The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling

Developmental Biology

Volumn 379, Issue 2, 2013, Pages 229-234

  Lewis, Ace E ^a   Vasudevan, Harish N ^b   O'Neill, Audrey K ^a   Soriano, Philippe ^b   Bush, Jeffrey O ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Craniofacial; Dopaminergic neurons; Midbrain; Neural crest; Wnt signaling; Wnt1 Cre

Indexed keywords

BETA CATENIN; WNT PROTEIN; WNT1 PROTEIN; BROXURIDINE; CRE RECOMBINASE; INTEGRASE; PRIMER DNA; WNT1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; DOPAMINERGIC NERVE CELL; EMBRYO; GENE EXPRESSION; INFERIOR COLLICULUS; MESENCEPHALON; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC MOUSE; VENTRAL MIDBRAIN; WNT1 CRE TRANSGENE; WNT1 GENE; ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; GENOTYPE; IN SITU HYBRIDIZATION; METABOLISM; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL CREST; PHYSIOLOGY; PRENATAL DEVELOPMENT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS MUSCULUS;

ANIMALS; BLOTTING, WESTERN; BROMODEOXYURIDINE; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; GENOTYPE; IN SITU HYBRIDIZATION; INTEGRASES; MESENCEPHALON; MICE; MICE, TRANSGENIC; NEURAL CREST; NEUROGENESIS; PHENOTYPE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WNT1 PROTEIN;

MLCS; MLOWN;

EID: 84878832554     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2013.04.026     Document Type: Article

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