A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

Nature

Volumn 481, Issue 7380, 2012, Pages 190-196

  Png, Kim J ^a   Halberg, Nils ^a   Yoshida, Mitsukuni ^a   Tavazoie, Sohail F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C MER TYROSINE KINASE RECEPTOR; GROWTH ARREST SPECIFIC PROTEIN 6; MICRORNA; MICRORNA 126; PITPNC1 PROTEIN; PROTEIN; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

BIOCHEMISTRY; BIOMARKER; BONE; CANCER; ENZYME ACTIVITY; MOLECULAR ANALYSIS; PROTEIN; PUBLIC HEALTH; RNA; TUMOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL; CELL INTERACTION; CONTROLLED STUDY; ENDOTHELIUM CELL; EPISTASIS; FEMALE; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; METASTASIS; METASTATIC BREAST CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

ANIMALS; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; ENDOTHELIUM, VASCULAR; EPISTASIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; LUNG NEOPLASMS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED NOD; MICE, SCID; MICRORNAS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, IGF TYPE 1; REGULON; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS;

EID: 84855813448     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10661     Document Type: Article

References (18)

1. Chiang, A. C. & Massague, J. Molecular basis of metastasis. N. Engl. J. Med. 359, 2814-2823 (2008).
2. Talmadge, J. E. & Fidler, I. J. AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res. 70, 5649-5669 (2010).
3. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
4. Valastyan, S. & Weinberg, R. A. MicroRNAs: crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle 8, 3506-3512 (2009).
5. Tavazoie, S. F. et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451, 147-152 (2008).
6. Png, K. J. et al. MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev. 25, 226-231 (2011).
7. Guo, C. et al. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosom. Cancer 47, 939-946 (2008).
8. Feng, R. et al. miR-126 functions as a tumour suppressor in humangastric cancer. Cancer Lett. 298, 50-63 (2010).
9. Gupta, G. P. et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 446, 765-770 (2007). (Pubitemid 46582040)
10. Jones, J. I.&Clemmons, D. R. Insulin-like growth factorsandtheir binding proteins: biological actions. Endocr. Rev. 16, 3-34 (1995).
11. Balogh, I. et al. Analysis of Gas6 in human platelets and plasma. Arterioscler. Thromb. Vasc. Biol. 25, 1280-1286 (2005). (Pubitemid 40776622)
12. Sather, S. et al. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood 109, 1026-1033 (2007). (Pubitemid 46220648)
13. Minn, A. J. et al. Genes that mediate breast cancer metastasis to lung. Nature 436, 518-524 (2005). (Pubitemid 41112921)
14. Kang, Y. et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3, 537-549 (2003). (Pubitemid 36808649)
15. Yin, J. J. et al. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J. Clin. Invest. 103, 197-206 (1999). (Pubitemid 29053137)
16. Arnold, S. A. et al. Lack of host SPARC enhances vascular function and tumor spread in an orthotopicmurinemodel of pancreatic carcinoma. Dis Model Mech 3, 57-72 (2010).
17. Chin, K. et al. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 10, 529-541 (2006). (Pubitemid 44854748)
18. Wang, Y. et al. Gene-expression profiles to predict distant metastasis of lymphnode-negative primary breast cancer. Lancet 365, 671-679 (2005). (Pubitemid 40260888)