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Volumn 118, Issue 5, 2008, Pages 1890-1898

Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN RET;

EID: 43049141138     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34425     Document Type: Article
Times cited : (142)

References (39)
  • 2
    • 0030139478 scopus 로고    scopus 로고
    • Hirschsprung's disease
    • Skinner, M.A. 1996. Hirschsprung's disease. Curr. Probl. Surg. 33:389-460.
    • (1996) Curr. Probl. Surg , vol.33 , pp. 389-460
    • Skinner, M.A.1
  • 3
    • 0033739538 scopus 로고    scopus 로고
    • Genetics of Hirschsprung disease
    • Parisi, M.A., and Kapur, R.P. 2000. Genetics of Hirschsprung disease. Curr. Opin. Pediatr. 12:610-617.
    • (2000) Curr. Opin. Pediatr , vol.12 , pp. 610-617
    • Parisi, M.A.1    Kapur, R.P.2
  • 4
    • 0034764984 scopus 로고    scopus 로고
    • Hirschsprung disease, associated syndromes, and genetics: A review
    • Amiel, J., and Lyonnet, S. 2001. Hirschsprung disease, associated syndromes, and genetics: a review. J. Med. Genet. 38:729-739.
    • (2001) J. Med. Genet , vol.38 , pp. 729-739
    • Amiel, J.1    Lyonnet, S.2
  • 5
    • 0036578787 scopus 로고    scopus 로고
    • Dissecting Hirschsprung disease
    • Passarge, E. 2002. Dissecting Hirschsprung disease. Nat. Genet. 31:11-12.
    • (2002) Nat. Genet , vol.31 , pp. 11-12
    • Passarge, E.1
  • 6
    • 0027972513 scopus 로고
    • Mutations of the RET proto-oncogene in Hirschsprung's disease
    • Edery, P., et al. 1994. Mutations of the RET proto-oncogene in Hirschsprung's disease. Nature. 367:378-380.
    • (1994) Nature , vol.367 , pp. 378-380
    • Edery, P.1
  • 7
    • 0028120882 scopus 로고
    • Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease
    • Romeo, G., et al. 1994. Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature. 367:377-378.
    • (1994) Nature , vol.367 , pp. 377-378
    • Romeo, G.1
  • 8
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • Airaksinen, M.S., and Saarma, M. 2002. The GDNF family: signalling, biological functions and therapeutic value. Nat. Rev. Neurosci. 3:383-394.
    • (2002) Nat. Rev. Neurosci , vol.3 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 9
    • 0033964411 scopus 로고    scopus 로고
    • The GDNF family ligands and receptors - implications for neural development
    • Baloh, R.H., Enomoto, H., Johnson, E.M., Jr., and Milbrandt, J. 2000. The GDNF family ligands and receptors - implications for neural development. Curr. Opin. Neurobiol. 10:103-110.
    • (2000) Curr. Opin. Neurobiol , vol.10 , pp. 103-110
    • Baloh, R.H.1    Enomoto, H.2    Johnson Jr., E.M.3    Milbrandt, J.4
  • 10
    • 0036832278 scopus 로고    scopus 로고
    • Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
    • Natarajan, D., Marcos-Gutierrez, C., Pachnis, V., and de Graaff, E. 2002. Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis. Development. 129:5151-5160.
    • (2002) Development , vol.129 , pp. 5151-5160
    • Natarajan, D.1    Marcos-Gutierrez, C.2    Pachnis, V.3    de Graaff, E.4
  • 11
    • 0028174023 scopus 로고
    • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    • Schuchardt, A., D'Agati, V., Larsson-Blomberg, L., Costantini, F., and Pachnis, V. 1994. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature. 367:380-383.
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt, A.1    D'Agati, V.2    Larsson-Blomberg, L.3    Costantini, F.4    Pachnis, V.5
  • 12
    • 0035862753 scopus 로고    scopus 로고
    • GDNF is a chemoattractant for enteric neural cells
    • Young, H.M., et al. 2001. GDNF is a chemoattractant for enteric neural cells. Dev. Biol. 229:503-516.
    • (2001) Dev. Biol , vol.229 , pp. 503-516
    • Young, H.M.1
  • 13
    • 0032535234 scopus 로고    scopus 로고
    • Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: Expression of GFRalpha-1 in vitro and in vivo
    • Chalazonitis, A., Rothman, T.P., Chen, J., and Gershon, M.D. 1998. Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1 in vitro and in vivo. Dev. Biol. 204:385-406.
    • (1998) Dev. Biol , vol.204 , pp. 385-406
    • Chalazonitis, A.1    Rothman, T.P.2    Chen, J.3    Gershon, M.D.4
  • 14
    • 0032145723 scopus 로고    scopus 로고
    • Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro
    • Heuckeroth, R.O., Lampe, P.A., Johnson, E.M., and Milbrandt, J. 1998. Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Dev. Biol. 200:116-129.
    • (1998) Dev. Biol , vol.200 , pp. 116-129
    • Heuckeroth, R.O.1    Lampe, P.A.2    Johnson, E.M.3    Milbrandt, J.4
  • 15
    • 0032786441 scopus 로고    scopus 로고
    • Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system
    • Taraviras, S., et al. 1999. Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development. 126:2785-2797.
    • (1999) Development , vol.126 , pp. 2785-2797
    • Taraviras, S.1
  • 16
    • 34250885111 scopus 로고    scopus 로고
    • Conditional ablation of GFRα1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype
    • Uesaka, T., et al. 2007. Conditional ablation of GFRα1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development. 134:2171-2181.
    • (2007) Development , vol.134 , pp. 2171-2181
    • Uesaka, T.1
  • 17
    • 17244383525 scopus 로고    scopus 로고
    • A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk
    • Emison, E.S., et al. 2005. A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk. Nature. 434:857-863.
    • (2005) Nature , vol.434 , pp. 857-863
    • Emison, E.S.1
  • 18
    • 33845873043 scopus 로고    scopus 로고
    • Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells
    • Asai, N., et al. 2006. Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development 133:4507-4516.
    • (2006) Development , vol.133 , pp. 4507-4516
    • Asai, N.1
  • 19
    • 33645456054 scopus 로고    scopus 로고
    • The Ret(C620R) mutation affects renal and enteric development in a mouse model of Hirschsprung's disease
    • Carniti, C., et al. 2006. The Ret(C620R) mutation affects renal and enteric development in a mouse model of Hirschsprung's disease. Am. J. Pathol. 168:1262-1275.
    • (2006) Am. J. Pathol , vol.168 , pp. 1262-1275
    • Carniti, C.1
  • 20
    • 0035883740 scopus 로고    scopus 로고
    • Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
    • de Graaff, E., et al. 2001. Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev. 15:2433-2444.
    • (2001) Genes Dev , vol.15 , pp. 2433-2444
    • de Graaff, E.1
  • 21
    • 9444225531 scopus 로고    scopus 로고
    • Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis
    • Jain, S., et al. 2004. Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development. 131:5503-5513.
    • (2004) Development , vol.131 , pp. 5503-5513
    • Jain, S.1
  • 22
    • 4444324911 scopus 로고    scopus 로고
    • A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia
    • Jijiwa, M., et al. 2004. A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia. Mol. Cell. Biol. 24:8026-8036.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 8026-8036
    • Jijiwa, M.1
  • 23
    • 27144467717 scopus 로고    scopus 로고
    • Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform
    • Wong, A., et al. 2005. Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Mol. Cell. Biol. 25:9661-9673.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 9661-9673
    • Wong, A.1
  • 24
    • 0023834887 scopus 로고
    • Hirschsprung disease associated with polydactyly, unilateral renal agenesis, hypertelorism, and congenital deafness: A new autosomal recessive syndrome
    • Santos, H., Mateus, J., and Leal, M.J. 1988. Hirschsprung disease associated with polydactyly, unilateral renal agenesis, hypertelorism, and congenital deafness: a new autosomal recessive syndrome. J. Med. Genet. 25:204-205.
    • (1988) J. Med. Genet , vol.25 , pp. 204-205
    • Santos, H.1    Mateus, J.2    Leal, M.J.3
  • 25
    • 32044436042 scopus 로고    scopus 로고
    • Critical and distinct roles for key RET tyrosine docking sites in renal development
    • Jain, S., Encinas, M., Johnson, E.M., Jr., and Milbrandt, J. 2006. Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes Dev. 20:321-333.
    • (2006) Genes Dev , vol.20 , pp. 321-333
    • Jain, S.1    Encinas, M.2    Johnson Jr., E.M.3    Milbrandt, J.4
  • 26
    • 0037194898 scopus 로고    scopus 로고
    • GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools
    • Haase, G., et al. 2002. GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. Neuron. 35:893-905.
    • (2002) Neuron , vol.35 , pp. 893-905
    • Haase, G.1
  • 27
    • 17744417682 scopus 로고    scopus 로고
    • A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture
    • Young, H.M., et al. 1998. A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture. Dev. Biol. 202:67-84.
    • (1998) Dev. Biol , vol.202 , pp. 67-84
    • Young, H.M.1
  • 28
    • 33751099301 scopus 로고    scopus 로고
    • RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice
    • Jain, S., et al. 2006. RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. J. Neurosci. 26:11230-11238.
    • (2006) J. Neurosci , vol.26 , pp. 11230-11238
    • Jain, S.1
  • 29
    • 33947278829 scopus 로고    scopus 로고
    • Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system
    • Kramer, E.R., et al. 2007. Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biol. 5:e39.
    • (2007) PLoS Biol , vol.5
    • Kramer, E.R.1
  • 30
    • 34249743706 scopus 로고    scopus 로고
    • A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons
    • Luo, W., et al. 2007. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 54:739-754.
    • (2007) Neuron , vol.54 , pp. 739-754
    • Luo, W.1
  • 31
    • 0034254457 scopus 로고    scopus 로고
    • The RET proto-oncogene induces apoptosis: A novel mechanism for Hirschsprung disease
    • Bordeaux, M.C., et al. 2000. The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J. 19:4056-4063.
    • (2000) EMBO J , vol.19 , pp. 4056-4063
    • Bordeaux, M.C.1
  • 32
    • 34247192417 scopus 로고    scopus 로고
    • The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth
    • Canibano, C., et al. 2007. The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth. EMBO J. 26:2015-2028.
    • (2007) EMBO J , vol.26 , pp. 2015-2028
    • Canibano, C.1
  • 33
    • 0034069860 scopus 로고    scopus 로고
    • RET and GDNF gene scanning in Hirschsprung patients using two dual denaturing gel systems
    • Hofstra, R.M., et al. 2000. RET and GDNF gene scanning in Hirschsprung patients using two dual denaturing gel systems. Hum. Mutat. 15:418-429.
    • (2000) Hum. Mutat , vol.15 , pp. 418-429
    • Hofstra, R.M.1
  • 34
    • 33846912037 scopus 로고    scopus 로고
    • A common variant located in the 3′UTR of the RET gene is associated with protection from Hirschsprung disease
    • Griseri, P., et al. 2007. A common variant located in the 3′UTR of the RET gene is associated with protection from Hirschsprung disease. Hum. Mutat. 28:168-176.
    • (2007) Hum. Mutat , vol.28 , pp. 168-176
    • Griseri, P.1
  • 35
    • 0034764503 scopus 로고    scopus 로고
    • RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons
    • Enomoto, H., et al. 2001. RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons. Development. 128:3963-3974.
    • (2001) Development , vol.128 , pp. 3963-3974
    • Enomoto, H.1
  • 36
    • 0037090881 scopus 로고    scopus 로고
    • Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation/inactivation in the mouse
    • Hayashi, S., and McMahon, A.P. 2002. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev. Biol. 244:305-318.
    • (2002) Dev. Biol , vol.244 , pp. 305-318
    • Hayashi, S.1    McMahon, A.P.2
  • 37
    • 20244381688 scopus 로고    scopus 로고
    • Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts
    • Kunath, T., et al. 2005. Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development. 132:1649-1661.
    • (2005) Development , vol.132 , pp. 1649-1661
    • Kunath, T.1
  • 38
    • 0032129239 scopus 로고    scopus 로고
    • GFR α1-deficient mice have deficits in the enteric nervous system and kidneys
    • Enomoto, H., et al. 1998. GFR α1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron. 21:317-324.
    • (1998) Neuron , vol.21 , pp. 317-324
    • Enomoto, H.1
  • 39
    • 2942625882 scopus 로고    scopus 로고
    • Dynamics of neural crestderived cell migration in the embryonic mouse gut
    • Young, H.M., et al. 2004. Dynamics of neural crestderived cell migration in the embryonic mouse gut. Dev. Biol. 270:455-473.
    • (2004) Dev. Biol , vol.270 , pp. 455-473
    • Young, H.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.