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Volumn 32, Issue 39, 2013, Pages 4721-4726

The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity

Author keywords

apoptosis; p73; protein ubiquitylation

Indexed keywords

CULLIN 4A; DNA BINDING PROTEIN; DNA BINDING PROTEIN 1; GLUTATHIONE TRANSFERASE; HISTONE H2AX; LIGASE; PROTEIN P53; PROTEIN P73; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

EID: 84884902595     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.463     Document Type: Article
Times cited : (26)

References (30)
  • 1
    • 0035930582 scopus 로고    scopus 로고
    • UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation
    • Chen X, Zhang Y, Douglas L, Zhou P. UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation. J Biol Chem 2001; 276: 4817548182.
    • (2001) J Biol Chem , vol.276 , pp. 4817548182
    • Chen, X.1    Zhang, Y.2    Douglas, L.3    Zhou, P.4
  • 2
    • 65549090186 scopus 로고    scopus 로고
    • DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress
    • Leung-Pineda V, Huh J, Piwnica-Worms H. DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res 2009; 69: 26302637.
    • (2009) Cancer Res , vol.69 , pp. 26302637
    • Leung-Pineda, V.1    Huh, J.2    Piwnica-Worms, H.3
  • 3
    • 0037509859 scopus 로고    scopus 로고
    • The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
    • Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 2003; 113: 357367.
    • (2003) Cell , vol.113 , pp. 357367
    • Groisman, R.1    Polanowska, J.2    Kuraoka, I.3    Sawada, J.4    Saijo, M.5    Drapkin, R.6
  • 4
    • 33749535905 scopus 로고    scopus 로고
    • Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery
    • Angers S, Li T, Yi X, MacCoss MJ, Moon RT, Zheng N. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 2006; 443: 590593.
    • (2006) Nature , vol.443 , pp. 590593
    • Angers, S.1    Li, T.2    Yi, X.3    MacCoss, M.J.4    Moon, R.T.5    Zheng, N.6
  • 5
    • 33750509178 scopus 로고    scopus 로고
    • CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
    • Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol 2006; 8: 12771283.
    • (2006) Nat Cell Biol , vol.8 , pp. 12771283
    • Higa, L.A.1    Wu, M.2    Ye, T.3    Kobayashi, R.4    Sun, H.5    Zhang, H.6
  • 6
    • 34250318465 scopus 로고    scopus 로고
    • DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
    • Lee J, Zhou P. DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase. Mol Cell 2007; 26: 775780.
    • (2007) Mol Cell , vol.26 , pp. 775780
    • Lee, J.1    Zhou, P.2
  • 7
    • 30344460705 scopus 로고    scopus 로고
    • Structure of DDB1 in complex with a paramyxovirus v protein: Viral hijack of a propeller cluster in ubiquitin ligase
    • Li T, Chen X, Garbutt KC, Zhou P, Zheng N. Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase. Cell 2006; 124: 105117.
    • (2006) Cell , vol.124 , pp. 105117
    • Li, T.1    Chen, X.2    Garbutt, K.C.3    Zhou, P.4    Zheng, N.5
  • 8
    • 5444274523 scopus 로고    scopus 로고
    • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage
    • Hu J, McCall CM, Ohta T, Xiong Y. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol 2004; 6: 10031009.
    • (2004) Nat Cell Biol , vol.6 , pp. 10031009
    • Hu, J.1    McCall, C.M.2    Ohta, T.3    Xiong, Y.4
  • 10
    • 57049133181 scopus 로고    scopus 로고
    • CDK Inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation
    • Nishitani H, Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T. CDK Inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. J Biol Chem 2008; 283: 2904529052.
    • (2008) J Biol Chem , vol.283 , pp. 2904529052
    • Nishitani, H.1    Shiomi, Y.2    Iida, H.3    Michishita, M.4    Takami, T.5    Tsurimoto, T.6
  • 11
    • 65649105790 scopus 로고    scopus 로고
    • CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis
    • Liu L, Lee S, Zhang J, Peters SB, Hannah J, Zhang Y et al. CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell 2009; 34: 451460.
    • (2009) Mol Cell , vol.34 , pp. 451460
    • Liu, L.1    Lee, S.2    Zhang, J.3    Peters, S.B.4    Hannah, J.5    Zhang, Y.6
  • 12
    • 77953934816 scopus 로고    scopus 로고
    • Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
    • Choi SH, Wright JB, Gerber SA, Cole MD. Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. Genes Dev 2010; 24: 12361241.
    • (2010) Genes Dev , vol.24 , pp. 12361241
    • Choi, S.H.1    Wright, J.B.2    Gerber, S.A.3    Cole, M.D.4
  • 13
    • 63049106823 scopus 로고    scopus 로고
    • Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases
    • Hannah J, Zhou P. Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases. DNA Repair (Amst) 2009; 8: 536543.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 536543
    • Hannah, J.1    Zhou, P.2
  • 14
    • 33751331884 scopus 로고    scopus 로고
    • Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells
    • Cang Y, Zhang J, Nicholas SA, Bastien J, Li B, Zhou P et al. Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell 2006; 127: 929940.
    • (2006) Cell , vol.127 , pp. 929940
    • Cang, Y.1    Zhang, J.2    Nicholas, S.A.3    Bastien, J.4    Li, B.5    Zhou, P.6
  • 16
    • 0031564954 scopus 로고    scopus 로고
    • P73 is a simian [correction of human] p53-related protein that can induce apoptosis
    • Jost CA, Marin MC, Kaelin Jr WG. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature 1997; 389: 191194.
    • (1997) Nature , vol.389 , pp. 191194
    • Jost, C.A.1    Marin, M.C.2    Kaelin Jr., W.G.3
  • 17
    • 1542379662 scopus 로고    scopus 로고
    • P73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
    • Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M et al. p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem 2004; 279: 80768083.
    • (2004) J Biol Chem , vol.279 , pp. 80768083
    • Melino, G.1    Bernassola, F.2    Ranalli, M.3    Yee, K.4    Zong, W.X.5    Corazzari, M.6
  • 18
    • 17444390129 scopus 로고    scopus 로고
    • Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family
    • Flores ER, Sengupta S, Miller JB, Newman JJ, Bronson R, Crowley D et al. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell 2005; 7: 363373.
    • (2005) Cancer Cell , vol.7 , pp. 363373
    • Flores, E.R.1    Sengupta, S.2    Miller, J.B.3    Newman, J.J.4    Bronson, R.5    Crowley, D.6
  • 19
    • 53549134949 scopus 로고    scopus 로고
    • TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
    • Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC et al. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 2008; 22: 26772691.
    • (2008) Genes Dev , vol.22 , pp. 26772691
    • Tomasini, R.1    Tsuchihara, K.2    Wilhelm, M.3    Fujitani, M.4    Rufini, A.5    Cheung, C.C.6
  • 21
    • 69849083542 scopus 로고    scopus 로고
    • The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
    • Peschiaroli A, Scialpi F, Bernassola F, Pagano M, Melino G. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene 2009; 28: 31573166.
    • (2009) Oncogene , vol.28 , pp. 31573166
    • Peschiaroli, A.1    Scialpi, F.2    Bernassola, F.3    Pagano, M.4    Melino, G.5
  • 22
    • 8544264616 scopus 로고    scopus 로고
    • Cul4A physically associates with MDM2 and participates in the proteolysis of p53
    • Nag A, Bagchi S, Raychaudhuri P. Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res 2004; 64: 81528155.
    • (2004) Cancer Res , vol.64 , pp. 81528155
    • Nag, A.1    Bagchi, S.2    Raychaudhuri, P.3
  • 24
    • 0035979738 scopus 로고    scopus 로고
    • Regulation of transcriptional activation domain function by ubiquitin
    • Salghetti SE, Caudy AA, Chenoweth JG, Tansey WP. Regulation of transcriptional activation domain function by ubiquitin. Science 2001; 293: 16511653.
    • (2001) Science , vol.293 , pp. 16511653
    • Salghetti, S.E.1    Caudy, A.A.2    Chenoweth, J.G.3    Tansey, W.P.4
  • 25
    • 0242708771 scopus 로고    scopus 로고
    • Enhancement of CIITA transcriptional function by ubiquitin
    • Greer SF, Zika E, Conti B, Zhu XS, Ting JP. Enhancement of CIITA transcriptional function by ubiquitin. Nat Immunol 2003; 4: 10741082.
    • (2003) Nat Immunol , vol.4 , pp. 10741082
    • Greer, S.F.1    Zika, E.2    Conti, B.3    Zhu, X.S.4    Ting, J.P.5
  • 26
    • 77955321215 scopus 로고    scopus 로고
    • NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63-gamma-dependent growth arrest
    • Hershkovitz Rokah O, Shpilberg O, Granot G. NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63-gamma-dependent growth arrest. PLoS One 2010; 5: e11401.
    • (2010) PLoS One , vol.5
    • Hershkovitz, R.O.1    Shpilberg, O.2    Granot, G.3
  • 27
    • 0032529631 scopus 로고    scopus 로고
    • The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers
    • Chen LC, Manjeshwar S, Lu Y, Moore D, Ljung BM, Kuo L et al. The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers. Cancer Res 1998; 58: 36773683.
    • (1998) Cancer Res , vol.58 , pp. 36773683
    • Chen, L.C.1    Manjeshwar, S.2    Lu, Y.3    Moore, D.4    Ljung, B.M.5    Kuo, L.6
  • 28
    • 33747823839 scopus 로고    scopus 로고
    • L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes
    • Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T et al. L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. Cell Cycle 2006; 5: 17191729.
    • (2006) Cell Cycle , vol.5 , pp. 17191729
    • Banks, D.1    Wu, M.2    Higa, L.A.3    Gavrilova, N.4    Quan, J.5    Ye, T.6


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