Ephrin signaling in vivo: Look both ways

Developmental Dynamics

Volumn 232, Issue 1, 2005, Pages 1-10

  Davy, Alice ^a   Soriano, Philippe ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Animal models; Eph receptors; Ephrin; Signaling

Indexed keywords

EPHRIN; EPHRIN RECEPTOR;

ANGIOGENESIS; ANIMAL MODEL; CAENORHABDITIS ELEGANS; CELL MIGRATION; EMBRYO; EMBRYO DEVELOPMENT; GENE MUTATION; GENE OVEREXPRESSION; NERVE FIBER GROWTH; NEURAL CREST CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; XENOPUS; ZEBRA FISH;

ANIMALS; AXONS; CELL MOVEMENT; EPHRINS; HUMANS; LIGANDS; MICE; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PHYSIOLOGIC; NEURAL CREST; RECEPTORS, EPH FAMILY; SIGNAL TRANSDUCTION; XENOPUS;

ANIMALIA;

EID: 11244299992     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.20200     Document Type: Review

References (60)

1. Adams RH. 2002. Vascular patterning by Eph receptor tyrosine kinases and ephrins. Cell Dev Biol 13:55-60.
2. Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R. 2001. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell 104:57-69.
3. Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R. 1999. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev 13:295-306.
4. Barrios A, Poole RJ, Durbin L, Brennan C, Holder N, Wilson SW. 2003. Eph/ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis. Curr Biol 13:1571-1582.
5. Birgbauer E, Cowan CA, Sretavan DW, Henkemeyer M. 2000. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development 127:1231-1241.
6. Bossing T, Brand AH. 2002. Dephrin, a transmembrane ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophila embryonic CNS. Development 129:4205-4218.
7. Bruckner K, Labrador JP, Scheiffele P, Herb A, Seeburg P, Klein R. 1999. EphrinB ligands recruit GRIP family PDZ adaptor proteins into rafts membrane microdomains. Neuron 22:511-524.
8. Chin-Sang ID, George SE, Ding M, Moseley SL, Lynch AS, Chisholm AD. 1999. The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans. Cell 99:781-790.
9. Chong LD, Park EK, Latimer E, Friesel R, Daar IO. 2000. Fibroblast growth factor receptor-mediated rescue of x-ephrin B1-induced cell dissociation in Xenopus embryos. Mol Cell Biol 20:724-734.
10. Cowan CA, Henkemeyer M. 2001. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature 413:174-179.
11. Cowan CA, Henkemeyer M. 2002. Ephrins in reverse, park and drive. Trends Cell Biol 12:339-346.
12. Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M. 2004. Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol (in press).
13. Davy A, Aubin J, Soriano P. 2004. EphrinB1 forward and reverse signaling are required during mouse development. Genes Dev 18:572-583.
14. Davy A, Gale NW, Murray EW, Feuerstein C, Klinghoffer R, Soriano P, Robbins SM. 1999. Compartmentalized signaling by GPI-anchored Ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev 13:3125-3135.
15. Davy A, Robbins SM. 2000. Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner. EMBO J 19:5396-5405.
16. Dottori M, Hartley L, Galea M, Paxinos G, Polizzotto M, Kilpatrick T, Hartley PF, Murphy M, Kontgen F, Boyd AW. 1998. EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc Natl Acad Sci USA 95:13248-13253.
17. Dravis C, Yokoyama N, Chumley MJ, Cowan CA, Silvany RE, Shay J, Baker LA, Henkemeyer M. 2004. Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol 271:272-290.
18. Durbin L, Brennan C, Shiomi K, Cooke J, Barrios A, Shammugalingam S, Guthrie B, Lindberg R, Holder N. 1998. Eph signaling is required for segmentation and differentiation of the somites. Genes Dev 12:3096-3109.
19. Eberhart J, Barr J, O'Connell S, Flagg A, Swartz ME, Cramer KS, Tosney KW, Pasquale EB, Krull CE. 2004. Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of Eph-A4-positive motor neurons. J Neurosci 24:1070-1078.
20. Feldheim DA, Kim YI, Bergemann AD, Frisen J, Barbacid M, Flanagan JG. 2000. Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron 25:563-574.
21. Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD. 1996. Eph receptors and ligands comprise two major specificity subclasses, and are reciprocally compartmentalized during embryogenesis. Neuron 17:9-19.
22. George SE, Simokat K, Hardin J, Chisholm AD. 1998. The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. Cell 92:633-643.
23. Gerety SS, Wang HU, Chen ZF, Anderson DJ. 1999. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrinB2 in cardiovascular development. Mol Cell 4:403-414.
24. Grunwald IC, Korte M, Wolfer D, Wilkinson GA, Unsicker K, Lipp HP, Bonhoeffer T, Klein R. 2001. Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron 32:1027-1040.
25. Helbing PM, Saulnier DME, Brandli AW. 2000. The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis. Development 127:269-278.
26. Henkemeyer M, Orioli D, Henderson JT, Saxton TM, Roder J, Pawson T, Klein R. 1996. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell 86:35-46.
27. Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, Nikolov DB. 2004. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci 7:501-509.
28. Hindges R, McLaughlin T, Genoud N, Henkemeyer M, O'Leary DD. 2002. EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping. Neuron 35:475-487.
29. Holder N, Klein R. 1999. Eph receptors and ephrins: effectors of morphogenesis. Development 126:2033-2044.
30. Hornberger M, Dutting D, Ciossek T, Yamada T, Handwerker C, Lang S, Weth F, Huf J, Webel R, Logan C, Tanaka H, Drescher U. 1999. Modulation of EphA receptor function by co-expressed ligands on retinal ganglion cell axons. Neuron 22:731-742.
31. Huai J, Drescher U. 2001. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. J Biol Chem 276:6689-6694.
32. Knoll B, Drescher U. 2002. Ephrin-As as receptors in topographic projections. Trends Neurosci 25:145-149.
33. Knoll B, Zarbalis K, Wurst W, Drescher U. 2001. A role for the EphA family in the topographic targeting of vomeronasal axons. Development 128:895-906.
34. Krull CE, Lansford R, Gale NW, Marcelle C, Collazo A, Yancopoulos GD. 1997. Interactions of Eph-related receptors and ligands confers rostrocaudal pattern to trunk neural crest migration. Curr Biol 7:571-580.
35. Kullander K, Groll SD, Zimmer M, Pan L, McClain J, Hughes V, Zabski S, DeChiara TM, Klein R, Yancopoulos GD, Gale NW. 2001a. Ephrin-B3 is the midline barrier that prevents corticospinal tracts axons from recrossing, allowing for unilateral motor control. Genes Dev 15:877-888.
36. Kullander K, Klein R. 2002. Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol 3:475-486.
37. Kullander K, Mather NK, Diella F, Dottori M, Boyd AW, Klein R. 2001b. Kinase-dependent and kinase-independent functions of EphA4 receptor in major axon tract formation in vivo. Neuron 29:73-84.
38. Mann F, Miranda E, Weinl C, Harmer E, Holt CE. 2003. B-type Eph receptors and ephrins induce growth cone collapse through distinct intracellular pathways. J Neurobiol 57:323-336.
39. Mann F, Ray S, Harris WA, Holt CE. 2002. Topographic mapping in dorsoventral axis of the Xenopus retinotectal system depends on signaling through ephrin-B-ligands. Neuron 35:461-473.
40. Martson DJ, Dickinson S, Nobes CD. 2003. Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion. Nat Cell Biol 5:879-888.
41. Mellitzer G, Xu Q, Wilkinson DG. 1999. Eph receptors and ephrins restrict cell intermingling and communication. Nature 400:77-81.
42. Moore KB, Mood K, Daar IO, Moody SA. 2004. Morphogenetic movements underlying eye field formation require interactions between the FGF and ephrinB1 signaling pathways. Dev Cell 6:55-67.
43. Murai KK, Pasquale EB. 2003. 'Eph'ective signaling: forward, reverse and cross-talk. J Cell Sci 116:2823-2832.
44. O'Leary DD, Wilkinson DG. 1999. Eph receptors and ephrins in neural development. Curr Opin Neurobiol 9:65-73.
45. Orioli D, Henkemeyer M, Lemke G, Klein R, Pawson T. 1996. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J 15:6035-6049.
46. Orioli D, Klein R. 1997. The Eph receptor family: axonal guidance by contact repulsion. TIG 13:354-359.
47. Palmer A, Klein R. 2003. Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function. Genes Dev 17:1429-1450.
48. Pasquale EB. 1997. The Eph family of receptors. Curr Opin Cell Biol 9:608-615.
49. Scully AL, McKeown M, Thomas JB. 1999. Isolation and characterization of Dek, a Drosophila Eph receptor protein tyrosine kinase. Mol Cell Neurosci 13:337-347.
50. Smith A, Robinson V, Patel K, Wilkinson DG. 1997. The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells. Curr Biol 7:561-570.
51. Tanaka M, Kamo T, Ota S, Sugimura H. 2003. Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion. EMBO J 22:847-858.
52. Tuzi NL, Gullick WJ. 1994. eph, the largest known family of putative growth factor receptors. Br J Cancer 69:417-421.
53. Wang HU, Anderson DJ. 1997. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron 18:383-396.
54. Wang HU, Chien Z-F, Anderson DJ. 1998. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor eph-B4. Cell 93:741-753.
55. Wang X, Roy PJ, Holland SJ, Zhang LW, Culotti JG, Pawson T. 1999. Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor. Mol Cell 4:903-913.
56. Wilkinson DG. 2000. Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol 196:177-244.
57. Xu Q, Alldus G, Holder N, Wilkinson DG. 1995. Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in Xenopus and zebrafish hindbrain. Development 121:4005-4016.
58. Xu Q, Mellitzer G, Robinson V, Wilkinson DG. 1999. In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature 399:267-271.
59. Yokoyama N, Romero MI, Cowan CA, Galvan P, Helmbacher F, Charnay P, Parada LF, Henkemeyer M. 2001. Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron 29:85-97.
60. Zimmer M, Palmer A, Kohler J, Klein R. 2003. EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat Cell Biol 5:869-878.