The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway

Genes to Cells

Volumn 8, Issue 7, 2003, Pages 645-654

  Oishi, Isao ^a   Suzuki, Hiroaki ^a   Onishi, Nobuyuki ^a   Takada, Ritsuko ^b   Kani, Shuichi ^a   Ohkawara, Bisei ^c   Koshida, Ikue ^b   Suzuki, Kentaro ^d   Yamada, General ^d   Schwabe, Georg C ^e   Mundlos, Stefan ^e   Shibuya, Hiroshi ^c   Takada, Shinji ^b,f,g   Minami, Yasuhiro ^a  

^a KOBE UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Tokyo Medical and Dental University ^*  (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

^e MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^f KYOTO UNIVERSITY   (Japan)

^g NATIONAL INSTITUTES OF NATURAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; JANUS KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE ROR2; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BINDING SITE; CELL CULTURE; CONTROLLED STUDY; DEVELOPMENT; DWARFISM; EMBRYO; FACE DEFORMITY; GENITAL MALFORMATION; HEART VENTRICLE SEPTUM DEFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; LIMB DEFORMITY; LUNG DYSPLASIA; MORPHOGENESIS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TAIL; XENOPUS;

ANIMALS; BLOTTING, WESTERN; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHENOTYPE; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; WNT PROTEINS;

ANIMALIA; JANUS;

EID: 10744219743     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2003.00662.x     Document Type: Article

References (42)

1. Barrantes, I.B., Elia, A.J., Wunsch, K., et al. (1999) Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr. Biol. 9, 470-480.
2. Boutros, M., Paricio, N., Strutt, D.I. & Mlodzik, M. (1998) Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94, 109-118.
3. Cadigan, K.M. & Nusse, R. (1997) Wnt signaling: a common theme in animal development. Genes Dev. 11, 3286-3305.
4. DeChiara, T.M., Kimble, R.B., Poueymirou, W.T., et al. (2000) Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nature Genet. 24, 271-274.
5. Djiane, A., Riou, J., Umbhauer, M., Boucaut, J. & Shi, D. (2000) Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 127, 3091-3100.
6. Forrester, W.C. (2002) The Ror receptor tyrosine kinase family. Cell. Mol. Life Sci. 59, 83-96.
7. Forrester, W.C., Dell, M., Perens, E. & Garriga, G. (1999) C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Nature 400, 881-885.
8. Halford, M.M., Armes, J., Buchert, M., et al. (2002) Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk. Nature Genet. 25, 414-418.
9. Haraguchi, R., Mo, R., Hui, C., et al. (2001) Unique functions of Sonic hedgehog signaling during external genitalia development. Development 128, 4241-4250.
10. He, X., Saint-Jeannet, J.P., Wang, Y., Nathans, J., Dawid, I. & Varmus, H. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275, 1652-1654.
11. Heisenberg, C.-P., Tada, M., Rauch, G.-J., et al. (2000) Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature 405, 76-81.
12. Hikasa, H., Shibata, M., Hiratani, I. & Taira, M. (2002) The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signalling. Development 129, 5227-5239.
13. Jessen, J.R., Topczewski, J., Bingham, S., et al. (2002) Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Nature Cell Biol. 4, 610-615.
14. 2+ pathway: a new vertebrate Wnt signaling pathway takes a shape. Trends Genet. 16, 279-283.
15. Li, C., Xiao, J., Hormi, K., Borok, Z. & Minoo, P. (2002) Wnt5a participates in distal lung morphogenesis. Dev. Biol. 248, 68-81.
16. Masiakowski, P. & Carroll, R.D. (1992) A novel family of cell surface receptors with tyrosine kinase-like domain. J. Biol. Chem. 267, 26181-26190.
17. Masiakowski, P. & Yancopoulos, G.D. (1998) The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases. Curr. Biol. 8, R407.
18. Matsuda, T., Nomi, M., Ikeya, M., et al. (2001) Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mech. Dev. 105, 153-156.
19. Moon, R.T., Campbell, R.M., Christian, J.L., McGrew, L.L., Shih, J. & Fraser, S. (1993) Xwnt-5a: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development 119, 97-111.
20. Nomi, M., Oishi, I., Kani, S., et al. (2001) Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol. Cell. Biol. 21, 8329-8335.
21. Oishi, I., Takeuchi, S., Hashimoto, R., et al. (1999) Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells 4, 41-56.
22. Oldridge, M., Fortuna, A.M., Maringa, M., et al. (2000) Dominant mutations in Ror2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. Nature Genet. 24, 275-278.
23. Pandur, P., Läsche, M., Eisenberg, L.M. & Kühl, M. (2002) Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature 418, 636-641.
24. Park, M. & Moon, R.T. (2002) The planar cell-polarity gene stbm regulates cell behavior and cell fate in vertebrate embryos. Nature Cell Biol. 4, 20-25.
25. Patton, M.A. & Afzal, A.R. (2002) Robinow syndrome. J. Med. Genet. 39, 305-310.
26. Rehn, M., Pihlajaniemi, T., Hofman, K. & Bucher, P. (1998) The frizzled motif: in how many different protein families does it occur? Trends Biochem. Sci. 23, 415-417.
27. Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103, 211-225.
28. Schwabe, G.C., Tinschert, S., Buschow, C., et al. (2000) Distinct mutations in the receptor tyrosine kinase gene Ror2 cause brachydactyly type B. Am. J. Hum. Genet. 67, 822-831.
29. Shibamoto, S., Higano, K., Takada, R., Ito, F., Takeichi, M. & Takada, S. (1998) Cytoskeletal reorganization by soluble Wnt-3a protein signalling. Genes Cells 3, 659-670.
30. Slusarski, D.C., Corces, V.G. & Moon, R.T. (1997) Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390, 410-413.
31. Sokol, S.Y. (1999) Wnt signaling and dorso-ventral axis specification in vertebrates. Curr. Opin. Genet. Dev. 9, 405-410.
32. Sokol, S. (2000) A role for Wnts in morphogenesis and tissue polarity. Nature Cell Biol. 2, E124-E126.
33. Tada, M. & Smith, J.C. (2000) Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development 127, 2227-2238.
34. Takeuchi, S., Takeda, K., Oishi, I., et al. (2000) Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells 5, 71-78.
35. Tamai, K., Semenov, M., Kato, Y., et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407, 530-535.
36. Wallingford, J.B., Rowning, B.A., Vogeli, K.M., Rothbächer, U., Fraser, S.E. & Harland, R.M. (2000) Dishevelled controls cell polarity during Xenopus gastrulation. Nature 405, 81-85.
37. Wodarz, A. & Nusse, R. (1998) Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol. 14, 59-88.
38. Yamaguchi, T.P., Bradley, A., McMahon, A.P. & Jones, S. (1999) A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 126, 1211-1223.
39. Yamanaka, H., Moriguchi, T., Masuyama, N., et al. (2002) JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep. 3, 69-75.
40. Yoda, A., Oishi, I. & Minami, Y. (2003) Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans. J. Recept. Signal Transduct. Res. 23, 1-15.
41. Yoshikawa, S., Bonkowsky, J.L., Kokel, M., Shyn, S. & Thomas, J.B. (2001) The derailed guidance receptor does not require kinase activity in vivo. J. Neurosci. 21, Rc119.
42. Yoshikawa, S., McKinnon, R.D., Kokel, M. & Thomas, J.B. (2003) Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature 422, 583-588.