, Yi ^b   Yang, Dajun ^d   Wang, Shaomeng ^a,b   more..

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d Ascenta Therapeutics   (United States)

Author keywords

Cancer therapy; MDM2 p53 protein protein interaction; Selective toxicity to tumors; Small molecule inhibitor

Indexed keywords

BETA ACTIN; BROXURIDINE; DOCETAXEL; GREEN FLUORESCENT PROTEIN; IRINOTECAN; LIPOCORTIN 5; MI 219; MI 61; MI 63; NUTLIN 3; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; ANTINEOPLASTIC AGENT; MDM2 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TUMOR XENOGRAFT; WILD TYPE; ANIMAL; BLOOD; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; METABOLISM; NEOPLASM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PROTEIN BINDING; TIME; TUMOR CELL LINE;

ANIMALIA;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MICE; MODELS, MOLECULAR; NEOPLASMS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 41649102468     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708917105     Document Type: Article

References (42)

1. Levine AJ (1997) Cell 88:323-331.
2. Vogelstein B, Lane D, Levine AJ (2000) Nature 408:307-310.
3. Vousden KH, Lu X (2002) Nat Rev Cancer 2:594-604.
4. Fridman JS, Lowe SW (2003) Oncogene 22:9030-9040.
5. Hainaut P, Hollstein M (2000) Adv Cancer Res 77:81-137.
6. Chene P (2003) Nat Rev Cancer 3:102-109.
7. Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, et al. (2004) Science 303:844-848.
8. Vassilev LT (2007) Trends Mol Med 13:23-31.
9. Wiman KG (2006) Cell Death Differ 13:921-926.
10. Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW (2007) Nature 445:656-660.
11. Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T (2007) Nature 445:661-665.
12. Martins CP, Brown-Swigart L, Evan GI (2006) Cell 127:1323-1334.
13. Sharpless NE, DePinho RA (2007) Nature 445:606-607.
14. Kastan MB (2007) Cell 128:837-840.
15. Feki A, Irminger-Finger I (2004) Crit Rev Oncol Hematol 52:103-116.
16. Freedman DA, Wu L, Levine AJ (1999) Cell Mol Life Sci 55:96-107.
17. Fakharzadeh SS, Rosenblum-Vos L, Murphy M, Hoffman EK, George DL (1993) Genomics 15:283-290.
18. Vassilev LT (2004) Cell Cycle 3:419-421.
19. Tovar C, Rosinski J, Filipovic Z, Higgins B, Kolinsky K, Hilton H, Zhao X, Vu BT, Qing W, Packman K, et al. (2006) Proc Natl Acad Sci USA 103:1888-1893.
20. Efeyan A, Ortega-Molina A, Velasco-Miguel S, Herranz D, Vassilev LT, Serrano M (2007) Cancer Res 67:7350-7357.
21. Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J (2006) J Biol Chem 281:33030-33035.
22. Chen L, Yin H, Farooqi B, Sebti S, Hamilton AD, Chen J (2005) Mol Cancer Ther 4:1019-1025.
23. Kojima K, Konopleva M, Samudio IJ, Shikami M, Cabreira-Hansen M, McQueen T, Ruvolo V, Tsao T, Zeng Z, Vassilev LT, Andreeff M (2005) Blood 106:3150-3159.
24. Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI (2006) Cancer Cell 10:501-514.
25. Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP (1996) Science 274:948-953.
26. Ding K, Lu Y, Nikolovska-Coleska Z, Qiu S, Ding Y, Gao W, Stuckey J, Krajewski K, Roller PP, Tomita Y, et al. (2005) J Am Chem Soc 127:10130-10131.
27. Ding K, Lu Y, Nikolovska-Coleska Z, Wang G, Qiu S, Shangary S, Gao W, Qin D, Stuckey J, Krajewski K, et al. (2006) J Med Chem 49:3432-3435.
28. Shvarts A, Steegenga WT, Riteco N, van Laar T, Dekker P, Bazuine M, van Ham RC, van der Houven van Oordt W, Hateboer G, van der Eb AJ, Jochemsen AG (1996) EMBO J 15:5349-5357.
29. Bottger V, Bottger A, Garcia-Echeverria C, Ramos YF, van der Eb AJ, Jochemsen AG, Lane DP (1999) Oncogene 18:189-199.
30. Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, et al. (2006) Nature 444:61-66.
31. el-Deiry WS (1998) Semin Cancer Biol 8:345-357.
32. Bouchet BP, de Fromentel CC, Puisieux A, Galmarini CM (2006) Crit Rev Oncol Hematol 58:190-207.
33. Maki CG, Huibregtse JM, Howley PM (1996) Cancer Res 56:2649-2654.
34. el-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, et al. (1994) Cancer Res 54:1169-1174.
35. Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B (1997) Mol Cell 1:3-11.
36. Patton JT, Mayo LD, Singhi AD, Gudkov AV, Stark GR, Jackson MW (2006) Cancer Res 66:3169-3176.
37. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T (1993) Nature 362:847-849.
38. Potten CS, Wilson JW, Booth C (1997) Stem Cells 15:82-93.
39. Rubin P, Casarett GW (1968) Cancer 22:767-778.
40. Mendrysa SM, McElwee MK, Michalowski J, O'Leary KA, Young KM, Perry ME (2003) Mol Cell Biol 23:462-472.
41. Brummelkamp TR, Bernards R, Agami R (2002) Science 296:550-553.
42. Saddler C, Ouillette P, Kujawski L, Shangary S, Talpaz M, Kaminski M, Erba H, Shedden K, Wang S, Malek SN (2008) Blood 111:1584-1593.