Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival

Developmental Biology

Volumn 232, Issue 2, 2001, Pages 471-483

  Wehrle Haller, Bernhard ^a,b   Meller, Margaret ^a,c   Weston, James A ^a  

^a UNIVERSITY OF OREGON   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c Targeted Genetics Corporation   (United States)

Author keywords

Cell migration; Chemoattraction; Neural crest; Neurofibromin; RAS GAP

Indexed keywords

GENE PRODUCT; INTERLEUKIN 3; NEUROFIBROMIN; PROTEIN; PROTEIN GAP; PROTEIN NF1; PROTEIN TYROSINE KINASE; RAS PROTEIN; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL MIGRATION; CELL SURVIVAL; EMBRYO; GENE FUNCTION; GENE LOCUS; GENE MUTATION; MELANOCYTE; MYOTOME; NEURAL CREST; NEURAL TUBE; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AVES; MURINAE;

EID: 0035871523     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2001.0167     Document Type: Article

References (81)

1. Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control directed cell migration
2. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons
3. The kit ligand encoded at the murine Steel locus: A pleiotropic growth and differentiation factor
4. The kit-ligand (steel factor) and its receptor c-kit/W: Pleiotropic roles in gametogenesis and melanogenesis
5. Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C
6. Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C
7. The c-kit receptor promotes cell survival via activation of PI3-kinase and subsequent akt-mediated phosphorylation of Bad on Ser136
8. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3-kinase is essential for male fertility
9. Proteins regulating Ras and its relatives
10. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells
11. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
12. F-Spondin, expressed in somite regions avoided by neural crest cells, mediates inhibition of distinct somite domains to neural crest migration
13. Signals to move cells
14. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signaling
15. An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
16. The cellular response to factors which induce motility in mammalian cells
17. p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein
18. Evidence for collapsin-1 functioning in the control of neural crest migration in both trunk and hindbrain regions
19. Descriptive and experimental analysis of the dispersion of neural crest cells
20. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
21. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant
22. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
23. Purification and characterization of scatter factor
24. Detection of DNA fragmentation in apoptosis: Application of in situ nick translation to cell culture systems and tissue sections
25. Ras-GTP levels are elevated in human NF1 peripheral nerve tumors
26. Rho GTPases and the actin cytoskeleton
27. Map kinase links the transcription factor microphthalmia to c-kit signaling in melanocytes
28. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
29. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
30. Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes
31. Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo
32. MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair follicles
33. Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors
34. Cell migration: A physically integrated molecular process
35. Multiple ras signals pattern the Drosophila ovarian follicle cells
36. Two distinct roles for ras in a developmentally regulated cell migration
37. Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/ c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction
38. Steel factor and c-kit protooncogene: Genetic lessons in signal transduction
39. A role for rhoB in the delamination of neural crest cells from the dorsal neural tube
40. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo
41. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
42. Hu neuronal proteins are expressed in proliferating neurogenic cells
43. Cell interactions within nascent neural crest cell populations transiently promote death of neurogenic precursors
44. Ras signaling and N.F1
45. The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development
46. Transient steel factor dependence by neural crest-derived melanocyte precursors
47. Activation of Akt/protein kinase B by G protein-coupled receptors. A role for the alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-OH kinasegamma
48. Cell-type specific roles for cdc42, rac and rhoL in Drosophila oogenesis
49. In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: Two distinct waves of c-kit-dependency during melanocyte development
50. Glycoconjugates mark a transient barrier to neural crest migration in the chick
51. Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan
52. Inhibition of neural crest cell migration by aggregating chondroitin sulfate proteoglycan by their hyaluronan-binding region
53. Waltzing with WASP
54. Elucidation of the role of breathless, Drosophila FGF receptor homolog, in tracheal cell migration
55. Multiple roles for endothelin in melanocyte development: Regulation of progenitor number and stimulation of differentiation
56. R-ras interacts with rasGAP. Neurofibromin and c-raf but does not regulate cell growth or differentiation
57. Deficiency of the hematopoietic cell-specific rho family GTPase rac2 is characterized by abnormalities in neutrophil function and host defense
58. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
59. Neurofibromatosis. A review of the clinical problem
60. Stem cell factor regulates human melanocyte-matrix interactions
61. Stem cell factor regulates the melanocyte cytoskeleton
62. Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells
63. The temporal requirement for endothelin receptor-B signaling during neural crest development
64. The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate branchial neural crest cells
65. A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material
66. A ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans
67. Steel factor enhances integrin-mediated tyrosine phosphorylation of focal adhesion kinase (pp125FAK) and paxillin
68. The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
69. Loss of Neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons
70. C-kit receptor signaling through its phosphatidylinositide-3-kinase-binding site and protein kinase C: Role in Mast cell enhancement of degranulation, adhesion and membrane raffling
71. Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase
72. Avian neural crest-derived neurogenic precursors undergo apoptosis on the lateral migration pathway
73. Dual function of tenascin: Simultaneous promotion of neurite growth and inhibition of migration
74. Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway
75. Receptor tyrosine kinase-dependent neural crest migration in response to differentially localized growth factors
76. 17H mutant mice
77. Tenascin-C suppresses Rho activation
78. Sequential segregation and fate of developmentally restricted intermediate cell populations in the neural crest lineage
79. Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
80. Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines