The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions

Molecular Cell

Volumn 7, Issue 2, 2001, Pages 343-354

  Klinghoffer, Richard A ^a   Mueting Nelsen, Peter F ^a   Faerman, Alexander ^b   Shani, Moshe ^b   Soriano, Philippe ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b VOLCANI CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME SPECIFICITY; GENE EXPRESSION; GENE TARGETING; MOUSE; NONHUMAN; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; VASCULAR DISEASE;

ANIMALIA;

EID: 0035106689     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00182-4     Document Type: Article

References (56)

1. Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy
2. Distribution and functions of platelet-derived growth factors and their receptors during embryogenesis
3. The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP
4. Phosphorylation of tyrosine 720 in the platelet-derived growth factor α-receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation
5. A plasticity window for blood vessel remodeling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
6. Chimeric analysis reveals role of PDGF receptors in all muscle lineages
7. Platelet-derived growth factor (PDGF) α receptor activation modulates the calcium mobilizing activity of the PDGFβ receptor in Balb/c3T3 fibroblasts
8. New insights into the control of MAP kinase pathways
9. PDGF α- and β-receptors activate unique and common signal transduction pathways
10. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
11. Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice
12. PDGF mediates a neuron-astrocyte interaction in the developing retina
13. A role for src in signal relay by the platelet-derived growth factor alpha receptor
14. Differences in substrate specificities of α and β platelet-derived growth factor (PDGF) receptors
15. Mechanism of action and in vivo role of platelet-derived growth factor
16. Signal transduction via platelet-derived growth factor receptors
17. Role of PDGF-B and PDGR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
18. Extraglomerular origin of the mesangial cell after injury
19. Platelet-derived growth factor and angiotensin II stimulate the mitogen-activated protein kinase cascade in renal mesangial cells: Comparison of hypertrophic and hyperplastic agonists
20. Differences in signal transduction between platelet-derived growth factor (PDGF) α and β receptors in vascular smooth muscle cells
21. Role of platelet-derived growth factor in glomerular disease
22. Functions of the major tyrosine phosphorylation site of the PDGF receptor β subunit
23. GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor β subunit
24. Src family kinases are required for integrin but not PDGFR signal transduction
25. Diabetic retinopathy
26. Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells
27. A requirement for fibroblast growth factor in regulation of skeletal muscle growth and differentiation cannot be replaced by activation of platelet-derived growth factor signaling pathways
28. The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo
29. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
30. PDGF-C is a new protease-activated ligand for the PDGF α-receptor
31. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
32. Paracrine PDGF-B/PDGF-Rβ signaling controls mesangial cell development in kidney glomeruli
33. Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
34. Independent expression of human α or β platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways
35. A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcription
36. Mitogen-activated protein kinase and proliferation of human vascular smooth muscle cells
37. A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells
38. Role of intrinsic renal cells versus infiltrating cells in glomerular crescent formation
39. MAPK superfamily activation in human airway smooth muscle: Mitogenesis requires prolonged p42/p44 activation
40. Signaling through scaffold, anchoring, and adaptor proteins
41. Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors
42. Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes
43. Regulation and role of PDGF receptor α-subunit expression during embryogenesis
44. Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes
45. Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice
46. The PDGFα receptor is required for neural crest cell development and normal patterning of the somites
47. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
48. Protein tyrosine kinase cDNAs from amphioxus, hagfish, and lamprey: Isoform duplications around the divergence of cyclostomes and gnathostomes
49. Retention of PDGFR-β function in mice in the absence of phosphatidylinositol-3′ kinase and phospholipase Cγ signaling pathways
50. Early myotome specification regulates PDGFA expression and axial skeletal development
51. A novel trangenic marker for migrating limb muscle precursors and for vascular smooth muscle cells
52. Identification of a domain within the carboxy-terminal region of the β platelet-derived growth factor receptor that mediates the high transforming activity of PDGF
53. Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
54. Identification of tyr-762 in the platelet-derived growth factor α-receptor as the binding site for crk proteins
55. Biological function of PDGF-induced PI-3 kinases activity: Its role in alpha PDGF receptor-mediated mitogenic or chemotactic signaling
56. Platelet-derived growth factor (PDGF) receptor-α activates c-jun NH2-terminal kinase-1 and antagonizes PDGF receptor-β-induced phenotypic transformation