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Volumn 14, Issue 12, 2014, Pages 769-785

The TAM family: Phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN TYROSINE KINASE INHIBITOR; TAM PROTEIN; UNCLASSIFIED DRUG; AXL RECEPTOR TYROSINE KINASE; MERTK PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATIDYLSERINE; PROTEIN TYROSINE KINASE;

EID: 84922481128     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3847     Document Type: Review
Times cited : (562)

References (199)
  • 2
    • 0026010027 scopus 로고
    • AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
    • O'Bryan, J. P. et al. AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol. Cell. Biol. 11, 5016-5031 (1991
    • (1991) Mol. Cell. Biol , vol.11 , pp. 5016-5031
    • O'bryan, J.P.1
  • 3
    • 0027934889 scopus 로고
    • Expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase
    • Lai, C., Gore, M. & Lemke, G. Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase. Oncogene 9, 2567-2578 (1994
    • (1994) Oncogene , vol.9 , pp. 2567-2578
    • Lai, C.1    Gore, M.2    Structure, L.G.3
  • 4
    • 46449103344 scopus 로고    scopus 로고
    • TAM receptor tyrosine kinases: Biologic functions, signaling, and potential therapeutic targeting in human cancer
    • Linger, R. M., Keating, A. K., Earp, H. S. & Graham, D. K. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv. Cancer Res. 100, 35-83 (2008
    • (2008) Adv. Cancer Res , vol.100 , pp. 35-83
    • Linger, R.M.1    Keating, A.K.2    Earp, H.S.3    Graham, D.K.4
  • 5
    • 42649140235 scopus 로고    scopus 로고
    • Immunobiology of the TAM receptors
    • Lemke, G. & Rothlin, C. V. Immunobiology of the TAM receptors. Nature Rev. Immunol. 8, 327-336 (2008
    • (2008) Nature Rev. Immunol , vol.8 , pp. 327-336
    • Lemke, G.1    Rothlin, C.V.2
  • 6
    • 0028875948 scopus 로고
    • Mitogenic signals and transforming potential of NYK, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase
    • Ling, L. & Kung, H. J. Mitogenic signals and transforming potential of NYK, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase. Mol. Cell. Biol. 15, 6582-6592 (1995
    • (1995) Mol. Cell. Biol , vol.15 , pp. 6582-6592
    • Ling, L.1    Kung, H.J.2
  • 7
    • 33846808910 scopus 로고    scopus 로고
    • RTK and TGF-β signaling pathways genes in the sea urchin genome
    • Lapraz, F. et al. RTK and TGF-β signaling pathways genes in the sea urchin genome. Dev. Biol. 300, 132-152 (2006
    • (2006) Dev. Biol , vol.300 , pp. 132-152
    • Lapraz, F.1
  • 8
    • 0025805606 scopus 로고
    • An extended family of protein-Tyrosine kinase genes differentially expressed in the vertebrate nervous system
    • Lai, C. & Lemke, G. An extended family of protein-Tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron 6, 691-704 (1991
    • (1991) Neuron , vol.6 , pp. 691-704
    • Lai, C.1    Lemke, G.2
  • 9
    • 0026660404 scopus 로고
    • A novel oncogene, v RYK, encoding a truncated receptor tyrosine kinase is transduced into the RPL30 virus without loss of viral sequences
    • Jia, R., Mayer, B. J., Hanafusa, T. & Hanafusa, H. A novel oncogene, v RYK, encoding a truncated receptor tyrosine kinase is transduced into the RPL30 virus without loss of viral sequences. J. Virol. 66, 5975-5987 (1992
    • (1992) J. Virol , vol.66 , pp. 5975-5987
    • Jia, R.1    Mayer, B.J.2    Hanafusa, T.3    Hanafusa, H.4
  • 10
    • 33749836690 scopus 로고    scopus 로고
    • Lymphoblastic leukemia/lymphoma in mice overexpressing the MER (MERTK) receptor tyrosine kinase
    • Keating, A. K. et al. Lymphoblastic leukemia/lymphoma in mice overexpressing the MER (MERTK) receptor tyrosine kinase. Oncogene 25, 6092-6100 (2006
    • (2006) Oncogene , vol.25 , pp. 6092-6100
    • Keating, A.K.1
  • 11
    • 0037025316 scopus 로고    scopus 로고
    • MER receptor tyrosine kinase signaling: Prevention of apoptosis and alteration of cytoskeletal architecture without stimulation or proliferation
    • Guttridge, K. L. et al. MER receptor tyrosine kinase signaling: prevention of apoptosis and alteration of cytoskeletal architecture without stimulation or proliferation. J. Biol. Chem. 277, 24057-24066 (2002
    • (2002) J. Biol. Chem , vol.277 , pp. 24057-24066
    • Guttridge, K.L.1
  • 12
    • 0033595099 scopus 로고    scopus 로고
    • GAS6 mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of RAS
    • Goruppi, S., Ruaro, E., Varnum, B. & Schneider, C. GAS6 mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of RAS. Oncogene 18, 4224-4236 (1999
    • (1999) Oncogene , vol.18 , pp. 4224-4236
    • Goruppi, S.1    Ruaro, E.2    Varnum, B.3    Schneider, C.4
  • 13
    • 4544263058 scopus 로고    scopus 로고
    • GAS6 inhibits apoptosis in vascular smooth muscle: Role of AXL kinase and AKT
    • Melaragno, M. G. et al. GAS6 inhibits apoptosis in vascular smooth muscle: role of AXL kinase and AKT. J. Mol. Cell Cardiol. 37, 881-887 (2004
    • (2004) J. Mol. Cell Cardiol , vol.37 , pp. 881-887
    • Melaragno, M.G.1
  • 14
    • 0030817336 scopus 로고    scopus 로고
    • Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation
    • Bellosta, P., Zhang, Q., Goff, S. P. & Basilico, C. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene 15, 2387-2397 (1997
    • (1997) Oncogene , vol.15 , pp. 2387-2397
    • Bellosta, P.1    Zhang, Q.2    Goff, S.P.3    Basilico, C.4
  • 15
    • 0028985212 scopus 로고
    • AXL receptor tyrosine kinase stimulated by the vitamin K dependent protein encoded by growth-Arrest-specific gene 6
    • Varnum, B. C. et al. AXL receptor tyrosine kinase stimulated by the vitamin K dependent protein encoded by growth-Arrest-specific gene 6. Nature 373, 623-626 (1995
    • (1995) Nature , vol.373 , pp. 623-626
    • Varnum, B.C.1
  • 16
    • 0028913076 scopus 로고
    • The anticoagulation factor protein S and its relative, GAS6, are ligands for the TYRO3/AXL family of receptor tyrosine kinases
    • Stitt, T. N. et al. The anticoagulation factor protein S and its relative, GAS6, are ligands for the TYRO3/AXL family of receptor tyrosine kinases. Cell 80, 661-670 (1995
    • (1995) Cell , vol.80 , pp. 661-670
    • Stitt, T.N.1
  • 17
    • 0029910706 scopus 로고    scopus 로고
    • Identification of the product of growth arrest-specific gene 6 as a common ligand for AXL SKY, and MER receptor tyrosine kinases
    • Nagata, K. et al. Identification of the product of growth arrest-specific gene 6 as a common ligand for AXL, SKY, and MER receptor tyrosine kinases. J. Biol. Chem. 271, 30022-30027 (1996
    • (1996) J. Biol. Chem , vol.271 , pp. 30022-30027
    • Nagata, K.1
  • 18
    • 30444433575 scopus 로고    scopus 로고
    • Structural basis for GAS6-AXL signalling
    • Sasaki, T. et al. Structural basis for GAS6-AXL signalling. EMBO J. 25, 80-87 (2006
    • (2006) EMBO J. , vol.25 , pp. 80-87
    • Sasaki, T.1
  • 19
    • 84907164891 scopus 로고    scopus 로고
    • Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation
    • Tsou, W. I. et al. Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation. J. Biol. Chem. 289, 25750-25763 (2014
    • (2014) J. Biol. Chem , vol.289 , pp. 25750-25763
    • Tsou, W.I.1
  • 20
    • 84992570470 scopus 로고    scopus 로고
    • Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities
    • Lew, E. D. et al. Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. eLife 3, e03385 (2014
    • (2014) ELife , vol.3 , pp. e03385
    • Lew, E.D.1
  • 22
    • 78649714537 scopus 로고    scopus 로고
    • And tubby-like protein 1 are new MERTK ligands for phagocytosis
    • Caberoy, N. B., Zhou, Y. & Li, W. Tubby and tubby-like protein 1 are new MERTK ligands for phagocytosis. EMBO J. 29, 3898-3910 (2010
    • (2010) EMBO J. , vol.29 , pp. 3898-3910
    • Caberoy, N.B.1    Zhou, Y.2    Tubby, L.W.3
  • 23
    • 84867143780 scopus 로고    scopus 로고
    • Tubby regulates microglial phagocytosis through MERTK
    • Caberoy, N. B., Alvarado, G. & Li, W. Tubby regulates microglial phagocytosis through MERTK. J. Neuroimmunol. 252, 40-48 (2012
    • (2012) J. Neuroimmunol , vol.252 , pp. 40-48
    • Caberoy, N.B.1    Alvarado, G.2    Li, W.3
  • 24
  • 25
    • 0035837323 scopus 로고    scopus 로고
    • Phagocytosis and clearance of apoptotic cells is mediated by MER
    • Scott, R. S. et al. Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411, 207-211 (2001
    • (2001) Nature , vol.411 , pp. 207-211
    • Scott, R.S.1
  • 26
    • 2942571210 scopus 로고    scopus 로고
    • Mer receptor tyrosine kinase signaling participates in platelet function
    • Chen, C. et al. Mer receptor tyrosine kinase signaling participates in platelet function. Arterioscler Thromb. Vasc. Biol. 24, 1118-1123 (2004
    • (2004) Arterioscler Thromb. Vasc. Biol , vol.24 , pp. 1118-1123
    • Chen, C.1
  • 27
    • 38849092767 scopus 로고    scopus 로고
    • Role of GAS6 in erythropoiesis and anemia in mice
    • Angelillo-Scherrer, A. et al. Role of GAS6 in erythropoiesis and anemia in mice. J. Clin. Invest. 118, 583-596 (2008
    • (2008) J. Clin. Invest , vol.118 , pp. 583-596
    • Angelillo-Scherrer, A.1
  • 28
    • 78650059543 scopus 로고    scopus 로고
    • Ectosomes released by polymorphonuclear neutrophils induce a MERTK-dependent anti-inflammatory pathway in macrophages
    • Eken, C. et al. Ectosomes released by polymorphonuclear neutrophils induce a MERTK-dependent anti-inflammatory pathway in macrophages. J. Biol. Chem. 285, 39914-39921 (2010
    • (2010) J. Biol. Chem , vol.285 , pp. 39914-39921
    • Eken, C.1
  • 29
    • 42549153337 scopus 로고    scopus 로고
    • Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells
    • Mercer, J. & Helenius, A. Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells. Science 320, 531-535 (2008
    • (2008) Science , vol.320 , pp. 531-535
    • Mercer, J.1    Helenius, A.2
  • 30
    • 84882338751 scopus 로고    scopus 로고
    • Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors
    • Bhattacharyya, S. et al. Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors. Cell Host Microbe 14, 136-147 (2013
    • (2013) Cell Host Microbe , vol.14 , pp. 136-147
    • Bhattacharyya, S.1
  • 31
    • 84881260689 scopus 로고    scopus 로고
    • MERTK inhibition in tumor leukocytes decreases tumor growth and metastasis
    • Cook, R. S. et al. MERTK inhibition in tumor leukocytes decreases tumor growth and metastasis. J. Clin. Invest. 123, 3231-3242 (2013
    • (2013) J. Clin. Invest , vol.123 , pp. 3231-3242
    • Cook, R.S.1
  • 32
    • 84897954522 scopus 로고    scopus 로고
    • The E3 ligase Cbl b and TAM receptors regulate cancer metastasis via natural killer cells
    • Paolino, M. et al. The E3 ligase Cbl b and TAM receptors regulate cancer metastasis via natural killer cells. Nature 507, 508-512 (2014
    • (2014) Nature , vol.507 , pp. 508-512
    • Paolino, M.1
  • 33
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • Rothlin, C. V., Ghosh, S., Zuniga, E. I., Oldstone, M. B. & Lemke, G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131, 1124-1136 (2007
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.4    Lemke, G.5
  • 34
    • 34247580796 scopus 로고    scopus 로고
    • Macrophages and dendritic cells use different AXL/MERTK/TYRO3 receptors in clearance of apoptotic cells
    • Seitz, H. M., Camenisch, T. D., Lemke, G., Earp, H. S. & Matsushima, G. K. Macrophages and dendritic cells use different AXL/MERTK/TYRO3 receptors in clearance of apoptotic cells. J. Immunol. 178, 5635-5642 (2007
    • (2007) J. Immunol , vol.178 , pp. 5635-5642
    • Seitz, H.M.1    Camenisch, T.D.2    Lemke, G.3    Earp, H.S.4    Matsushima, G.K.5
  • 35
    • 77956919603 scopus 로고    scopus 로고
    • Proinflammatory clearance of apoptotic neutrophils induces an IL 12lowIL 10high regulatory phenotype in macrophages
    • Filardy, A. A. et al. Proinflammatory clearance of apoptotic neutrophils induces an IL 12lowIL 10high regulatory phenotype in macrophages. J. Immunol. 185, 2044-2050 (2010
    • (2010) J. Immunol , vol.185 , pp. 2044-2050
    • Filardy, A.A.1
  • 36
    • 0034163837 scopus 로고    scopus 로고
    • Mutation of the receptor tyrosine kinase gene MERTK in the retinal dystrophic RCS rat
    • D'Cruz, P. M. et al. Mutation of the receptor tyrosine kinase gene MERTK in the retinal dystrophic RCS rat. Hum. Mol. Genet. 9, 645-651 (2000
    • (2000) Hum. Mol. Genet , vol.9 , pp. 645-651
    • D'cruz, P.M.1
  • 37
    • 0033757463 scopus 로고    scopus 로고
    • Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
    • Gal, A. et al. Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nature Genet. 26, 270-271 (2000
    • (2000) Nature Genet , vol.26 , pp. 270-271
    • Gal, A.1
  • 38
    • 0037311089 scopus 로고    scopus 로고
    • An RCS-like retinal dystrophy phenotype in Mer-knockout mice
    • Duncan, J. L. et al. An RCS-like retinal dystrophy phenotype in Mer-knockout mice. Invest. Ophthalmol. Vis. Sci. 44, 826-838 (2003
    • (2003) Invest. Ophthalmol. Vis. Sci , vol.44 , pp. 826-838
    • Duncan, J.L.1
  • 39
    • 84886744742 scopus 로고    scopus 로고
    • Preclinical potency and safety studies of an AAV2 mediated gene therapy vector for the treatment of MERTK associated retinitis pigmentosa
    • Conlon, T. J. et al. Preclinical potency and safety studies of an AAV2 mediated gene therapy vector for the treatment of MERTK associated retinitis pigmentosa. Hum. Gene Ther. Clin. Dev. 24, 23-28 (2013
    • (2013) Hum. Gene Ther. Clin. Dev , vol.24 , pp. 23-28
    • Conlon, T.J.1
  • 40
    • 78650602365 scopus 로고    scopus 로고
    • Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation
    • Sandahl, M., Hunter, D. M., Strunk, K. E., Earp, H. S. & Cook, R. S. Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation. BMC Dev. Biol. 10, 122 (2010
    • (2010) BMC Dev. Biol , vol.10 , Issue.122
    • Sandahl, M.1    Hunter, D.M.2    Strunk, K.E.3    Earp, H.S.4    Cook, R.S.5
  • 41
    • 77954309871 scopus 로고    scopus 로고
    • A protective role of MER receptor tyrosine kinase in nephrotoxic serum-induced nephritis
    • Shao, W. H. et al. A protective role of MER receptor tyrosine kinase in nephrotoxic serum-induced nephritis. Clin. Immunol. 136, 236-244 (2010
    • (2010) Clin. Immunol , vol.136 , pp. 236-244
    • Shao, W.H.1
  • 42
    • 77954505329 scopus 로고    scopus 로고
    • Sertoli cell-initiated testicular innate immune response through Toll-like receptor 3 activation is negatively regulated by TYRO3 AXL, and MER receptors
    • Sun, B. et al. Sertoli cell-initiated testicular innate immune response through Toll-like receptor 3 activation is negatively regulated by TYRO3, AXL, and MER receptors. Endocrinology 151, 2886-2897 (2010
    • (2010) Endocrinology , vol.151 , pp. 2886-2897
    • Sun, B.1
  • 43
    • 84890388574 scopus 로고    scopus 로고
    • TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation
    • Ji, R. et al. TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. J. Immunol. 191, 6165-6177 (2013
    • (2013) J. Immunol , vol.191 , pp. 6165-6177
    • Ji, R.1
  • 44
    • 84890547494 scopus 로고    scopus 로고
    • Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
    • Chung, W. S. et al. Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature 504, 394-400 (2013
    • (2013) Nature , vol.504 , pp. 394-400
    • Chung, W.S.1
  • 45
    • 84866554651 scopus 로고    scopus 로고
    • Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MERTK induction
    • Zizzo, G., Hilliard, B. A., Monestier, M. & Cohen, P. L. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MERTK induction. J. Immunol. 189, 3508-3520 (2012
    • (2012) J. Immunol , vol.189 , pp. 3508-3520
    • Zizzo, G.1    Hilliard, B.A.2    Monestier, M.3    Cohen, P.L.4
  • 46
    • 69949158152 scopus 로고    scopus 로고
    • The MER receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses GAS6 as its ligand for uptake of apoptotic cells
    • Shao, W. H., Zhen, Y., Eisenberg, R. A. & Cohen, P. L. The MER receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses GAS6 as its ligand for uptake of apoptotic cells. Clin. Immunol. 133, 138-144 (2009
    • (2009) Clin. Immunol , vol.133 , pp. 138-144
    • Shao, W.H.1    Zhen, Y.2    Eisenberg, R.A.3    Cohen, P.L.4
  • 47
    • 84888000018 scopus 로고    scopus 로고
    • Aberrant MER receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia
    • Lee-Sherick, A. B. et al. Aberrant MER receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia. Oncogene 32, 5359-5368 (2013
    • (2013) Oncogene , vol.32 , pp. 5359-5368
    • Lee-Sherick, A.B.1
  • 48
    • 0142211201 scopus 로고    scopus 로고
    • An SH2 domain-dependent, phosphotyrosine-independent interaction between VAV1 and the MER receptor tyrosine kinase: A mechanism for localizing guanine nucleotide-exchange factor action
    • Mahajan, N. P. & Earp, H. S. An SH2 domain-dependent, phosphotyrosine-independent interaction between VAV1 and the MER receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action. J. Biol. Chem. 278, 42596-42603 (2003
    • (2003) J. Biol. Chem , vol.278 , pp. 42596-42603
    • Mahajan, N.P.1    Earp, H.S.2
  • 49
    • 84864135401 scopus 로고    scopus 로고
    • Preventing cleavage of MER promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice
    • Lee, Y. J. et al. Preventing cleavage of MER promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice. Toxicol. Appl. Pharmacol. 263, 61-72 (2012
    • (2012) Toxicol. Appl. Pharmacol , vol.263 , pp. 61-72
    • Lee, Y.J.1
  • 50
    • 84885318684 scopus 로고    scopus 로고
    • Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid-epithelial-reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction
    • Wan, E. et al. Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid-epithelial-reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction. Circ. Res. 113, 1004-1012 (2013
    • (2013) Circ. Res , vol.113 , pp. 1004-1012
    • Wan, E.1
  • 51
    • 0033559140 scopus 로고    scopus 로고
    • A novel receptor tyrosine kinase, MER, inhibits TNFa production and lipopolysaccharide-induced endotoxic shock
    • Camenisch, T. D., Koller, B. H., Earp, H. S. & Matsushima, G. K. A novel receptor tyrosine kinase, MER, inhibits TNFa production and lipopolysaccharide-induced endotoxic shock. J. Immunol. 162, 3498-3503 (1999
    • (1999) J. Immunol , vol.162 , pp. 3498-3503
    • Camenisch, T.D.1    Koller, B.H.2    Earp, H.S.3    Matsushima, G.K.4
  • 52
    • 41249092199 scopus 로고    scopus 로고
    • Autophosphorylation docking site Tyr 867 in MER receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation
    • Tibrewal, N. et al. Autophosphorylation docking site Tyr 867 in MER receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation. J. Biol. Chem. 283, 3618-3627 (2008
    • (2008) J. Biol. Chem , vol.283 , pp. 3618-3627
    • Tibrewal, N.1
  • 53
    • 33846193992 scopus 로고    scopus 로고
    • Apoptotic cells induce MER tyrosine kinase-dependent blockade of NF-κB activation in dendritic cells
    • Sen, P. et al. Apoptotic cells induce MER tyrosine kinase-dependent blockade of NF-κB activation in dendritic cells. Blood 109, 653-660 (2007
    • (2007) Blood , vol.109 , pp. 653-660
    • Sen, P.1
  • 54
    • 38749108510 scopus 로고    scopus 로고
    • MERTK is required for apoptotic cell-induced T cell tolerance
    • Wallet, M. A. et al. MERTK is required for apoptotic cell-induced T cell tolerance. J. Exp. Med. 205, 219-232 (2008
    • (2008) J. Exp. Med , vol.205 , pp. 219-232
    • Wallet, M.A.1
  • 55
    • 77952490280 scopus 로고    scopus 로고
    • IL 6, and IL 1 Expression Is Inhibited by GAS6 in Monocytes/macrophages
    • Alciato, F., Sainaghi, P. P., Sola, D., Castello, L. & Avanzi, G. C. TNFa, IL 6, and IL 1 expression is inhibited by GAS6 in monocytes/macrophages. J. Leukoc. Biol. 87, 869-875 (2010
    • (2010) J. Leukoc. Biol , vol.87 , pp. 869-875
    • Alciato, F.1    Sainaghi, P.P.2    Sola, D.3    Castello, L.4    Tnfa, C.A.G.5
  • 56
    • 84871899423 scopus 로고    scopus 로고
    • The TAM-family receptor MER mediates production of HGF through the RHOA-dependent pathway in response to apoptotic cells
    • Park, H. J., Baen, J. Y., Lee, Y. J., Choi, Y. H. & Kang, J. L. The TAM-family receptor MER mediates production of HGF through the RHOA-dependent pathway in response to apoptotic cells. Mol. Biol. Cell 23, 3254-3265 (2012
    • (2012) Mol. Biol. Cell , vol.23 , pp. 3254-3265
    • Park, H.J.1    Baen, J.Y.2    Lee, Y.J.3    Choi, Y.H.4    Kang, J.L.5
  • 57
    • 84880730041 scopus 로고    scopus 로고
    • T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response
    • Carrera Silva, E. A. et al. T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity 39, 160-170 (2013
    • (2013) Immunity , vol.39 , pp. 160-170
    • Carrera Silva, E.A.1
  • 58
    • 0036645294 scopus 로고    scopus 로고
    • Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c MER membrane tyrosine kinase
    • Cohen, P. L. et al. Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c MER membrane tyrosine kinase. J. Exp. Med. 196, 135-140 (2002
    • (2002) J. Exp. Med , vol.196 , pp. 135-140
    • Cohen, P.L.1
  • 59
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the TYRO3 family
    • Lu, Q. & Lemke, G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the TYRO3 family. Science 293, 306-311 (2001
    • (2001) Science , vol.293 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 60
    • 84905498077 scopus 로고    scopus 로고
    • TYRO3 AXL, and MERTK receptor signaling in inflammatory bowel disease and colitis-Associated cancer
    • Rothlin, C. V., Leighton, J. A. & Ghosh, S. TYRO3, AXL, and MERTK receptor signaling in inflammatory bowel disease and colitis-Associated cancer. Inflamm. Bowel Dis. 20, 1472-1480 (2014
    • (2014) Inflamm. Bowel Dis , vol.20 , pp. 1472-1480
    • Rothlin, C.V.1    Leighton, J.A.2    Ghosh, S.3
  • 61
    • 79959588042 scopus 로고    scopus 로고
    • Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages Role of MERTK in enhanced phagocytosis
    • Zahuczky, G., Kristof, E., Majai, G. & Fesus, L. Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of MERTK in enhanced phagocytosis. PLoS ONE 6, e21349 (2011
    • (2011) PLoS ONE , vol.6 , pp. e21349
    • Zahuczky, G.1    Kristof, E.2    Majai, G.3    Fesus, L.4
  • 62
    • 68949145931 scopus 로고    scopus 로고
    • Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
    • A. Gonzalez, N. et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 31, 245-258 (2009
    • (2009) Immunity , vol.31 , pp. 245-258
    • Gonzalez N, A.1
  • 63
    • 80051613002 scopus 로고    scopus 로고
    • Genome-wide characterization of miR 34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis
    • M111 010462
    • Kaller, M. et al. Genome-wide characterization of miR 34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. Mol. Cell Proteomics 10, M111 010462 (2011
    • (2011) Mol. Cell Proteomics , vol.10
    • Kaller, M.1
  • 64
    • 79959673368 scopus 로고    scopus 로고
    • Regulation of AXL receptor tyrosine kinase expression by miR 34a and miR 199a/b in solid cancer
    • Mudduluru, G. et al. Regulation of AXL receptor tyrosine kinase expression by miR 34a and miR 199a/b in solid cancer. Oncogene 30, 2888-2899 (2011
    • (2011) Oncogene , vol.30 , pp. 2888-2899
    • Mudduluru, G.1
  • 65
    • 82955248085 scopus 로고    scopus 로고
    • Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR 34a microRNA
    • Mackiewicz, M. et al. Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR 34a microRNA. Breast Cancer Res. Treat. 130, 663-679 (2011
    • (2011) Breast Cancer Res. Treat , vol.130 , pp. 663-679
    • MacKiewicz, M.1
  • 66
    • 84887438346 scopus 로고    scopus 로고
    • AXL mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib
    • Giles, K. M. et al. AXL mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib. Mol. Cancer Ther. 12, 2541-2558 (2013
    • (2013) Mol. Cancer Ther , vol.12 , pp. 2541-2558
    • Giles, K.M.1
  • 67
    • 84855813448 scopus 로고    scopus 로고
    • A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
    • Png, K. J., Halberg, N., Yoshida, M. & Tavazoie, S. F. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature 481, 190-194 (2012
    • (2012) Nature , vol.481 , pp. 190-194
    • Png, K.J.1    Halberg, N.2    Yoshida, M.3    Tavazoie, S.F.4
  • 68
    • 0141818959 scopus 로고    scopus 로고
    • Identification of a gene encoding a typical ?-carboxyglutamic acid domain in the tunicate Halocynthia roretzi
    • Wang, C. P. et al. Identification of a gene encoding a typical ?-carboxyglutamic acid domain in the tunicate Halocynthia roretzi. J. Thromb. Haemost. 1, 118-123 (2003
    • (2003) J. Thromb. Haemost , vol.1 , pp. 118-123
    • Wang, C.P.1
  • 69
    • 33750462753 scopus 로고    scopus 로고
    • Vitamin K dependent proteins in Ciona intestinalis, a basal chordate lacking a blood coagulation cascade
    • Kulman, J. D. et al. Vitamin K dependent proteins in Ciona intestinalis, a basal chordate lacking a blood coagulation cascade. Proc. Natl Acad. Sci. USA 103, 15794-15799 (2006
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 15794-15799
    • Kulman, J.D.1
  • 70
    • 0030981120 scopus 로고    scopus 로고
    • Identification of GAS6 as a ligand for MER, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation
    • Chen, J., Carey, K. & Godowski, P. J. Identification of GAS6 as a ligand for MER, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation. Oncogene 14, 2033-2039 (1997
    • (1997) Oncogene , vol.14 , pp. 2033-2039
    • Chen, J.1    Carey, K.2    Godowski, P.J.3
  • 71
    • 84871382164 scopus 로고    scopus 로고
    • Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis
    • Burstyn-Cohen, T. et al. Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis. Neuron 76, 1123-1132 (2012
    • (2012) Neuron , vol.76 , pp. 1123-1132
    • Burstyn-Cohen, T.1
  • 72
    • 0035126319 scopus 로고    scopus 로고
    • Deficiency or inhibition of GAS6 causes platelet dysfunction and protects mice against thrombosis
    • Angelillo-Scherrer, A. et al. Deficiency or inhibition of GAS6 causes platelet dysfunction and protects mice against thrombosis. Nature Med. 7, 215-221 (2001
    • (2001) Nature Med , vol.7 , pp. 215-221
    • Angelillo-Scherrer, A.1
  • 73
    • 85047694191 scopus 로고    scopus 로고
    • Role of GAS6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy
    • Angelillo-Scherrer, A. et al. Role of GAS6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J. Clin. Invest. 115, 237-246 (2005
    • (2005) J. Clin. Invest , vol.115 , pp. 237-246
    • Angelillo-Scherrer, A.1
  • 74
    • 84887460450 scopus 로고    scopus 로고
    • MER receptor tyrosine kinase is a therapeutic target in pre B cell acute lymphoblastic leukemia
    • Linger, R. M. et al. MER receptor tyrosine kinase is a therapeutic target in pre B cell acute lymphoblastic leukemia. Blood 122, 1599-1609 (2013
    • (2013) Blood , vol.122 , pp. 1599-1609
    • Linger, R.M.1
  • 75
    • 84873638978 scopus 로고    scopus 로고
    • Inhibition of MERTK increases chemosensitivity and decreases oncogenic potential in T cell acute lymphoblastic leukemia
    • Brandao, L. N. et al. Inhibition of MERTK increases chemosensitivity and decreases oncogenic potential in T cell acute lymphoblastic leukemia. Blood Cancer J. 3, e101 (2013
    • (2013) Blood Cancer J. , vol.3 , pp. e101
    • Brandao, L.N.1
  • 76
    • 84924387947 scopus 로고    scopus 로고
    • Role of growth arrest-specific gene 6-MER axis in multiple myeloma
    • Waizenegger, J. S. et al. Role of growth arrest-specific gene 6-MER axis in multiple myeloma. Leukemia http://dx.doi.org/10.1038/leu.2014.236 (2014
    • Leukemia , vol.2014
    • Waizenegger, J.S.1
  • 77
    • 0028129416 scopus 로고
    • Expression of AXL, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis
    • Neubauer, A. et al. Expression of AXL, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis. Blood 84, 1931-1941 (1994
    • (1994) Blood , vol.84 , pp. 1931-1941
    • Neubauer, A.1
  • 78
    • 0032820867 scopus 로고    scopus 로고
    • AXL expression is associated with adverse prognosis and with expression of BCL 2 and CD34 in de novo acute myeloid leukemia (AML): Results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK)
    • Rochlitz, C. et al. AXL expression is associated with adverse prognosis and with expression of BCL 2 and CD34 in de novo acute myeloid leukemia (AML): results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK). Leukemia 13, 1352-1358 (1999
    • (1999) Leukemia , vol.13 , pp. 1352-1358
    • Rochlitz, C.1
  • 79
    • 84877611775 scopus 로고    scopus 로고
    • Inhibition of the receptor tyrosine kinase AXL impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: Implications for AXL as a potential therapeutic target
    • Park, I. K. et al. Inhibition of the receptor tyrosine kinase AXL impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for AXL as a potential therapeutic target. Blood 121, 2064-2073 (2013
    • (2013) Blood , vol.121 , pp. 2064-2073
    • Park, I.K.1
  • 80
    • 84887743438 scopus 로고    scopus 로고
    • AXL, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma
    • Ben-Batalla, I. et al. AXL, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma. Blood 122, 2443-2452 (2013
    • (2013) Blood , vol.122 , pp. 2443-2452
    • Ben-Batalla, I.1
  • 81
    • 0032981548 scopus 로고    scopus 로고
    • Expression of the growth arrest-specific gene 6 (GAS6) in leukemia and lymphoma cell lines
    • Dirks, W. et al. Expression of the growth arrest-specific gene 6 (GAS6) in leukemia and lymphoma cell lines. Leuk. Res. 23, 643-651 (1999
    • (1999) Leuk. Res , vol.23 , pp. 643-651
    • Dirks, W.1
  • 82
    • 79951470770 scopus 로고    scopus 로고
    • The novel receptor tyrosine kinase AXL is constitutively active in B cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: Implications for therapy
    • Ghosh, A. K. et al. The novel receptor tyrosine kinase AXL is constitutively active in B cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy. Blood 117, 1928-1937 (2011
    • (2011) Blood , vol.117 , pp. 1928-1937
    • Ghosh, A.K.1
  • 83
    • 0029125978 scopus 로고
    • Identification of a novel receptor tyrosine kinase expressed in acute myeloid leukemic blasts
    • Crosier, P. S., Hall, L. R., Vitas, M. R., Lewis, P. M. & Crosier, K. E. Identification of a novel receptor tyrosine kinase expressed in acute myeloid leukemic blasts. Leuk. Lymphoma 18, 443-449 (1995
    • (1995) Leuk. Lymphoma , vol.18 , pp. 443-449
    • Crosier, P.S.1    Hall, L.R.2    Vitas, M.R.3    Lewis, P.M.4    Crosier, K.E.5
  • 84
    • 0035437195 scopus 로고    scopus 로고
    • Identifying intercellular signaling genes expressed in malignant plasma cells by using complementary DNA arrays
    • De Vos, J. et al. Identifying intercellular signaling genes expressed in malignant plasma cells by using complementary DNA arrays. Blood 98, 771-780 (2001
    • (2001) Blood , vol.98 , pp. 771-780
    • De Vos, J.1
  • 85
    • 84888791736 scopus 로고    scopus 로고
    • 27 Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology
    • Nelson, E. R. et al. 27 Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science 342, 1094-1098 (2013
    • (2013) Science , vol.342 , pp. 1094-1098
    • Nelson, E.R.1
  • 86
    • 6344292288 scopus 로고    scopus 로고
    • The c MER gene is induced by Epstein-Barr virus immediate-early protein BRLF1
    • Li, Y. et al. The c MER gene is induced by Epstein-Barr virus immediate-early protein BRLF1. J. Virol. 78, 11778-11785 (2004
    • (2004) J. Virol , vol.78 , pp. 11778-11785
    • Li, Y.1
  • 87
    • 84907192193 scopus 로고    scopus 로고
    • Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET
    • Rankin, E. B. et al. Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proc. Natl Acad. Sci. USA 111, 13373-13378 (2014
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 13373-13378
    • Rankin, E.B.1
  • 88
    • 48549094691 scopus 로고    scopus 로고
    • Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia
    • Hong, C. C. et al. Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia. Cancer Lett. 268, 314-324 (2008
    • (2008) Cancer Lett , vol.268 , pp. 314-324
    • Hong, C.C.1
  • 89
    • 66149130903 scopus 로고    scopus 로고
    • The human receptor tyrosine kinase Axl gene - Promoter characterization and regulation of constitutive expression by Sp1 Sp3 and CpG methylation
    • Mudduluru, G. & Allgayer, H. The human receptor tyrosine kinase Axl gene - promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation. Biosci. Rep. 28, 161-176 (2008
    • (2008) Biosci. Rep , vol.28 , pp. 161-176
    • Mudduluru, G.1    Allgayer, H.2
  • 90
    • 77955475326 scopus 로고    scopus 로고
    • Induction, regulation, and biologic function of AXL receptor tyrosine kinase in Kaposi sarcoma
    • Liu, R. et al. Induction, regulation, and biologic function of AXL receptor tyrosine kinase in Kaposi sarcoma. Blood 116, 297-305 (2010
    • (2010) Blood , vol.116 , pp. 297-305
    • Liu, R.1
  • 91
    • 70849095560 scopus 로고    scopus 로고
    • Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer
    • Kubo, T. et al. Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer. Carcinogenesis 30, 1857-1864 (2009
    • (2009) Carcinogenesis , vol.30 , pp. 1857-1864
    • Kubo, T.1
  • 92
    • 67449106767 scopus 로고    scopus 로고
    • DNA copy number variation and gene expression analyses reveal the implication of specific oncogenes and genes in GBM
    • Margareto, J. et al. DNA copy number variation and gene expression analyses reveal the implication of specific oncogenes and genes in GBM. Cancer Invest. 27, 541-548 (2009
    • (2009) Cancer Invest , vol.27 , pp. 541-548
    • Margareto, J.1
  • 93
    • 84879786795 scopus 로고    scopus 로고
    • MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL
    • Tworkoski, K. A. et al. MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL. Pigment Cell. Melanoma Res. 26, 527-541 (2013
    • (2013) Pigment Cell. Melanoma Res , vol.26 , pp. 527-541
    • Tworkoski, K.A.1
  • 94
    • 84868309107 scopus 로고    scopus 로고
    • The transcriptional landscape and mutational profile of lung adenocarcinoma
    • Seo, J. S. et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res. 22, 2109-2119 (2012
    • (2012) Genome Res , vol.22 , pp. 2109-2119
    • Seo, J.S.1
  • 95
    • 84907164518 scopus 로고    scopus 로고
    • Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain of function capacity
    • Nguyen, K. Q. et al. Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain of function capacity. J. Biol. Chem. 289, 25737-25749 (2014
    • (2014) J. Biol. Chem , vol.289 , pp. 25737-25749
    • Nguyen, K.Q.1
  • 96
    • 84880922644 scopus 로고    scopus 로고
    • MER or AXL receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer
    • Linger, R. M. et al. MER or AXL receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer. Oncogene 32, 3420-3431 (2013
    • (2013) Oncogene , vol.32 , pp. 3420-3431
    • Linger, R.M.1
  • 97
    • 76749109371 scopus 로고    scopus 로고
    • GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche
    • Shiozawa, Y. et al. GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. Neoplasia 12, 116-127 (2010
    • (2010) Neoplasia , vol.12 , pp. 116-127
    • Shiozawa, Y.1
  • 98
    • 73949130412 scopus 로고    scopus 로고
    • GAS6/ MER axis regulates the homing and survival of the E2A/PBX1 positive B cell precursor acute lymphoblastic leukemia in the bone marrow niche
    • Shiozawa, Y., Pedersen, E. A. & Taichman, R. S. GAS6/ MER axis regulates the homing and survival of the E2A/PBX1 positive B cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp. Hematol. 38, 132-140 (2010
    • (2010) Exp. Hematol , vol.38 , pp. 132-140
    • Shiozawa, Y.1    Pedersen, E.A.2    Taichman, R.S.3
  • 99
    • 0032926887 scopus 로고    scopus 로고
    • Biological effects of c MER receptor tyrosine kinase in hematopoietic cells depend on the GRB2 binding site
    • Georgescu, M. M., Kirsch, K. H., Shishido, T., Zong, C. & Hanafusa, H. Biological effects of c MER receptor tyrosine kinase in hematopoietic cells depend on the GRB2 binding site. Mol. Cell. Biol. 19, 1171-1181 (1999
    • (1999) Mol. Cell. Biol , vol.19 , pp. 1171-1181
    • Georgescu, M.M.1    Kirsch, K.H.2    Shishido, T.3    Zong, C.4    Hanafusa, H.5
  • 100
    • 0034047441 scopus 로고    scopus 로고
    • ETK2 receptor tyrosine kinase promotes survival of factor-dependent FDC P1 progenitor cells
    • Darby, C., Giannola, D. M., Couzens, M. S. & Emerson, S. G. ETK2 receptor tyrosine kinase promotes survival of factor-dependent FDC P1 progenitor cells. Exp. Hematol. 28, 716-725 (2000
    • (2000) Exp. Hematol , vol.28 , pp. 716-725
    • Darby, C.1    Giannola, D.M.2    Couzens, M.S.3    Emerson, S.G.4
  • 101
    • 66349119361 scopus 로고    scopus 로고
    • Expression of MER on Jurkat cells and its anti-Apoptosis effect
    • in Chinese
    • Fan, L. et al. Expression of MER on Jurkat cells and its anti-Apoptosis effect. Ai Zheng 26, 698-702 (2007) (in Chinese
    • (2007) Ai Zheng , vol.26 , pp. 698-702
    • Fan, L.1
  • 102
    • 84866535796 scopus 로고    scopus 로고
    • MER receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology
    • Rogers, A. E. et al. MER receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology. Oncogene 31, 4171-4181 (2012
    • (2012) Oncogene , vol.31 , pp. 4171-4181
    • Rogers, A.E.1
  • 103
    • 84877114887 scopus 로고    scopus 로고
    • MERTK receptor tyrosine kinase is a therapeutic target in melanoma
    • Schlegel, J. et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J. Clin. Invest. 123, 2257-2267 (2013
    • (2013) J. Clin. Invest , vol.123 , pp. 2257-2267
    • Schlegel, J.1
  • 104
    • 84861004701 scopus 로고    scopus 로고
    • Cross-phosphorylation signaling and proliferative functions of the TYRO3 and AXL receptors in Rat2 cells
    • Brown, J. E., Krodel, M., Pazos, M., Lai, C. & Prieto, A. L. Cross-phosphorylation, signaling and proliferative functions of the TYRO3 and AXL receptors in Rat2 cells. PLoS ONE 7, e36800 (2012
    • (2012) PLoS ONE , vol.7 , pp. e36800
    • Brown, J.E.1    Krodel, M.2    Pazos, M.3    Lai, C.4    Prieto, A.L.5
  • 105
    • 84857423087 scopus 로고    scopus 로고
    • Prolonged exposure to a MER ligand in leukemia: GAS6 favors expression of a partial MER glycoform and reveals a novel role for MER in the nucleus
    • Migdall-Wilson, J. et al. Prolonged exposure to a MER ligand in leukemia: GAS6 favors expression of a partial MER glycoform and reveals a novel role for MER in the nucleus. PLoS ONE 7, e31635 (2012
    • (2012) PLoS ONE , vol.7 , pp. e31635
    • Migdall-Wilson, J.1
  • 106
    • 85047698138 scopus 로고    scopus 로고
    • AKT is required for AXL-GAS6 signaling to protect cells from E1A mediated apoptosis
    • Lee, W. P., Wen, Y., Varnum, B. & Hung, M. C. AKT is required for AXL-GAS6 signaling to protect cells from E1A mediated apoptosis. Oncogene 21, 329-336 (2002
    • (2002) Oncogene , vol.21 , pp. 329-336
    • Lee, W.P.1    Wen, Y.2    Varnum, B.3    Hung, M.C.4
  • 107
    • 33646753793 scopus 로고    scopus 로고
    • Ectopic expression of the proto-oncogene MER in pediatric T cell acute lymphoblastic leukemia
    • Graham, D. K. et al. Ectopic expression of the proto-oncogene MER in pediatric T cell acute lymphoblastic leukemia. Clin. Cancer Res. 12, 2662-2669 (2006
    • (2006) Clin. Cancer Res , vol.12 , pp. 2662-2669
    • Graham, D.K.1
  • 108
    • 70349705633 scopus 로고    scopus 로고
    • AXL as a potential therapeutic target in cancer: Role of AXL in tumor growth, metastasis and angiogenesis
    • Li, Y. et al. AXL as a potential therapeutic target in cancer: role of AXL in tumor growth, metastasis and angiogenesis. Oncogene 28, 3442-3455 (2009
    • (2009) Oncogene , vol.28 , pp. 3442-3455
    • Li, Y.1
  • 109
    • 78549245919 scopus 로고    scopus 로고
    • The AXL receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma
    • Hector, A. et al. The AXL receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma. Cancer Biol. Ther. 10, 1009-1018 (2010
    • (2010) Cancer Biol. Ther , vol.10 , pp. 1009-1018
    • Hector, A.1
  • 110
    • 76749123429 scopus 로고    scopus 로고
    • R428, a selective small molecule inhibitor of AXL kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer
    • Holland, S. J. et al. R428, a selective small molecule inhibitor of AXL kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 70, 1544-1554 (2010
    • (2010) Cancer Res. , vol.70 , pp. 1544-1554
    • Holland, S.J.1
  • 111
    • 77957109253 scopus 로고    scopus 로고
    • An anti-AXL monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
    • Ye, X. et al. An anti-AXL monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies. Oncogene 29, 5254-5264 (2010
    • (2010) Oncogene , vol.29 , pp. 5254-5264
    • Ye, X.1
  • 112
    • 80855138159 scopus 로고    scopus 로고
    • Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional AXL receptor kinase
    • Sensi, M. et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional AXL receptor kinase. J. Invest. Dermatol. 131, 2448-2457 (2011
    • (2011) J. Invest. Dermatol , vol.131 , pp. 2448-2457
    • Sensi, M.1
  • 113
    • 79551709511 scopus 로고    scopus 로고
    • Overexpression of receptor tyrosine kinase AXL promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma
    • Song, X. et al. Overexpression of receptor tyrosine kinase AXL promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma. Cancer 117, 734-743 (2011
    • (2011) Cancer , vol.117 , pp. 734-743
    • Song, X.1
  • 114
    • 84887421432 scopus 로고    scopus 로고
    • UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo
    • Christoph, S. et al. UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol. Cancer Ther. 12, 2367-2377 (2013
    • (2013) Mol. Cancer Ther , vol.12 , pp. 2367-2377
    • Christoph, S.1
  • 115
    • 84887514966 scopus 로고    scopus 로고
    • Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy
    • Leconet, W. et al. Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy. Oncogene http://dx.doi.org/10.1038/ onc.2013.487 (2013
    • (2013) Oncogene
    • Leconet, W.1
  • 116
    • 77952205519 scopus 로고    scopus 로고
    • Inhibition of MER and AXL receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity
    • Keating, A. K. et al. Inhibition of MER and AXL receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity. Mol. Cancer Ther. 9, 1298-1307 (2010
    • (2010) Mol. Cancer Ther , vol.9 , pp. 1298-1307
    • Keating, A.K.1
  • 117
    • 84892158897 scopus 로고    scopus 로고
    • AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer
    • Dunne, P. D. et al. AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer. Clin. Cancer Res. 20, 164-175 (2014
    • (2014) Clin. Cancer Res , vol.20 , pp. 164-175
    • Dunne, P.D.1
  • 118
    • 34248562252 scopus 로고    scopus 로고
    • Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL
    • Lay, J. D. et al. Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL. Cancer Res. 67, 3878-3887 (2007
    • (2007) Cancer Res , vol.67 , pp. 3878-3887
    • Lay, J.D.1
  • 119
    • 46449096930 scopus 로고    scopus 로고
    • AXL promotes cell invasion by inducing MMP 9 activity through activation of NF-κB and Brg 1
    • Tai, K. Y., Shieh, Y. S., Lee, C. S., Shiah, S. G. & Wu, C. W. AXL promotes cell invasion by inducing MMP 9 activity through activation of NF-κB and Brg 1. Oncogene 27, 4044-4055 (2008
    • (2008) Oncogene , vol.27 , pp. 4044-4055
    • Tai, K.Y.1    Shieh, Y.S.2    Lee, C.S.3    Shiah, S.G.4    Wu, C.W.5
  • 120
    • 84873736003 scopus 로고    scopus 로고
    • The receptor tyrosine kinase AXL is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target
    • Paccez, J. D. et al. The receptor tyrosine kinase AXL is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target. Oncogene 32, 689-698 (2013
    • (2013) Oncogene , vol.32 , pp. 689-698
    • Paccez, J.D.1
  • 121
    • 84895922043 scopus 로고    scopus 로고
    • AXL induces epithelial-To mesenchymal transition and regulates the function of breast cancer stem cells
    • Asiedu, M. K. et al. AXL induces epithelial-To mesenchymal transition and regulates the function of breast cancer stem cells. Oncogene 33, 1316-1324 (2014
    • (2014) Oncogene , vol.33 , pp. 1316-1324
    • Asiedu, M.K.1
  • 122
    • 84896694386 scopus 로고    scopus 로고
    • Tumor-Associated macrophages promote oral cancer progression through activation of the AXL signaling pathway
    • Lee, C. H. et al. Tumor-Associated macrophages promote oral cancer progression through activation of the AXL signaling pathway. Ann. Surg. Oncol. 21, 1031-1037 (2014
    • (2014) Ann. Surg. Oncol , vol.21 , pp. 1031-1037
    • Lee, C.H.1
  • 123
    • 78651392223 scopus 로고    scopus 로고
    • AXL promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-Apoptotic BCL 2 family members
    • Papadakis, E. S. et al. AXL promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-Apoptotic BCL 2 family members. J. Invest. Dermatol. 131, 509-517 (2011
    • (2011) J. Invest. Dermatol , vol.131 , pp. 509-517
    • Papadakis, E.S.1
  • 124
    • 18544379614 scopus 로고    scopus 로고
    • Requirement of activated CDC42 associated kinase for survival of v RAS-Transformed mammalian cells
    • Nur, E. K. A. et al. Requirement of activated CDC42 associated kinase for survival of v RAS-Transformed mammalian cells. Mol. Cancer Res. 3, 297-305 (2005
    • (2005) Mol. Cancer Res , vol.3 , pp. 297-305
    • Nur, E.K.A.1
  • 125
    • 0033294311 scopus 로고    scopus 로고
    • The GAS6/AXL system: A novel regulator of vascular cell function
    • Melaragno, M. G., Fridell, Y. W. & Berk, B. C. The GAS6/AXL system: a novel regulator of vascular cell function. Trends Cardiovasc. Med. 9, 250-253 (1999
    • (1999) Trends Cardiovasc. Med , vol.9 , pp. 250-253
    • Melaragno, M.G.1    Fridell, Y.W.2    Berk, B.C.3
  • 126
    • 84859432817 scopus 로고    scopus 로고
    • AXL is essential for VEGF A dependent activation of PI3K/AKT
    • Ruan, G. X. & Kazlauskas, A. AXL is essential for VEGF A dependent activation of PI3K/AKT. EMBO J. 31, 1692-1703 (2012
    • (2012) EMBO J. , vol.31 , pp. 1692-1703
    • Ruan, G.X.1    Kazlauskas, A.2
  • 127
    • 84871056650 scopus 로고    scopus 로고
    • The vitamin K dependent anticoagulant factor, protein S, inhibits multiple VEGF A induced angiogenesis events in a MER- and SHP2 dependent manner
    • Fraineau, S. et al. The vitamin K dependent anticoagulant factor, protein S, inhibits multiple VEGF A induced angiogenesis events in a MER- and SHP2 dependent manner. Blood 120, 5073-5083 (2012
    • (2012) Blood , vol.120 , pp. 5073-5083
    • Fraineau, S.1
  • 128
    • 84888304601 scopus 로고    scopus 로고
    • A multifunctional anticoagulant vitamin K dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer
    • Suleiman, L., Negrier, C. & Boukerche, H. Protein S: A multifunctional anticoagulant vitamin K dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer. Crit. Rev. Oncol. Hematol. 88, 637-654 (2013
    • (2013) Crit. Rev. Oncol. Hematol , vol.88 , pp. 637-654
    • Suleiman, L.1    Negrier, C.2    Boukerche, H.3    Protein, S.4
  • 129
    • 70349656483 scopus 로고    scopus 로고
    • Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis
    • Burstyn-Cohen, T., Heeb, M. J. & Lemke, G. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J. Clin. Invest. 119, 2942-2953 (2009
    • (2009) J. Clin. Invest , vol.119 , pp. 2942-2953
    • Burstyn-Cohen, T.1    Heeb, M.J.2    Lemke, G.3
  • 130
    • 55049120215 scopus 로고    scopus 로고
    • AXL and TYRO3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration
    • Pierce, A. et al. AXL and TYRO3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Mol. Endocrinol. 22, 2481-2495 (2008
    • (2008) Mol. Endocrinol , vol.22 , pp. 2481-2495
    • Pierce, A.1
  • 131
    • 84878744349 scopus 로고    scopus 로고
    • AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival
    • Salian-Mehta, S., Xu, M. & Wierman, M. E. AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival. Mol. Cell. Endocrinol. 374, 92-100 (2013
    • (2013) Mol. Cell. Endocrinol , vol.374 , pp. 92-100
    • Salian-Mehta, S.1    Xu, M.2    Wierman, M.E.3
  • 132
    • 84898663718 scopus 로고    scopus 로고
    • GAS6/AXL pathway promotes tumor invasion through the transcriptional activation of Slug in hepatocellular carcinoma
    • Lee, H. J., Jeng, Y. M., Chen, Y. L., Chung, L. & Yuan, R. H. GAS6/AXL pathway promotes tumor invasion through the transcriptional activation of Slug in hepatocellular carcinoma. Carcinogenesis 35, 769-775 (2014
    • (2014) Carcinogenesis , vol.35 , pp. 769-775
    • Lee, H.J.1    Jeng, Y.M.2    Chen, Y.L.3    Chung, L.4    Yuan, R.H.5
  • 133
    • 0036135698 scopus 로고    scopus 로고
    • Novel mechanism for gonadotropin-releasing hormone neuronal migration involving GAS6/ARK signaling to p38 mitogen-Activated protein kinase
    • Allen, M. P. et al. Novel mechanism for gonadotropin-releasing hormone neuronal migration involving GAS6/ARK signaling to p38 mitogen-Activated protein kinase. Mol. Cell. Biol. 22, 599-613 (2002
    • (2002) Mol. Cell. Biol , vol.22 , pp. 599-613
    • Allen, M.P.1
  • 134
    • 0037064051 scopus 로고    scopus 로고
    • Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires RAC activation of the extracellular signal-regulated kinase pathway
    • Allen, M. P. et al. Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires RAC activation of the extracellular signal-regulated kinase pathway. J. Biol. Chem. 277, 38133-38140 (2002
    • (2002) J. Biol. Chem , vol.277 , pp. 38133-38140
    • Allen, M.P.1
  • 135
    • 84924425611 scopus 로고    scopus 로고
    • An engineered AXL 'decoy receptor' effectively silences the GAS6-AXL signaling axis
    • Kariolis, M. S. et al. An engineered AXL 'decoy receptor' effectively silences the GAS6-AXL signaling axis. Nature Chem. Biol. 10, 977-983 (2014
    • (2014) Nature Chem. Biol , vol.10 , pp. 977-983
    • Kariolis, M.S.1
  • 136
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • Biswas, S. K. & Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nature Immunol. 11, 889-896 (2010
    • (2010) Nature Immunol , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 137
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: A magic bullet?
    • Coussens, L. M., Zitvogel, L. & Palucka, A. K. Neutralizing tumor-promoting chronic inflammation: a magic bullet?. Science 339, 286-291 (2013
    • (2013) Science , vol.339 , pp. 286-291
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 138
    • 78649848107 scopus 로고    scopus 로고
    • TAM receptor signaling and autoimmune disease
    • Rothlin, C. V. & Lemke, G. TAM receptor signaling and autoimmune disease. Curr. Opin. Immunol. 22, 740-746 (2010
    • (2010) Curr. Opin. Immunol , vol.22 , pp. 740-746
    • Rothlin, C.V.1    Lemke, G.2
  • 139
    • 84873539950 scopus 로고    scopus 로고
    • Prolonged apoptotic cell accumulation in germinal centers of MER-deficient mice causes elevated B cell and CD4+ TH cell responses leading to autoantibody production
    • Khan, T. N., Wong, E. B., Soni, C. & Rahman, Z. S. Prolonged apoptotic cell accumulation in germinal centers of MER-deficient mice causes elevated B cell and CD4+ TH cell responses leading to autoantibody production. J. Immunol. 190, 1433-1446 (2013
    • (2013) J. Immunol , vol.190 , pp. 1433-1446
    • Khan, T.N.1    Wong, E.B.2    Soni, C.3    Rahman, Z.S.4
  • 140
    • 84901215262 scopus 로고    scopus 로고
    • The cellular and molecular origin of tumor-Associated macrophages
    • Franklin, R. A. et al. The cellular and molecular origin of tumor-Associated macrophages. Science 344, 921-925 (2014
    • (2014) Science , vol.344 , pp. 921-925
    • Franklin, R.A.1
  • 141
    • 33846889318 scopus 로고    scopus 로고
    • Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes
    • Ehrchen, J. et al. Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes. Blood 109, 1265-1274 (2007
    • (2007) Blood , vol.109 , pp. 1265-1274
    • Ehrchen, J.1
  • 142
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • DeNardo, D. G. et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1, 54-67 (2011
    • (2011) Cancer Discov , vol.1 , pp. 54-67
    • Denardo, D.G.1
  • 143
    • 84887481716 scopus 로고    scopus 로고
    • CSF 1R inhibition alters macrophage polarization and blocks glioma progression
    • Pyonteck, S. M. et al. CSF 1R inhibition alters macrophage polarization and blocks glioma progression. Nature Med. 19, 1264-1272 (2013
    • (2013) Nature Med , vol.19 , pp. 1264-1272
    • Pyonteck, S.M.1
  • 144
    • 77950422149 scopus 로고    scopus 로고
    • Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen GAS6
    • Loges, S. et al. Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen GAS6. Blood 115, 2264-2273 (2010
    • (2010) Blood , vol.115 , pp. 2264-2273
    • Loges, S.1
  • 145
    • 84927163445 scopus 로고    scopus 로고
    • Targeted inhibition of MER tyrosine kinase in the tumor microenvironment decreases tumor growth in a mouse model of breast cancer in Proc
    • Jacobsen, K. M. et al. Targeted inhibition of MER tyrosine kinase in the tumor microenvironment decreases tumor growth in a mouse model of breast cancer in Proc. 104th Annual Meeting of the American Association for Cancer Research (2013
    • 104th Annual Meeting of the American Association for Cancer Research , vol.2013
    • Jacobsen, K.M.1
  • 146
    • 84908637378 scopus 로고    scopus 로고
    • Efferocytosis produces a pro-metastatic landscape during post-partum mammary gland involution
    • Stanford, J. C. et al. Efferocytosis produces a pro-metastatic landscape during post-partum mammary gland involution. J. Clin. Invest. http://dx.doi. org/10.1172/JCI76375 (2014
    • J. Clin. Invest , vol.2014
    • Stanford, J.C.1
  • 147
    • 84860188906 scopus 로고    scopus 로고
    • Differential expression of AXL and correlation with invasion and multidrug resistance in cancer cells
    • Zhao, Y. et al. Differential expression of AXL and correlation with invasion and multidrug resistance in cancer cells. Cancer Invest. 30, 287-294 (2012
    • (2012) Cancer Invest , vol.30 , pp. 287-294
    • Zhao, Y.1
  • 148
    • 23044504066 scopus 로고    scopus 로고
    • Altered ERBB receptor signaling and gene expression in cisplatin-resistant ovarian cancer
    • Macleod, K. et al. Altered ERBB receptor signaling and gene expression in cisplatin-resistant ovarian cancer. Cancer Res. 65, 6789-6800 (2005
    • (2005) Cancer Res , vol.65 , pp. 6789-6800
    • MacLeod, K.1
  • 149
    • 70350133599 scopus 로고    scopus 로고
    • A genomic screen identifies TYRO3 as a MITF regulator in melanoma
    • Zhu, S. et al. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proc. Natl Acad. Sci. USA 106, 17025-17030 (2009
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 17025-17030
    • Zhu, S.1
  • 150
    • 84874112354 scopus 로고    scopus 로고
    • MER receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme
    • Wang, Y. et al. MER receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme. Oncogene 32, 872-882 (2013
    • (2013) Oncogene , vol.32 , pp. 872-882
    • Wang, Y.1
  • 151
    • 34249985524 scopus 로고    scopus 로고
    • A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors
    • Mahadevan, D. et al. A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors. Oncogene 26, 3909-3919 (2007
    • (2007) Oncogene , vol.26 , pp. 3909-3919
    • Mahadevan, D.1
  • 152
    • 84858602428 scopus 로고    scopus 로고
    • Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells
    • Dufies, M. et al. Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells. Oncotarget 2, 874-885 (2011
    • (2011) Oncotarget , vol.2 , pp. 874-885
    • Dufies, M.1
  • 153
    • 80052164672 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics revealed interplay between SYK and LYN in the resistance to nilotinib in chronic myeloid leukemia cells
    • Gioia, R. et al. Quantitative phosphoproteomics revealed interplay between SYK and LYN in the resistance to nilotinib in chronic myeloid leukemia cells. Blood 118, 2211-2221 (2011
    • (2011) Blood , vol.118 , pp. 2211-2221
    • Gioia, R.1
  • 154
    • 70149109569 scopus 로고    scopus 로고
    • Novel mechanism of lapatinib resistance in HER2 positive breast tumor cells: Activation of AXL
    • Liu, L. et al. Novel mechanism of lapatinib resistance in HER2 positive breast tumor cells: activation of AXL. Cancer Res. 69, 6871-6878 (2009
    • (2009) Cancer Res , vol.69 , pp. 6871-6878
    • Liu, L.1
  • 155
    • 84884167635 scopus 로고    scopus 로고
    • The receptor AXL diversifies EGFR signaling and limits the response to EGFR-Targeted inhibitors in triple-negative breast cancer cells
    • Meyer, A. S., Miller, M. A., Gertler, F. B. & Lauffenburger, D. A. The receptor AXL diversifies EGFR signaling and limits the response to EGFR-Targeted inhibitors in triple-negative breast cancer cells. Sci. Signal. 6, ra66 (2013
    • (2013) Sci. Signal , vol.6 , pp. ra66
    • Meyer, A.S.1    Miller, M.A.2    Gertler, F.B.3    Lauffenburger, D.A.4
  • 156
    • 84880525684 scopus 로고    scopus 로고
    • A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop
    • Ware, K. E. et al. A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop. Oncogenesis 2, e39 (2013
    • (2013) Oncogenesis , vol.2 , pp. e39
    • Ware, K.E.1
  • 157
    • 84887994377 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4-ALK translocation
    • Kim, H. R. et al. Epithelial-mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4-ALK translocation. Mol. Oncol. 7, 1093-1102 (2013
    • (2013) Mol. Oncol , vol.7 , pp. 1093-1102
    • Kim, H.R.1
  • 158
    • 77956922669 scopus 로고    scopus 로고
    • Differential mechanisms of acquired resistance to insulin-like growth factor 1 receptor antibody therapy or to a small-molecule inhibitor, BMS 754807, in a human rhabdomyosarcoma model
    • Huang, F. et al. Differential mechanisms of acquired resistance to insulin-like growth factor 1 receptor antibody therapy or to a small-molecule inhibitor, BMS 754807, in a human rhabdomyosarcoma model. Cancer Res. 70, 7221-7231 (2010
    • (2010) Cancer Res , vol.70 , pp. 7221-7231
    • Huang, F.1
  • 159
    • 84907546631 scopus 로고    scopus 로고
    • AXL mediates resistance to cetuximab therapy
    • Brand, T. M. et al. AXL mediates resistance to cetuximab therapy. Cancer Res. 74, 5152-5164 (2014
    • (2014) Cancer Res , vol.74 , pp. 5152-5164
    • Brand, T.M.1
  • 160
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-Targeted therapy in lung cancer
    • Zhang, Z. et al. Activation of the AXL kinase causes resistance to EGFR-Targeted therapy in lung cancer. Nature Genet. 44, 852-860 (2012
    • (2012) Nature Genet , vol.44 , pp. 852-860
    • Zhang, Z.1
  • 161
    • 84859836481 scopus 로고    scopus 로고
    • Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure
    • Khoury, H. J. et al. Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure. Blood 119, 3403-3412 (2012
    • (2012) Blood , vol.119 , pp. 3403-3412
    • Khoury, H.J.1
  • 162
    • 40949156351 scopus 로고    scopus 로고
    • AXL is a potential target for therapeutic intervention in breast cancer progression
    • Zhang, Y. X. et al. AXL is a potential target for therapeutic intervention in breast cancer progression. Cancer Res. 68, 1905-1915 (2008
    • (2008) Cancer Res , vol.68 , pp. 1905-1915
    • Zhang, Y.X.1
  • 163
    • 84898619559 scopus 로고    scopus 로고
    • MERTK inhibition is a novel therapeutic approach for glioblastoma multiforme
    • Knubel, K. H. et al. MERTK inhibition is a novel therapeutic approach for glioblastoma multiforme. Oncotarget 5, 1338-1351 (2014
    • (2014) Oncotarget , vol.5 , pp. 1338-1351
    • Knubel, K.H.1
  • 164
    • 84882428581 scopus 로고    scopus 로고
    • Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines
    • Rettew, A. N. et al. Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines. Oncogenesis 1, e34 (2012
    • (2012) Oncogenesis , vol.1 , pp. e34
    • Rettew, A.N.1
  • 165
    • 84863131669 scopus 로고    scopus 로고
    • Discovery of novel small molecule MER kinase inhibitors for the treatment of pediatric acute lymphoblastic leukemia
    • Liu, J. et al. Discovery of novel small molecule MER kinase inhibitors for the treatment of pediatric acute lymphoblastic leukemia. ACS Med. Chem. Lett. 3, 129-134 (2012
    • (2012) ACS Med. Chem. Lett , vol.3 , pp. 129-134
    • Liu, J.1
  • 166
    • 84877845714 scopus 로고    scopus 로고
    • UNC1062, a new and potent MER inhibitor
    • Liu, J. et al. UNC1062, a new and potent MER inhibitor. Eur. J. Med. Chem. 65, 83-93 (2013
    • (2013) Eur. J. Med. Chem , vol.65 , pp. 83-93
    • Liu, J.1
  • 167
    • 84906878027 scopus 로고    scopus 로고
    • UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor
    • Zhang, W. et al. UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor. J. Med. Chem. 57, 7031-7041 (2014
    • (2014) J. Med. Chem , vol.57 , pp. 7031-7041
    • Zhang, W.1
  • 168
    • 84927163443 scopus 로고    scopus 로고
    • Development of a novel small molecule MER tyrosine kinase inhibitor with therapeutic activity in cell culture and mouse models of acute lymphoblastic leukemia
    • DeRyckere, D. et al. Development of a novel small molecule MER tyrosine kinase inhibitor with therapeutic activity in cell culture and mouse models of acute lymphoblastic leukemia. in Proc. 104th Annual Meeting of the American Association for Cancer Research (2013
    • (2013) Proc 104th Annual Meeting of the American Association for Cancer Research
    • Deryckere, D.1
  • 169
    • 84927163442 scopus 로고    scopus 로고
    • A small molecule MER tyrosine kinase inhibitor (UNC MERTKi) effectively inhibits growth of murine melanoma
    • Earp, H. S. et al. A small molecule MER tyrosine kinase inhibitor (UNC MERTKi) effectively inhibits growth of murine melanoma. in Proc. 104th Annual Meeting of the American Association for Cancer Research (2013
    • Proc. 104th Annual Meeting of the American Association for Cancer Research , vol.2013
    • Earp, H.S.1
  • 170
    • 84655164835 scopus 로고    scopus 로고
    • Novel and selective spiroindoline-based inhibitors of SKY kinase
    • Powell, N. A. et al. Novel and selective spiroindoline-based inhibitors of SKY kinase. Bioorg. Med. Chem. Lett. 22, 190-193 (2012
    • (2012) Bioorg. Med. Chem. Lett , vol.22 , pp. 190-193
    • Powell, N.A.1
  • 171
    • 84872892894 scopus 로고    scopus 로고
    • Optimization of highly selective 2, 4 diaminopyrimidine 5 carboxamide inhibitors of SKY kinase
    • Powell, N. A. et al. Optimization of highly selective 2, 4 diaminopyrimidine 5 carboxamide inhibitors of SKY kinase. Bioorg. Med. Chem. Lett. 23, 1051-1055 (2013
    • (2013) Bioorg. Med. Chem. Lett , vol.23 , pp. 1051-1055
    • Powell, N.A.1
  • 172
    • 84872915717 scopus 로고    scopus 로고
    • Highly selective 2, 4 diaminopyrimidine 5 carboxamide inhibitors of SKY kinase
    • Powell, N. A. et al. Highly selective 2, 4 diaminopyrimidine 5 carboxamide inhibitors of SKY kinase. Bioorg. Med. Chem. Lett. 23, 1046-1050 (2013
    • (2013) Bioorg. Med. Chem. Lett , vol.23 , pp. 1046-1050
    • Powell, N.A.1
  • 173
    • 84916888486 scopus 로고    scopus 로고
    • Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer
    • June
    • Cummings, C. T. et al. Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer. Oncotarget 26 June 2014
    • (2014) Oncotarget , vol.26
    • Cummings, C.T.1
  • 174
    • 84877331690 scopus 로고    scopus 로고
    • Evaluation of TYRO3 expression GAS6 mediated AKT phosphorylation, and the impact of anti TYRO3 antibodies in melanoma cell lines
    • Demarest, S. J. et al. Evaluation of TYRO3 expression, GAS6 mediated AKT phosphorylation, and the impact of anti TYRO3 antibodies in melanoma cell lines. Biochemistry 52, 3102-3118 (2013
    • (2013) Biochemistry , vol.52 , pp. 3102-3118
    • Demarest, S.J.1
  • 175
    • 84870615894 scopus 로고    scopus 로고
    • Targeting AXL with an high-Affinity inhibitory aptamer
    • Cerchia, L. et al. Targeting AXL with an high-Affinity inhibitory aptamer. Mol. Ther. 20, 2291-2303 (2012
    • (2012) Mol. Ther , vol.20 , pp. 2291-2303
    • Cerchia, L.1
  • 176
    • 79952220537 scopus 로고    scopus 로고
    • Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer
    • Avilla, E. et al. Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer. Cancer Res. 71, 1792-1804 (2011
    • (2011) Cancer Res , vol.71 , pp. 1792-1804
    • Avilla, E.1
  • 177
    • 33846872571 scopus 로고    scopus 로고
    • A soluble form of the MER receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation
    • Sather, S. et al. A soluble form of the MER receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood 109, 1026-1033 (2007
    • (2007) Blood , vol.109 , pp. 1026-1033
    • Sather, S.1
  • 178
    • 79955051520 scopus 로고    scopus 로고
    • The soluble serum protein GAS6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase AXL to mediate viral entry
    • Morizono, K. et al. The soluble serum protein GAS6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase AXL to mediate viral entry. Cell Host Microbe 9, 286-298 (2011
    • (2011) Cell Host Microbe , vol.9 , pp. 286-298
    • Morizono, K.1
  • 179
    • 33749464038 scopus 로고    scopus 로고
    • TYRO3 family-mediated cell entry of Ebola and Marburg viruses
    • Shimojima, M. et al. TYRO3 family-mediated cell entry of Ebola and Marburg viruses. J. Virol. 80, 10109-10116 (2006
    • (2006) J. Virol , vol.80 , pp. 10109-10116
    • Shimojima, M.1
  • 180
    • 84896955320 scopus 로고    scopus 로고
    • The role of phosphatidylserine receptors in enveloped virus infection
    • Morizono, K. & Chen, I. S. The role of phosphatidylserine receptors in enveloped virus infection. J. Virol. 88, 4275-4290 (2014
    • (2014) J. Virol , vol.88 , pp. 4275-4290
    • Morizono, K.1    Chen, I.S.2
  • 181
    • 84867647748 scopus 로고    scopus 로고
    • The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry
    • Meertens, L. et al. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe 12, 544-557 (2012
    • (2012) Cell Host Microbe , vol.12 , pp. 544-557
    • Meertens, L.1
  • 182
    • 78650648219 scopus 로고    scopus 로고
    • Impaired apoptotic cell clearance in the germinal center by MER-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses
    • Rahman, Z. S., Shao, W. H., Khan, T. N., Zhen, Y. & Cohen, P. L. Impaired apoptotic cell clearance in the germinal center by MER-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses. J. Immunol. 185, 5859-5868 (2010
    • (2010) J. Immunol , vol.185 , pp. 5859-5868
    • Rahman, Z.S.1    Shao, W.H.2    Khan, T.N.3    Zhen, Y.4    Cohen, P.L.5
  • 183
    • 77953644519 scopus 로고    scopus 로고
    • Increased hematopoietic cells in the Mertk-/- mouse peritoneal cavity: A result of augmented migration
    • Williams, J. C., Wagner, N. J., Earp, H. S., Vilen, B. J. & Matsushima, G. K. Increased hematopoietic cells in the Mertk-/- mouse peritoneal cavity: a result of augmented migration. J. Immunol. 184, 6637-6648 (2010
    • (2010) J. Immunol , vol.184 , pp. 6637-6648
    • Williams, J.C.1    Wagner, N.J.2    Earp, H.S.3    Vilen, B.J.4    Matsushima, G.K.5
  • 184
    • 79955836709 scopus 로고    scopus 로고
    • Loss of the receptor tyrosine kinase AXL leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis
    • Weinger, J. G. et al. Loss of the receptor tyrosine kinase AXL leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis. J. Neuroinflamm. 8, 49 (2011
    • (2011) J. Neuroinflamm , vol.8 , Issue.49
    • Weinger, J.G.1
  • 185
    • 84896786643 scopus 로고    scopus 로고
    • An AXL/LRP1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo
    • Subramanian, M. et al. An AXL/LRP1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. J. Clin. Invest. 124, 1296-1308 (2014
    • (2014) J. Clin. Invest , vol.124 , pp. 1296-1308
    • Subramanian, M.1
  • 186
    • 84881426249 scopus 로고    scopus 로고
    • Paradoxical role of the proto-oncogene AXL and MER receptor tyrosine kinases in colon cancer
    • Bosurgi, L. et al. Paradoxical role of the proto-oncogene AXL and MER receptor tyrosine kinases in colon cancer. Proc. Natl Acad. Sci. USA 110, 13091-13096 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 13091-13096
    • Bosurgi, L.1
  • 187
    • 62949223266 scopus 로고    scopus 로고
    • TAM receptors and the regulation of erythropoiesis in mice
    • Tang, H. et al. TAM receptors and the regulation of erythropoiesis in mice. Haematologica 94, 326-334 (2009
    • (2009) Haematologica , vol.94 , pp. 326-334
    • Tang, H.1
  • 188
    • 0033594411 scopus 로고    scopus 로고
    • TYRO3 family receptors are essential regulators of mammalian spermatogenesis
    • Lu, Q. et al. TYRO3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398, 723-728 (1999
    • (1999) Nature , vol.398 , pp. 723-728
    • Lu, Q.1
  • 189
    • 84879273566 scopus 로고    scopus 로고
    • Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death
    • Li, Q., Lu, Q., Lu, H., Tian, S. & Lu, Q. Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death. PLoS ONE 8, e64812 (2013
    • (2013) PLoS ONE , vol.8 , pp. e64812
    • Li, Q.1    Lu, Q.2    Lu, H.3    Tian, S.4    Lu, Q.5
  • 190
    • 84879155277 scopus 로고    scopus 로고
    • Development of a spontaneous liver disease resembling autoimmune hepatitis in mice lacking tyro3 axl and mer receptor tyrosine kinases
    • Qi, N. et al. Development of a spontaneous liver disease resembling autoimmune hepatitis in mice lacking TYRO3, AXL and MER receptor tyrosine kinases. PLoS ONE 8, e66604 (2013
    • (2013) PLoS ONE , vol.8 , pp. e66604
    • Qi, N.1
  • 191
    • 33745208276 scopus 로고    scopus 로고
    • Natural killer cell differentiation driven by TYRO3 receptor tyrosine kinases
    • Caraux, A. et al. Natural killer cell differentiation driven by TYRO3 receptor tyrosine kinases. Nature Immunol. 7, 747-754 (2006
    • (2006) Nature Immunol , vol.7 , pp. 747-754
    • Caraux, A.1
  • 192
    • 34447343841 scopus 로고    scopus 로고
    • The role of TYRO 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis
    • Wang, H. et al. The role of TYRO 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis. Haematologica 92, 643-650 (2007
    • (2007) Haematologica , vol.92 , pp. 643-650
    • Wang, H.1
  • 193
    • 45549108475 scopus 로고    scopus 로고
    • GAS6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    • Binder, M. D. et al. GAS6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination. J. Neurosci. 28, 5195-5206 (2008
    • (2008) J. Neurosci , vol.28 , pp. 5195-5206
    • Binder, M.D.1
  • 194
    • 79952506823 scopus 로고    scopus 로고
    • GAS6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination
    • Binder, M. D. et al. GAS6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination. PLoS ONE 6, e17727 (2011
    • (2011) PLoS ONE , vol.6 , pp. e17727
    • Binder, M.D.1
  • 195
    • 79957955754 scopus 로고    scopus 로고
    • GAS6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice
    • Fourcot, A. et al. GAS6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice. Am. J. Physiol-Gaster. L. 300, G1043-G1053 (2011
    • (2011) Am. J. Physiol-Gaster L. , vol.300 , pp. G1043-G1053
    • Fourcot, A.1
  • 196
    • 0032759729 scopus 로고    scopus 로고
    • Retinal degeneration in Tulp1-/- mice: Vesicular accumulation in the interphotoreceptor matrix
    • Hagstrom, S. A., Duyao, M., North, M. A. & Li, T. Retinal degeneration in Tulp1-/- mice: vesicular accumulation in the interphotoreceptor matrix. Invest. Ophthalmol. Vis. Sci. 40, 2795-2802 (1999
    • (1999) Invest. Ophthalmol. Vis. Sci , vol.40 , pp. 2795-2802
    • Hagstrom, S.A.1    Duyao, M.2    North, M.A.3    Li, T.4
  • 197
    • 0033971939 scopus 로고    scopus 로고
    • Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss of function mutation
    • Stubdal, H. et al. Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss of function mutation. Mol. Cell. Biol. 20, 878-882 (2000
    • (2000) Mol. Cell. Biol , vol.20 , pp. 878-882
    • Stubdal, H.1
  • 198
    • 0042388118 scopus 로고    scopus 로고
    • Critical role of galectin 3 in phagocytosis by macrophages
    • Sano, H. et al. Critical role of galectin 3 in phagocytosis by macrophages. J. Clin. Invest. 112, 389-397 (2003
    • (2003) J. Clin. Invest , vol.112 , pp. 389-397
    • Sano, H.1
  • 199
    • 43449131256 scopus 로고    scopus 로고
    • Targeted disruption of the galectin 3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: An oligonucleotide microarray study
    • Abdel-Aziz, H. O. et al. Targeted disruption of the galectin 3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study. J. Cancer Res. Clin. Oncol. 134, 777-788 (2008
    • (2008) J. Cancer Res. Clin. Oncol , vol.134 , pp. 777-788
    • Abdel-Aziz, H.O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.