USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis

Cell Death and Disease

Volumn 3, Issue 11, 2012, Pages

  Santin, I ^a   Moore, F ^a   Grieco, F A ^a   Marchetti, P ^b   Brancolini, C ^c   Eizirik, D L ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF UDINE   (Italy)

Author keywords

Apoptosis; Beta cells; Inflammation; Type 1 diabetes; Type I IFNs; USP18

Indexed keywords

BIM PROTEIN; DOUBLE STRANDED RNA; INTERFERON; PEPTIDASE; PROTEIN BCL 2; PROTEINASE; PUMA PROTEIN; STAT PROTEIN; UBIQUITIN SPECIFIC PEPTIDASE 18; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 5 GENE; MOLECULAR INTERACTION; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREATITIS; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT;

AGED; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; ENDOPEPTIDASES; FEMALE; GENE REGULATORY NETWORKS; HUMANS; INSULIN-SECRETING CELLS; INTERFERON-ALPHA; MALE; MIDDLE AGED; RATS; RATS, WISTAR; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR;

EID: 84870508724     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.158     Document Type: Article

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