Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

Genes and Development

Volumn 27, Issue 10, 2013, Pages 1101-1114

  Inoue, Satoshi ^a   Hao, Zhenyue ^a   Elia, Andrew J ^a   Cescon, David ^a   Zhou, Lily ^a   Silvester, Jennifer ^a   Snow, Bryan ^a   Harris, Isaac S ^a   Sasaki, Masato ^a   Li, Wanda Y ^a   Itsumi, Momoe ^a   Yamamoto, Kazuo ^a   Ueda, Takeshi ^a   Dominguez Brauer, Carmen ^a   Gorrini, Chiara ^a   Christine Chio, Iok In ^a   Haight, Jillian ^a   You Ten, Annick ^a   McCracken, Susan ^a   Wakeham, Andrew ^a   Ghazarian, Danny ^b   Penn, Linda J Z ^a,c   Melino, Gerry ^d,e   Mak, Tak W ^a   more..

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d MEDICAL RESEARCH COUNCIL   (United Kingdom)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

c Myc; Huwe1; Miz1; Mule; p21; Ras

Indexed keywords

ARF BP1 UBIQUITIN LIGASE; HUWE1 UBIQUITIN LIGASE; MIZ1 PROTEIN; MULE UBIQUITIN LIGASE; PROTEIN P15; PROTEIN P21; RAS PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; KERATINOCYTE; MALE; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; SKIN CARCINOGENESIS; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

C-MYC; HUWE1; MIZ1; MULE; P21; RAS;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; FEMALE; GENES, RAS; KERATINOCYTES; MALE; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; ONCOGENE PROTEIN P21(RAS); PROTEIN INHIBITORS OF ACTIVATED STAT; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 84878154617     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.214577.113     Document Type: Article

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