Agrin acts via a MuSK receptor complex

Cell

Volumn 85, Issue 4, 1996, Pages 513-523

  Glass, David J ^a   Bowen, David C ^a   Stitt, Trevor N ^a   Radziejewski, Czeslaw ^a   Bruno, JoAnne ^a   Ryan, Terence E ^a   Gies, David R ^a   Shah, Sonal ^a   Mattsson, Karen ^a   Burden, Steven J ^b   DiStefano, Peter S ^a   Valenzuela, David M ^a   DeChiara, Thomas M ^a   Yancopoulos, George D ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGRIN; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MYOTUBE; NERVE CELL DIFFERENTIATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SYNAPTOGENESIS;

EID: 15844380040     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81252-0     Document Type: Article

References (49)

1. Apel, E.D., Roberds, S.L., Campbell, K.P., and Merlie, J.P. (1995). Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex. Neuron 15, 115-126.
2. Barbacid, M. (1993). Nerve growth factor: a tale of two receptors. Oncogene 8, 2033-2042.
3. Bowe, M.A., and Fallon, J.R. (1995). The role of agrin in synapse formation. Annu. Rev. Neurosci. 18, 443-462.
4. Bowe, M.A., Deyst, K.A., Leszyk, J.D., and Fallon, J.R. (1994). Identification and purification of an agrin receptor from Torpedo postsynaptic membranes: a heteromeric complex related to dystroglycans. Neuron 12, 1173-1180.
5. Burden, S.J., Jo, S.A., Tang, J., Zhu, X., Yeadon, J.E., and Simon, A.M. (1995). Polarity in skeletal muscle cells is induced by innervation. Dev. Biol. 6, 59-65.
6. Campanelli, J.T., Roberds, S.L., Campbell, K.P., and Scheller, R.H. (1994). A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering. Cell 77, 663-674.
7. Campbell, K.P. (1995). Three muscular dystrophies: loss of cytoskeleton-extracellular matrix linkage. Cell 80, 675-679.
8. Davis, S., Aldrich, T.H., Stahl, N., Taga, T., Kishimoto, T., Ip, N.Y., and Yancopoulos, G.D. (1993). LIFRβ and gp130as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 260, 1805-1808.
9. Davis, S., Gale, N.W., Aldrich, T.H., Maisonpierre, P.C., Lhotak, V., Pawson, T., Goldfarb, M., and Yancopoulos, G.D. (1994). Ligands for the EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 266, 816-819.
10. DeChiara, T.M., Bowen, D.C., Valenzuela, D.M., Simmons, M.V., Poueymirou, W.T., Thomas, S., Kinetz, E., Compton, D.L., Rojas, E., Parks, J.S., Smith, C., DiStefano, P.S., Glass, D.J., Burden, S.J., and Yancopoulos, G.D. (1996). The receptor tyrosine kinase MuSK is required for all aspects of neuromuscular junction formation in vivo. Cell, this issue.
11. DiStefano, P.S., Friedman, B., Radziejewski, C., Alexander, C., Boland, P., Schick, C.M., Lindsay, R.M., and Weigand, S.J. (1992). The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons. Neuron 8, 983-993.
12. Fagerstam, L. (1991). A non-label technology for real time biospecific interaction analysis. Tech. Protein Chem. 2, 65-71.
13. Fallon, J.R., and Hall, Z.W. (1994). Building synapses: agrin and dystroglycan stick together. Trends Neurosci. 17, 469-473.
14. Ferns, M., Hoch, W., Camapnelli, J.T., Rupp, F., Hall, Z.W., and Scheller, R.H. (1992). RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes. Neuron 8, 1079-1086.
15. Ferns, M., Campanelli, J.T., Hoch, W., Scheller, R.H., and Hall, Z.W. (1993). The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans. Neuron 11, 491-502.
16. Ferns, M., Deiner, M., and Hall, Z. (1996). Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation. J. Cell Biol. 132, 937-944.
17. Gautam, M., Noakes, P.G., Mudd, J., Nichol, M., Chu, G.C., Sanes, J.R., and Merlie, J.P. (1995). Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice. Nature 377, 232-236.
18. Gautam, M., Noakes, P.G., Moscoso, L., Rupp, F., Scheller, R.H., Merlie, J.P., and Sanes, J.R. (1996).Defective neuromuscular synaptogenesis in agrin-deficient mice. Cell, this issue.
19. Gee, S.H., Montanaro, F., Lindenbaum, M.H., and Carbonetto, S. (1994). Dystroglycan-α, a dystrophin-associated glycoprotein, is a functional agrin receptor. Cell 77, 675-686.
20. Glass, D.J., and Yancopoulos, G.D. (1993). The neurotrophins and their receptors. Trends Cell Biol. 3, 262-268.
21. Glass, D.J., Nye, S.H., Hantzopoulos, P., Macchi, M.J., Squinto, S.P., Goldfarb, M., and Yancopoulos, G.D. (1991). TrkB mediates BDNF/ NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor. Cell 66, 405-413.
22. Godfrey, E.W., Nitkin, R.M., Wallace, B.G., Rubin, L.L., and McMahan, U.J. (1984). Components of Torpedo electric organ and muscle that cause aggregation of acetylcholine receptors on cultured muscle cells. J. Cell Biol. 99, 615-627.
23. Goldfarb, M. (1990). The fibroblast growth factor family. Cell Growth Differ. 1, 439-445.
24. Hall, Z.W., and Sanes, J.R. (1993). Synaptic structure and development: the neuromuscular junction. Cell 77/Neuron 10 (Suppl.), 99-121.
25. Hoch, W., Ferns, M., Campanelli, J.T., Hall, Z.W., and Scheller, R.H. (1993). Developmental regulation of highly active alternatively spliced forms of agrin. Neuron 11, 479-490.
26. Hoch, W., Campanelli, J.T., Harrison, S., and Scheller, R.H. (1994). Structural domains of agrin required for clustering of nicotinic acetylcholine receptors. EMBO J. 13, 2814-2821.
27. Ip, N.Y., Ibanez, C.F., Nye, S.H., McClain, J., Jones, P.F., Gies, D.R., Belluscio, L., LeBeau, M.M., Espinossa, R., III, Squinto, S.P., Persson, H., and Yancopoulos, G.D. (1992). Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc. Natl. Acad. Sci. USA 89, 3060-3064.
28. Johnsson, B., Lofas, S., and Lindquist, G. (1991). Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. Anal. Biochem. 198, 268-277.
29. Ip, N.Y., Stitt, T.N., Tapley, P., Klein, R., Glass, D.J., Fandl, J., Greene, L.A., Barbacid, M., and Yancopoulos, G.D. (1993). Similarities and differences in the way neurotrophins interact with the Trks in neuronal and nonneuronal cells. Neuron 10, 137-149.
30. Kaplan, D.R., Martin-Zanca, D., and Parada, L. (1991). Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350, 158-160.
31. Martin, P.T., and Sanes, J.R. (1995). Role for a synapse-specific carbohydrate in agrin-induced clustering of acetylcholine receptors. Neuron 14, 743-754.
32. McMahan, U.J. (1990). The agrin hypothesis. Cold Spring Harbor Symp. Quant. Biol. 55, 407-418.
33. Noakes, P.G., Phillips, W.D., Hanley, T.A., Sanes, J.R., and Merlie, J.P. (1993). 43K protein and acetylcholine receptors colocalize during the initial stages of neuromuscular synapse formation in vivo. Dev. Biol. 155, 275-280.
34. Peng, H.B., Baker, L.P., and Chen, Q. (1991). Induction of synaptic development in cultured muscle cells by basic fibroblast growth factor. Neuron 6, 237-246.
35. Qu, Z., and Huganir, R.L. (1994). Comparison of innervation and agrin-induced tyrosine phosphorylation of the nicotinic acetylcholine receptor. J. Neurosci. 14, 6834-6841.
36. Reist, N.E., Werle, M.J., and McMahan, U.J. (1992). Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions. Neuron 8, 865-868.
37. Ruegg, M.A., Tsim, K.W.K., Horton, S.E., Kroger, S., Escher, G., Gensch, E.M., and McMahan, U.J. (1992). The agrin gene encodes for a family of basal lamina proteins that differ in function and distribution. Neuron 8, 691-699.
38. Rupp, F., Payan, D.G., Magill-Solc, C., Cowan, D.M., and Scheller, R.H. (1991). Structure and expression of a rat agrin. Neuron 6, 811-823.
39. Schlessinger, J., and Ullrich, A. (1992). Growth factor signaling by receptor tyrosine kinases. Neuron 9, 383-391.
40. Sealock, R., and Froehner, S.C. (1994). Dystrophin-associated proteins and synapse formation: is α-dystroglycan the agrin receptor? Cell 77, 617-619.
41. Stahl, N., and Yancopoulos, G.D. (1993). The alphas, betas, and kinases of cytokine receptor complexes. Cell 74, 587-590.
42. Stitt, T.N., Conn, G., Gore, M., Lai, C., Bruno, J., Radziejewski, C., Mattson, K., Fisher, J., Gies, D.R., Jones, P.F., Masiakowski, P., Ryan, T.E., Tobkes, N.J., Chen, D.H., DiStefano, P.S., Long, G.L., Basilico, C., Goldfarb, M.P., Lemke, G., Glass, D.J., and Yancopoulos, G.D. (1995). The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 80, 661-670.
43. Sugiyama, J., Bowen, D.C., and Hall, Z.W. (1994). Dystroglycan binds nerve and muscle agrin. Neuron 13, 103-115.
44. Tsim, K.W., Ruegg, M.A., Escher, G., Kroger, S., and McMahan, U.J. (1992). cDNA that encodes active agrin. Neuron 8, 677-689.
45. Valenzuela, D.M., Stitt, T.N., DiStefano, P.S., Rojas, E., Mattsson, K., Compton, D.L., Nunez, L., Park, J.S., Stark, J.L., Gies, D.R., Thomas, S., Le Beau, M.M., Fernald, A.A., Copeland, N.G., Jenkins, N.A., Burden, S.J., Glass, D.J., and Yancopoulos, G.D. (1995). Receptor tyrosine kinase specific for the skeltal muscle lineage: expression in embryonic muscle, at the neuromuscualr junction, and after injury. Neuron 15, 573-584.
46. Wallace, B.G. (1989). Agrin-induced specializations contain cytoplasmic, membrane, and extracellular matrix-associated components of the postsynaptic apparatus. J. Neurosci. 9, 1294-1302.
47. Wallace, B.G. (1994). Staurosporine inhibits agrin-induced acetylcholine receptor phosphorylation and aggregation. J. Cell Biol. 125, 661-668.
48. Wallace, B.G. (1995). Regulation of the interaction of nicotinic acetylcholine receptors with the cytoskeleton by agrin-activated protein tyrosine kinase. J. Cell Biol. 128, 1121-1129.
49. Wallace, B.G., Qu, Z., and Huganir, R.L. (1991). Agrin induces phosphorylation of the nicotinic acetylcholine receptor. Neuron 6, 869-878.