Mesodermal expression of Fgfr2S252W is necessary and sufficient to induce craniosynostosis in a mouse model of Apert syndrome

Developmental Biology

Volumn 368, Issue 2, 2012, Pages 283-293

  Holmes, Greg ^a,b   Basilico, Claudio ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apert syndrome; Craniosynostosis; Mesoderm; Neural crest

Indexed keywords

BETA GALACTOSIDASE; CRE RECOMBINASE; FIBROBLAST GROWTH FACTOR RECEPTOR 2; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST1; UNCLASSIFIED DRUG; FGFR2 PROTEIN, MOUSE;

ACROCEPHALOSYNDACTYLY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CELL MIGRATION; CONTROLLED STUDY; CRANIOFACIAL SYNOSTOSIS; DURA MATER; EMBRYO DEVELOPMENT; FRONTAL BONE; GENE MUTATION; GENETIC RECOMBINATION; HAPLOINSUFFICIENCY; MESODERM; MOLECULAR PATHOLOGY; MOUSE; MOUSE MUTANT; NEURAL CREST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKULL BASE; AMINO ACID SUBSTITUTION; ANIMAL; CRANIAL SUTURE; CYTOCHEMISTRY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MUTATION; NEWBORN; PRENATAL DEVELOPMENT; TRANSGENIC MOUSE;

MUS;

ACROCEPHALOSYNDACTYLIA; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, NEWBORN; BETA-GALACTOSIDASE; CRANIAL SUTURES; CRANIOSYNOSTOSES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTOCYTOCHEMISTRY; HUMANS; MESODERM; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; NEURAL CREST; OSTEOGENESIS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2;

EID: 84864027660     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2012.05.026     Document Type: Article

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