The ubiquitin ligase COP1 is a critical negative regulator of p53

Nature

Volumn 429, Issue 6987, 2004, Pages 86-92

  Dornan, David ^a   Wertz, Ingrid ^a,b   Shimizu, Harumi ^a   Arnott, David ^a   Frantz, Gretchen D ^a   Dowd, Patrick ^a   O'Rourke, Karen ^a   Koeppen, Hartmut ^a   Dixit, Vishva M ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GENES; NATURAL SCIENCES; PLANTS (BOTANY); PROTEINS; RNA;

CELL CYCLES; PHOTOMORPHOGENESIS; PLANT DEVELOPMENT;

ENZYME KINETICS;

GLUTATHIONE TRANSFERASE; PROTEIN; PROTEIN MDM2; PROTEIN P53; PROTEIN PIRH2; RECOMBINANT PROTEIN; RING FINGER PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE COP1; UNCLASSIFIED DRUG; CARRIER PROTEIN; CYSTEINE PROTEINASE; MDM2 PROTEIN, HUMAN; MULTIENZYME COMPLEX; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEASOME; RFWD2 PROTEIN, HUMAN; UBIQUITIN;

MEDICINE;

APOPTOSIS; ARABIDOPSIS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOPRECIPITATION; MORPHOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT DEVELOPMENT; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; AMINO ACID SEQUENCE; CELL CYCLE G1 PHASE; CELL LINE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROMOTER REGION; PROTEIN BINDING; TUMOR CELL LINE;

ARABIDOPSIS; MAMMALIA;

AMINO ACID SEQUENCE; APOPTOSIS; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; G1 PHASE; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 2342447397     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02514     Document Type: Article

References (24)

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