NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1

Cell Death and Differentiation

Volumn 19, Issue 9, 2012, Pages 1424-1434

  Craxton, A ^a   Butterworth, M ^a   Harper, N ^a   Fairall, L ^a   Schwabe, J ^a   Ciechanover, A ^b   Cohen, G M ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

apoptosis; MCL 1; NOXA; proteasome; ubiquitin

Indexed keywords

MUTANT PROTEIN; PROTEASOME; PROTEIN MCL 1; PROTEIN NOXA; UBIQUITIN;

ARTICLE; CELL DEATH; CONTROLLED STUDY; HALF LIFE TIME; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

APOPTOSIS; HELA CELLS; HUMANS; MUTATION, MISSENSE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; UBIQUITIN; UBIQUITINATION;

EID: 84865200787     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.16     Document Type: Article

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