CHFR-Associated Early G2/M Checkpoint Defects in Breast Cancer Cells

Molecular Carcinogenesis

Volumn 39, Issue 1, 2004, Pages 26-33

  Erson, Ayse E ^a   Petty, Elizabeth M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Breast cancer; Checkpoint; CHFR; G2 M, mitosis

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; NOCODAZOLE; PHOSPHOTRANSFERASE; POLO LIKE KINASE 1; PROTEIN CHFR; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANEUPLOIDY; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE G2 PHASE; CELL DIVISION; CHROMOSOME CONDENSATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

AZACITIDINE; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE PROTEINS; CPG ISLANDS; DNA METHYLATION; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOSIS; MITOTIC INDEX; NEOPLASM PROTEINS; TUMOR CELLS, CULTURED;

EID: 0347988069     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.10161     Document Type: Article

References (31)

1. Cahill DP, Lengauer C, Yu J, et al. Mutations of mitotic checkpoint genes in human cancers. Nature 1998;392:300-303.
2. Scolnick DM, Halazonetis TD. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 2000;406:430-435.
3. King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell 1994;79:563-571.
4. Murray AW, Kirschner MW. Cyclin synthesis drives the early embryonic cell cycle. Nature 1989;339:275-280.
5. Solomon MJ, Glotzer M, Lee TH, Philippe M, Kirschner MW. Cyclin activation of p34cdc2. Cell 1990;63:1013-1024.
6. Russell P, Nurse P. Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell 1987;49:559-567.
7. Draetta G, Piwnica-Worms H, Morrison D, Druker B, Roberts T, Beach D. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature 1988;336:738-744.
8. Featherstone C, Russell P. Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase. Nature 1991;349:808-811.
9. Kornbluth S, Sebastian B, Hunter T, Newport J. Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. Mol Biol Cell 1994;5:273-282.
10. Mueller PR, Coleman TR, Kumagai A, Dunphy WG. Myt1: A membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 1995;270:86-90.
11. Russell P, Nurse P. cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell 1986;45:145-153.
12. Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 1991;67:197-211.
13. Kumagai A, Dunphy WG. Thecdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. Cell 1991;64:903-914.
14. Osmani AH, McGuire SL, Osmani SA. Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans. Cell 1991;67:283-291.
15. 2 to M transition. J Cell Biol 2002;156:249-259.
16. Mizuno K, Osada H, Koniski H, et al. Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers. Oncogene 2002;21:2328-2333.
17. Shibata Y, Haruki N, Kuwabara Y, et al. Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer. Carcinogenesis 2002;23:1695-1699.
18. Corn PG, Summers MK, Fogt F, et al. Frequent hypermethylation of the 5′ CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis 2003;24:47-51.
19. Toyota M, Sasaki Y, Satoh A, et al. Epigenetic inactivation of CHFR in human tumors. Proc Natl Acad Sci USA 2003;24:7818-7823.
20. Kramer A, Ho AD. Centrosome aberrations and cancer. Onkologie 2001;24:538-544.
21. Kramer A, Neben K, Ho AD. Centrosome replication, genomic instability, and cancer. Leukemia 2002;16:767-775.
22. Brinkley BR. Managing the centrosome numbers game: From chaos to stability in cancer cell division. Trends Cell Biol 2001;11:18-21.
23. Ethier SP, Mahacek ML, Gullick WJ, Frank TS, Weber BL. Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media. Cancer Res 1993;53:627-635.
24. Ethier SP, Kokeny KE, Ridings JW, Dilts CA. ErbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line. Cancer Res 1996;56:899-907.
25. Ignatoski KM, Ethier SP. Constitutive activation of pp125fak in newly isolated human breast cancer cell lines. Breast Cancer Res Treat 1999;54:173-182.
26. www.cancer.med.umich.edu/breast_cell/clines/clines.html
27. Erson AE, Niell BL, DeMers SK, Rouillard JM, Hanash SM, Petty EM. Overexpressed genes/ESTs and characterization of distinct amplicons on 17q23 in breast cancer cells. Neoplasia 2001;3:521-526.
28. Feinberg AP, Fogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1983;132:6-13.
29. Ganguly A, Rock MJ, Prockop DJ. Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: Evidence for solvent-induced bends in DNA heteroduplexes. Proc Natl Acad Sci USA 1993;90:10325-10329.
30. Percy MJ, Myrie KA, Neeley CK, Azim JN, Ethier SP, Petty EM. Expression and mutational analyses of the human MAD2L1 gene in breast cancer cells. Genes Chromosomes Cancer 2000;29:356-362.
31. Chaturvedi P, Sudakin V, Bobiak ML, et al. Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. Cancer Res 2002;62:1797-17801.