Receptor tyrosine kinase signaling: Regulating neural crest development one phosphate at a time

Current Topics in Developmental Biology

Volumn 111, Issue , 2015, Pages 135-182

  Fantauzzo, Katherine A ^a   Soriano, Philippe ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Allelic series; Biosensors; Growth factor; Mass spectrometry; Mouse; Neural crest; Phospho antibodies; Proteomics; Receptor tyrosine kinase

Indexed keywords

PHOSPHATE; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE;

ANIMAL; CYTOLOGY; EMBRYOLOGY; GENETICS; HUMAN; MAMMAL; METABOLISM; MOUSE; MULTIGENE FAMILY; NEURAL CREST; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAMMALS; MICE; MULTIGENE FAMILY; NEURAL CREST; PHOSPHATES; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 84922855902     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.ctdb.2014.11.005     Document Type: Chapter

References (271)

1. Abu-Issa R., Smyth G., Smoak I., Yamamura K., Meyers E.N. Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development 2002, 129:4613-4625.
2. Adams R.H., Diella F., Hennig S., Helmbacher F., Deutsch U., Klein R. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell 2001, 104:57-69.
3. Afzal A.R., Rajab A., Fenske C.D., Oldridge M., Elanko N., Ternes-Pereira E., et al. Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nature Genetics 2000, 25:419-422.
4. Agosti V., Corbacioglu S., Ehlers I., Waskow C., Sommer G., Berrozpe G., et al. Critical role of Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development. Journal of Experimental Medicine 2004, 199:867-878.
5. Ahmad Y., Lamond A.I. A perspective on proteomics in cell biology. Trends in Cell Biology 2014, 24:257-264.
6. Alessi D.R., Caudwell F.B., Andjelkovic M., Hemmings B.A., Cohen P. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Letters 1996, 399:333-338.
7. Al-Shawi R., Ashton S.V., Underwood C., Simons J.P. Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Development Genes and Evolution 2001, 211:161-171.
8. Andermarcher E., Surani M.A., Gherardi E. Co-expression of the HGF/SF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis. Developmental Genetics 1996, 18:254-266.
9. Anderson D.M., Williams D.E., Tushinski R., Gimpel S., Eisenman J., Cannizzaro L.A., et al. Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24. Cell Growth & Differentiation 1991, 2:373-378.
10. Asai N., Fukuda T., Wu Z., Enomoto A., Pachnis V., Takahashi M., et al. Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development 2006, 133:4507-4516.
11. Avivi A., Yayon A., Givol D. A novel form of FGF receptor-3 using an alternative exon in the immunoglobulin domain III. FEBS Letters 1993, 330:249-252.
12. Bajaj M., Waterfield M.D., Schlessinger J., Taylor W.R., Blundell T. On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors. Biochimica et Biophysica Acta 1987, 916:220-226.
13. Baloh R.H., Tansey M.G., Lampe P.A., Fahrner T.J., Enomoto H., Simburger K.S., et al. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signaling through the GFRalpha3-RET receptor complex. Neuron 1998, 21:1291-1302.
14. Banerjee S., Gordon L., Donn T.M., Berti C., Moens C.B., Burden S.J., et al. A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration. Development 2011, 138:3287-3296.
15. Benito-Gutiérrez E., Garcia-Fernàndez J., Comella J.X. Origin and evolution of the Trk family of neurotrophic receptors. Molecular and Cellular Neuroscience 2006, 31:179-192.
16. Bennett D. Developmental analysis of a mutation with pleiotropic effects in the mouse. Journal of Morphology 1956, 98:199-233.
17. Bladt F., Riethmacher D., Isenmann S., Aguzzi A., Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 1995, 376:768-771.
18. Bolande R.P. The neurocristopathies: A unifying concept of disease arising in neural crest maldevelopment. Human Pathology 1974, 5:409-429.
19. Bolande R.P. Neurocristopathy: Its growth and development in 20 years. Pediatric Pathology & Laboratory Medicine 1997, 17:1-25.
20. Boström H., Willetts K., Pekny M., Levéen P., Lindahl P., Hedstrand H., et al. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 1996, 85:863-873.
21. Bottaro D.P., Rubin J.S., Faletto D.L., Chan A.M., Kmiecik T.E., Vande Woude G.F., et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991, 251:802-804.
22. Brewis I.A., Brennan P. Proteomics technologies for the global identification and quantification of proteins. Advances in Protein Chemistry and Structural Biology 2010, 80:1-44.
23. Britsch S., Li L., Kirchhoff S., Theuring F., Brinkmann V., Birchmeier C., et al. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes & Development 1998, 12:1825-1836.
24. Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994, 369:756-758.
25. Brückner K., Pasquale E.B., Klein R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science 1997, 275:1640-1643.
26. Buchdunger E., Zimmermann J., Mett H., Meyer T., Müller M., Druker B.J., et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Research 1996, 56:100-104.
27. Buj-Bello A., Adu J., Piñón L.G., Horton A., Thompson J., Rosenthal A., et al. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 1997, 387:721-724.
28. Bush J.O., Soriano P. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes & Development 2009, 23:1586-1599.
29. Bush J.O., Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes & Development 2010, 24:2068-2080.
30. Cable J., Jackson I.J., Steel K.P. Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse. Mechanisms of Development 1995, 50:139-150.
31. Chabot B., Stephenson D.A., Chapman V.M., Besmer P., Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 1988, 335:88-89.
32. Chan R., Hardy W.R., Dankort D., Laing M.A., Muller W.J. Modulation of Erbb2 signaling during development: A threshold level of Erbb2 signaling is required for development. Development 2004, 131:5551-5560.
33. Chan R., Hardy W.R., Laing M.A., Hardy S.E., Muller W.J. The catalytic activity of the ErbB-2 receptor tyrosine kinase is essential for embryonic development. Molecular and Cellular Biology 2002, 22:1073-1078.
34. Chen B., Bronson R.T., Klaman L.D., Hampton T.G., Wang J.F., Green P.J., et al. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nature Genetics 2000, 24:296-299.
35. Chen Y., Moon A.M., Gaufo G.O. Influence of mesodermal Fgf8 on the differentiation of neural crest-derived postganglionic neurons. Developmental Biology 2012, 361:125-136.
36. Citri A., Skaria K.B., Yarden Y. The deaf and the dumb: The biology of ErbB-2 and ErbB-3. Experimental Cell Research 2003, 284:54-65.
37. Copeland N.G., Gilbert D.J., Cho B.C., Donovan P.J., Jenkins N.A., Cosman D., et al. Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles. Cell 1990, 63:175-183.
38. Corson L.B., Yamanaka Y., Lai K.M., Rossant J. Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 2003, 130:4527-4537.
39. Danielian P.S., Muccino D., Rowitch D.H., Michael S.K., McMahon A.P. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Current Biology 1998, 8:1323-1326.
40. Davis S., Gale N.W., Aldrich T.H., Maisonpierre P.C., Lhotak V., Pawson T., et al. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 1994, 266:816-819.
41. Davy A., Aubin J., Soriano P. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes & Development 2004, 18:572-583.
42. Davy A., Bush J.O., Soriano P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biology 2006, 4:e315.
43. Davy A., Soriano P. Ephrin signaling in vivo: Look both ways. Developmental Dynamics 2005, 232:1-10.
44. Davy A., Soriano P. Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development. Developmental Biology 2007, 304:182-193.
45. DeChiara T.M., Bowen D.C., Valenzuela D.M., Simmons M.V., Poueymirou W.T., Thomas S., et al. The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell 1996, 85:501-512.
46. DeChiara T.M., Kimble R.B., Poueymirou W.T., Rojas J., Masiakowski P., Valenzuela D.M., et al. Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nature Genetics 2000, 24:271-274.
47. Delmas V., Martinozzi S., Bourgeois Y., Holzenberger M., Larue L. Cre-mediated recombination in the skin melanocyte lineage. Genesis 2003, 36:73-80.
48. De Moerlooze L., Spencer-Dene B., Revest J.-M., Hajihosseini M., Rosewell I., Dickson C. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signaling during mouse organogenesis. Development 2000, 127:483-492.
49. Deng C.-X., Wynshaw-Boris A., Shen M.M., Daugherty C., Ornitz D.M., Leder P. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes & Development 1994, 8:3045-3057.
50. De Vries L., Finana F., Cachoux F., Vacher B., Sokoloff P., Cussac D. Cellular BRET assay suggests a conformational rearrangement of preformed TrkB/Shc complexes following BDNF-dependent activation. Cellular Signalling 2010, 22:158-165.
51. Ding H., Wu X., Boström H., Kim I., Wong N., Tsoi B., et al. A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nature Genetics 2004, 36:1111-1116.
52. Ding H., Wu X., Kim I., Tam P.P., Koh G.Y., Nagy A. The mouse Pdgfc gene: Dynamic expression in embryonic tissues during organogenesis. Mechanisms of Development 2000, 96:209-213.
53. Dodé C., Levilliers J., Dupont J.M., De Paepe A., Le DÛ N., Soussi-Yanicostas N., et al. Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome. Nature Genetics 2003, 33:463-465.
54. Druker B.J., Mamon B.S., Roberts T.M. Oncogenes, growth factors, and signal transduction. The New England Journal of Medicine 1989, 321:1383-1391.
55. Dunn L.C. Studies on spotting patterns: II. Genetic analysis of variegated spotting in the house mouse. Genetics 1937, 22:43-64.
56. Edery P., Lyonnet S., Mulligan L.M., Pelet A., Dow E., Abel L., et al. Mutations of the RET proto-oncogene in Hirschsprung's disease. Nature 1994, 367:378-380.
57. Eketjäll S., Ibáñez C.F. Functional characterization of mutations in the GDNF gene of patients with Hirschsprung disease. Human Molecular Genetics 2002, 11:325-329.
58. Ekman S., Thuresson E.R., Heldin C.H., Rönnstrand L. Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding. Oncogene 1999, 18:2481-2488.
59. Enokido Y., de Sauvage F., Hongo J.A., Ninkina N., Rosenthal A., Buchman V.L. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Current Biology 1998, 8:1019-1022.
60. Erickson S.L., O'Shea K.S., Ghaboosi N., Loverro L., Frantz G., Bauer M., et al. ErbB3 is required for normal cerebellar and cardiac development: A comparison with ErbB2- and heregulin-deficient mice. Development 1997, 124:4999-5011.
61. Eswarakumar V.P., Monsonego-Ornan E., Pines M., Antonopoulou I., Morriss-Kay G.M., Lonai P. The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development 2002, 129:3783-3793.
62. Etchevers H.C., Amiel J., Lyonnet S. Molecular basis of human neurocristopathies. Advances in Experimental Medicine and Biology 2006, 589:213-234.
63. Falardeau J., Chung W.C., Beenken A., Raivio T., Plummer L., Sidis Y., et al. Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. Journal of Clinical Investigation 2008, 118:2822-2831.
64. Fantauzzo K.A., Soriano P. PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. Genes & Development 2014, 28:1005-1017.
65. Fernández R.M., Sánchez-Mejías A., Mena M.D., Ruiz-Ferrer M., López-Alonso M., Antiñolo G., et al. A novel point variant in NTRK3, R645C, suggests a role for this gene in the pathogenesis of Hirschsprung disease. Annals of Human Genetics 2009, 73:19-25.
66. Foster K.E., Gordon J., Cardenas K., Veiga-Fernandes H., Makinen T., Grigorieva E., et al. EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:13414-13419.
67. Frank D.U., Fotheringham L.K., Brewer J.A., Muglia L.J., Tristani-Firouzi M., Capecchi M.R., et al. An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development 2002, 129:4591-4603.
68. Gale N.W., Holland S.J., Valenzuela D.M., Flenniken A., Pan L., Ryan T.E., et al. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron 1996, 17:9-19.
69. Garcia-Osta A., Tsokas P., Pollonini G., Landau E.M., Blitzer R., Alberini C.M. MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation. Journal of Neuroscience 2006, 26:7919-7932.
70. García-Suárez O., Germanà A., Hannestad J., Ciriaco E., Laurà R., Naves J., et al. TrkA is necessary for the normal development of the murine thymus. Journal of Neuroimmunology 2000, 108:11-21.
71. Gassmann M., Casagranda F., Orioli D., Simon H., Lai C., Klein R., et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 1995, 378:390-394.
72. Gautam M., Noakes P.G., Moscoso L., Rupp F., Scheller R.H., Merlie J.P., et al. Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell 1996, 85:525-535.
73. Geissler E.N., McFarland E.C., Russell E.S. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: A description of ten new W alleles. Genetics 1981, 97:337-361.
74. Geissler E.N., Ryan M.A., Housman D.E. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 1988, 55:185-192.
75. Glass D.J., Bowen D.C., Stitt T.N., Radziejewski C., Bruno J., Ryan T.E., et al. Agrin acts via a MuSK receptor complex. Cell 1996, 85:513-523.
76. Glenney J.R., Zokas L., Kamps M.P. Monoclonal antibodies to phosphotyrosine. Journal of Immunological Methods 1988, 109:277-285.
77. Golding J.P., Trainor P., Krumlauf R., Gassmann M. Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4. Nature Cell Biology 2000, 2:103-109.
78. Goto A., Sumiyama K., Kamioka Y., Nakasyo E., Ito K., Iwasaki M., et al. GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1. Journal of Neuroscience 2013, 33:4901-4912.
79. Graveel C.R., Tolbert D., Vande Woude G.F. MET: A critical player in tumorigenesis and therapeutic target. Cold Spring Harbor Perspectives in Biology 2013, 5:a009209.
80. Gruneberg H. Inherited macrocytic anaemias in the house mouse. II. Dominance relationships. Journal of Genetics 1942, 43:285-293.
81. Gu C., Rodriguez E.R., Reimert D.V., Shu T., Fritzsch B., Richards L.J., et al. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Developmental Cell 2003, 5:45-57.
82. Guris D.L., Fantes J., Tara D., Druker B.J., Imamoto A. Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome. Nature Genetics 2001, 27:293-298.
83. Guy P.M., Platko J.V., Cantley L.C., Cerione R.A., Carraway K.L. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:8132-8136.
84. Hamilton T.G., Klinghoffer R.A., Corrin P.D., Soriano P. Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. Molecular and Cellular Biology 2003, 23:4013-4025.
85. He F., Soriano P. A critical role for PDGFRα signaling in medial nasal process development. PLoS Genetics 2013, 9:e1003851.
86. He Z., Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin II. Cell 1997, 90:739-751.
87. He F., Xiong W., Yu X., Espinoza-Lewis R., Liu C., Gu S., et al. Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development 2008, 135:3871-3879.
88. Hébert J.M., McConnell S.K. Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Developmental Biology 2000, 222:296-306.
89. Hellmich H.L., Kos L., Cho E.S., Mahon K.A., Zimmer A. Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mechanisms of Development 1996, 54:95-105.
90. Heuckeroth R.O., Lampe P.A., Johnson E.M., Milbrandt J. Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Developmental Biology 1998, 200:116-129.
91. Heuzé Y., Singh N., Basilico C., Jabs E.W., Holmes G., Richtsmeier J.T. Morphological comparison of the craniofacial phenotypes of mouse models expressing the Apert FGFR2 S252W mutation in neural crest- or mesoderm-derived tissues. Bone 2014, 63:101-109.
92. Hirai H., Maru Y., Hagiwara K., Nishida J., Takaku F. A novel putative tyrosine kinase receptor encoded by the eph gene. Science 1987, 238:1717-1720.
93. Hoch R.V., Soriano P. Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 2006, 133:663-673.
94. Holland S.J., Gale N.W., Mbamalu G., Yancopoulos G.D., Henkemeyer M., Pawson T. Bidirectional signaling through the EPH-family receptor Nuk and its transmembrane ligands. Nature 1996, 383:722-725.
95. Holmes G., Basilico C. Mesodermal expression of Fgfr2S252W is necessary and sufficient to induce craniosynostosis in a mouse model of Apert syndrome. Developmental Biology 2012, 368:283-293.
96. Huang E., Nocka K., Beier D.R., Chu T.-Y., Buck J., Lahm H.-W., et al. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand for the c-kit receptor, the gene product of the W locus. Cell 1990, 63:225-233.
97. Indo Y., Tsuruta M., Hayashida Y., Karim M.A., Ohta K., Kawano T., et al. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nature Genetics 1996, 13:485-488.
98. Iwamoto T., Taniguchi M., Asai N., Ohkusu K., Nakashima I., Takahashi M. cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily. Oncogene 1993, 8:1087-1091.
99. Jain S., Knoten A., Hoshi M., Wang H., Vohra B., Heuckeroth R.O., et al. Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. Journal of Clinical Investigation 2010, 120:778-790.
100. Jijiwa M., Fukuda T., Kawai K., Nakamura A., Kurokawa K., Murakumo Y., et al. A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia. Molecular and Cellular Biology 2004, 24:8026-8036.
101. Jing L., Lefebvre J.L., Gordon L.R., Granato M. Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor. Neuron 2009, 61:721-733.
102. Jing S., Wen D., Yu Y., Hoist P.L., Luo Y., Fang M., et al. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell 1996, 85:1113-1124.
103. Johnson D.E., Lu J., Chen H., Werner S., Williams L.T. The human fibroblast growth factor receptor genes: A common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Molecular and Cellular Biology 1991, 11:4627-4634.
104. Jung J.W., Shin W.S., Song J., Lee S.T. Cloning and characterization of the full-length mouse Ptk7 cDNA encoding a defective receptor protein tyrosine kinase. Gene 2004, 328:75-84.
105. Kamioka Y., Sumiyama K., Mizuno R., Sakai Y., Hirata E., Kiyokawa E., et al. Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors. Cell Structure and Function 2012, 37:65-73.
106. Kaplan D.R., Hempstead B.L., Martin-Zanca D., Chao M.V., Parada L.F. The trk proto-oncogene product: A signal transducing receptor for nerve growth factor. Science 1991, 252:554-558.
107. Kawakami A., Kitsukawa T., Takagi S., Fujisawa H. Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system. Journal of Neurobiology 1996, 29:1-17.
108. Kelleher F.C., O'Sullivan H., Smyth E., McDermott R., Viterbo A. Fibroblast growth factor receptors, developmental corruption and malignant disease. Carcinogenesis 2013, 34:2198-2205.
109. Kim N., Stiegler A.L., Cameron T.O., Hallock P.T., Gomez A.M., Huang J.H., et al. Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell 2008, 135(2):334-342.
110. Kimura Y., Jones N., Klüppel M., Hirashima M., Tachibana K., Cohn J.B., et al. Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:6015-6020.
111. Klapper L.N., Glathe S., Vaisman N., Hynes N.E., Andrews G.C., Sela M., et al. The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:4995-5000.
112. Klein R., Jing S.Q., Nanduri V., O'Rourke E., Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 1991, 65:189-197.
113. Klein R., Martin-Zanca D., Barbacid M., Parada L.F. Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system. Development 1990, 109:845-850.
114. Klein R., Nanduri V., Jing S.A., Lamballe F., Tapley P., Bryant S., et al. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 1991, 66:395-403.
115. Klein R.D., Sherman D., Ho W.H., Stone D., Bennett G.L., Moffat B., et al. A GPI-liked protein that interacts with Ret to form a candidate neurturin receptor. Nature 1997, 387:717-721.
116. Klein R., Silos-Santiago I., Smeyne R.J., Lira S.A., Brambilla R., Bryant S., et al. Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature 1994, 368:249-251.
117. Klein R., Smeyne R.J., Wurst W., Long L.K., Auerbach B.A., Joyner A.L., et al. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 1993, 75:113-122.
118. Klinghoffer R.A., Hamilton T.G., Hoch R., Soriano P. An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development. Developmental Cell 2002, 2:103-113.
119. Klinghoffer R.A., Mueting-Nelsen P.F., Faerman A., Shani M., Soriano P. The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Molecular Cell 2001, 7:343-354.
120. Koch S., Claesson-Welsh L. Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harbor Perspectives in Medicine 2012, 2:a006502.
121. Kolodkin A.L., Levengood D.V., Rowe E.G., Tai Y.T., Giger R.J., Ginty D.D. Neuropilin is a semaphorin III receptor. Cell 1997, 90:753-762.
122. Komatsu N., Aoki K., Yamada M., Yukinaga H., Fujita Y., Kamioka Y., et al. Development of an optimized backbone of FRET biosensors for kinases and GTPases. Molecular Biology of the Cell 2011, 22:4647-4656.
123. Kos L., Aronzon A., Takayama H., Maina F., Ponzetto C., Merlino G., et al. Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte development. Pigment Cell Research 1999, 12:13-21.
124. Kumar P., Ferns M.J., Meizel S. Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) in sperm. Biochemical and Biophysical Research Communications 2006, 342:522-528.
125. Lamballe F., Klein R., Barbacid M. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 1991, 66:967-979.
126. Leahy D.J. Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors. Advances in Protein Chemistry 2004, 68:1-27.
127. Lee P.L., Johnson D.E., Cousens L.S., Fried V.A., Williams L.T. Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Science 1989, 245:57-60.
128. Lee K.F., Simon H., Chen H., Bates B., Hung M.C., Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 1995, 378:394-398.
129. Lemmon M.A., Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2010, 141:1117-1134.
130. Levanti M.B., Esteban I., Ciriaco E., Pérez-Piñera P., Cabo R., García-Suarez O., et al. Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development. Neuroscience Letters 2009, 454:16-21.
131. Levéen P., Pekny M., Gebre-Medhin S., Swolin B., Larsson E., Betsholtz C. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes & Development 1994, 8:1875-1887.
132. Lewis A.E., Vasudevan H.N., O'Neill A.K., Soriano P., Bush J.O. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Developmental Biology 2013, 379:229-234.
133. Li J., Chen F., Epstein J.A. Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice. Genesis 2000, 26:162-164.
134. Lin D., Gish G.D., Songyang Z., Pawson T. The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. Journal of Biological Chemistry 1999, 274:3726-3733.
135. Liu H., Sadygov R.G., Yates J.R. A model for random sampling and estimation of relative protein abundance in shotgun proteomics. Analytical Chemistry 2004, 76:4193-4201.
136. Lu X., Borchers A.G., Jolicoeur C., Rayburn H., Baker J.C., Tessier-Lavigne M. PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 2004, 430:93-98.
137. Luikart B.W., Nef S., Shipman T., Parada L.F. In vivo role of truncated trkb receptors during sensory ganglion neurogenesis. Neuroscience 2003, 117:847-858.
138. Luo W., Wickramasinghe S.R., Savitt J.M., Griffin J.W., Dawson T.M., Ginty D.D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 2007, 54:739-754.
139. MacArthur C.A., Lawshé A., Xu J., Santos-Ocampo S., Heikinheimo M., Chellaiah A.T., et al. FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. Development 1995, 121:3603-3613.
140. Macatee T.L., Hammond B.P., Arenkiel B.R., Frances L., Frank D.U., Moon A.M. Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development 2003, 130:6361-6374.
141. MacKenzie M.A.F., Jordan S.A., Budd P.S., Jackson I.J. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo. Developmental Biology 1997, 192:99-107.
142. Manning B.D., Tee A.R., Logsdon M.N., Blenis J., Cantley L.C. Identification of the tuberous-sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway. Molecular Cell 2002, 10:151-162.
143. Martin-Zanca D., Barbacid M., Parada L.F. Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes & Development 1990, 4:683-694.
144. Masiakowski P., Carroll R.D. A novel family of cell surface receptors with tyrosine kinase-like domain. Journal of Biological Chemistry 1992, 267:26181-26190.
145. Masiakowski P., Yancopoulos G.D. The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases. Current Biology 1998, 8:R407.
146. Matsuda T., Nomi M., Ikeya M., Kani S., Oishi I., Terashima T., et al. Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mechanisms of Development 2001, 105:153-156.
147. Matsui Y., Zsebo K.M., Hogan B.L. Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. Nature 1990, 347:667-669.
148. Mayor R., Theveneau E. The neural crest. Development 2013, 140:2247-2251.
149. McCoshen J.A., McCallion D.J. A study of the primordial germ cells during their migratory phase in Steel mutant mice. Experientia 1975, 31:589-590.
150. McLennan R., Teddy J.M., Kasemeier-Kulesa J.C., Romine M.H., Kulesa P.M. Vascular endothelial growth factor (VEGF) regulates cranial neural crest migration in vivo. Developmental Biology 2010, 339:114-125.
151. Merrill A.E., Bochukova E.G., Brugger S.M., Ishii M., Pilz D.T., Wall S.A., et al. Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Human Molecular Genetics 2006, 15:1319-1328.
152. Meyer D., Yamaai T., Garratt A., Riethmacher-Sonnenberg E., Kane D., Theill L.E., et al. Isoform-specific expression and function of neuregulin. Development 1997, 124:3575-3586.
153. Meyers E.N., Lewandoski M., Martin G.R. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nature Genetics 1998, 18:136-141.
154. Miettinen P.J., Berger J.E., Meneses J., Phung Y., Pedersen R.A., Werb Z., et al. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 1995, 376:337-341.
155. Miettinen P.J., Chin J.R., Shum L., Slavkin H.C., Shuler C.F., Derynck R., et al. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Nature Genetics 1999, 22:69-73.
156. Miki T., Bottaro D.P., Fleming T.P., Smith C.L., Burgess W.H., Chan A.M., et al. Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene. Proceedings of the National Academy of Sciences of the United States of America 1992, 89:246-250.
157. Moon A.M., Guris D.L., Seo J., Li L., Hammond J., Talbot A., et al. Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes. Developmental Cell 2006, 10:71-80.
158. Moore M.W., Klein R.D., Fariñas I., Sauer H., Armanini M., Phillips H., et al. Renal and neuronal abnormalities in mice lacking GDNF. Nature 1996, 382:76-79.
159. Moqrich A., Earley T.J., Watson J., Andahazy M., Backus C., Martin-Zanca D., et al. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nature Neuroscience 2004, 7:812-818.
160. Moritz A., Li Y., Gui A., Villén J., Wang Y., MacNeill J., et al. Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Science Signaling 2010, 3:ra64.
161. Morris J.K., Lin W., Hauser C., Marchuk Y., Getman D., Lee K.F. Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. Neuron 1999, 23:273-283.
162. Morrison-Graham K., Schatteman G.C., Bork T., Bowen-Pope D.F., Weston J.A. A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development 1992, 115:133-142.
163. Muzumdar M.D., Tasic B., Miyamichi K., Li L., Luo L. A global double-fluorescent Cre reporter mouse. Genesis 2007, 45:593-605.
164. Nelson D.K., Williams T. Frontonasal process-specific disruption of AP-2alpha results in postnatal midfacial hypoplasia, vascular anomalies, and nasal cavity defects. Developmental Biology 2004, 267:72-92.
165. Nishita M., Yoo S.K., Nomachi A., Kani S., Sougawa N., Ohta Y., et al. Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration. Journal of Cell Biology 2006, 175:555-562.
166. Noh H., Park E., Park S. In vivo expression of ephrinA5-Fc in mice results in cephalic neural crest agenesis and craniofacial abnormalities. Molecules and Cells 2014, 37:59-65.
167. Nomachi A., Nishita M., Inaba D., Enomoto M., Hamasaki M., Minami Y. Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. Journal of Biological Chemistry 2008, 283:27973-27981.
168. Nomi M., Oishi I., Kani S., Suzuki H., Matsuda T., Yoda A., et al. Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: Redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Molecular and Cellular Biology 2001, 21:8329-8335.
169. Obata T., Yaffe M.B., Leparc G.G., Piro E.T., Maegawa H., Kashiwagi A., et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. Journal of Biological Chemistry 2000, 17:36108-36115.
170. Oishi I., Suzuki H., Onishi N., Takada R., Kani S., Ohkaware B., et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signaling pathway. Genes to Cells 2003, 8:645-654.
171. Oishi I., Takeuchi S., Hashimoto R., Nagabukuro A., Ueda T., Liu Z.J., et al. Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: Implications in development and function of the nervous system. Genes to Cells 1999, 4:41-56.
172. Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2006, 127:635-648.
173. Ong S.E., Blagoev B., Kratchmarovak I., Kristensen D.B., Steen H., Pandey A., et al. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Molecular & Cellular Proteomics 2002, 1:376-386.
174. Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., et al. Receptor specificity of the fibroblast growth factor family. Journal of Biological Chemistry 1996, 271:15292-15297.
175. Orr-Urtreger A., Avivi A., Zimmer Y., Givol D., Yarden Y., Lonai P. Developmental expression of c-kit, a proto-oncogene encoded by the W locus. Development 1990, 109:911-923.
176. Orr-Urtreger A., Bedford M.T., Burakova T., Arman E., Zimmer Y., Yayon A., et al. Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Developmental Biology 1993, 158:475-486.
177. Orr-Urtreger A., Lonai P. Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cells layers of the mouse embryo. Development 1992, 115:1045-1058.
178. Pachnis V., Mankoo B., Costantini F. Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 1993, 119:1005-1017.
179. Park S.K., Lee H.S., Lee S.T. Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. Journal of Biochemistry 1996, 119:235-239.
180. Park E.J., Ogden L.A., Talbot A., Evans S., Cai C.-L., Black B.L., et al. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development 2006, 133:2419-2433.
181. Park E.J., Sun X., Nichol P., Saijoh Y., Martin J.F., Moon A.M. System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in mice. Developmental Dynamics 2008, 237:447-453.
182. Partanen J., Schwartz L., Rossant J. Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes & Development 1998, 12:2332-2344.
183. Paudyal A., Damrau C., Patterson V.L., Ermakov A., Formstone C., Lalanne Z., et al. The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Developmental Biology 2010, 10:87.
184. Person A.D., Beiraghi S., Sieben C.M., Hermanson S., Neumann A.N., Robu M.E., et al. WNT5A mutations in patients with autosomal dominant Robinow syndrome. Developmental Dynamics 2010, 239:327-337.
185. Pichel J.G., Shen L., Sheng H.Z., Granholm A.-C., Drago J., Grinberg A., et al. Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 1996, 382:73-76.
186. Pietri T., Eder O., Blanche M., Thiery J.P., Dufour S. The human tissue plasminogen activator-Cre mouse: A new tool for targeting specifically neural crest cells and their derivatives in vivo. Developmental Biology 2003, 259:176-187.
187. Postigo A., Calella A.M., Fritzsch B., Knipper M., Katz D., Ellers A., et al. Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons. Genes & Development 2002, 16:633-645.
188. Prigge J.R., Wiley J.A., Talago E.A., Young E.M., Johns L.L., Kundert J.A., et al. Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei. Mammalian Genome 2013, 24:389-399.
189. Qui F.H., Ray P., Brown K., Barker P.E., Jhanwar S., Ruddle F.H., et al. Primary structure of c-kit: Relationship with the CSF-1/PDGF receptor kinase family-Oncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO Journal 1988, 7:1003-1011.
190. Rapraeger A.C., Krufka A., Olwin B.B. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science 1991, 252:1705-1708.
191. Reid B.S., Yang H., Melvin V.S., Taketo M.M., Williams T. Ectodermal Wnt/β-catenin signaling shapes the mouse face. Developmental Biology 2011, 349:261-269.
192. Richarte A.M., Mead H.B., Tallquist M.D. Cooperation between the PDGF receptors in cardiac neural crest cell migration. Developmental Biology 2007, 306:785-796.
193. Riethmacher D., Sonnenberg-Riethmacher E., Brinkmann V., Yamaai T., Lewin G.R., Birchmeier C. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 1997, 389:725-730.
194. Romeo G., Ronchetto P., Luo Y., Barone V., Seri M., Ceccherini I., et al. Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature 1994, 367:377-378.
195. Ross P.L., Huang Y.N., Marchese J.N., Williamson B., Parker K., Hattan S., et al. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Molecular & Cellular Proteomics 2004, 3:1154-1169.
196. Ruiz-Ferrer M., Fernandez R.M., Antiñolo G., Lopez-Alonso M., Borrego S. NTF-3, a gene involved in the enteric nervous system development, as a candidate gene for Hirschsprung disease. Journal of Pediatric Surgery 2008, 43:1308-1311.
197. Rupp E., Siegbahn A., Rönnstrand L., Wernstedt C., Claesson-Welsh L., Heldin C.H. A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex. European Journal of Biochemistry 1994, 225:29-41.
198. Saga Y., Miyagawa-Tomita S., Takagi A., Kitajima S., Miyazaki J., Inoue T. MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development 1999, 126:3437-3447.
199. Sánchez M.P., Silos-Santiago I., Frisén J., He B., Lira S.A., Barbacid M. Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 1996, 382:70-73.
200. Sarvella P.A., Russell L.B. Steel, a new dominant gene in the house mouse. Journal of Heredity 1956, 47:123-128.
201. Schleiffarth J.R., Person A.D., Martinsen B.J., Sukovich D.J., Neumann A., Baker C.V., et al. Wnt5a is required for cardiac outflow tract septation in mice. Pediatric Research 2007, 61:386-391.
202. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000, 103:211-225.
203. Schmidt C., Bladt F., Goedecke S., Brinkmann V., Zschiesche W., Sharpe M., et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995, 373:699-702.
204. Schuchardt A., D'Agati V., Larsson-Blomberg L., Costantini F., Pachnis V. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 1994, 367:380-383.
205. Shibuya M., Yamaguchi S., Yamane A., Ikeda T., Tojo A., Matsushime H., et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 1990, 5:519-524.
206. Sibilia M., Wagner E.F. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 1995, 269:234-238.
207. Siddiqui S., Cong W.-N., Daimon C.M., Martin B., Maudsley S. BRET biosensor analysis of receptor tyrosine kinase functionality. Frontiers in Endocrinology 2013, 4:46.
208. Smeyne R.J., Klein R., Schnapp A., Long L.K., Bryant S., Lewin A., et al. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 1994, 368:246-249.
209. Sonnenberg E., Meyer D., Weidner K.M., Birchmeier C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. Journal of Cell Biology 1993, 123:223-235.
210. Soriano P. Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes & Development 1994, 8:1888-1896.
211. Soriano P. The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 1997, 124:2691-2700.
212. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genetics 1999, 21:70-71.
213. Spivak-Kroizman T., Lemmon M.A., Dikic I., Ladbury J.E., Pinchasi D., Huang J., et al. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell 1994, 79:1015-1024.
214. Squinto S.P., Stitt T.N., Aldrich T.H., Davis S., Bianco S.M., Radziejewski C., et al. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell 1991, 65:885-893.
215. Stalmans I., Lambrechts D., De Smet F., Jansen S., Wang J., Maity S., et al. VEGF: A modifier of the del22q11 (DiGeorge) syndrome?. Nature Medicine 2003, 9:173-182.
216. Steel K.P., Davidson D.R., Jackson I.J. TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor. Development 1992, 115:1111-1119.
217. Stein R.A., Staros J.V. Evolutionary analysis of the ErbB receptor and ligand families. Journal of Molecular Evolution 2000, 50:397-412.
218. Stine Z.E., Huynh J.L., Loftus S.K., Gorkin D.U., Salmasi A.H., Novak T., et al. Oligodendroglial and pan-neural crest expression of Cre recombinase directed by Sox10 enhancer. Genesis 2009, 47:765-770.
219. Tabler J.M., Barrell W.B., Szabo-Rogers H.L., Healy C., Yeung Y., Perdiguero E.G., et al. Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromes. Developmental Cell 2013, 25:623-635.
220. Takayama H., La Rochelle W.J., Anver M., Bockman D.E., Merlino G. Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:5866-5871.
221. Takeuchi S., Takeda K., Oishi I., Nomi M., Ikeya M., Itoh K., et al. Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes to Cells 2000, 5:71-78.
222. Tallquist M.D., Soriano P. Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development 2003, 130:507-518.
223. Tallquist M.D., Weismann K.E., Hellström M., Soriano P. Early myotome specification regulates PDGFA expression and axial skeleton development. Development 2000, 127:5059-5070.
224. Tan P.K., Wang J., littler P.-L.H., Wong K.K., Sweetnam T.A., Keefe W., et al. Monitoring interactions between receptor tyrosine kinases and their downstream effector proteins in living cells using bioluminescence resonance energy transfer. Molecular Pharmacology 2007, 72:1440-1446.
225. Taravira S., Marcos-Gutierrez C.V., Durbec P., Jani H., Grigoriou M., Sukumaran M., et al. Signaling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development 1999, 126:2785-2797.
226. Tavares A.L., Garcia E.L., Kuhn K., Woods C.M., Williams T., Clouthier D.E. Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Developmental Biology 2012, 371:47-56.
227. Tessarollo L., Tsoulfas P., Donovan M.J., Palko M.E., Blair-Flynn J., Hempstead B.L., et al. Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:14776-14781.
228. Tessarollo L., Tsoulfas P., Martin-Zanca D., Gilbert D.J., Jenkins N.A., Copeland N.G., et al. trkC, a receptor for neurotropin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development 1993, 118:463-475.
229. Threadgill D.W., Dlugosz A.A., Hansen L.A., Tennenbaum T., Lichti U., Yee D., et al. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 1995, 269:230-234.
230. Ting M.-C., Wu N.L., Roybal P.G., Sun J., Lui L., Yen Y., et al. EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis. Development 2009, 136:855-864.
231. Tokuda M. An eighteenth century Japanese guide-book on mouse-breeding. Journal of Heredity 1935, 26:481-484.
232. Tonks I.D., Nurcombe V., Paterson C., Zournazi A., Prather C., Mould A.W., et al. Tyrosinase-Cre mice for tissue-specific gene ablation in neural crest and neuroepithelial-derived tissues. Genesis 2003, 37:131-138.
233. Trainor P.A. Specification of neural crest cell formation and migration in mouse embryos. Seminars in Cell & Developmental Biology 2005, 16:683-693.
234. Treanor J.J., Goodman L., de Sauvage F., Stone D.M., Poulsen K.T., Beck C.D., et al. Characterization of a multicomponent receptor for GDNF. Nature 1996, 382:80-83.
235. Trokovic N., Trokovic R., Mai P., Partanen J. Fgfr1 regulates patterning of the pharyngeal region. Genes & Development 2003, 17:141-153.
236. Trumpp A., Depew M.J., Rubenstein J.L.R., Bishop J.M., Martin G.R. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes & Development 1999, 13:3136-3148.
237. Tucker A.S., Yamada G., Grigoriou M., Pachnis V., Sharpe P.T. Fgf-8 determines rostral-caudal polarity in the first branchial arch. Development 1999, 126:51-61.
238. Twigg S.R.F., Kan R., Babbs C., Bochukova E.G., Robertson S.P., Wall S.A., et al. Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:8652-8657.
239. Uehara Y., Minowa O., Mori C., Shiota K., Kuno J., Noda T., et al. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 1995, 373:702-705.
240. Uesaka T., Enomoto H. Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice. Journal of Neuroscience 2010, 30:5211-5218.
241. Uesaka T., Nagashimada M., Yonemura S., Enomoto H. Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice. Journal of Clinical Investigation 2008, 118:1890-1898.
242. Ullrich A., Coussens L., Hayflick J.S., Dull T.J., Gray A., Tam A., et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 1984, 309:418-425.
243. Valenzuela D.M., Stitt T.N., DiStefano P.S., Rojas E., Mattsson K., Compton D.L., et al. Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury. Neuron 1995, 15:573-584.
244. van Bokhoven H., Celli J., Kayserili H., van Beusekom E., Balci S., Brussel W., et al. Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nature Genetics 2000, 25:423-426.
245. Van den Akker N.M., Winkel L.C., Nisancioglu M.H., Maas S., Wisse L.J., Armulik A., et al. PDGF-B signaling is important for murine cardiac development: Its role in developing atrioventricular valves, coronaries, and cardiac innervation. Developmental Dynamics 2008, 237:494-503.
246. Vlahos C.J., Matter W.F., Hui K.Y., Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry 1994, 269:5241-5248.
247. Wagner J.P., Wolf-Yadlin A., Sevecka M., Grenier J.K., Root D.E., Lauffenburger D.A., et al. Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks. Science Signaling 2013, 6:ra58.
248. Wang H.U., Anderson D.J. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron 1997, 18:383-396.
249. Wang C., Chang J.Y.F., Yang C., Huang Y., Liu J., You P., et al. Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis. Journal of Biological Chemistry 2013, 288:22174-22183.
250. Wehrle-Haller B., Meller M., Weston J.A. Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival. Developmental Biology 2001, 232:471-483.
251. Wehrle-Haller B., Weston J.A. Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development 1995, 121:731-742.
252. Wehrle-Haller B., Weston J.A. Altered cell-surface targeting of stem cell factor causes loss of melanocytes precursors in Stell17H mutant mice. Developmental Biology 1999, 210:71-86.
253. Williams L.T. Signal transduction by the platelet-derived growth factor receptor. Science 1989, 243:1564-1570.
254. Williams D.E., Eisenman J., Baird A., Rauch C., Van Ness K., March C.J., et al. Identification of a ligand for the c-kit proto-oncogene. Cell 1990, 63:167-174.
255. Woldeyesus M.T., Britsch S., Riethmacher D., Xu L., Sonnenberg-Riethmacher E., Abou-Rebyeh F., et al. Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development. Genes & Development 1999, 13:2538-2548.
256. Wong A., Bogni S., Kotka P., de Graaff E., D'Agati V., Costantini F., et al. Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Molecular and Cellular Biology 2005, 25:9661-9673.
257. Xu Y.K., Nusse R. The Frizzled CRD domain is conserved in diverse proteins including several receptor tyrosine kinases. Current Biology 1998, 8:R405-R406.
258. Xu X., Weinstein M., Li C., Naski M., Cohen R.I., Ornitz D.M., et al. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 1998, 125:753-765.
259. Yamaguchi T.P., Bradley A., McMahon A.P., Jones S. A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 1999, 126:1211-1223.
260. Yamaguchi T.P., Harpal K., Henkemeyer M., Rossant J. fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes & Development 1994, 8:3032-3044.
261. Yamamoto H., Yoo S.K., Nishita M., Kikuchi A., Minami Y. Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes to Cells 2007, 12:1215-1223.
262. Yamauchi Y., Abe K., Mantani A., Hitoshi Y., Suzuki M., Osuzu F., et al. A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice. Developmental Biology 1999, 212:191-203.
263. Yarden Y., Kuang W.-J., Yang-Feng T., Coussens L., Munemitsu S., Dull T.J., et al. Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO Journal 1987, 6:3341-3351.
264. Yayon A., Klagsbrun M., Esko J.D., Leder P., Ornitz D.M. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991, 64:841-848.
265. Yayon A., Zimmer Y., Shen G.H., Avivi A., Yarden Y., Givol D. A confined variable region confers ligand specificity on fibroblast growth factor receptors: Implications for the origin of the immunoglobulin fold. EMBO Journal 1992, 11:1885-1890.
266. Yu J.C., Heidaran M.A., Pierce J.H., Gutkind J.S., Lombardi D., Ruggiero M., et al. Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction. Molecular and Cellular Biology 1991, 11:3780-3785.
267. Zhang B., Luo S., Wang Q., Suzuki T., Xiong W.C., Mei L. LRP4 serves as a coreceptor of agrin. Neuron 2008, 60:285-297.
268. Zhang Z.-J., Sieber-Blum M. Essential role of stem cell factor signaling in primary sensory neuron development. Developmental Neuroscience 2009, 31:202-211.
269. Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., Lauffenburger D.A., et al. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Molecular & Cellular Proteomics 2005, 4:1240-1250.
270. Zhou J., Pashmforoush M., Sucov H.M. Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1. PLoS One 2012, 7:e32429.
271. Zsebo K.M., Williams D.A., Geissler E.N., Broudy V.C., Martin F.H., Atkins H.L., et al. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 1990, 63:213-224.